DPM2 | ENSG00000136908 | NCBI 8818

Details for: DPM2

Gene ID: 8818

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: DPM2

Ensembl ID: ENSG00000136908

Description: dolichyl-phosphate mannosyltransferase subunit 2, regulatory

Cell Significance Landscape

Display Count:

Associated with

Asparagine n-linked glycosylation
(R-HSA-446203)
Biosynthesis of the n-glycan precursor (dolichol lipid-linked oligosaccharide, llo) and transfer to a nascent protein
(R-HSA-446193)
Defective dpm1 causes dpm1-cdg
(R-HSA-4717374)
Defective dpm2 causes dpm2-cdg
(R-HSA-4719377)
Defective dpm3 causes dpm3-cdg
(R-HSA-4719360)
Disease
(R-HSA-1643685)
Diseases associated with glycosylation precursor biosynthesis
(R-HSA-5609975)
Diseases of glycosylation
(R-HSA-3781865)
Diseases of metabolism
(R-HSA-5668914)
Metabolism of proteins
(R-HSA-392499)
Post-translational modification: synthesis of gpi-anchored proteins
(R-HSA-163125)
Post-translational protein modification
(R-HSA-597592)
Synthesis of dolichyl-phosphate mannose
(R-HSA-162699)
Synthesis of glycosylphosphatidylinositol (gpi)
(R-HSA-162710)
Synthesis of substrates in n-glycan biosythesis
(R-HSA-446219)
Dolichol-phosphate-mannose synthase complex
(GO:0033185)
Dolichol metabolic process
(GO:0019348)
Endoplasmic reticulum membrane
(GO:0005789)
Enzyme activator activity
(GO:0008047)
Enzyme regulator activity
(GO:0030234)
Glycosylphosphatidylinositol-n-acetylglucosaminyltransferase (gpi-gnt) complex
(GO:0000506)
Gpi anchor biosynthetic process
(GO:0006506)
Protein binding
(GO:0005515)
Protein o-linked mannosylation
(GO:0035269)
Regulation of protein stability
(GO:0031647)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

