Details for: DPM1
Gene ID: 8813
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: DPM1
Ensembl ID: ENSG00000000419
Description: dolichyl-phosphate mannosyltransferase subunit 1, catalytic
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 15.44rCSI 19.23%PRS 42.02
-
CSI 15.29rCSI 26.97%PRS 39.46
-
CSI 12.44rCSI 10.43%PRS 36.44
-
CSI 10.03rCSI 9.14%PRS 45.66
-
CSI 8.03rCSI 12.28%PRS 47.57
-
CSI 7.85rCSI 8.13%PRS 36.8
-
CSI 7.75rCSI 10.56%PRS 60.4
-
CSI 5.34rCSI 6.17%PRS 27.65
-
CSI 5.32rCSI 14.21%PRS 26.75
-
CSI 5.17rCSI 11.55%PRS 36.85
-
CSI 5.15rCSI 14.78%PRS 46.29
-
CSI 5.07rCSI 8.21%PRS 31.12
-
CSI 4.88rCSI 28%PRS 42.78
-
CSI 4.82rCSI 15.07%PRS 20.83
-
CSI 4.65rCSI 6.35%PRS 35.42
-
CSI 4.62rCSI 10.36%PRS 20.44
-
CSI 4.1rCSI 12.17%PRS 41.85
-
CSI 4.09rCSI 9.34%PRS 31.13
-
CSI 4.07rCSI 3.92%PRS 24.2
-
CSI 3.9rCSI 10.13%PRS 37.72
-
CSI 3.78rCSI 3%PRS 51.99
-
CSI 3.73rCSI 2.99%PRS 51.79
-
CSI 3.68rCSI 19.82%PRS 48.29
-
CSI 3.64rCSI 4.27%PRS 35.27
-
CSI 3.5rCSI 25.76%PRS 21.92
-
CSI 3.45rCSI 9.92%PRS 50.52
-
CSI 3.44rCSI 11.07%PRS 32.21
-
CSI 3.4rCSI 8.62%PRS 30.04
-
CSI 3.32rCSI 2.87%PRS 34.99
-
CSI 3.31rCSI 9.78%PRS 36.27
-
CSI 3.04rCSI 2.37%PRS 45.75
-
CSI 2.84rCSI 11.05%PRS 49.85
-
CSI 2.83rCSI 1.97%PRS 38.13
-
CSI 2.75rCSI 5.3%PRS 61.5
-
CSI 2.73rCSI 2.85%PRS 32.15
-
CSI 2.6rCSI 3.83%PRS 29.35
-
CSI 2.53rCSI 18.98%PRS 51.95
-
CSI 2.52rCSI 2.48%PRS 33.81
-
CSI 2.48rCSI 2.24%PRS 28.98
-
CSI 2.38rCSI 3.64%PRS 39.75
-
CSI 2.38rCSI 1.87%PRS 37.32
-
CSI 2.36rCSI 2.27%PRS 32.51
-
CSI 2.34rCSI 1.73%PRS 27.25
-
CSI 2.3rCSI 2.85%PRS 28.21
-
CSI 2.3rCSI 5.83%PRS 24.63
-
CSI 2.29rCSI 4.36%PRS 47.31
-
CSI 2.26rCSI 1.87%PRS 32.21
-
CSI 2.25rCSI 5.7%PRS 38.55
-
CSI 2.24rCSI 3.2%PRS 34.36
-
CSI 2.24rCSI 1.93%PRS 42.16
-
CSI 2.23rCSI 3.32%PRS 35.08
-
CSI 2.21rCSI 13.83%PRS 25.86
-
CSI 2.2rCSI 2.8%PRS 36.19
-
CSI 2.19rCSI 2.15%PRS 45.74
-
CSI 2.15rCSI 2.14%PRS 27.16
-
CSI 2.12rCSI 3.2%PRS 32.65
-
CSI 2.07rCSI 1.69%PRS 32.6
-
CSI 2.06rCSI 4.76%PRS 26.04
-
CSI 2.02rCSI 1.63%PRS 43.35
-
CSI 2.01rCSI 3.77%PRS 23.86
-
CSI 1.99rCSI 3.44%PRS 24.56
-
CSI 1.99rCSI 2.82%PRS 29.43
-
CSI 1.97rCSI 7.45%PRS 20.7
