Details for: GPAA1
Gene ID: 8733
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: GPAA1
Ensembl ID: ENSG00000197858
Description: glycosylphosphatidylinositol anchor attachment 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 39.51rCSI 38.04%PRS 24.2
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CSI 16.89rCSI 32.85%PRS 23.99
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CSI 15.03rCSI 18.6%PRS 20.51
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CSI 14.69rCSI 29.81%PRS 12.4
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CSI 14.55rCSI 15.24%PRS 24.78
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CSI 14.48rCSI 46.97%PRS 27.8
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CSI 12.62rCSI 31.23%PRS 21.65
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CSI 11.88rCSI 17.04%PRS 18.19
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CSI 11.83rCSI 17.31%PRS 24.77
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CSI 11.6rCSI 17.51%PRS 23.89
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CSI 11.24rCSI 17.36%PRS 21.82
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CSI 11.12rCSI 16.95%PRS 21.53
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CSI 8.85rCSI 6.96%PRS 28.37
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CSI 8.65rCSI 10.15%PRS 26.71
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CSI 8.56rCSI 5.06%PRS 32.96
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CSI 7.75rCSI 30.84%PRS 39.06
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CSI 7.01rCSI 12.49%PRS 38.1
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CSI 6.71rCSI 10.59%PRS 23.44
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CSI 6.4rCSI 14.15%PRS 16.66
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CSI 6.15rCSI 8.37%PRS 20.42
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CSI 5.99rCSI 21.01%PRS 39.6
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CSI 5.9rCSI 11.27%PRS 48.07
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CSI 5.67rCSI 3.96%PRS 25
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CSI 5.52rCSI 5.32%PRS 17.09
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CSI 5.28rCSI 5.54%PRS 21.78
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CSI 5.1rCSI 27.44%PRS 39.93
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CSI 5.08rCSI 18.4%PRS 39.83
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CSI 4.39rCSI 11.14%PRS 17.73
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CSI 4.35rCSI 10.32%PRS 28.75
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CSI 4.08rCSI 9.69%PRS 34.39
-
CSI 4.05rCSI 9.05%PRS 27.47
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CSI 3.65rCSI 6.62%PRS 35.42
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CSI 3.6rCSI 5.32%PRS 26.62