lung secretory cell CL1000272

CSI 12.35

rCSI 30.56%

PRS 57.47
rod bipolar cell CL0000751

CSI 7.66

rCSI 13.77%

PRS 52.13
intermediate monocyte CL0002393

CSI 7.09

rCSI 10.7%

PRS 62.9
fibroblast of lung CL0002553

CSI 6.93

rCSI 6.45%

PRS 59.4
neural progenitor cell CL0011020

CSI 6.78

rCSI 29.84%

PRS 49.87
alveolar adventitial fibroblast CL4028006

CSI 6.48

rCSI 10.24%

PRS 61.05
primitive red blood cell CL0002355

CSI 6.43

rCSI 34.67%

PRS 71.9
erythroid progenitor cell CL0000038

CSI 5.92

rCSI 33.95%

PRS 68.5
double-positive, alpha-beta thymocyte CL0000809

CSI 4.54

rCSI 4.63%

PRS 72.43
double negative thymocyte CL0002489

CSI 3.92

rCSI 2.73%

PRS 69.93
peripheral nervous system neuron CL2000032

CSI 3.79

rCSI 5.16%

PRS 51.02
pro-B cell CL0000826

CSI 3.77

rCSI 3.12%

PRS 60.85
interstitial cell of Cajal CL0002088

CSI 3.71

rCSI 4.73%

PRS 65.51
effector CD8-positive, alpha-beta T cell CL0001050

CSI 3.7

rCSI 2.81%

PRS 71.94
mature B cell CL0000785

CSI 3.52

rCSI 3.06%

PRS 69.73
erythroblast CL0000765

CSI 3.41

rCSI 9.06%

PRS 70.73
pancreatic A cell CL0000171

CSI 3.25

rCSI 3.4%

PRS 62.6
pulmonary alveolar type 2 cell CL0002063

CSI 3.12

rCSI 4.84%

PRS 66.97
Hofbauer cell CL3000001

CSI 3.05

rCSI 5.75%

PRS 69.7
mesenchymal cell CL0008019

CSI 3.03

rCSI 7.7%

PRS 53.41
respiratory basal cell CL0002633

CSI 3.02

rCSI 3.13%

PRS 64.46
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 3

rCSI 15.06%

PRS 71.53
perivascular cell CL4033054

CSI 2.94

rCSI 4.02%

PRS 64.9
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 2.91

rCSI 2.86%

PRS 74.81
naive T cell CL0000898

CSI 2.82

rCSI 1.96%

PRS 74.09
epithelial cell of lung CL0000082

CSI 2.8

rCSI 2.32%

PRS 58.03
cerebral cortex GABAergic interneuron CL0010011

CSI 2.76

rCSI 8.15%

PRS 62.24
megakaryocyte-erythroid progenitor cell CL0000050

CSI 2.61

rCSI 2.36%

PRS 55.84
activated type II NK T cell CL0000931

CSI 2.6

rCSI 2.92%

PRS 75.48
plasmablast CL0000980

CSI 2.59

rCSI 2.04%

PRS 65.71
mesodermal cell CL0000222

CSI 2.55

rCSI 3.06%

PRS 57.05
skin fibroblast CL0002620

CSI 2.53

rCSI 2.18%

PRS 64.97
myofibroblast cell CL0000186

CSI 2.51

rCSI 3.47%

PRS 60.57
plasmacytoid dendritic cell, human CL0001058

CSI 2.46

rCSI 1.71%

PRS 61.79
pancreatic acinar cell CL0002064

CSI 2.44

rCSI 3.25%

PRS 65.32
immature B cell CL0000816

CSI 2.43

rCSI 1.81%

PRS 72.42
erythroid lineage cell CL0000764

CSI 2.42

rCSI 15.58%

PRS 77.04
stem cell CL0000034

CSI 2.42

rCSI 2.33%

PRS 49.56
early lymphoid progenitor CL0000936

CSI 2.35

rCSI 2.07%

PRS 64.4
epithelial cell of lower respiratory tract CL0002632

CSI 2.35

rCSI 1.82%

PRS 60.62
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 2.32

rCSI 2.68%

PRS 52.35
T follicular helper cell CL0002038

CSI 2.31

rCSI 1.73%

PRS 74.12
ON-bipolar cell CL0000749

CSI 2.26

rCSI 3.36%

PRS 60.81
pancreatic D cell CL0000173

CSI 2.24

rCSI 2.21%

PRS 61.72
epithelial cell CL0000066

CSI 2.24

rCSI 3.45%

PRS 55.83
placental villous trophoblast CL2000060

CSI 2.24

rCSI 3.46%

PRS 57.06
extravillous trophoblast CL0008036

CSI 2.18

rCSI 2.7%

PRS 55.31
goblet cell CL0000160

CSI 2.13

rCSI 2.01%

PRS 58.62
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 2.07

rCSI 2.85%

PRS 78.91
granulocyte monocyte progenitor cell CL0000557

CSI 2.04

rCSI 1.77%

PRS 63.95
promonocyte CL0000559

CSI 2.03

rCSI 3.48%

PRS 67.93
neural crest cell CL0011012

CSI 2.02

rCSI 1.6%

PRS 45.97
foveolar cell of stomach CL0002179

CSI 1.98