-
CSI 1.96rCSI 2.83%PRS 45.36
-
CSI 1.95rCSI 3.04%PRS 59.14
-
CSI 1.95rCSI 3.91%PRS 23.92
-
CSI 1.92rCSI 1.82%PRS 32.76
-
CSI 1.92rCSI 3.62%PRS 39.89
-
CSI 1.92rCSI 1.43%PRS 45.72
-
CSI 1.89rCSI 3.34%PRS 30.8
-
CSI 1.88rCSI 3.56%PRS 67.68
-
CSI 1.87rCSI 1.45%PRS 31.15
-
CSI 1.87rCSI 2.68%PRS 25.11
-
CSI 1.83rCSI 3%PRS 24.84
-
CSI 1.83rCSI 2.35%PRS 36.16
-
CSI 1.8rCSI 7.98%PRS 30.47
-
CSI 1.78rCSI 2.48%PRS 31.87
-
CSI 1.76rCSI 2.58%PRS 33.68
-
CSI 1.75rCSI 2.69%PRS 37.27
-
CSI 1.73rCSI 1.02%PRS 43.74
-
CSI 1.72rCSI 3.03%PRS 19.27
-
CSI 1.71rCSI 1.42%PRS 30.17
-
CSI 1.68rCSI 2.42%PRS 41.17
-
CSI 1.66rCSI 1.82%PRS 35.02
-
CSI 1.64rCSI 2.64%PRS 21.62
-
CSI 1.64rCSI 2.19%PRS 38.96
-
CSI 1.63rCSI 1.71%PRS 29.58
-
CSI 1.63rCSI 5.1%PRS 22.59
-
CSI 1.62rCSI 1.97%PRS 38.42
-
CSI 1.6rCSI 2.06%PRS 30.21
-
CSI 1.6rCSI 1.12%PRS 33.23
-
CSI 1.6rCSI 1.08%PRS 39.46
-
CSI 1.6rCSI 1.4%PRS 35.93
-
CSI 1.59rCSI 1.46%PRS 37.52
-
CSI 1.59rCSI 2.86%PRS 26.64
-
CSI 1.59rCSI 1.7%PRS 29.55
-
CSI 1.58rCSI 2.11%PRS 33.67
-
CSI 1.57rCSI 3.81%PRS 19.37
-
CSI 1.55rCSI 37.16%PRS 19.21
-
CSI 1.54rCSI 1.22%PRS 22.22
-
CSI 0.1rCSI 2.9%PRS 54.0%
-
CSI 0.1rCSI 1.2%PRS 20.9%
-
CSI 0.2rCSI 0.3%PRS 41.5%
-
CSI 0.2rCSI 2.6%PRS 70.4%
-
CSI 0.3rCSI 2.7%PRS 64.5%
-
CSI 0.3rCSI 3.7%PRS 67.7%
-
CSI 0.3rCSI 7.5%PRS 63.2%
-
CSI 0.3rCSI 1.8%PRS 43.4%
-
CSI 0.3rCSI 1.7%PRS 47.0%
-
CSI 0.4rCSI 1.9%PRS 41.6%
-
CSI 0.5rCSI 11.5%PRS 64.7%
-
CSI 0.5rCSI 2.9%PRS 21.0%
-
CSI 0.6rCSI 1.7%PRS 47.2%
-
CSI 0.6rCSI 1.4%PRS 23.0%
-
CSI 0.6rCSI 1.4%PRS 29.3%
-
CSI 0.7rCSI 1.9%PRS 34.5%
-
CSI 0.7rCSI 2.9%PRS 27.7%
-
CSI 0.7rCSI 1.1%PRS 18.0%
-
CSI 0.7rCSI 1.6%PRS 31.5%
-
CSI 0.7rCSI 1.4%PRS 32.8%
-
CSI 0.7rCSI 3.7%PRS 43.5%
-
CSI 0.7rCSI 1.2%PRS 24.6%
-
CSI 0.7rCSI 0.6%PRS 39.2%
-
CSI 0.7rCSI 0.9%PRS 33.3%
-
CSI 0.8rCSI 0.9%PRS 30.5%
-
CSI 0.8rCSI 1.4%PRS 46.4%
-
CSI 0.8rCSI 1.6%PRS 55.9%
-
CSI 0.9rCSI 3.0%PRS 48.3%
-
CSI 0.9rCSI 1.4%PRS 30.0%
-
CSI 0.9rCSI 0.6%PRS 36.0%
-
CSI 0.9rCSI 2.3%PRS 54.6%
-
CSI 0.9rCSI 2.0%PRS 45.4%
-
CSI 0.9rCSI 1.3%PRS 40.9%
-
CSI 0.9rCSI 3.3%PRS 18.9%
-
CSI 0.9rCSI 3.9%PRS 49.5%
-
CSI 0.9rCSI 2.4%PRS 37.3%
-
