Details for: DPM1

Gene ID: 8813

Symbol: DPM1

Ensembl ID: ENSG00000000419

Description: dolichyl-phosphate mannosyltransferase subunit 1, catalytic

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 221.2218
    Cell Significance Index: -34.4100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 141.8133
    Cell Significance Index: -35.9700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 107.8535
    Cell Significance Index: -44.4300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 96.8816
    Cell Significance Index: -45.7400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 90.4353
    Cell Significance Index: -36.7400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 82.5840
    Cell Significance Index: -42.4800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 68.7012
    Cell Significance Index: -46.1000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 38.5654
    Cell Significance Index: -36.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.3402
    Cell Significance Index: -42.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.7102
    Cell Significance Index: -31.3700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.1960
    Cell Significance Index: -44.1800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.6334
    Cell Significance Index: -32.6600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.3198
    Cell Significance Index: -16.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.9584
    Cell Significance Index: 26.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.6257
    Cell Significance Index: 44.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3589
    Cell Significance Index: 272.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2651
    Cell Significance Index: 33.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1415
    Cell Significance Index: 226.5400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0925
    Cell Significance Index: 177.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8593
    Cell Significance Index: 64.0400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8330
    Cell Significance Index: 28.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7229
    Cell Significance Index: 93.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7040
    Cell Significance Index: 36.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6734
    Cell Significance Index: 82.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6310
    Cell Significance Index: 344.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6175
    Cell Significance Index: 221.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6146
    Cell Significance Index: 84.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6037
    Cell Significance Index: 266.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5885
    Cell Significance Index: 41.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5800
    Cell Significance Index: 104.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5599
    Cell Significance Index: 71.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5244
    Cell Significance Index: 24.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4836
    Cell Significance Index: 92.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4254
    Cell Significance Index: 294.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3959
    Cell Significance Index: 30.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3898
    Cell Significance Index: 8.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3761
    Cell Significance Index: 25.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3708
    Cell Significance Index: 17.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2892
    Cell Significance Index: 28.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2762
    Cell Significance Index: 7.4000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2483
    Cell Significance Index: 17.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2204
    Cell Significance Index: 12.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2116
    Cell Significance Index: 36.1300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1884
    Cell Significance Index: 4.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1823
    Cell Significance Index: 8.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1568
    Cell Significance Index: 18.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0959
    Cell Significance Index: 6.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0626
    Cell Significance Index: 117.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0185
    Cell Significance Index: 11.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0094
    Cell Significance Index: 0.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0052
    Cell Significance Index: 9.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0036
    Cell Significance Index: 2.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0037
    Cell Significance Index: -5.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0092
    Cell Significance Index: -4.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0128
    Cell Significance Index: -0.6700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0169
    Cell Significance Index: -10.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0177
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0179
    Cell Significance Index: -13.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0248
    Cell Significance Index: -0.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0267
    Cell Significance Index: -19.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0297
    Cell Significance Index: -0.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0308
    Cell Significance Index: -17.3800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0371
    Cell Significance Index: -0.6500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0644
    Cell Significance Index: -0.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0812