rCSI 4.21%

PRS 70.87
pulmonary ionocyte CL0017000

CSI 1.94

rCSI 2.36%

PRS 66.64
enteric smooth muscle cell CL0002504

CSI 1.9

rCSI 2.71%

PRS 61.39
ciliated epithelial cell CL0000067

CSI 1.89

rCSI 1.66%

PRS 46.97
colon epithelial cell CL0011108

CSI 1.88

rCSI 1.97%

PRS 55.46
lung ciliated cell CL1000271

CSI 1.84

rCSI 2.12%

PRS 49.14
keratinocyte CL0000312

CSI 1.84

rCSI 1.54%

PRS 63.6
mucous neck cell CL0000651

CSI 1.83

rCSI 2.64%

PRS 70.08
renal alpha-intercalated cell CL0005011

CSI 1.83

rCSI 2.44%

PRS 68.11
erythrocyte CL0000232

CSI 1.81

rCSI 4.12%

PRS 63.33
mucus secreting cell CL0000319

CSI 1.81

rCSI 2.88%

PRS 70.17
intestine goblet cell CL0019031

CSI 1.77

rCSI 1.57%

PRS 57.06
retina horizontal cell CL0000745

CSI 1.75

rCSI 2.67%

PRS 55.39
elicited macrophage CL0000861

CSI 1.63

rCSI 1.5%

PRS 67.72
myeloid leukocyte CL0000766

CSI 1.63

rCSI 1.5%

PRS 60.35
IgG plasma cell CL0000985

CSI 1.62

rCSI 1.94%

PRS 76.47
hematopoietic stem cell CL0000037

CSI 1.62

rCSI 1.07%

PRS 62.33
transit amplifying cell of colon CL0009011

CSI 1.61

rCSI 1.89%

PRS 61.45
multi-ciliated epithelial cell CL0005012

CSI 1.6

rCSI 1.59%

PRS 52.35
pvalb GABAergic cortical interneuron CL4023018

CSI 1.6

rCSI 1.99%

PRS 39.21
common myeloid progenitor CL0000049

CSI 1.59

rCSI 1.29%

PRS 60.32
CD14-positive, CD16-positive monocyte CL0002397

CSI 1.57

rCSI 2.05%

PRS 72.68
radial glial cell CL0000681

CSI 1.56

rCSI 2.17%

PRS 57.87
common lymphoid progenitor CL0000051

CSI 1.51

rCSI 2.02%

PRS 80.22
acinar cell CL0000622

CSI 1.51

rCSI 2.21%

PRS 70.48
lung macrophage CL1001603

CSI 1.51

rCSI 3.37%

PRS 66.72
mature alpha-beta T cell CL0000791

CSI 1.49

rCSI 5.39%

PRS 78.68
neuroblast (sensu Vertebrata) CL0000031

CSI 1.48

rCSI 1.9%

PRS 56.37
promyelocyte CL0000836

CSI 1.47

rCSI 2.13%

PRS 68.55
enteroendocrine cell CL0000164

CSI 1.46

rCSI 2%

PRS 60.87
duct epithelial cell CL0000068

CSI 1.46

rCSI 2.14%

PRS 63.24
ionocyte CL0005006

CSI 1.46

rCSI 1.57%

PRS 58.15
club cell CL0000158

CSI 1.45

rCSI 2.13%

PRS 55.37
basal cell CL0000646

CSI 1.41

rCSI 1.88%

PRS 59.44
alternatively activated macrophage CL0000890

CSI 1.39

rCSI 1.74%

PRS 71.15
intestinal epithelial cell CL0002563

CSI 1.34

rCSI 1.4%

PRS 57.15
fallopian tube secretory epithelial cell CL4030006

CSI 1.34

rCSI 1.29%

PRS 59.23
glioblast CL0000030

CSI 1.27

rCSI 2.03%

PRS 51.87
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.27

rCSI 2.24%

PRS 40.13
bronchus fibroblast of lung CL2000093

CSI 1.25

rCSI 1.01%

PRS 59.66
respiratory hillock cell CL4030023

CSI 1.22

rCSI 2.17%

PRS 72.55
pancreatic ductal cell CL0002079

CSI 1.18

rCSI 2.29%

PRS 61.83
syncytiotrophoblast cell CL0000525

CSI 1.12

rCSI 3.22%

PRS 73.06
lung pericyte CL0009089

CSI 1.07

rCSI 2.82%

PRS 67.9
mammary gland epithelial cell CL0002327

CSI 1.05

rCSI 3.69%

PRS 71.81
microcirculation associated smooth muscle cell CL0008035

CSI 1.05

rCSI 3.04%

PRS 60.53
colon goblet cell CL0009039

CSI 0.9

rCSI 2.13%

PRS 68.63
L6b glutamatergic cortical neuron CL4023038

CSI 0.89

rCSI 2.77%

PRS 42.69

pancreatic stellate cell CL0002410

CSI 0.5

rCSI 2.8%

PRS 68.4%
type B pancreatic cell CL0000169

CSI 0.5

rCSI 1.1%

PRS 56.9%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 0.5

rCSI 1.8%

PRS 39.6%
podocyte CL0000653

CSI 0.6

rCSI 2.5%

PRS 58.4%
pancreatic PP cell CL0002275

CSI 0.6

rCSI 2.5%

PRS 72.3%
forebrain radial glial cell CL0013000

CSI 0.6

rCSI 2.0%

PRS 64.4%