CSI 0.9rCSI 1.6%PRS 40.6%
-
CSI 0.9rCSI 2.2%PRS 42.9%
-
CSI 0.9rCSI 1.8%PRS 52.9%
-
CSI 0.9rCSI 3.0%PRS 40.5%
-
CSI 1.0rCSI 1.9%PRS 32.1%
-
CSI 1.0rCSI 1.4%PRS 27.3%
-
CSI 1.0rCSI 1.7%PRS 19.9%
-
CSI 1.0rCSI 3.0%PRS 53.7%
-
CSI 1.1rCSI 2.3%PRS 40.8%
-
CSI 1.1rCSI 1.4%PRS 43.1%
-
CSI 1.1rCSI 2.8%PRS 40.0%
-
CSI 1.1rCSI 1.6%PRS 29.3%
-
CSI 1.1rCSI 0.8%PRS 34.0%
-
CSI 1.1rCSI 1.4%PRS 35.0%
-
CSI 1.1rCSI 3.7%PRS 67.9%
-
CSI 1.1rCSI 2.0%PRS 29.9%
-
CSI 1.1rCSI 1.4%PRS 37.8%
-
CSI 1.1rCSI 4.1%PRS 49.6%
-
CSI 1.1rCSI 1.8%PRS 27.1%
-
CSI 1.2rCSI 1.8%PRS 40.3%
-
CSI 1.2rCSI 3.0%PRS 60.0%
-
CSI 1.2rCSI 3.4%PRS 49.6%
-
CSI 1.2rCSI 1.5%PRS 20.6%
-
CSI 1.2rCSI 1.1%PRS 32.8%
-
CSI 1.2rCSI 1.5%PRS 44.7%
-
CSI 1.2rCSI 2.5%PRS 55.0%
-
CSI 1.3rCSI 1.6%PRS 40.0%
-
CSI 1.3rCSI 7.2%PRS 43.7%
-
CSI 1.3rCSI 1.6%PRS 18.7%
-
CSI 1.3rCSI 2.0%PRS 32.0%
-
CSI 1.3rCSI 31.9%PRS 20.0%
-
CSI 1.3rCSI 2.1%PRS 32.2%
-
CSI 1.3rCSI 3.7%PRS 29.6%
-
CSI 1.4rCSI 1.9%PRS 30.3%
-
CSI 1.4rCSI 1.6%PRS 23.9%
-
CSI 1.4rCSI 7.0%PRS 71.3%
-
CSI 1.4rCSI 1.9%PRS 34.3%
-
CSI 1.4rCSI 2.2%PRS 26.8%
-
CSI 1.4rCSI 3.5%PRS 29.9%
-
CSI 1.4rCSI 2.9%PRS 18.5%
-
CSI 1.4rCSI 1.3%PRS 31.4%
-
CSI 1.4rCSI 1.7%PRS 19.8%
-
CSI 1.4rCSI 1.3%PRS 23.4%
-
CSI 1.4rCSI 1.2%PRS 31.8%
-
CSI 1.5rCSI 1.6%PRS 33.6%
-
CSI 1.5rCSI 3.2%PRS 46.3%
-
CSI 1.5rCSI 2.6%PRS 25.4%
-
CSI 1.5rCSI 2.5%PRS 36.4%
-
CSI 1.5rCSI 2.2%PRS 35.7%
-
CSI 1.5rCSI 4.8%PRS 35.9%
-
CSI 1.5rCSI 1.6%PRS 66.1%
-
CSI 1.5rCSI 2.7%PRS 21.8%
-
CSI 1.5rCSI 1.2%PRS 22.2%
-
CSI 1.6rCSI 37.2%PRS 19.2%
-
CSI 1.6rCSI 3.8%PRS 19.4%
-
CSI 1.6rCSI 2.1%PRS 33.7%
-
CSI 1.6rCSI 1.7%PRS 29.6%
-
CSI 1.6rCSI 2.9%PRS 26.6%
-
CSI 1.6rCSI 1.5%PRS 37.5%
-
CSI 1.6rCSI 1.4%PRS 35.9%
-
CSI 1.6rCSI 1.1%PRS 39.5%
-
CSI 1.6rCSI 1.1%PRS 33.2%
-
CSI 1.6rCSI 2.1%PRS 30.2%
-
CSI 1.6rCSI 2.0%PRS 38.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3310769846
Symbol: DPM1_HUMAN
Name: Dolichol-phosphate mannosyltransferase subunit 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9535917
Title: A homologue of Saccharomyces cerevisiae Dpm1p is not sufficient for synthesis of dolichol-phosphate-mannose in mammalian cells.
