Details for: DPM2

Gene ID: 8818

Symbol: DPM2

Ensembl ID: ENSG00000136908

Description: dolichyl-phosphate mannosyltransferase subunit 2, regulatory

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 87.6427
    Cell Significance Index: -22.2300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 71.6596
    Cell Significance Index: -29.5200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 60.3339
    Cell Significance Index: -28.4900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 59.3220
    Cell Significance Index: -24.1000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 54.3756
    Cell Significance Index: -27.9700
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 50.1462
    Cell Significance Index: -7.8000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 42.7482
    Cell Significance Index: -28.6900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.6928
    Cell Significance Index: -24.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.6525
    Cell Significance Index: -15.6000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.3053
    Cell Significance Index: -19.5700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.0121
    Cell Significance Index: -27.6700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.5897
    Cell Significance Index: -20.2400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.7872
    Cell Significance Index: -6.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.3827
    Cell Significance Index: 64.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0298
    Cell Significance Index: 14.0500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.9782
    Cell Significance Index: 24.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7939
    Cell Significance Index: 109.0300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.7699
    Cell Significance Index: 8.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6652
    Cell Significance Index: 18.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6503
    Cell Significance Index: 355.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6104
    Cell Significance Index: 28.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5869
    Cell Significance Index: 30.4900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5666
    Cell Significance Index: 13.0900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5445
    Cell Significance Index: 28.5900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.5435
    Cell Significance Index: 4.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5320
    Cell Significance Index: 95.9100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5053
    Cell Significance Index: 14.8400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.4814
    Cell Significance Index: 14.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4767
    Cell Significance Index: 210.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4765
    Cell Significance Index: 32.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4690
    Cell Significance Index: 76.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4676
    Cell Significance Index: 57.5000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4481
    Cell Significance Index: 15.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4422
    Cell Significance Index: 12.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4275
    Cell Significance Index: 31.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4238
    Cell Significance Index: 8.8700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4164
    Cell Significance Index: 21.6900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4113
    Cell Significance Index: 48.5100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3917
    Cell Significance Index: 4.4500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3882
    Cell Significance Index: 4.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3823
    Cell Significance Index: 24.6700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3770
    Cell Significance Index: 26.6600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3647
    Cell Significance Index: 9.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3281
    Cell Significance Index: 14.8700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3111
    Cell Significance Index: 280.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3101
    Cell Significance Index: 39.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3045
    Cell Significance Index: 8.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3023
    Cell Significance Index: 57.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3016
    Cell Significance Index: 38.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2754
    Cell Significance Index: 47.0200
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.2492
    Cell Significance Index: 1.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2314
    Cell Significance Index: 46.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1714
    Cell Significance Index: 4.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1553
    Cell Significance Index: 9.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1458
    Cell Significance Index: 28.9300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1221
    Cell Significance Index: 1.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1108
    Cell Significance Index: 83.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0970
    Cell Significance Index: 34.7800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0626
    Cell Significance Index: 0.5000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0566
    Cell Significance Index: 39.1300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.0374
    Cell Significance Index: 0.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0338
    Cell Significance Index: 0.5700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0299
    Cell Significance Index: 0.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0251
    Cell Significance Index: 2.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0044
    Cell Significance Index: -0.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0052
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0061
    Cell Significance Index: -3.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0067
    Cell Significance Index: -4.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0079
    Cell Significance Index: -14.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0109
    Cell Significance Index: -8.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0157
    Cell Significance Index: -1.6000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0160
    Cell Significance Index: -29.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0183
    Cell Significance Index: -28.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0197
    Cell Significance Index: -26.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0239
    Cell Significance Index: -0.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0281
    Cell Significance Index: -15.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0297
    Cell Significance Index: -18.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0512
    Cell Significance Index: -23.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0536
    Cell Significance Index: -11.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0594
    Cell Significance Index: -6.8000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0625
    Cell Significance Index: -0.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0774
    Cell Significance Index: -22.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0860
    Cell Significance Index: -2.3100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1058
    Cell Significance Index: -1.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1315
    Cell Significance Index: -15.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1357
    Cell Significance Index: -19.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1484
    Cell Significance Index: -3.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2180
    Cell Significance Index: -13.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2191
    Cell Significance Index: -14.7300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2256
    Cell Significance Index: -25.7500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2432
    Cell Significance Index: -2.2400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2595
    Cell Significance Index: -6.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2649
    Cell Significance Index: -20.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2659
    Cell Significance Index: -27.6900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2965
    Cell Significance Index: -23.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3067
    Cell Significance Index: -17.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3247
    Cell Significance Index: -11.4100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.3326
    Cell Significance Index: -4.6200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3653
    Cell Significance Index: -4.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3840
    Cell Significance Index: -23.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of the Dolichol-Phosphate-Mannose Synthase Complex**: DPM2 is a regulatory subunit of the dolichol-phosphate-mannose synthase complex, which catalyzes the synthesis of dolichol phosphate mannose (DPM), a key glycosylation precursor. 2. **Regulatory Function**: DPM2 modulates the activity of the dolichol-phosphate-mannose synthase complex, influencing the efficiency and accuracy of glycosylation precursor biosynthesis. 3. **Specific Expression in Cells**: DPM2 is significantly expressed in various cell types, including pneumocytes, erythroid progenitor cells, and placental villous trophoblasts, highlighting its importance in differentiating and functional cell types. 4. **Disease Association**: Defects in DPM2 have been linked to congenital disorders of glycosylation (CDG), which are characterized by abnormalities in glycosylation precursor biosynthesis. **Pathways and Functions:** 1. **Asparagine-N-Linked Glycosylation**: DPM2 is involved in the biosynthesis of glycosylation precursors for asparagine-N-linked glycosylation, a process critical for protein folding, stability, and function. 2. **Biosynthesis of N-Glycan Precursors**: DPM2 plays a key role in the synthesis of dolichol lipid-linked oligosaccharides (DLOs), which are the primary glycosylation precursors for N-glycosylation. 3. **Glycosylation of Proteins**: DPM2 is involved in the glycosylation of proteins, particularly those destined for the secretory pathway, influencing their stability, folding, and function. 4. **Regulation of Protein Stability**: DPM2 modulates the stability of glycosylated proteins, influencing their half-life and overall cellular function. **Clinical Significance:** 1. **Congenital Disorders of Glycosylation (CDG)**: Defects in DPM2 have been implicated in CDG, a group of disorders characterized by abnormalities in glycosylation precursor biosynthesis. 2. **Glycosylation Defects**: Abnormalities in DPM2 function can lead to glycosylation defects, influencing protein folding, stability, and function, and potentially contributing to various diseases. 3. **Therapeutic Implications**: Understanding the regulatory role of DPM2 in glycosylation precursor biosynthesis has implications for the development of therapeutic strategies targeting glycosylation defects, particularly in the context of CDG. In conclusion, DPM2 is a critical regulatory enzyme involved in glycosylation precursor biosynthesis, influencing the quality and quantity of glycosylation events in cells. Defects in DPM2 have been implicated in various diseases, highlighting the importance of this enzyme in maintaining cellular function and overall health. Further research into the role of DPM2 in glycosylation precursor biosynthesis will provide valuable insights into the development of therapeutic strategies for glycosylation-related disorders.