    Cell Significance Index: -8.2900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0882
    Cell Significance Index: -3.3400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0939
    Cell Significance Index: -0.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1076
    Cell Significance Index: -22.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1256
    Cell Significance Index: -36.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1298
    Cell Significance Index: -14.8700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1476
    Cell Significance Index: -9.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1518
    Cell Significance Index: -22.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1736
    Cell Significance Index: -6.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2058
    Cell Significance Index: -6.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2109
    Cell Significance Index: -24.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2485
    Cell Significance Index: -15.6600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2676
    Cell Significance Index: -7.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2864
    Cell Significance Index: -7.1600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3273
    Cell Significance Index: -8.3600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3841
    Cell Significance Index: -10.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3863
    Cell Significance Index: -40.2200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3954
    Cell Significance Index: -45.1400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4370
    Cell Significance Index: -34.6100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4572
    Cell Significance Index: -5.4500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4855
    Cell Significance Index: -8.3200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4903
    Cell Significance Index: -14.4000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4995
    Cell Significance Index: -4.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5334
    Cell Significance Index: -11.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5342
    Cell Significance Index: -27.8300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5498
    Cell Significance Index: -10.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5556
    Cell Significance Index: -16.3700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5594
    Cell Significance Index: -3.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5712
    Cell Significance Index: -15.2800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5954
    Cell Significance Index: -8.7900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5987
    Cell Significance Index: -15.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6004
    Cell Significance Index: -36.8100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6315
    Cell Significance Index: -13.4500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.6646
    Cell Significance Index: -9.4600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7657
    Cell Significance Index: -17.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Catalytic function:** DPM1 is a subunit of the dolichol-phosphate-mannose synthase complex, responsible for transferring mannose residues to dolichol phosphate, creating the llo precursor. 2. **Cellular expression:** DPM1 is highly expressed in various cell types, including placental villous trophoblast, erythroid progenitor cells, and epithelial cells of the esophagus, prostate, and urethra. 3. **Pathway involvement:** DPM1 is integral to the biosynthesis of llo, which is then transferred to nascent proteins, enabling glycosylation and post-translational modification. 4. **Clinical significance:** Defects in DPM1 have been associated with Congenital Dysglycans (CDG) syndromes, highlighting the importance of this gene in maintaining proper glycosylation pathways. **Pathways and Functions:** 1. **N-linked glycosylation:** DPM1 is involved in the biosynthesis of llo, which is then transferred to nascent proteins, enabling glycosylation and post-translational modification. 2. **Asparagine n-linked glycosylation:** DPM1 plays a critical role in the transfer of mannose residues to asparagine-containing proteins, a process essential for protein function and stability. 3. **Biosynthesis of the n-glycan precursor (dolichol lipid-linked oligosaccharide, llo):** DPM1 is essential for the creation of the llo precursor, which is then used to synthesize various glycoproteins and glycolipids. 4. **Dolichol metabolic process:** DPM1 is involved in the synthesis and degradation of dolichol, a key component of the llo biosynthetic pathway. **Clinical Significance:** 1. **Congenital Dysglycans (CDG) syndromes:** Defects in DPM1 have been linked to various CDG syndromes, highlighting the importance of this gene in maintaining proper glycosylation pathways. 2. **Immunological disorders:** Abnormal glycosylation patterns have been implicated in various immunological disorders, including autoimmune diseases and cancer. 3. **Metabolic disorders:** Defects in DPM1 have been associated with metabolic disorders, including glycogen storage diseases and lipid metabolism disorders. 4. **Cancer:** Aberrant glycosylation patterns have been observed in various cancers, suggesting that DPM1 may play a role in cancer development and progression. In conclusion, DPM1 plays a critical role in the biosynthesis of the glycosylation precursor dolichol lipid-linked oligosaccharide (llo), a process essential for N-linked glycosylation and post-translational modification. Defects in DPM1 have been linked to various diseases, including Congenital Dysglycans (CDG) syndromes, highlighting the importance of this gene in maintaining proper glycosylation pathways. Further research is necessary to fully understand the mechanisms underlying DPM1-mediated glycosylation and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 3310769846