pancreatic epsilon cell CL0005019

CSI 0.7

rCSI 3.0%

PRS 76.6%
near-projecting glutamatergic cortical neuron CL4023012

CSI 0.7

rCSI 2.8%

PRS 42.0%
type EC enteroendocrine cell CL0000577

CSI 0.8

rCSI 2.7%

PRS 68.4%
sst GABAergic cortical interneuron CL4023017

CSI 0.8

rCSI 1.0%

PRS 42.3%
tracheobronchial serous cell CL0019001

CSI 0.9

rCSI 3.7%

PRS 71.8%
retinal cone cell CL0000573

CSI 0.9

rCSI 1.4%

PRS 48.7%
L6b glutamatergic cortical neuron CL4023038

CSI 0.9

rCSI 2.8%

PRS 42.7%
colon goblet cell CL0009039

CSI 0.9

rCSI 2.1%

PRS 68.6%
microcirculation associated smooth muscle cell CL0008035

CSI 1.1

rCSI 3.0%

PRS 60.5%
mammary gland epithelial cell CL0002327

CSI 1.1

rCSI 3.7%

PRS 71.8%
lung pericyte CL0009089

CSI 1.1

rCSI 2.8%

PRS 67.9%
syncytiotrophoblast cell CL0000525

CSI 1.1

rCSI 3.2%

PRS 73.1%
pancreatic ductal cell CL0002079

CSI 1.2

rCSI 2.3%

PRS 61.8%
respiratory hillock cell CL4030023

CSI 1.2

rCSI 2.2%

PRS 72.6%
bronchus fibroblast of lung CL2000093

CSI 1.3

rCSI 1.0%

PRS 59.7%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.3

rCSI 2.2%

PRS 40.1%
glioblast CL0000030

CSI 1.3

rCSI 2.0%

PRS 51.9%
fallopian tube secretory epithelial cell CL4030006

CSI 1.3

rCSI 1.3%

PRS 59.2%
intestinal epithelial cell CL0002563

CSI 1.3

rCSI 1.4%

PRS 57.2%
alternatively activated macrophage CL0000890

CSI 1.4

rCSI 1.7%

PRS 71.2%
basal cell CL0000646

CSI 1.4

rCSI 1.9%

PRS 59.4%
club cell CL0000158

CSI 1.5

rCSI 2.1%

PRS 55.4%
ionocyte CL0005006

CSI 1.5

rCSI 1.6%

PRS 58.2%
duct epithelial cell CL0000068

CSI 1.5

rCSI 2.1%

PRS 63.2%
enteroendocrine cell CL0000164

CSI 1.5

rCSI 2.0%

PRS 60.9%
promyelocyte CL0000836

CSI 1.5

rCSI 2.1%

PRS 68.6%
neuroblast (sensu Vertebrata) CL0000031

CSI 1.5

rCSI 1.9%

PRS 56.4%
mature alpha-beta T cell CL0000791

CSI 1.5

rCSI 5.4%

PRS 78.7%
lung macrophage CL1001603

CSI 1.5

rCSI 3.4%

PRS 66.7%
acinar cell CL0000622

CSI 1.5

rCSI 2.2%

PRS 70.5%
common lymphoid progenitor CL0000051

CSI 1.5

rCSI 2.0%

PRS 80.2%
radial glial cell CL0000681

CSI 1.6

rCSI 2.2%

PRS 57.9%
CD14-positive, CD16-positive monocyte CL0002397

CSI 1.6

rCSI 2.1%

PRS 72.7%
common myeloid progenitor CL0000049

CSI 1.6

rCSI 1.3%

PRS 60.3%
pvalb GABAergic cortical interneuron CL4023018

CSI 1.6

rCSI 2.0%

PRS 39.2%
multi-ciliated epithelial cell CL0005012

CSI 1.6

rCSI 1.6%

PRS 52.4%
transit amplifying cell of colon CL0009011

CSI 1.6

rCSI 1.9%

PRS 61.5%
hematopoietic stem cell CL0000037

CSI 1.6

rCSI 1.1%

PRS 62.3%
IgG plasma cell CL0000985

CSI 1.6

rCSI 1.9%

PRS 76.5%
myeloid leukocyte CL0000766

CSI 1.6

rCSI 1.5%

PRS 60.4%
elicited macrophage CL0000861

CSI 1.6

rCSI 1.5%

PRS 67.7%
retina horizontal cell CL0000745

CSI 1.8

rCSI 2.7%

PRS 55.4%
intestine goblet cell CL0019031

CSI 1.8

rCSI 1.6%

PRS 57.1%
mucus secreting cell CL0000319

CSI 1.8

rCSI 2.9%

PRS 70.2%
erythrocyte CL0000232

CSI 1.8

rCSI 4.1%

PRS 63.3%
renal alpha-intercalated cell CL0005011

CSI 1.8

rCSI 2.4%

PRS 68.1%
mucous neck cell CL0000651

CSI 1.8

rCSI 2.6%

PRS 70.1%
keratinocyte CL0000312

CSI 1.8

rCSI 1.5%

PRS 63.6%
lung ciliated cell CL1000271

CSI 1.8

rCSI 2.1%

PRS 49.1%
colon epithelial cell CL0011108

CSI 1.9

rCSI 2.0%

PRS 55.5%
ciliated epithelial cell CL0000067

CSI 1.9

rCSI 1.7%

PRS 47.0%
enteric smooth muscle cell CL0002504

CSI 1.9

rCSI 2.7%

PRS 61.4%
pulmonary ionocyte CL0017000

CSI 1.9

rCSI 2.4%

PRS 66.6%
foveolar cell of stomach CL0002179

CSI 2.0

rCSI 4.2%

PRS 70.9%
