Details for: CTSF

Gene ID: 8722

Symbol: CTSF

Ensembl ID: ENSG00000174080

Description: cathepsin F

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 216.4001
    Cell Significance Index: -33.6600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 122.2780
    Cell Significance Index: -31.0200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 70.0242
    Cell Significance Index: -33.0600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.3002
    Cell Significance Index: -33.6600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.0163
    Cell Significance Index: -32.1900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.5313
    Cell Significance Index: -33.6700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 7.1671
    Cell Significance Index: 114.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.8027
    Cell Significance Index: 252.1600
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.2506
    Cell Significance Index: 24.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.5164
    Cell Significance Index: 215.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.5081
    Cell Significance Index: 116.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.6771
    Cell Significance Index: 214.9900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.6377
    Cell Significance Index: 20.3100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.3454
    Cell Significance Index: 10.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0682
    Cell Significance Index: 29.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9780
    Cell Significance Index: 134.3100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.9152
    Cell Significance Index: 14.5200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8989
    Cell Significance Index: 24.0900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.8730
    Cell Significance Index: 11.1800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.8649
    Cell Significance Index: 5.8600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7179
    Cell Significance Index: 92.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6688
    Cell Significance Index: 134.1600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6360
    Cell Significance Index: 22.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6135
    Cell Significance Index: 553.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5936
    Cell Significance Index: 44.2400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5292
    Cell Significance Index: 15.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5276
    Cell Significance Index: 33.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4273
    Cell Significance Index: 153.2800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.4205
    Cell Significance Index: 6.9300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4151
    Cell Significance Index: 67.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3982
    Cell Significance Index: 176.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3460
    Cell Significance Index: 37.6300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2639
    Cell Significance Index: 6.9400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2312
    Cell Significance Index: 13.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2298
    Cell Significance Index: 16.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1884
    Cell Significance Index: 18.6400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1686
    Cell Significance Index: 2.0100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1650
    Cell Significance Index: 114.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1504
    Cell Significance Index: 25.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1466
    Cell Significance Index: 27.8900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1050
    Cell Significance Index: 1.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0612
    Cell Significance Index: 44.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0588
    Cell Significance Index: 4.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0430
    Cell Significance Index: 2.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0285
    Cell Significance Index: 3.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0229
    Cell Significance Index: 12.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0213
    Cell Significance Index: 40.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0023
    Cell Significance Index: -3.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0038
    Cell Significance Index: -0.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0075
    Cell Significance Index: -13.8000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0125
    Cell Significance Index: -0.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0127
    Cell Significance Index: -0.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0129
    Cell Significance Index: -8.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0135
    Cell Significance Index: -9.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0167
    Cell Significance Index: -0.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0170
    Cell Significance Index: -23.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0241
    Cell Significance Index: -4.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0258
    Cell Significance Index: -2.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0259
    Cell Significance Index: -16.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0292
    Cell Significance Index: -16.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0300
    Cell Significance Index: -5.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0311
    Cell Significance Index: -0.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0380
    Cell Significance Index: -28.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0514
    Cell Significance Index: -23.3500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0556
    Cell Significance Index: -0.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0706
    Cell Significance Index: -1.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0859
    Cell Significance Index: -3.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0927
    Cell Significance Index: -19.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0952
    Cell Significance Index: -27.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1093
    Cell Significance Index: -7.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1434
    Cell Significance Index: -16.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1441
    Cell Significance Index: -20.9400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1514
    Cell Significance Index: -3.1700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1655
    Cell Significance Index: -3.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1766
    Cell Significance Index: -9.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1805
    Cell Significance Index: -21.0400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1945
    Cell Significance Index: -22.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2755
    Cell Significance Index: -32.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2838
    Cell Significance Index: -7.9300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3066
    Cell Significance Index: -4.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3108
    Cell Significance Index: -32.3600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3201
    Cell Significance Index: -6.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3344
    Cell Significance Index: -17.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3520
    Cell Significance Index: -27.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4042
    Cell Significance Index: -31.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4087
    Cell Significance Index: -13.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4337
    Cell Significance Index: -27.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4355
    Cell Significance Index: -19.2700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4377
    Cell Significance Index: -12.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4442
    Cell Significance Index: -6.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4869
    Cell Significance Index: -13.0000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5008
    Cell Significance Index: -14.7500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5082
    Cell Significance Index: -26.4700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.5159
    Cell Significance Index: -10.7600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5319
    Cell Significance Index: -9.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5441
    Cell Significance Index: -20.6100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.5560
    Cell Significance Index: -4.6700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6073
    Cell Significance Index: -15.6100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6459
    Cell Significance Index: -15.4900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7115
    Cell Significance Index: -22.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Cathepsin F is a member of the cathepsin family, which is characterized by its lysosomal localization and cysteine protease activity. CTSF is a type II transmembrane protein, with a large extracellular domain that contains a collagen-like domain and a small intracellular domain that interacts with the lysosomal membrane. The gene encoding CTSF is highly conserved across species, suggesting its importance in evolution. CTSF is also known to be involved in the processing and presentation of exogenous antigens via MHC class II molecules, making it a key player in the adaptive immune response. **Pathways and Functions:** CTSF is involved in several key pathways, including: 1. **Antigen processing and presentation of exogenous peptide antigen via MHC class II**: CTSF is responsible for the processing and presentation of exogenous antigens to CD4+ T cells via MHC class II molecules. 2. **Proteolysis**: CTSF is a lysosomal cysteine protease that cleaves and degrades proteins, playing a crucial role in protein degradation and turnover. 3. **Immune system regulation**: CTSF is involved in the regulation of immune responses, including the activation and differentiation of immune cells. 4. **Endoplasmic reticulum and Golgi apparatus**: CTSF is also involved in the processing and maturation of proteins in the endoplasmic reticulum and Golgi apparatus. **Clinical Significance:** Dysregulation of CTSF has been implicated in several diseases, including: 1. **Autoimmune disorders**: CTSF has been implicated in the pathogenesis of autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: CTSF is overexpressed in several types of cancer, including breast, lung, and prostate cancer, and has been shown to promote tumor progression and metastasis. 3. **Neurological disorders**: CTSF has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, Cathepsin F is a multifaceted gene that plays a crucial role in immune regulation, antigen presentation, and protein degradation. Its dysregulation has been implicated in several diseases, highlighting the importance of understanding the mechanisms of CTSF in normal and diseased states. Further research is needed to fully elucidate the role of CTSF in human health and disease.

