Details for: VAMP8

Gene ID: 8673

Symbol: VAMP8

Ensembl ID: ENSG00000118640

Description: vesicle associated membrane protein 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 207.9138
    Cell Significance Index: -32.3400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 124.4532
    Cell Significance Index: -50.5600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 123.0375
    Cell Significance Index: -50.6900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 103.9243
    Cell Significance Index: -49.0700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 103.1328
    Cell Significance Index: -53.0500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 72.6578
    Cell Significance Index: -48.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 54.2240
    Cell Significance Index: -51.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.6053
    Cell Significance Index: -37.7400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.4296
    Cell Significance Index: -44.3200
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 11.4334
    Cell Significance Index: 86.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.7475
    Cell Significance Index: -42.4100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 10.7008
    Cell Significance Index: 286.2400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 9.6284
    Cell Significance Index: 59.2600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 9.0420
    Cell Significance Index: 83.2700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 9.0279
    Cell Significance Index: 95.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 7.8160
    Cell Significance Index: 364.4200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.2787
    Cell Significance Index: -15.9300
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 7.0229
    Cell Significance Index: 39.0900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 6.0651
    Cell Significance Index: 112.1000
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 5.5752
    Cell Significance Index: 35.5900
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 5.3993
    Cell Significance Index: 35.8200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 4.8354
    Cell Significance Index: 111.7200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.5667
    Cell Significance Index: 134.1200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.2518
    Cell Significance Index: 199.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.2277
    Cell Significance Index: 272.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.7809
    Cell Significance Index: 281.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.4384
    Cell Significance Index: 93.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.2582
    Cell Significance Index: 587.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.0553
    Cell Significance Index: 158.7200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 3.0339
    Cell Significance Index: 26.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.9335
    Cell Significance Index: 360.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.2519
    Cell Significance Index: 1229.8400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.1264
    Cell Significance Index: 250.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.0670
    Cell Significance Index: 267.0500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.9498
    Cell Significance Index: 137.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.8194
    Cell Significance Index: 804.4100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.7832
    Cell Significance Index: 26.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.7398
    Cell Significance Index: 172.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.5410
    Cell Significance Index: 106.5700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2449
    Cell Significance Index: 33.2400
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.2278
    Cell Significance Index: 5.1100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.1169
    Cell Significance Index: 6.9400
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.9762
    Cell Significance Index: 20.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6174
    Cell Significance Index: 105.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5907
    Cell Significance Index: 26.7800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5674
    Cell Significance Index: 4.5300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5299
    Cell Significance Index: 105.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.4863
    Cell Significance Index: 368.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3211
    Cell Significance Index: 61.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.2773
    Cell Significance Index: 173.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2507
    Cell Significance Index: 72.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2497
    Cell Significance Index: 7.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1950
    Cell Significance Index: 5.4500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1700
    Cell Significance Index: 124.6400
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.0929
    Cell Significance Index: 0.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0463
    Cell Significance Index: 4.7300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0336
    Cell Significance Index: 3.8400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0031
    Cell Significance Index: -2.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0105
    Cell Significance Index: -19.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0186
    Cell Significance Index: -34.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0250
    Cell Significance Index: -38.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0291
    Cell Significance Index: -39.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0520
    Cell Significance Index: -29.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0559
    Cell Significance Index: -35.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0567
    Cell Significance Index: -4.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0705
    Cell Significance Index: -25.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0881
    Cell Significance Index: -18.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0920
    Cell Significance Index: -10.5400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0928
    Cell Significance Index: -2.3700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0947
    Cell Significance Index: -0.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1079
    Cell Significance Index: -48.9700
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.1101
    Cell Significance Index: -0.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1246
    Cell Significance Index: -3.9900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1301
    Cell Significance Index: -21.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1579
    Cell Significance Index: -21.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1747
    Cell Significance Index: -35.0500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2053
    Cell Significance Index: -10.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2061
    Cell Significance Index: -24.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2250
    Cell Significance Index: -3.0700
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: -0.2387
    Cell Significance Index: -0.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3064
    Cell Significance Index: -44.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3096
    Cell Significance Index: -39.6900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3671
    Cell Significance Index: -15.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3962
    Cell Significance Index: -41.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4170
    Cell Significance Index: -32.0000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4571
    Cell Significance Index: -7.8800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5262
    Cell Significance Index: -27.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5557
    Cell Significance Index: -12.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6782
    Cell Significance Index: -45.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6985
    Cell Significance Index: -17.4600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7285
    Cell Significance Index: -15.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7529
    Cell Significance Index: -46.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7530
    Cell Significance Index: -46.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7923
    Cell Significance Index: -44.4600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.7984
    Cell Significance Index: -1.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8084
    Cell Significance Index: -28.0900
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.8370
    Cell Significance Index: -7.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8709
    Cell Significance Index: -54.8900
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.8722
    Cell Significance Index: -5.3900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8742
    Cell Significance Index: -25.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** VAMP8 is a member of the VAMP (Vesicle-Associated Membrane Protein) family, which consists of proteins that are involved in the formation and fusion of vesicles. VAMP8 is a small protein that is approximately 100 amino acids in length and contains a characteristic VAMP domain. The protein is highly conserved across species, suggesting that it plays a critical role in cellular processes. VAMP8 is also a member of the SNARE complex, which is a group of proteins that are involved in the fusion of vesicles with target membranes. **Pathways and Functions** VAMP8 is involved in several cellular pathways, including: 1. **Vesicle trafficking**: VAMP8 is involved in the formation and fusion of vesicles, which are essential for the transport of proteins and lipids within cells. 2. **Protein transport**: VAMP8 plays a critical role in the transport of proteins between different compartments within cells, including the endoplasmic reticulum, Golgi apparatus, and lysosomes. 3. **Immune system function**: VAMP8 is involved in the regulation of immune responses, particularly in the context of antigen presentation and processing. The protein is expressed in immune cells such as monocytes and macrophages, and is involved in the formation and fusion of vesicles that contain antigens. 4. **Antigen processing and presentation**: VAMP8 is involved in the processing and presentation of antigens to T-cells, which is a critical step in the initiation of an immune response. 5. **Autophagy**: VAMP8 is also involved in the regulation of autophagy, a process by which cells recycle damaged or dysfunctional proteins and organelles. **Clinical Significance** VAMP8 has been implicated in several diseases, including: 1. **Autoimmune disorders**: VAMP8 has been implicated in the pathogenesis of autoimmune disorders such as rheumatoid arthritis and lupus, where dysregulation of immune responses leads to tissue damage and inflammation. 2. **Cancer**: VAMP8 has been found to be overexpressed in certain types of cancer, including breast and lung cancer, where it may contribute to tumor progression and metastasis. 3. **Neurodegenerative diseases**: VAMP8 has been implicated in the pathogenesis of neurodegenerative diseases such as Alzheimer's and Parkinson's disease, where dysregulation of immune responses and autophagy contribute to disease progression. In conclusion, VAMP8 is a gene that encodes a protein involved in various cellular processes, including vesicle trafficking, protein transport, and immune system function. The gene is significantly expressed in multiple cell types and is involved in the regulation of immune responses, particularly in the context of antigen presentation and processing. Further research is needed to fully understand the role of VAMP8 in human disease and to develop potential therapeutic strategies.

