Details for: RGS9

Gene ID: 8787

Symbol: RGS9

Ensembl ID: ENSG00000108370

Description: regulator of G protein signaling 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 69.5618
    Cell Significance Index: -10.8200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 42.7766
    Cell Significance Index: -10.8500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 23.6796
    Cell Significance Index: -9.6200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 12.8483
    Cell Significance Index: 153.1600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.8081
    Cell Significance Index: -10.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 8.7128
    Cell Significance Index: 549.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 4.8966
    Cell Significance Index: 216.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 4.3930
    Cell Significance Index: 166.3500
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.6363
    Cell Significance Index: 16.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1388
    Cell Significance Index: 112.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9575
    Cell Significance Index: 864.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6373
    Cell Significance Index: 69.3200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.6211
    Cell Significance Index: 10.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6143
    Cell Significance Index: 99.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5260
    Cell Significance Index: 100.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4982
    Cell Significance Index: 58.7500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4604
    Cell Significance Index: 53.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4476
    Cell Significance Index: 57.3800
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.4334
    Cell Significance Index: 5.4100
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.4192
    Cell Significance Index: 3.2300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.4173
    Cell Significance Index: 6.6200
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.3418
    Cell Significance Index: 4.7800
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.3186
    Cell Significance Index: 3.3900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2690
    Cell Significance Index: 365.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2659
    Cell Significance Index: 95.3900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2279
    Cell Significance Index: 4.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2171
    Cell Significance Index: 11.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1918
    Cell Significance Index: 5.2200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1790
    Cell Significance Index: 11.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1634
    Cell Significance Index: 8.4900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1631
    Cell Significance Index: 4.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1326
    Cell Significance Index: 3.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1258
    Cell Significance Index: 15.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1243
    Cell Significance Index: 8.7900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1187
    Cell Significance Index: 2.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1185
    Cell Significance Index: 5.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1146
    Cell Significance Index: 50.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1133
    Cell Significance Index: 20.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1053
    Cell Significance Index: 162.1100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1007
    Cell Significance Index: 1.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0965
    Cell Significance Index: 177.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0710
    Cell Significance Index: 49.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0675
    Cell Significance Index: 9.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0650
    Cell Significance Index: 122.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0645
    Cell Significance Index: 1.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0569
    Cell Significance Index: 9.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0482
    Cell Significance Index: 9.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0351
    Cell Significance Index: 2.3600
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.0343
    Cell Significance Index: 0.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0199
    Cell Significance Index: 2.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0175
    Cell Significance Index: 11.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0047
    Cell Significance Index: 0.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0019
    Cell Significance Index: 1.4400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0047
    Cell Significance Index: -0.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0047
    Cell Significance Index: -0.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0056
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0068
    Cell Significance Index: -4.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0091
    Cell Significance Index: -5.1100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0100
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0104
    Cell Significance Index: -2.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0122
    Cell Significance Index: -5.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0124
    Cell Significance Index: -9.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0154
    Cell Significance Index: -11.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0169
    Cell Significance Index: -9.2100
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0185
    Cell Significance Index: -0.2100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0286
    Cell Significance Index: -0.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0319
    Cell Significance Index: -9.1800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0337
    Cell Significance Index: -3.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0386
    Cell Significance Index: -5.3000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0405
    Cell Significance Index: -0.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0411
    Cell Significance Index: -5.3100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0458
    Cell Significance Index: -0.9500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0470
    Cell Significance Index: -1.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0557
    Cell Significance Index: -2.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0875
    Cell Significance Index: -9.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0910
    Cell Significance Index: -9.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0985
    Cell Significance Index: -3.4600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0998
    Cell Significance Index: -1.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1121
    Cell Significance Index: -5.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1191
    Cell Significance Index: -7.3000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1223
    Cell Significance Index: -1.8100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1234
    Cell Significance Index: -1.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1237
    Cell Significance Index: -6.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1250
    Cell Significance Index: -8.0700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1280
    Cell Significance Index: -3.2700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1308
    Cell Significance Index: -10.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1320
    Cell Significance Index: -10.1300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1342
    Cell Significance Index: -3.5300
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.1377
    Cell Significance Index: -2.1000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1506
    Cell Significance Index: -2.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1574
    Cell Significance Index: -4.4000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1630
    Cell Significance Index: -4.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1691
    Cell Significance Index: -5.3900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1787
    Cell Significance Index: -3.0900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1864
    Cell Significance Index: -1.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1940
    Cell Significance Index: -5.1800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1984
    Cell Significance Index: -4.9600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2019
    Cell Significance Index: -6.6100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2054
    Cell Significance Index: -8.9300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2117
    Cell Significance Index: -1.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RGS9 is a member of the RGS (Regulator of G protein signaling) family of proteins, which are characterized by their ability to regulate GTPase activity. RGS9 is a GTPase-activating protein (GAP) that specifically targets the Gαi subunit of G proteins, which are involved in inhibitory signaling pathways. The expression of RGS9 is highly restricted to photoreceptor cells of the retina, where it is co-expressed with other key phototransduction components. RGS9 has been shown to interact with other proteins, including the phototransduction pathway components, to regulate GPCR signaling. **Pathways and Functions** RGS9 is involved in several key signaling pathways, including: 1. **Phototransduction**: RGS9 plays a crucial role in the regulation of visual perception and adaptation to light. It is highly expressed in photoreceptor cells of the retina, where it regulates the desensitization and internalization of GPCRs. 2. **G protein-coupled receptor signaling pathway**: RGS9 is a negative regulator of GTPase activity, which is essential for the desensitization and internalization of GPCRs. 3. **Protein folding**: RGS9 has been implicated in the regulation of protein folding, particularly in the context of GPCRs. 4. **Calcium ion regulation**: RGS9 has been shown to regulate calcium ion export across the plasma membrane, which is essential for maintaining cellular homeostasis. **Clinical Significance** Dysregulation of RGS9 has been implicated in various diseases, including: 1. **Retinal degeneration**: Mutations in the RGS9 gene have been associated with retinal degeneration, including retinitis pigmentosa and cone-rod dystrophy. 2. **Visual impairment**: RGS9 has been implicated in visual impairment, including photoreceptor dysfunction and visual acuity loss. 3. **Neurological disorders**: RGS9 has been implicated in neurological disorders, including Parkinson's disease and Alzheimer's disease, where it may play a role in the regulation of GPCR signaling pathways. In conclusion, RGS9 is a critical gene involved in the regulation of GPCR signaling pathways, particularly in phototransduction, sensory perception, and metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of RGS9 in maintaining normal cellular function and preventing disease. Further research is needed to fully elucidate the role of RGS9 in human health and disease.

