Details for: TNFRSF14

Gene ID: 8764

Symbol: TNFRSF14

Ensembl ID: ENSG00000157873

Description: TNF receptor superfamily member 14

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 172.6829
    Cell Significance Index: -26.8600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 85.1984
    Cell Significance Index: -21.6100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 72.7126
    Cell Significance Index: -29.5400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 70.7614
    Cell Significance Index: -29.1500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 62.2491
    Cell Significance Index: -32.0200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 61.4988
    Cell Significance Index: -29.0400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 43.3108
    Cell Significance Index: -29.0600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.6211
    Cell Significance Index: -30.1900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.2636
    Cell Significance Index: -27.4500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.9183
    Cell Significance Index: -17.3300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.5469
    Cell Significance Index: -23.1800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.2867
    Cell Significance Index: -19.5200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.1819
    Cell Significance Index: -28.3400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.4077
    Cell Significance Index: 70.7100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.0138
    Cell Significance Index: 37.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6165
    Cell Significance Index: 35.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4121
    Cell Significance Index: 64.0100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.3112
    Cell Significance Index: 19.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2364
    Cell Significance Index: 1116.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.1790
    Cell Significance Index: 61.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8640
    Cell Significance Index: 44.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8444
    Cell Significance Index: 152.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7935
    Cell Significance Index: 37.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6848
    Cell Significance Index: 84.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6682
    Cell Significance Index: 77.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.6034
    Cell Significance Index: 16.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5801
    Cell Significance Index: 16.7200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5729
    Cell Significance Index: 39.6200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.5641
    Cell Significance Index: 4.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5061
    Cell Significance Index: 59.6800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5050
    Cell Significance Index: 49.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4842
    Cell Significance Index: 13.1800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4761
    Cell Significance Index: 11.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4465
    Cell Significance Index: 840.7200
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.4333
    Cell Significance Index: 2.8300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3784
    Cell Significance Index: 9.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3418
    Cell Significance Index: 65.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3392
    Cell Significance Index: 46.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3312
    Cell Significance Index: 16.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3298
    Cell Significance Index: 15.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2757
    Cell Significance Index: 150.5800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2605
    Cell Significance Index: 33.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2526
    Cell Significance Index: 50.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2428
    Cell Significance Index: 8.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2074
    Cell Significance Index: 13.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2000
    Cell Significance Index: 88.4400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1887
    Cell Significance Index: 5.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1825
    Cell Significance Index: 23.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1606
    Cell Significance Index: 32.2300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1347
    Cell Significance Index: 1.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1148
    Cell Significance Index: 2.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0896
    Cell Significance Index: 2.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0046
    Cell Significance Index: 2.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0004
    Cell Significance Index: -0.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0073
    Cell Significance Index: -11.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0090
    Cell Significance Index: -16.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0150
    Cell Significance Index: -11.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0196
    Cell Significance Index: -26.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0259
    Cell Significance Index: -1.9300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0304
    Cell Significance Index: -21.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0363
    Cell Significance Index: -26.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0396
    Cell Significance Index: -29.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0452
    Cell Significance Index: -20.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0477
    Cell Significance Index: -26.8900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0512
    Cell Significance Index: -3.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0537
    Cell Significance Index: -33.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0702
    Cell Significance Index: -25.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0707
    Cell Significance Index: -12.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0734
    Cell Significance Index: -10.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0857
    Cell Significance Index: -24.6600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1231
    Cell Significance Index: -3.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1268
    Cell Significance Index: -13.2000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1491
    Cell Significance Index: -3.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1561
    Cell Significance Index: -32.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1569
    Cell Significance Index: -17.9800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2593
    Cell Significance Index: -5.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2602
    Cell Significance Index: -3.5500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2692
    Cell Significance Index: -4.6400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2903
    Cell Significance Index: -3.0100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3019
    Cell Significance Index: -5.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3519
    Cell Significance Index: -27.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3655
    Cell Significance Index: -22.4100
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.3740
    Cell Significance Index: -3.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3908
    Cell Significance Index: -30.9500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.3943
    Cell Significance Index: -2.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4755
    Cell Significance Index: -29.9700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5264
    Cell Significance Index: -18.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5286
    Cell Significance Index: -29.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5466
    Cell Significance Index: -28.7000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5603
    Cell Significance Index: -22.9600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.6284
    Cell Significance Index: -9.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6390
    Cell Significance Index: -28.2700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6613
    Cell Significance Index: -21.6500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6829
    Cell Significance Index: -25.0700
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.6946
    Cell Significance Index: -5.3100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.6956
    Cell Significance Index: -22.0000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.7091
    Cell Significance Index: -30.8400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.7370
    Cell Significance Index: -10.6000
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.7385
    Cell Significance Index: -6.9200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7487
    Cell Significance Index: -28.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TNFRSF14 is a transmembrane receptor that binds to various ligands, including tumor necrosis factor (TNF) and TNF-like cytokines. Its unique structure and ligand-binding capabilities allow it to modulate immune responses in distinct ways. Notably, TNFRSF14 is involved in negative regulation of adaptive immune memory response and alpha-beta T cell proliferation, suggesting its role as a brake on excessive immune activation. Additionally, its interaction with CD28 family members and cytokines indicates its involvement in positive regulation of cytokine production and T cell migration. **Pathways and Functions:** The TNFRSF14 gene is intricately linked to various signaling pathways, including: 1. **Adaptive Immune Response:** TNFRSF14 modulates the adaptive immune response by regulating T cell activation, proliferation, and memory formation. 2. **Cell Surface Receptor Signaling Pathway:** The gene's receptor structure allows it to interact with ligands, triggering downstream signaling cascades. 3. **Costimulation by the CD28 Family:** TNFRSF14 collaborates with CD28 to enhance T cell activation and proliferation. 4. **Cytokine Signaling in Immune System:** The gene's interaction with cytokines, such as TNF and IL-2, regulates immune responses and inflammation. 5. **Defense Response to Gram-Negative and Gram-Positive Bacteria:** TNFRSF14 is involved in the defense against bacterial infections, highlighting its role in innate immunity. **Clinical Significance:** The clinical implications of TNFRSF14 are multifaceted: 1. **Immunological Disorders:** Dysregulation of TNFRSF14 has been implicated in autoimmune diseases, such as rheumatoid arthritis, and inflammatory conditions, like psoriasis. 2. **Cancer Immunotherapy:** Targeting TNFRSF14 may provide a novel approach to modulating immune responses in cancer patients. 3. **Infectious Diseases:** The gene's role in defense against bacterial infections makes it a potential target for the development of novel antimicrobial therapies. 4. **Immunomodulatory Therapies:** Understanding the complex functions of TNFRSF14 can inform the design of immunomodulatory therapies aimed at modulating immune responses in various diseases. In conclusion, TNFRSF14 is a complex gene that plays a multifaceted role in regulating immune responses. Its involvement in various signaling pathways and its expression in multiple cell types underscore its potential as a therapeutic target for treating immune-related disorders. Further research is needed to fully elucidate the functions of TNFRSF14 and its clinical significance.