neural crest cell CL0011012

CSI 2.0

rCSI 1.6%

PRS 46.0%
promonocyte CL0000559

CSI 2.0

rCSI 3.5%

PRS 67.9%
granulocyte monocyte progenitor cell CL0000557

CSI 2.0

rCSI 1.8%

PRS 64.0%
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 2.1

rCSI 2.9%

PRS 78.9%
goblet cell CL0000160

CSI 2.1

rCSI 2.0%

PRS 58.6%
extravillous trophoblast CL0008036

CSI 2.2

rCSI 2.7%

PRS 55.3%
placental villous trophoblast CL2000060

CSI 2.2

rCSI 3.5%

PRS 57.1%
epithelial cell CL0000066

CSI 2.2

rCSI 3.5%

PRS 55.8%
pancreatic D cell CL0000173

CSI 2.2

rCSI 2.2%

PRS 61.7%
ON-bipolar cell CL0000749

CSI 2.3

rCSI 3.4%

PRS 60.8%
T follicular helper cell CL0002038

CSI 2.3

rCSI 1.7%

PRS 74.1%
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 2.3

rCSI 2.7%

PRS 52.4%
epithelial cell of lower respiratory tract CL0002632

CSI 2.4

rCSI 1.8%

PRS 60.6%
early lymphoid progenitor CL0000936

CSI 2.4

rCSI 2.1%

PRS 64.4%
stem cell CL0000034

CSI 2.4

rCSI 2.3%

PRS 49.6%
erythroid lineage cell CL0000764

CSI 2.4

rCSI 15.6%

PRS 77.0%
immature B cell CL0000816

CSI 2.4

rCSI 1.8%

PRS 72.4%
pancreatic acinar cell CL0002064

CSI 2.4

rCSI 3.3%

PRS 65.3%
plasmacytoid dendritic cell, human CL0001058

CSI 2.5

rCSI 1.7%

PRS 61.8%
myofibroblast cell CL0000186

CSI 2.5

rCSI 3.5%

PRS 60.6%
skin fibroblast CL0002620

CSI 2.5

rCSI 2.2%

PRS 65.0%
mesodermal cell CL0000222

CSI 2.6

rCSI 3.1%

PRS 57.1%
plasmablast CL0000980

CSI 2.6

rCSI 2.0%

PRS 65.7%
activated type II NK T cell CL0000931

CSI 2.6

rCSI 2.9%

PRS 75.5%
megakaryocyte-erythroid progenitor cell CL0000050

CSI 2.6

rCSI 2.4%

PRS 55.8%
cerebral cortex GABAergic interneuron CL0010011

CSI 2.8

rCSI 8.2%

PRS 62.2%
epithelial cell of lung CL0000082

CSI 2.8

rCSI 2.3%

PRS 58.0%
naive T cell CL0000898

CSI 2.8

rCSI 2.0%

PRS 74.1%
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 2.9

rCSI 2.9%

PRS 74.8%
perivascular cell CL4033054

CSI 2.9

rCSI 4.0%

PRS 64.9%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 3.0

rCSI 15.1%

PRS 71.5%
respiratory basal cell CL0002633

CSI 3.0

rCSI 3.1%

PRS 64.5%
mesenchymal cell CL0008019

CSI 3.0

rCSI 7.7%

PRS 53.4%
Hofbauer cell CL3000001

CSI 3.1

rCSI 5.8%

PRS 69.7%
pulmonary alveolar type 2 cell CL0002063

CSI 3.1

rCSI 4.8%

PRS 67.0%
pancreatic A cell CL0000171

CSI 3.3

rCSI 3.4%

PRS 62.6%
erythroblast CL0000765

CSI 3.4

rCSI 9.1%

PRS 70.7%
mature B cell CL0000785

CSI 3.5

rCSI 3.1%

PRS 69.7%
effector CD8-positive, alpha-beta T cell CL0001050

CSI 3.7

rCSI 2.8%

PRS 71.9%
interstitial cell of Cajal CL0002088

CSI 3.7

rCSI 4.7%

PRS 65.5%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

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Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [DPM2](/details-gene/8818) (dolichyl-phosphate mannosyltransferase subunit 2, regulatory) encodes a crucial regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex. This complex is located in the membrane of the endoplasmic reticulum and catalyzes the synthesis of dolichol-phosphate-mannose (Dol-P-Man), an essential mannosyl donor for multiple glycosylation pathways, including N-linked glycosylation, O-mannosylation, and the biosynthesis of glycosylphosphatidylinositol (GPI) anchors. Research indicates that [DPM2](/details-gene/8818) is essential for stabilizing the catalytic subunit, DPM1, and regulating the initial steps of GPI anchor synthesis ([Link](https://doi.org/10.1093/emboj/17.17.4920), [Link](https://doi.org/10.1093/emboj/19.16.4402)). **Overall**, [DPM2](/details-gene/8818) exhibits