Genular Protein ID: 1863063411

Symbol: VAMP8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9614193

Title: Endobrevin, a novel synaptobrevin/VAMP-like protein preferentially associated with the early endosome.

PubMed ID: 9614193

DOI: 10.1091/mbc.9.6.1549

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12130530

Title: Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion.

PubMed ID: 12130530

DOI: 10.1182/blood.v100.3.1081

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23217709

Title: The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes.

PubMed ID: 23217709

DOI: 10.1016/j.cell.2012.11.001

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25648148

Title: Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion.

PubMed ID: 25648148

DOI: 10.15252/embr.201439464

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 31806350

Title: The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1.

PubMed ID: 31806350

DOI: 10.1016/j.molcel.2019.10.035

PubMed ID: 33422265

Title: ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation.

PubMed ID: 33422265

DOI: 10.1016/j.devcel.2020.12.010

PubMed ID: 31694946

Title: VAMP8 Contributes to the TRIM6-Mediated Type I Interferon Antiviral Response during West Nile Virus Infection.

PubMed ID: 31694946

DOI: 10.1128/jvi.01454-19

PubMed ID: 30061757

Title: Nepsilon-fatty acylation of multiple membrane-associated proteins by Shigella IcsB effector to modulate host function.

PubMed ID: 30061757

DOI: 10.1038/s41564-018-0215-6

PubMed ID: 25686604

Title: ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes.

PubMed ID: 25686604

DOI: 10.1038/nature14147

Sequence Information:

  • Length: 100
  • Mass: 11438
  • Checksum: 018B986442BBD9B6
  • Sequence:
  • MEEASEGGGN DRVRNLQSEV EGVKNIMTQN VERILARGEN LEHLRNKTED LEATSEHFKT 
    TSQKVARKFW WKNVKMIVLI CVIVFIIILF IVLFATGAFS

Genular Protein ID: 2800197288

Symbol: B8ZZT4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 99
  • Mass: 11192
  • Checksum: B10BC86EE764B9A8
  • Sequence:
  • MEEASEGGGN DRVRNLQSEV EGVKNIMTQN VERILARGEN LEHLRNKTED LEATPGAEAS 
    CFREEVTPKL SKVWSLKFCV QRGGWLWLSE SCVNSWLLV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.