Symbol: DPM1_HUMAN

Name: Dolichol-phosphate mannosyltransferase subunit 1

UniProtKB Accession Codes:

O60762 O15157 Q6IB78 Q96HK0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 20 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EC 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 17 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 4 Rhea 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9535917

Title: A homologue of Saccharomyces cerevisiae Dpm1p is not sufficient for synthesis of dolichol-phosphate-mannose in mammalian cells.

PubMed ID: 9535917

DOI: 10.1074/jbc.273.15.9249

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9223280

Title: Human and Saccharomyces cerevisiae dolichol phosphate mannose synthases represent two classes of the enzyme, but both function in Schizosaccharomyces pombe.

PubMed ID: 9223280

DOI: 10.1073/pnas.94.15.7873

PubMed ID: 10835346

Title: Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3.

PubMed ID: 10835346

DOI: 10.1093/emboj/19.11.2475

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16280320

Title: DPM1, the catalytic subunit of dolichol-phosphate mannose synthase, is tethered to and stabilized on the endoplasmic reticulum membrane by DPM3.

PubMed ID: 16280320

DOI: 10.1074/jbc.m511311200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10642597

Title: Dolichol phosphate mannose synthase (DPM1) mutations define congenital disorder of glycosylation Ie (CDG-Ie).

PubMed ID: 10642597

DOI: 10.1172/jci7302

PubMed ID: 10642602

Title: Deficiency of dolichol-phosphate-mannose synthase-1 causes congenital disorder of glycosylation type Ie.

PubMed ID: 10642602

DOI: 10.1172/jci8691

PubMed ID: 15669674

Title: Congenital disorder of glycosylation (CDG) type Ie. A new patient.

PubMed ID: 15669674

DOI: 10.1023/b:boli.0000042984.42433.d8

PubMed ID: 23856421

Title: Congenital disorder of glycosylation due to DPM1 mutations presenting with dystroglycanopathy-type congenital muscular dystrophy.

PubMed ID: 23856421

DOI: 10.1016/j.ymgme.2013.06.016

PubMed ID: 19576565

Title: Deficiency of Dol-P-Man synthase subunit DPM3 bridges the congenital disorders of glycosylation with the dystroglycanopathies.

PubMed ID: 19576565

DOI: 10.1016/j.ajhg.2009.06.006

Sequence Information:

  • Length: 260
  • Mass: 29634
  • Checksum: 9792145BFC8F0514
  • Sequence:
    • MASLEVSRSP RRSRRELEVR SPRQNKYSVL LPTYNERENL PLIVWLLVKS FSESGINYEI 
IIIDDGSPDG TRDVAEQLEK IYGSDRILLR PREKKLGLGT AYIHGMKHAT GNYIIIMDAD 
LSHHPKFIPE FIRKQKEGNF DIVSGTRYKG NGGVYGWDLK RKIISRGANF LTQILLRPGA 
SDLTGSFRLY RKEVLEKLIE KCVSKGYVFQ MEMIVRARQL NYTIGEVPIS FVDRVYGESK 
LGGNEIVSFL KGLLTLFATT

Genular Protein ID: 3518972724

Symbol: Q5QPK2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5QPK2

Database IDs:

ARBA 10 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 7 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 3 GeneTree 1 HGNC 1 IntAct 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 3 RuleBase 1 SUPFAM 1 UCSC 1 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 287
  • Mass: 32426
  • Checksum: 0C7CB228C00D97B1
  • Sequence:
    • MASLEVSRSP RRSRRELEVR SPRQNKYSVL LPTYNERENL PLIVWLLVKS FSESGINYEI 
IIIDDGSPDG TRDVAEQLEK IYGSDRILLR PREKKLGLGT AYIHGMKHAT GNYIIIMDAD 
LSHHPKFIPE FIRKQKEGNF DIVSGTRYKG NGGVYGWDLK RKIISDGVLP CCPGWSLLGS 
SDPAILASWD YSRGANFLTQ ILLRPGASDL TGSFRLYRKE VLEKLIEKCV SKGYVFQMEM 
IVRARQLNYT IGEVPISFVD RVYGESKLGG NEIVSFLKGL LTLFATT

Genular Protein ID: 12343708

Symbol: H0Y368_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0Y368

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChEBI 7 ChiTaRS 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 GeneTree 1 HGNC 1 IntAct 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 1 Pfam 2 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 3 RuleBase 1 SMR 1 SUPFAM 1 SwissPalm 1 UCSC 1 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 295
  • Mass: 33350
  • Checksum: 6CF7AF779A54AF93
  • Sequence:
    • MASLEVSRSP RRSRRELEVR SPRQNKYSVL LPTYNERENL PLIVWLLVKS FSESGINYEI 
IIIDDGSPDG TRDVAEQLEK IYGSDRILLR PREKKLGLGT AYIHGMKHAT GNYIIIMDAD 
LSHHPKFIPE FIRKQKEGNF DIVSGTRYKG NGGVYGWDLK RKIISDGVLP CCPGWSLLGS 
SDPAILASWD YRCEPPRLAS RGANFLTQIL LRPGASDLTG SFRLYRKEVL EKLIEKCVSK 
GYVFQMEMIV RARQLNYTIG EVPISFVDRV YGESKLGGNE IVSFLKGLLT LFATT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.