Genular Protein ID: 1746476266

Symbol: RGS9_HUMAN

Name: Regulator of G-protein signaling 9

UniProtKB Accession Codes:

O75916 A8K3C0 O75573 Q696R2 Q8TD64 Q8TD65 Q9HC32 Q9HC33

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 42 EMDB 2 Ensembl 2 ExpressionAtlas 1 GO 20 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 3 RefSeq 2 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9765512

Title: Molecular characterization of human and rat RGS9L, a novel splice variant enriched in dopamine target regions, and chromosomal localization of the RGS9 gene.

PubMed ID: 9765512

PubMed ID: 10564809

Title: Structure, alternative splicing, and expression of the human RGS9 gene.

PubMed ID: 10564809

DOI: 10.1016/s0378-1119(99)00393-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 14614075

Title: The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo.

PubMed ID: 14614075

DOI: 10.1523/jneurosci.23-32-10175.2003

PubMed ID: 14702087

Title: Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation.

PubMed ID: 14702087

DOI: 10.1038/nature02170

Sequence Information:

  • Length: 674
  • Mass: 76966
  • Checksum: 8E2B11104B448364
  • Sequence:
    • MTIRHQGQQY RPRMAFLQKI EALVKDMQNP ETGVRMQNQR VLVTSVPHAM TGSDVLQWIV 
QRLWISSLEA QNLGNFIVRY GYIYPLQDPK NLILKPDGSL YRFQTPYFWP TQQWPAEDTD 
YAIYLAKRNI KKKGILEEYE KENYNFLNQK MNYKWDFVIM QAKEQYRAGK ERNKADRYAL 
DCQEKAYWLV HRCPPGMDNV LDYGLDRVTN PNEVKVNQKQ TVVAVKKEIM YYQQALMRST 
VKSSVSLGGI VKYSEQFSSN DAIMSGCLPS NPWITDDTQF WDLNAKLVEI PTKMRVERWA 
FNFSELIRDP KGRQSFQYFL KKEFSGENLG FWEACEDLKY GDQSKVKEKA EEIYKLFLAP 
GARRWINIDG KTMDITVKGL KHPHRYVLDA AQTHIYMLMK KDSYARYLKS PIYKDMLAKA 
IEPQETTKKS STLPFMRRHL RSSPSPVILR QLEEEAKARE AANTVDITQP GQHMAPSPHL 
TVYTGTCMPP SPSSPFSSSC RSPRKPFASP SRFIRRPSTT ICPSPIRVAL ESSSGLEQKG 
ECSGSMAPRG PSVTESSEAS LDTSWPRSRP RAPPKARMAL SFSRFLRRGC LASPVFARLS 
PKCPAVSHGR VQPLGDVGQQ LPRLKSKRVA NFFQIKMDVP TGSGTCLMDS EDAGTGESGD 
RATEKEVICP WESL

Genular Protein ID: 3989090098

Symbol: A8K1G1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K1G1

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 9 Gene3D 4 InterPro 12 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 SAM 1 SMART 4 SUPFAM 3

Sequence Information:

  • Length: 674
  • Mass: 76994
  • Checksum: 62FB119D65E70E4A
  • Sequence:
    • MTIRHQGQQY RPRMAFLQKI EALVKDMQNP ETGVRMQNQR VLVTSVPHAM TGSDVLQWIV 
QRLWISSLEA QNLGNFIVRY GYIYPLQDPK NLILKPDGSL YRFRTPYFWP TQQWPAEDTD 
YAIYLAKRNI KKKGILEEYE KENYNFLNQK MNYKWDFVIM QAKEQYRAGK ERNKADRYAL 
DCQEKAYWLV HRCPPGMDNV LDYGLDRVTN PNEVKVNQKQ TVVAVKKEIM YYQQALMRST 
VKSSVSLGGI VKYSEQFSSN DAIMSGCLPS NPWITDDTQF WDLNAKLVEI PTKMRVERWA 
FNFSELIRDP KGRQSFQYFL KKEFSGENLG FWEACEDLKY GDQSKVKEKA EEIYKLFLAP 
GARRWINIDG KTMDITVKGL KHPHRYVLDA AQTHIYMLMK KDSYARYLKS PIYKDMLAKA 
IEPQETTKKS STLPFMRRHL RSSPSPVILR QLEEEAKARE AANTVDITQP GQHMAPSPHL 
TVYTGTCMPP SPSSPFSSSC RSPRKPFASP SRFIRRPSTT ICPSPIRVAL ESSSGLEQKG 
ECSGSMAPRG PSVTESSEAS LDTSWPRSRP RAPPKARMAL SFSRFLRRGC LASPVFARLS 
PKCPAVSHGR VQPLGDVGQQ LPRLKSKRVA NFFQIKMDVP TGSGTCLMDS EDAGTGESGD 
RATEKEVICP WESL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.