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CSI 3.46rCSI 3.61%PRS 24.29
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CSI 3.39rCSI 5.04%PRS 27.37
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CSI 3.28rCSI 2.28%PRS 28.26
-
CSI 3.18rCSI 4.35%PRS 26.38
-
CSI 3.17rCSI 9.14%PRS 41.65
-
CSI 3.03rCSI 2.78%PRS 27.69
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CSI 2.98rCSI 6.57%PRS 26.85
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CSI 2.96rCSI 4.03%PRS 52.04
-
CSI 2.96rCSI 2.67%PRS 21.25
-
CSI 2.94rCSI 6.58%PRS 14.55
-
CSI 2.93rCSI 3%PRS 41.76
-
CSI 2.92rCSI 3.74%PRS 26.99
-
CSI 2.91rCSI 7.68%PRS 27.92
-
CSI 2.9rCSI 2.44%PRS 36.98
-
CSI 2.82rCSI 16.41%PRS 34.23
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CSI 2.7rCSI 10.78%PRS 46.89
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CSI 2.66rCSI 2.16%PRS 24.48
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CSI 2.65rCSI 4.34%PRS 17.91
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CSI 2.64rCSI 2.6%PRS 25.09
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CSI 2.63rCSI 3.04%PRS 17.26
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CSI 2.55rCSI 2.96%PRS 33.43
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CSI 2.45rCSI 2.4%PRS 36.18
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CSI 2.4rCSI 1.59%PRS 27.92
-
CSI 2.39rCSI 1.98%PRS 22.19
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CSI 2.37rCSI 2.84%PRS 22.74
-
CSI 2.37rCSI 3.28%PRS 31.81
-
CSI 2.34rCSI 3.59%PRS 28.12
-
CSI 2.31rCSI 2.03%PRS 27.02
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CSI 2.28rCSI 3.11%PRS 25.95
-
CSI 2.27rCSI 2.14%PRS 24.49
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CSI 2.25rCSI 7.04%PRS 15.96
-
CSI 2.24rCSI 1.56%PRS 32.94
-
CSI 2.2rCSI 3.13%PRS 26.14
-
CSI 2.2rCSI 1.89%PRS 35.12
-
CSI 2.17rCSI 1.61%PRS 34.25
-
CSI 2.15rCSI 1.87%PRS 26.33
-
CSI 2.15rCSI 1.63%PRS 31
-
CSI 2.12rCSI 2.12%PRS 19.99
-
CSI 2.09rCSI 1.83%PRS 30.91
-
CSI 2.09rCSI 3.38%PRS 23.46
-
CSI 2.08rCSI 4.76%PRS 22.81
-
CSI 2.07rCSI 2.27%PRS 26.18
-
CSI 2.07rCSI 4.16%PRS 17.23
-
CSI 2.04rCSI 2.73%PRS 43.31
-
CSI 2.02rCSI 3.08%PRS 23.54
-
CSI 2.01rCSI 10.11%PRS 30.87
-
CSI 2rCSI 2.94%PRS 30.55
-
CSI 2rCSI 2.73%PRS 35.18
-
CSI 1.95rCSI 1.54%PRS 16.04
-
CSI 1.94rCSI 2.02%PRS 23.93
-
CSI 1.94rCSI 3.52%PRS 19.94
-
CSI 1.93rCSI 2.45%PRS 26.97
-
CSI 1.87rCSI 2.11%PRS 36.96
-
CSI 1.87rCSI 1.45%PRS 22.55
-
CSI 1.87rCSI 2.87%PRS 31.03
-
CSI 1.86rCSI 2.56%PRS 44.18
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CSI 1.85rCSI 2.51%PRS 34.97
-
CSI 1.83rCSI 2.19%PRS 13.75
-
CSI 1.83rCSI 2.96%PRS 34.71
-
CSI 1.83rCSI 1.94%PRS 39.01
-
CSI 1.82rCSI 2.89%PRS 29.94
-
CSI 1.8rCSI 2.07%PRS 20.23
-
CSI 1.8rCSI 2.19%PRS 29.19
-
CSI 1.79rCSI 1.57%PRS 16.99
-
CSI 1.77rCSI 4.01%PRS 30.53
-
CSI 1.73rCSI 3.03%PRS 17.85
-
