Details for: NAPA

Gene ID: 8775

Symbol: NAPA

Ensembl ID: ENSG00000105402

Description: NSF attachment protein alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 179.2405
    Cell Significance Index: -27.8800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 144.6125
    Cell Significance Index: -36.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 99.0260
    Cell Significance Index: -40.2300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 92.0524
    Cell Significance Index: -43.4600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 85.7334
    Cell Significance Index: -44.1000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 64.9159
    Cell Significance Index: -43.5600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 42.6293
    Cell Significance Index: -40.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.3579
    Cell Significance Index: -37.4300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.5473
    Cell Significance Index: -41.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.5381
    Cell Significance Index: -28.2300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.6220
    Cell Significance Index: -18.8700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 4.2132
    Cell Significance Index: 35.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.2275
    Cell Significance Index: 116.9500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.0208
    Cell Significance Index: 37.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.7763
    Cell Significance Index: 1603.8400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.5893
    Cell Significance Index: 14.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.5315
    Cell Significance Index: 114.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5205
    Cell Significance Index: 274.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3337
    Cell Significance Index: 163.9900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2982
    Cell Significance Index: 141.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2736
    Cell Significance Index: 255.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1019
    Cell Significance Index: 179.2200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.0974
    Cell Significance Index: 32.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8926
    Cell Significance Index: 394.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8693
    Cell Significance Index: 45.2800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8195
    Cell Significance Index: 96.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8064
    Cell Significance Index: 104.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8050
    Cell Significance Index: 56.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7782
    Cell Significance Index: 106.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6569
    Cell Significance Index: 45.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6164
    Cell Significance Index: 28.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5936
    Cell Significance Index: 76.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5378
    Cell Significance Index: 106.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5142
    Cell Significance Index: 13.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5036
    Cell Significance Index: 180.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.4972
    Cell Significance Index: 310.4900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4717
    Cell Significance Index: 12.6400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4494
    Cell Significance Index: 30.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4421
    Cell Significance Index: 28.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4333
    Cell Significance Index: 236.6300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4173
    Cell Significance Index: 288.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2917
    Cell Significance Index: 28.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2762
    Cell Significance Index: 7.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2704
    Cell Significance Index: 7.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2564
    Cell Significance Index: 11.6200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2518
    Cell Significance Index: 6.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1903
    Cell Significance Index: 14.6100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1859
    Cell Significance Index: 3.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1553
    Cell Significance Index: 7.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1461
    Cell Significance Index: 27.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0811
    Cell Significance Index: 61.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0590
    Cell Significance Index: 1.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0536
    Cell Significance Index: 72.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0386
    Cell Significance Index: 72.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0293
    Cell Significance Index: 45.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0182
    Cell Significance Index: 0.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0146
    Cell Significance Index: 26.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0009
    Cell Significance Index: 0.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0062
    Cell Significance Index: -4.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0064
    Cell Significance Index: -4.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0076
    Cell Significance Index: -0.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0111
    Cell Significance Index: -0.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0140
    Cell Significance Index: -1.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0145
    Cell Significance Index: -9.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0265
    Cell Significance Index: -4.5200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0466
    Cell Significance Index: -0.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0493
    Cell Significance Index: -27.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0533
    Cell Significance Index: -1.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0748
    Cell Significance Index: -10.8800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0780
    Cell Significance Index: -0.4800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0887
    Cell Significance Index: -1.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0913
    Cell Significance Index: -19.2300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0978
    Cell Significance Index: -1.2100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0986
    Cell Significance Index: -2.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1241
    Cell Significance Index: -35.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1384
    Cell Significance Index: -16.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1863
    Cell Significance Index: -9.6800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2056
    Cell Significance Index: -23.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2156
    Cell Significance Index: -13.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2752
    Cell Significance Index: -5.7600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2762
    Cell Significance Index: -6.7400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3019
    Cell Significance Index: -8.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3132
    Cell Significance Index: -32.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3207
    Cell Significance Index: -10.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3431
    Cell Significance Index: -17.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3553
    Cell Significance Index: -19.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3872
    Cell Significance Index: -23.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4097
    Cell Significance Index: -18.1200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4098
    Cell Significance Index: -32.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4233
    Cell Significance Index: -14.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4282
    Cell Significance Index: -9.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4643
    Cell Significance Index: -17.5800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4785
    Cell Significance Index: -7.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5116
    Cell Significance Index: -6.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5404
    Cell Significance Index: -33.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6215
    Cell Significance Index: -10.6500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6254
    Cell Significance Index: -14.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7578
    Cell Significance Index: -19.4800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.8095
    Cell Significance Index: -33.1700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.8355
    Cell Significance Index: -9.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NAPA is a member of the NSF (N-ethylmaleimide-sensitive factor) family of proteins, which are involved in the regulation of vesicle fusion and fission. The NAPA protein is specifically localized to the Golgi apparatus and is involved in the transport of proteins and lipids to the plasma membrane. It interacts with other proteins, such as SNAP-25 and syntaxin, to form the SNARE complex, which is essential for the fusion of vesicles with target membranes. **Pathways and Functions** NAPA is involved in several cellular pathways, including: 1. **Apical protein localization**: NAPA helps to regulate the localization of proteins to the apical surface of cells, which is critical for cell polarity and development. 2. **Asparagine n-linked glycosylation**: NAPA is involved in the glycosylation of proteins, which is essential for their proper functioning and stability. 3. **Brain development**: NAPA plays a critical role in the development of the brain, particularly in the formation of synapses and the regulation of synaptic transmission. 4. **Copii-mediated vesicle transport**: NAPA is involved in the Copii-mediated transport of vesicles, which is essential for the regulation of synaptic transmission and the development of the nervous system. 5. **Regulation of synaptic vesicle priming**: NAPA helps to regulate the priming of synaptic vesicles, which is critical for the release of neurotransmitters and the transmission of signals. **Clinical Significance** Dysregulation of NAPA has been implicated in various neurological and immunological disorders, including: 1. **Neurodegenerative diseases**: Mutations in the NAPA gene have been associated with neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Immune disorders**: NAPA is involved in the regulation of immune responses, and dysregulation of the NAPA gene has been implicated in autoimmune diseases, such as multiple sclerosis. 3. **Developmental disorders**: NAPA plays a critical role in the development of the nervous system and the regulation of synaptic transmission. Dysregulation of the NAPA gene has been implicated in developmental disorders, such as autism spectrum disorder. In conclusion, the NAPA gene plays a crucial role in various cellular processes, including protein transport, vesicle formation, and synaptic transmission. Its dysregulation has been implicated in various neurological and immunological disorders, highlighting the importance of NAPA in human health and disease.

