Details for: SUCLG1

Gene ID: 8802

Symbol: SUCLG1

Ensembl ID: ENSG00000163541

Description: succinate-CoA ligase GDP/ADP-forming subunit alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 345.1408
    Cell Significance Index: -53.6900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 190.6811
    Cell Significance Index: -48.3700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 152.7379
    Cell Significance Index: -62.9200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 137.8879
    Cell Significance Index: -65.1000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 137.1791
    Cell Significance Index: -55.7300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 123.3122
    Cell Significance Index: -63.4300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 97.0758
    Cell Significance Index: -65.1400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 59.3039
    Cell Significance Index: -56.6200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 49.5395
    Cell Significance Index: -61.0800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.6124
    Cell Significance Index: -49.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.8944
    Cell Significance Index: -62.7200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.3552
    Cell Significance Index: -41.0200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.3511
    Cell Significance Index: -13.9000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.1430
    Cell Significance Index: 17.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.8915
    Cell Significance Index: 88.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4710
    Cell Significance Index: 295.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4308
    Cell Significance Index: 257.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3710
    Cell Significance Index: 18.7100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.3461
    Cell Significance Index: 20.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2508
    Cell Significance Index: 153.8000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.2504
    Cell Significance Index: 88.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1969
    Cell Significance Index: 25.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1379
    Cell Significance Index: 84.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0982
    Cell Significance Index: 599.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0911
    Cell Significance Index: 149.8400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.0723
    Cell Significance Index: 474.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0470
    Cell Significance Index: 49.2100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.0137
    Cell Significance Index: 23.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9474
    Cell Significance Index: 122.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9418
    Cell Significance Index: 42.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.9236
    Cell Significance Index: 48.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9059
    Cell Significance Index: 47.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8697
    Cell Significance Index: 52.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7113
    Cell Significance Index: 19.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6968
    Cell Significance Index: 138.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6953
    Cell Significance Index: 36.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6488
    Cell Significance Index: 585.8100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6478
    Cell Significance Index: 5.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6326
    Cell Significance Index: 81.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6169
    Cell Significance Index: 47.3400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6156
    Cell Significance Index: 39.7200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5961
    Cell Significance Index: 20.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5428
    Cell Significance Index: 194.7100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5230
    Cell Significance Index: 15.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.5047
    Cell Significance Index: 39.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4838
    Cell Significance Index: 57.0600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4314
    Cell Significance Index: 9.0300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4063
    Cell Significance Index: 40.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3870
    Cell Significance Index: 66.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3609
    Cell Significance Index: 11.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3482
    Cell Significance Index: 9.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3449
    Cell Significance Index: 65.6400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3048
    Cell Significance Index: 210.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.3047
    Cell Significance Index: 223.4300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2174
    Cell Significance Index: 3.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1820
    Cell Significance Index: 4.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0879
    Cell Significance Index: 3.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0732
    Cell Significance Index: 11.9000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0570
    Cell Significance Index: 107.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0135
    Cell Significance Index: 24.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0060
    Cell Significance Index: 2.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0053
    Cell Significance Index: -4.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0108
    Cell Significance Index: -16.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0141
    Cell Significance Index: -8.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0257
    Cell Significance Index: -19.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0345
    Cell Significance Index: -46.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0529
    Cell Significance Index: -33.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0531
    Cell Significance Index: -5.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0559
    Cell Significance Index: -0.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0795
    Cell Significance Index: -44.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1215
    Cell Significance Index: -8.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1484
    Cell Significance Index: -31.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1655
    Cell Significance Index: -10.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1793
    Cell Significance Index: -51.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2294
    Cell Significance Index: -33.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2564
    Cell Significance Index: -29.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3021
    Cell Significance Index: -20.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3071
    Cell Significance Index: -35.7900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3182
    Cell Significance Index: -8.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3320
    Cell Significance Index: -5.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3358
    Cell Significance Index: -8.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3662
    Cell Significance Index: -23.0800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4147
    Cell Significance Index: -10.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4384
    Cell Significance Index: -19.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4903
    Cell Significance Index: -27.5200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5007
    Cell Significance Index: -57.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5282
    Cell Significance Index: -55.0000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.5363
    Cell Significance Index: -5.8300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5381
    Cell Significance Index: -5.5700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5535
    Cell Significance Index: -20.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.6482
    Cell Significance Index: -18.6800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7280
    Cell Significance Index: -20.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7896
    Cell Significance Index: -21.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7991
    Cell Significance Index: -48.9900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.8561
    Cell Significance Index: -12.0000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9927
    Cell Significance Index: -29.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.1252
    Cell Significance Index: -30.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.1997
    Cell Significance Index: -29.9900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.2500
    Cell Significance Index: -10.5000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.2986
    Cell Significance Index: -42.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Subunit alpha**: SUCLG1 is a subunit of the succinate-CoA ligase complex, which consists of two subunits: alpha and beta. The alpha subunit is responsible for the formation of GDP and ADP from succinate-CoA. 2. **Mitochondrial localization**: SUCLG1 is predominantly expressed in the mitochondrial matrix, where it plays a key role in the tCA cycle. 3. **Energy metabolism**: The enzyme is involved in the regulation of energy metabolism, particularly in the conversion of succinate-CoA to GDP and ADP, which is a critical step in the production of ATP. 4. **Tissue specificity**: SUCLG1 is highly expressed in epithelial cells of various tissues, including the kidney, intestines, and salivary glands, as well as in erythroid progenitor cells. **Pathways and Functions** 1. **Citric Acid Cycle (tCA cycle)**: SUCLG1 is a critical component of the tCA cycle, also known as the Krebs cycle or tricarboxylic acid cycle. The enzyme catalyzes the conversion of succinate-CoA to GDP and ADP, which is a key step in the production of ATP. 2. **Mitochondrial matrix**: SUCLG1 is predominantly expressed in the mitochondrial matrix, where it plays a key role in the regulation of energy metabolism. 3. **Energy production**: The enzyme is involved in the production of ATP, which is essential for various cellular processes, including cell growth, differentiation, and survival. 4. **Redox balance**: SUCLG1 helps maintain the redox balance in the mitochondrial matrix by regulating the levels of NAD+ and FAD. **Clinical Significance** 1. **Mitochondrial dysfunction**: Mutations in the SUCLG1 gene have been associated with mitochondrial dysfunction, which can lead to various diseases, including metabolic disorders, neurodegenerative diseases, and cancer. 2. **Energy metabolism disorders**: SUCLG1 dysfunction can disrupt energy metabolism, leading to conditions such as lactic acidosis, rhabdomyolysis, and acute kidney injury. 3. **Cancer**: The enzyme's role in energy metabolism makes it a potential target for cancer therapy. 4. **Neurological disorders**: SUCLG1 dysfunction has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. In conclusion, SUCLG1 is a critical component of the succinate-CoA ligase complex, which plays a pivotal role in energy metabolism, particularly in the mitochondrial matrix. The gene's expression pattern and functional characteristics suggest its involvement in various cellular processes, including energy production, redox balance, and cell growth and differentiation. Further research is needed to fully understand the clinical significance of SUCLG1 and its role in human disease.