Genular Protein ID: 972997655

Symbol: TNR14_HUMAN

Name: Tumor necrosis factor receptor superfamily member 14

UniProtKB Accession Codes:

Q92956 B3KW30 B9DI89 Q6IB95 Q8N634 Q8WXR1 Q96J31 Q9UM65

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CPTC 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 14 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8898196

Title: Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family.

PubMed ID: 8898196

DOI: 10.1016/s0092-8674(00)81363-x

PubMed ID: 9162061

Title: A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation.

PubMed ID: 9162061

DOI: 10.1074/jbc.272.22.14272

PubMed ID: 11756979

Title: Search for polymorphisms in the genes for herpesvirus entry mediator, Nectin-1, and Nectin-2 in immune seronegative individuals.

PubMed ID: 11756979

DOI: 10.1086/338116

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 9153189

Title: ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5.

PubMed ID: 9153189

DOI: 10.1074/jbc.272.21.13471

PubMed ID: 9162022

Title: Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1.

PubMed ID: 9162022

DOI: 10.1074/jbc.272.22.14029

PubMed ID: 9462508

Title: LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator.

PubMed ID: 9462508

DOI: 10.1016/s1074-7613(00)80455-0

PubMed ID: 9696799

Title: Herpes simplex virus glycoprotein D can bind to poliovirus receptor-related protein 1 or herpesvirus entry mediator, two structurally unrelated mediators of virus entry.

PubMed ID: 9696799

DOI: 10.1128/jvi.72.9.7064-7074.1998

PubMed ID: 10754304

Title: LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response.

PubMed ID: 10754304

DOI: 10.4049/jimmunol.164.8.4105

PubMed ID: 18193050

Title: CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator.

PubMed ID: 18193050

DOI: 10.1038/ni1554

PubMed ID: 19915044

Title: T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment.

PubMed ID: 19915044

DOI: 10.4049/jimmunol.0902490

PubMed ID: 23761635

Title: CD160 activation by herpesvirus entry mediator augments inflammatory cytokine production and cytolytic function by NK cells.

PubMed ID: 23761635

DOI: 10.4049/jimmunol.1300894

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 11511370

Title: Herpes simplex virus glycoprotein D bound to the human receptor HveA.

PubMed ID: 11511370

DOI: 10.1016/s1097-2765(01)00298-2

PubMed ID: 16169851

Title: Attenuating lymphocyte activity: the crystal structure of the BTLA-HVEM complex.

PubMed ID: 16169851

DOI: 10.1074/jbc.m507629200

Sequence Information:

  • Length: 283
  • Mass: 30392
  • Checksum: 46CE13C2C70242C1
  • Sequence:
    • MEPPGDWGPP PWRSTPKTDV LRLVLYLTFL GAPCYAPALP SCKEDEYPVG SECCPKCSPG 
YRVKEACGEL TGTVCEPCPP GTYIAHLNGL SKCLQCQMCD PAMGLRASRN CSRTENAVCG 
CSPGHFCIVQ DGDHCAACRA YATSSPGQRV QKGGTESQDT LCQNCPPGTF SPNGTLEECQ 
HQTKCSWLVT KAGAGTSSSH WVWWFLSGSL VIVIVCSTVG LIICVKRRKP RGDVVKVIVS 
VQRKRQEAEG EATVIEALQA PPDVTTVAVE ETIPSFTGRS PNH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.