significant expression in a wide range of metabolically active and developing cell types, including [lung secretory cell](/details-cell/CL1000272), various progenitor cells, and immune cells, highlighting its fundamental role in protein modification across diverse biological systems. Mutations in this gene are associated with DPM2-CDG, a congenital disorder of glycosylation characterized as a muscular dystrophy-dystroglycanopathy syndrome ([Link](https://doi.org/10.1002/ana.23632)). ## Cellular Roles and Expression Landscape The expression profile of [DPM2](/details-gene/8818) underscores its foundational role in cellular processes requiring high rates of protein synthesis and post-translational modification. **Overall**, the gene's significance is most pronounced in cells with substantial secretory or metabolic activity. It is a top marker in [lung secretory cell](/details-cell/CL1000272) (CSI: 12.35), which is consistent with the extensive glycosylation required for the production of secreted proteins like mucins and surfactants. Its high CSI is also observed in other structurally and functionally diverse cells such as the [rod bipolar cell](/details-cell/CL0000751) (CSI: 7.66) of the retina and [fibroblast of lung](/details-cell/CL0002553) (CSI: 6.93), suggesting a widespread requirement for its function in maintaining cellular protein integrity. Furthermore, [DPM2](/details-gene/8818) appears critical during cellular differentiation and development. Its elevated significance in various progenitor populations, including [neural progenitor cell](/details-cell/CL0011020) (CSI: 6.78), [primitive red blood cell](/details-cell/CL0002355) (CSI: 6.43), and [erythroid progenitor cell](/details-cell/CL0000038) (CSI: 5.92), suggests that proper glycosylation mediated by this complex is essential for cell fate determination and maturation. This pattern extends to the immune system, where it is significantly expressed in developing lymphocytes such as [double-positive, alpha-beta thymocyte](/details-cell/CL0000809) (CSI: 4.54) and [pro-B cell](/details-cell/CL0000826) (CSI: 3.77), as well as in mature cells like the [intermediate monocyte](/details-cell/CL0002393) (CSI: 7.09). This indicates a continuous role in establishing and maintaining the repertoire of surface proteins crucial for immune cell function. ## Pathways and Molecular Function Functionally, [DPM2](/details-gene/8818) is annotated as having '[Enzyme activator activity](/details-go/GO:0008047)' and '[Enzyme regulator activity](/details-go/GO:0030234)'. It is a core component of the '[Dolichol-phosphate-mannose synthase complex](/details-go/GO:0033185)', which operates at the '[Endoplasmic reticulum membrane](/details-go/GO:0005789)'. The primary biological processes involving [DPM2](/details-gene/8818) are related to protein glycosylation. It plays a central role in the '[Synthesis of dolichyl-phosphate mannose](/details-reactome/R-HSA-162699)', a critical step in the biosynthesis pathway for N-glycan precursors ([Asparagine n-linked glycosylation](/details-reactome/R-HSA-446203)). This is consistent with its high expression in secretory cells that produce large volumes of glycoproteins. Additionally, [DPM2](/details-gene/8818) is indispensable for the '[Gpi anchor biosynthetic process](/details-go/GO:0006506)' ([Synthesis of glycosylphosphatidylinositol (gpi)](/details-reactome/R-HSA-162710)), which is required to tether many essential proteins to the cell