CSI 1.73rCSI 2.64%PRS 26.64
-
CSI 0.1rCSI 0.7%PRS 40.3%
-
CSI 0.1rCSI 0.3%PRS 37.8%
-
CSI 0.1rCSI 0.4%PRS 14.8%
-
CSI 0.2rCSI 2.6%PRS 43.4%
-
CSI 0.3rCSI 6.9%PRS 42.9%
-
CSI 0.4rCSI 2.6%PRS 57.9%
-
CSI 0.4rCSI 1.5%PRS 13.1%
-
CSI 0.4rCSI 1.8%PRS 41.3%
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CSI 0.5rCSI 1.4%PRS 38.4%
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CSI 0.5rCSI 2.3%PRS 53.9%
-
CSI 0.5rCSI 2.0%PRS 14.4%
-
CSI 0.6rCSI 2.5%PRS 22.8%
-
CSI 0.7rCSI 3.6%PRS 38.8%
-
CSI 0.7rCSI 1.3%PRS 16.9%
-
CSI 0.7rCSI 1.7%PRS 13.7%
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CSI 0.7rCSI 3.9%PRS 34.2%
-
CSI 0.7rCSI 2.0%PRS 26.3%
-
CSI 0.7rCSI 3.1%PRS 39.6%
-
CSI 0.8rCSI 2.7%PRS 37.4%
-
CSI 0.8rCSI 4.5%PRS 14.6%
-
CSI 0.8rCSI 0.8%PRS 27.6%
-
CSI 0.8rCSI 3.4%PRS 42.0%
-
CSI 0.8rCSI 5.2%PRS 62.6%
-
CSI 0.8rCSI 2.7%PRS 36.2%
-
CSI 0.8rCSI 1.5%PRS 21.6%
-
CSI 0.9rCSI 1.1%PRS 40.1%
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CSI 0.9rCSI 1.5%PRS 13.9%
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CSI 1.0rCSI 1.6%PRS 15.2%
-
CSI 1.0rCSI 2.3%PRS 23.9%
-
CSI 1.0rCSI 2.3%PRS 21.6%
-
CSI 1.0rCSI 1.8%PRS 13.7%
-
CSI 1.1rCSI 2.0%PRS 44.1%
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CSI 1.1rCSI 1.3%PRS 35.5%
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CSI 1.1rCSI 2.3%PRS 43.8%
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CSI 1.1rCSI 1.6%PRS 32.5%
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CSI 1.1rCSI 1.6%PRS 36.3%
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CSI 1.1rCSI 1.4%PRS 14.5%
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CSI 1.2rCSI 1.6%PRS 23.1%
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CSI 1.2rCSI 2.2%PRS 29.7%
-
CSI 1.2rCSI 2.9%PRS 22.7%
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CSI 1.2rCSI 1.0%PRS 27.7%
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CSI 1.2rCSI 3.1%PRS 21.6%
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CSI 1.3rCSI 2.2%PRS 31.6%
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CSI 1.3rCSI 2.0%PRS 40.3%
-
CSI 1.3rCSI 1.7%PRS 25.6%
-
CSI 1.3rCSI 1.0%PRS 25.1%
-
CSI 1.3rCSI 1.3%PRS 46.0%
-
CSI 1.3rCSI 1.6%PRS 13.0%
-
CSI 1.3rCSI 3.5%PRS 44.4%
-
CSI 1.3rCSI 7.5%PRS 13.8%
-
CSI 1.3rCSI 2.7%PRS 24.4%
-
CSI 1.4rCSI 1.1%PRS 23.6%
-
CSI 1.4rCSI 2.4%PRS 19.3%
-
CSI 1.4rCSI 2.9%PRS 36.6%
-
CSI 1.4rCSI 2.0%PRS 31.2%
-
CSI 1.4rCSI 1.8%PRS 22.4%
-
CSI 1.4rCSI 2.1%PRS 26.4%
-
CSI 1.4rCSI 1.3%PRS 23.4%
-
CSI 1.5rCSI 2.0%PRS 23.6%
-
CSI 1.5rCSI 1.6%PRS 21.5%
-
CSI 1.5rCSI 1.8%PRS 24.9%
-
CSI 1.5rCSI 1.1%PRS 21.9%
-
CSI 1.5rCSI 2.0%PRS 25.4%
-
CSI 1.5rCSI 8.3%PRS 50.7%
-
CSI 1.5rCSI 2.5%PRS 17.8%
-
CSI 1.5rCSI 1.4%PRS 23.6%
-
CSI 1.6rCSI 1.3%PRS 23.8%
-
CSI 1.6rCSI 2.5%PRS 19.9%
-
CSI 1.6rCSI 2.1%PRS 30.0%
-
CSI 1.6rCSI 1.2%PRS 36.6%
-
CSI 1.6rCSI 1.1%PRS 29.0%
-