Genular Protein ID: 2123590231

Symbol: CATF_HUMAN

Name: Cathepsin F

UniProtKB Accession Codes:

Q9UBX1 B2R964 O95240 Q9NSU4 Q9UKQ5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EC 2 EMBL 10 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10318784

Title: Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain.

PubMed ID: 10318784

DOI: 10.1074/jbc.274.20.13800

PubMed ID: 10198209

Title: Full-length cDNA of human cathepsin F predicts the presence of a cystatin domain at the N-terminus of the cysteine protease zymogen.

PubMed ID: 10198209

DOI: 10.1006/bbrc.1999.0461

PubMed ID: 10661872

Title: The human cathepsin F gene -- a fusion product between an ancestral cathepsin and cystatin gene.

PubMed ID: 10661872

DOI: 10.1515/bc.1999.185

PubMed ID: 10362521

Title: Human cathepsins F and W: a new subgroup of cathepsins.

PubMed ID: 10362521

DOI: 10.1006/bbrc.1999.0700

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9822672

Title: Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization.

PubMed ID: 9822672

DOI: 10.1074/jbc.273.48.32000

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 12225749

Title: The crystal structure of human cathepsin F and its implications for the development of novel immunomodulators.

PubMed ID: 12225749

DOI: 10.1016/s0022-2836(02)00780-5

PubMed ID: 23297359

Title: Cathepsin F mutations cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis.

PubMed ID: 23297359

DOI: 10.1093/hmg/dds558

Sequence Information:

  • Length: 484
  • Mass: 53366
  • Checksum: 1D5D551B489D822B
  • Sequence:
    • MAPWLQLLSL LGLLPGAVAA PAQPRAASFQ AWGPPSPELL APTRFALEMF NRGRAAGTRA 
VLGLVRGRVR RAGQGSLYSL EATLEEPPCN DPMVCRLPVS KKTLLCSFQV LDELGRHVLL 
RKDCGPVDTK VPGAGEPKSA FTQGSAMISS LSQNHPDNRN ETFSSVISLL NEDPLSQDLP 
VKMASIFKNF VITYNRTYES KEEARWRLSV FVNNMVRAQK IQALDRGTAQ YGVTKFSDLT 
EEEFRTIYLN TLLRKEPGNK MKQAKSVGDL APPEWDWRSK GAVTKVKDQG MCGSCWAFSV 
TGNVEGQWFL NQGTLLSLSE QELLDCDKMD KACMGGLPSN AYSAIKNLGG LETEDDYSYQ 
GHMQSCNFSA EKAKVYINDS VELSQNEQKL AAWLAKRGPI SVAINAFGMQ FYRHGISRPL 
RPLCSPWLID HAVLLVGYGN RSDVPFWAIK NSWGTDWGEK GYYYLHRGSG ACGVNTMASS 
AVVD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.