PubMed ID: 9535917
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9223280
Title: Human and Saccharomyces cerevisiae dolichol phosphate mannose synthases represent two classes of the enzyme, but both function in Schizosaccharomyces pombe.
PubMed ID: 9223280
PubMed ID: 10835346
Title: Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3.
PubMed ID: 10835346
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16280320
Title: DPM1, the catalytic subunit of dolichol-phosphate mannose synthase, is tethered to and stabilized on the endoplasmic reticulum membrane by DPM3.
PubMed ID: 16280320
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 10642597
Title: Dolichol phosphate mannose synthase (DPM1) mutations define congenital disorder of glycosylation Ie (CDG-Ie).
PubMed ID: 10642597
DOI: 10.1172/jci7302
PubMed ID: 10642602
Title: Deficiency of dolichol-phosphate-mannose synthase-1 causes congenital disorder of glycosylation type Ie.
PubMed ID: 10642602
DOI: 10.1172/jci8691
PubMed ID: 15669674
Title: Congenital disorder of glycosylation (CDG) type Ie. A new patient.
PubMed ID: 15669674
PubMed ID: 23856421
Title: Congenital disorder of glycosylation due to DPM1 mutations presenting with dystroglycanopathy-type congenital muscular dystrophy.
PubMed ID: 23856421
PubMed ID: 19576565
Title: Deficiency of Dol-P-Man synthase subunit DPM3 bridges the congenital disorders of glycosylation with the dystroglycanopathies.
PubMed ID: 19576565
Sequence Information:
- Length: 260
- Mass: 29634
- Checksum: 9792145BFC8F0514
- Sequence:
MASLEVSRSP RRSRRELEVR SPRQNKYSVL LPTYNERENL PLIVWLLVKS FSESGINYEI IIIDDGSPDG TRDVAEQLEK IYGSDRILLR PREKKLGLGT AYIHGMKHAT GNYIIIMDAD LSHHPKFIPE FIRKQKEGNF DIVSGTRYKG NGGVYGWDLK RKIISRGANF LTQILLRPGA SDLTGSFRLY RKEVLEKLIE KCVSKGYVFQ MEMIVRARQL NYTIGEVPIS FVDRVYGESK LGGNEIVSFL KGLLTLFATT
Genular Protein ID: 3518972724
Symbol: Q5QPK2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 26871637
Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
PubMed ID: 26871637
Sequence Information:
- Length: 287
- Mass: 32426
- Checksum: 0C7CB228C00D97B1
- Sequence:
MASLEVSRSP RRSRRELEVR SPRQNKYSVL LPTYNERENL PLIVWLLVKS FSESGINYEI IIIDDGSPDG TRDVAEQLEK IYGSDRILLR PREKKLGLGT AYIHGMKHAT GNYIIIMDAD LSHHPKFIPE FIRKQKEGNF DIVSGTRYKG NGGVYGWDLK RKIISDGVLP CCPGWSLLGS SDPAILASWD YSRGANFLTQ ILLRPGASDL TGSFRLYRKE VLEKLIEKCV SKGYVFQMEM IVRARQLNYT IGEVPISFVD RVYGESKLGG NEIVSFLKGL LTLFATT
Genular Protein ID: 12343708
Symbol: H0Y368_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 295
- Mass: 33350
- Checksum: 6CF7AF779A54AF93
- Sequence:
MASLEVSRSP RRSRRELEVR SPRQNKYSVL LPTYNERENL PLIVWLLVKS FSESGINYEI IIIDDGSPDG TRDVAEQLEK IYGSDRILLR PREKKLGLGT AYIHGMKHAT GNYIIIMDAD LSHHPKFIPE FIRKQKEGNF DIVSGTRYKG NGGVYGWDLK RKIISDGVLP CCPGWSLLGS SDPAILASWD YRCEPPRLAS RGANFLTQIL LRPGASDLTG SFRLYRKEVL EKLIEKCVSK GYVFQMEMIV RARQLNYTIG EVPISFVDRV YGESKLGGNE IVSFLKGLLT LFATT