Genular Protein ID: 3102598763

Symbol: DPM2_HUMAN

Name: Dolichol-phosphate mannose synthase subunit 2

UniProtKB Accession Codes:

O94777 Q5XKK9 Q6FGH3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 9 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9724629

Title: DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate.

PubMed ID: 9724629

DOI: 10.1093/emboj/17.17.4920

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10835346

Title: Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3.

PubMed ID: 10835346

DOI: 10.1093/emboj/19.11.2475

PubMed ID: 10944123

Title: Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2.

PubMed ID: 10944123

DOI: 10.1093/emboj/19.16.4402

PubMed ID: 16162815

Title: The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component.

PubMed ID: 16162815

DOI: 10.1091/mbc.e05-08-0743

PubMed ID: 23109149

Title: DPM2-CDG: a muscular dystrophy-dystroglycanopathy syndrome with severe epilepsy.

PubMed ID: 23109149

DOI: 10.1002/ana.23632

Sequence Information:

  • Length: 84
  • Mass: 9312
  • Checksum: 0247A0843A711EE9
  • Sequence:
    • MATGTDQVVG LGLVAVSLII FTYYTAWVIL LPFIDSQHVI HKYFLPRAYA VAIPLAAGLL 
LLLFVGLFIS YVMLKTKRVT KKAQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.