CSI 1.6rCSI 1.4%PRS 29.6%
-
CSI 1.6rCSI 7.5%PRS 48.7%
-
CSI 1.6rCSI 2.3%PRS 36.4%
-
CSI 1.6rCSI 4.7%PRS 18.1%
-
CSI 1.6rCSI 1.5%PRS 24.4%
-
CSI 1.7rCSI 4.3%PRS 23.2%
-
CSI 1.7rCSI 3.9%PRS 20.0%
-
CSI 1.7rCSI 4.4%PRS 28.8%
-
CSI 1.7rCSI 2.2%PRS 30.4%
-
CSI 1.7rCSI 3.3%PRS 47.6%
-
CSI 1.7rCSI 2.6%PRS 26.6%
-
CSI 1.7rCSI 3.0%PRS 17.9%
-
CSI 1.8rCSI 4.0%PRS 30.5%
-
CSI 1.8rCSI 1.6%PRS 17.0%
-
CSI 1.8rCSI 2.2%PRS 29.2%
-
CSI 1.8rCSI 2.1%PRS 20.2%
-
CSI 1.8rCSI 2.9%PRS 29.9%
-
CSI 1.8rCSI 1.9%PRS 39.0%
-
CSI 1.8rCSI 3.0%PRS 34.7%
-
CSI 1.8rCSI 2.2%PRS 13.8%
-
CSI 1.9rCSI 2.5%PRS 35.0%
-
CSI 1.9rCSI 2.6%PRS 44.2%
-
CSI 1.9rCSI 2.9%PRS 31.0%
-
CSI 1.9rCSI 1.5%PRS 22.6%
-
CSI 1.9rCSI 2.1%PRS 37.0%
-
CSI 1.9rCSI 2.5%PRS 27.0%
-
CSI 1.9rCSI 3.5%PRS 19.9%
-
CSI 1.9rCSI 2.0%PRS 23.9%
-
CSI 2.0rCSI 1.5%PRS 16.0%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Comma-separated if multiple.
Comma-separated if multiple.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.
Genular Protein ID: 3563959304
Symbol: GPAA1_HUMAN
Name: Glycosylphosphatidylinositol anchor attachment 1 protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9468317
Title: Molecular cloning of human homolog of yeast GAA1 which is required for attachment of glycosylphosphatidylinositols to proteins.
PubMed ID: 9468317
PubMed ID: 10393431
Title: Human and mouse GPAA1 (glycosylphosphatidylinositol anchor attachment 1) genes: genomic structures, chromosome loci and the presence of a minor class intron.
PubMed ID: 10393431
DOI: 10.1159/000015258
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11483512
Title: PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8.
PubMed ID: 11483512
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 29100095
Title: Mutations in GPAA1, encoding a GPI transamidase complex protein, cause developmental delay, epilepsy, cerebellar atrophy, and osteopenia.
PubMed ID: 29100095
PubMed ID: 34576938
Title: Functional analysis of the GPI transamidase complex by screening for amino acid mutations in each subunit.
PubMed ID: 34576938
Sequence Information:
- Length: 621
- Mass: 67623
- Checksum: A70AC8758A919A98
- Sequence:
MGLLSDPVRR RALARLVLRL NAPLCVLSYV AGIAWFLALV FPPLTQRTYM SENAMGSTMV EEQFAGGDRA RAFARDFAAH RKKSGALPVA WLERTMRSVG LEVYTQSFSR KLPFPDETHE RYMVSGTNVY GILRAPRAAS TESLVLTVPC GSDSTNSQAV GLLLALAAHF RGQIYWAKDI VFLVTEHDLL GTEAWLEAYH DVNVTGMQSS PLQGRAGAIQ AAVALELSSD VVTSLDVAVE GLNGQLPNLD LLNLFQTFCQ KGGLLCTLQG KLQPEDWTSL DGPLQGLQTL LLMVLRQASG RPHGSHGLFL RYRVEALTLR GINSFRQYKY DLVAVGKALE GMFRKLNHLL ERLHQSFFLY LLPGLSRFVS IGLYMPAVGF LLLVLGLKAL ELWMQLHEAG MGLEEPGGAP GPSVPLPPSQ GVGLASLVAP LLISQAMGLA LYVLPVLGQH VATQHFPVAE AEAVVLTLLA IYAAGLALPH NTHRVVSTQA PDRGWMALKL VALIYLALQL GCIALTNFSL GFLLATTMVP TAALAKPHGP RTLYAALLVL TSPAATLLGS LFLWRELQEA PLSLAEGWQL FLAALAQGVL EHHTYGALLF PLLSLGLYPC WLLFWNVLFW K