Genular Protein ID: 2181582560

Symbol: SNAA_HUMAN

Name: Alpha-soluble NSF attachment protein

UniProtKB Accession Codes:

P54920 A8K879 Q96IK3 Q9BVJ3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9269766

Title: Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery.

PubMed ID: 9269766

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15029241

Title: Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi.

PubMed ID: 15029241

DOI: 10.1038/sj.emboj.7600135

PubMed ID: 15980433

Title: G alpha12 interaction with alphaSNAP induces VE-cadherin localization at endothelial junctions and regulates barrier function.

PubMed ID: 15980433

DOI: 10.1074/jbc.m502844200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 295
  • Mass: 33233
  • Checksum: 7704A619A441E609
  • Sequence:
    • MDNSGKEAEA MALLAEAERK VKNSQSFFSG LFGGSSKIEE ACEIYARAAN MFKMAKNWSA 
AGNAFCQAAQ LHLQLQSKHD AATCFVDAGN AFKKADPQEA INCLMRAIEI YTDMGRFTIA 
AKHHISIAEI YETELVDIEK AIAHYEQSAD YYKGEESNSS ANKCLLKVAG YAALLEQYQK 
AIDIYEQVGT NAMDSPLLKY SAKDYFFKAA LCHFCIDMLN AKLAVQKYEE LFPAFSDSRE 
CKLMKKLLEA HEEQNVDSYT ESVKEYDSIS RLDQWLTTML LRIKKTIQGD EEDLR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.