Genular Protein ID: 635803579

Symbol: SUCA_HUMAN

Name: N/A

UniProtKB Accession Codes:

P53597 Q9BWB0 Q9UNP6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 15 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9128182

Title: The molecular basis for cross-reaction anti-dystrophin antibody with alpha-actinin.

PubMed ID: 9128182

DOI: 10.1016/s0925-4439(96)00076-2

PubMed ID: 17668387

Title: Deficiency of the alpha subunit of succinate-coenzyme A ligase causes fatal infantile lactic acidosis with mitochondrial DNA depletion.

PubMed ID: 17668387

DOI: 10.1086/519222

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 19526370

Title: A novel missense mutation in SUCLG1 associated with mitochondrial DNA depletion, encephalomyopathic form, with methylmalonic aciduria.

PubMed ID: 19526370

DOI: 10.1007/s00431-009-1007-z

PubMed ID: 20693550

Title: The severity of phenotype linked to SUCLG1 mutations could be correlated with residual amount of SUCLG1 protein.

PubMed ID: 20693550

DOI: 10.1136/jmg.2009.073445

PubMed ID: 20453710

Title: Succinyl-CoA ligase deficiency: a mitochondrial hepatoencephalomyopathy.

PubMed ID: 20453710

DOI: 10.1203/pdr.0b013e3181e5c3a4

PubMed ID: 26566883

Title: Homozygous missense mutation in the LMAN2L gene segregates with intellectual disability in a large consanguineous Pakistani family.

PubMed ID: 26566883

DOI: 10.1136/jmedgenet-2015-103179

Sequence Information:

  • Length: 346
  • Mass: 36250
  • Checksum: 76EF06F323CD5188
  • Sequence:
    • MTATLAAAAD IATMVSGSSG LAAARLLSRS FLLPQNGIRH CSYTASRQHL YVDKNTKIIC 
QGFTGKQGTF HSQQALEYGT KLVGGTTPGK GGQTHLGLPV FNTVKEAKEQ TGATASVIYV 
PPPFAAAAIN EAIEAEIPLV VCITEGIPQQ DMVRVKHKLL RQEKTRLIGP NCPGVINPGE 
CKIGIMPGHI HKKGRIGIVS RSGTLTYEAV HQTTQVGLGQ SLCVGIGGDP FNGTDFIDCL 
EIFLNDSATE GIILIGEIGG NAEENAAEFL KQHNSGPNSK PVVSFIAGLT APPGRRMGHA 
GAIIAGGKGG AKEKISALQS AGVVVSMSPA QLGTTIYKEF EKRKML

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.