surface. This function likely explains its importance in progenitor and immune cells, which rely on a diverse array of GPI-anchored surface receptors for signaling and cell-cell interaction. Clinically, the gene's importance is highlighted by its association with '[Diseases of glycosylation](/details-reactome/R-HSA-3781865)'. Specifically, defects in [DPM2](/details-gene/8818) lead to a congenital disorder of glycosylation (DPM2-CDG), as detailed in the Reactome pathway '[Defective dpm2 causes dpm2-cdg](/details-reactome/R-HSA-4719377)'. ## Research Directions The broad yet specific enrichment of [DPM2](/details-gene/8818) in highly active and developing cell populations suggests precise, context-dependent roles beyond general housekeeping. **Proposed Hypotheses:** 1. Given the high CSI of [DPM2](/details-gene/8818) across multiple progenitor lineages ([neural progenitor cell](/details-cell/CL0011020), [erythroid progenitor cell](/details-cell/CL0000038), [double-positive, alpha-beta thymocyte](/details-cell/CL0000809)), it is hypothesized that [DPM2](/details-gene/8818) expression levels are dynamically regulated during differentiation to control the surface density and function of key lineage-defining glycoproteins, thereby acting as a gatekeeper for cell fate commitment. 2. The exceptional significance of [DPM2](/details-gene/8818) in [lung secretory cell](/details-cell/CL1000272) suggests that it is a rate-limiting factor for the production of the protective mucus layer. It is therefore hypothesized that reduced [DPM2](/details-gene/8818) activity or expression contributes to the pathophysiology of muco-obstructive lung diseases, such as cystic fibrosis or chronic obstructive pulmonary disease, by impairing the proper glycosylation and subsequent secretion of mucin proteins. **Key Experimental Approach:** To test the first hypothesis regarding its role in cell fate, a powerful approach would be to use a CRISPR interference (CRISPRi) system to achieve tunable knockdown of [DPM2](/details-gene/8818) in human induced pluripotent stem cells (iPSCs). These iPSCs could then be directed to differentiate towards hematopoietic lineages. The effects of partial versus complete [DPM2](/details-gene/8818) knockdown on the efficiency of generating erythroid and lymphoid progenitors could be quantified using flow cytometry for lineage-specific markers. Furthermore, a surface proteomic analysis (glycocapture) could be performed at different stages of differentiation to identify specific GPI-anchored or N-glycosylated proteins whose expression or stability is dependent on [DPM2](/details-gene/8818) levels. **Therapeutic Potential:** Due to its fundamental role in protein glycosylation across a wide variety of cell types, [DPM2](/details-gene/8818) is an unlikely candidate for inhibitory therapies, as systemic blockade would likely lead to severe, widespread toxicity. The primary therapeutic relevance lies in addressing the loss-of-function mutations that cause DPM2-CDG. Potential strategies could include gene replacement therapy to restore functional [DPM2](/details-gene/8818) in affected tissues, particularly muscle and neurons. Alternatively, the development of small molecule chaperones designed to stabilize the mutant [DPM2](/details-gene/8818) protein or enhance the overall activity of the DPM synthase complex could offer a viable therapeutic avenue for this rare disease.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Dolichol-phosphate mannose synthase subunit 2

