Details for: STX16

Gene ID: 8675

Symbol: STX16

Ensembl ID: ENSG00000124222

Description: syntaxin 16

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 220.2575
    Cell Significance Index: -34.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 125.4123
    Cell Significance Index: -31.8100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 76.2726
    Cell Significance Index: -36.0100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 74.8910
    Cell Significance Index: -30.4300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 67.0218
    Cell Significance Index: -34.4800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 32.2338
    Cell Significance Index: -30.7800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.7292
    Cell Significance Index: -45.2400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.9902
    Cell Significance Index: -32.1200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.3714
    Cell Significance Index: -36.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.3925
    Cell Significance Index: 688.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.2832
    Cell Significance Index: 458.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.7370
    Cell Significance Index: 1568.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3736
    Cell Significance Index: 105.4100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.3708
    Cell Significance Index: 51.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.3586
    Cell Significance Index: 60.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.2809
    Cell Significance Index: 71.8800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2329
    Cell Significance Index: 134.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.2215
    Cell Significance Index: 63.6300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2081
    Cell Significance Index: 72.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1677
    Cell Significance Index: 418.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1041
    Cell Significance Index: 179.5700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.0457
    Cell Significance Index: 8.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9466
    Cell Significance Index: 170.6400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9433
    Cell Significance Index: 25.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8768
    Cell Significance Index: 120.4100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7875
    Cell Significance Index: 50.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7518
    Cell Significance Index: 46.2100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7354
    Cell Significance Index: 16.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7227
    Cell Significance Index: 37.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7194
    Cell Significance Index: 88.4600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6506
    Cell Significance Index: 45.0000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.6367
    Cell Significance Index: 15.2700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.6360
    Cell Significance Index: 13.6000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.6159
    Cell Significance Index: 31.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6070
    Cell Significance Index: 28.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5468
    Cell Significance Index: 298.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5400
    Cell Significance Index: 11.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4824
    Cell Significance Index: 47.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4677
    Cell Significance Index: 13.4800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3551
    Cell Significance Index: 4.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3353
    Cell Significance Index: 15.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2853
    Cell Significance Index: 54.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2751
    Cell Significance Index: 121.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2597
    Cell Significance Index: 33.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2509
    Cell Significance Index: 29.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1975
    Cell Significance Index: 8.9500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1642
    Cell Significance Index: 4.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1577
    Cell Significance Index: 26.9200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1445
    Cell Significance Index: 2.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1096
    Cell Significance Index: 3.8500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0806
    Cell Significance Index: 5.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0064
    Cell Significance Index: 0.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0027
    Cell Significance Index: -0.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0106
    Cell Significance Index: -7.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0145
    Cell Significance Index: -10.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0146
    Cell Significance Index: -26.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0150
    Cell Significance Index: -28.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0154
    Cell Significance Index: -23.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0180
    Cell Significance Index: -24.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0231
    Cell Significance Index: -17.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0238
    Cell Significance Index: -14.8800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0255
    Cell Significance Index: -0.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0405
    Cell Significance Index: -4.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0461
    Cell Significance Index: -26.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0513
    Cell Significance Index: -32.5700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0559
    Cell Significance Index: -0.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0625
    Cell Significance Index: -12.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0661
    Cell Significance Index: -3.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0718
    Cell Significance Index: -32.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0768
    Cell Significance Index: -16.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0825
    Cell Significance Index: -9.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0925
    Cell Significance Index: -6.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0990
    Cell Significance Index: -7.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1298
    Cell Significance Index: -15.1300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1331
    Cell Significance Index: -3.9100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1557
    Cell Significance Index: -2.6100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1655
    Cell Significance Index: -1.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2215
    Cell Significance Index: -32.2000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2246
    Cell Significance Index: -25.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2665
    Cell Significance Index: -7.6400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3166
    Cell Significance Index: -4.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3534
    Cell Significance Index: -36.8000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3914
    Cell Significance Index: -31.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4320
    Cell Significance Index: -9.2000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4373
    Cell Significance Index: -15.2000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4435
    Cell Significance Index: -5.5300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4667
    Cell Significance Index: -8.0700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5128
    Cell Significance Index: -13.1000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5252
    Cell Significance Index: -10.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5264
    Cell Significance Index: -16.8600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5333
    Cell Significance Index: -13.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5381
    Cell Significance Index: -36.1800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.5383
    Cell Significance Index: -7.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5751
    Cell Significance Index: -35.2600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.6410
    Cell Significance Index: -8.0900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7203
    Cell Significance Index: -26.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7381
    Cell Significance Index: -19.7500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7495
    Cell Significance Index: -24.5400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8148
    Cell Significance Index: -22.7700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.8243
    Cell Significance Index: -18.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** STX16 is a soluble syntaxin protein that shares structural homology with other syntaxins, including syntaxin-1 (STX1A) and syntaxin-2 (STX2). Its primary function is to facilitate the fusion of vesicles with the plasma membrane, a process crucial for neurotransmission and immune cell function. STX16 is specifically expressed in various neuronal populations, including astrocytes, GABAergic neurons, and cortical interneurons, suggesting a role in the regulation of neural circuitry. **Pathways and Functions:** STX16 is involved in several key cellular pathways, including: 1. **Endocytic recycling:** STX16 facilitates the recycling of endosomes to the Golgi apparatus, ensuring the proper sorting and processing of membrane proteins. 2. **Golgi apparatus function:** STX16 regulates the trafficking of proteins within the Golgi apparatus, including the transport of vesicles and the formation of vesicle-containing compartments. 3. **Synaptic transmission:** STX16 plays a critical role in the fusion of synaptic vesicles with the plasma membrane, allowing for the release of neurotransmitters and the transmission of neural signals. 4. **Immune cell function:** STX16 is expressed in immune cells, including dendritic cells and T cells, where it regulates the trafficking of vesicles and the formation of immune synapses. **Clinical Significance:** Dysregulation of STX16 has been implicated in various immunological disorders, including: 1. **Autoimmune diseases:** Alterations in STX16 expression and function have been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Neurodegenerative disorders:** STX16 has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, where impaired synaptic transmission and vesicle trafficking contribute to disease progression. 3. **Cancer:** STX16 has been found to be overexpressed in certain types of cancer, including glioblastoma and breast cancer, where it promotes tumor growth and metastasis. In conclusion, STX16 plays a critical role in regulating cellular trafficking and synaptic transmission, with implications for immunological disorders and neurodegenerative diseases. Further research is needed to fully elucidate the functions and dysregulations of STX16 in human health and disease. **References:** * [Insert relevant references to support the discussion] **Future Directions:** * Investigate the specific mechanisms by which STX16 regulates endocytic recycling and Golgi apparatus function. * Explore the role of STX16 in the development and progression of autoimmune diseases and neurodegenerative disorders. * Investigate the potential therapeutic applications of STX16 as a target for the treatment of immunological disorders and neurodegenerative diseases.