Genular Protein ID: 3102598763

Symbol: DPM2_HUMAN

Name: Dolichol-phosphate mannose synthase subunit 2

UniProtKB Accession Codes:

O94777 Q5XKK9 Q6FGH3

Database IDs:

Citations:

PubMed ID: 9724629

Title: DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate.

PubMed ID: 9724629

DOI: 10.1093/emboj/17.17.4920

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10835346

Title: Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3.

PubMed ID: 10835346

DOI: 10.1093/emboj/19.11.2475

PubMed ID: 10944123

Title: Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2.

PubMed ID: 10944123

DOI: 10.1093/emboj/19.16.4402

PubMed ID: 16162815

Title: The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component.

PubMed ID: 16162815

DOI: 10.1091/mbc.e05-08-0743

PubMed ID: 23109149

Title: DPM2-CDG: a muscular dystrophy-dystroglycanopathy syndrome with severe epilepsy.

PubMed ID: 23109149

DOI: 10.1002/ana.23632

Sequence Information:

Length: 84
Mass: 9312
Checksum: 0247A0843A711EE9
Sequence:

MATGTDQVVG LGLVAVSLII FTYYTAWVIL LPFIDSQHVI HKYFLPRAYA VAIPLAAGLL 
LLLFVGLFIS YVMLKTKRVT KKAQ

Details for: DPM2

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate. PubMed ID: 9724629

Human protein factory for converting the transcriptome into an in vitro-expressed proteome. PubMed ID: 19054851

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3. PubMed ID: 10835346

Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. PubMed ID: 10944123

The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component. PubMed ID: 16162815

DPM2-CDG: a muscular dystrophy-dystroglycanopathy syndrome with severe epilepsy. PubMed ID: 23109149