Genular Protein ID: 3386260784

Symbol: STX16_HUMAN

Name: Syntaxin-16

UniProtKB Accession Codes:

O14662 A6NK32 A6NN69 A8MPP0 B7ZBN1 B7ZBN2 B7ZBN3 E1P5M0 E1P607 O14661 O14663 O60517 Q5W084 Q5W086 Q5W087 Q5XKI6 Q6GMS8 Q9H0Z0 Q9H1T7 Q9H1T8 Q9UIX5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CORUM 1 CTD 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 6 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9587053

Title: Syntaxin-16, a putative Golgi t-SNARE.

PubMed ID: 9587053

DOI: 10.1016/s0171-9335(98)80116-7

PubMed ID: 9464276

Title: Molecular cloning and localization of human syntaxin 16, a member of the syntaxin family of SNARE proteins.

PubMed ID: 9464276

DOI: 10.1006/bbrc.1997.8029

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14561710

Title: Autosomal dominant pseudohypoparathyroidism type Ib is associated with a heterozygous microdeletion that likely disrupts a putative imprinting control element of GNAS.

PubMed ID: 14561710

DOI: 10.1172/jci19159

PubMed ID: 15800843

Title: A novel STX16 deletion in autosomal dominant pseudohypoparathyroidism type Ib redefines the boundaries of a cis-acting imprinting control element of GNAS.

PubMed ID: 15800843

DOI: 10.1086/429932

PubMed ID: 18195106

Title: A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells.

PubMed ID: 18195106

DOI: 10.1083/jcb.200707136

PubMed ID: 28626000

Title: BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells.

PubMed ID: 28626000

DOI: 10.1083/jcb.201702099

Sequence Information:

  • Length: 325
  • Mass: 37031
  • Checksum: 65F566541A042C3C
  • Sequence:
    • MATRRLTDAF LLLRNNSIQN RQLLAEQVSS HITSSPLHSR SIAAELDELA DDRMALVSGI 
SLDPEAAIGV TKRPPPKWVD GVDEIQYDVG RIKQKMKELA SLHDKHLNRP TLDDSSEEEH 
AIEITTQEIT QLFHRCQRAV QALPSRARAC SEQEGRLLGN VVASLAQALQ ELSTSFRHAQ 
SGYLKRMKNR EERSQHFFDT SVPLMDDGDD NTLYHRGFTE DQLVLVEQNT LMVEEREREI 
RQIVQSISDL NEIFRDLGAM IVEQGTVLDR IDYNVEQSCI KTEDGLKQLH KAEQYQKKNR 
KMLVILILFV IIIVLIVVLV GVKSR

Genular Protein ID: 3114214888

Symbol: B4DJX9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DJX9

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 6 GO 7 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 139
  • Mass: 16278
  • Checksum: E5666CDBB006EDD9
  • Sequence:
    • MKNREERSQH FFDTSVPLMD DGDDNTLYHR GFTEDQLVLV EQNTLMVEER EREIRQIVQS 
ISDLNEIFRD LGAMIVEQGT VLDRIDYNVE QSCIKTEDGL KQLHKAEQYQ KKNRKMLVIL 
ILFVIIIVLI VVLVGVKSR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.