Details for: TMEM11

Gene ID: 8834

Symbol: TMEM11

Ensembl ID: ENSG00000178307

Description: transmembrane protein 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 131.3444
    Cell Significance Index: -20.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 95.1730
    Cell Significance Index: -24.1400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 74.1842
    Cell Significance Index: -30.5600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 62.3567
    Cell Significance Index: -29.4400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 54.5311
    Cell Significance Index: -28.0500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 43.8585
    Cell Significance Index: -29.4300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.4833
    Cell Significance Index: -24.3300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.6367
    Cell Significance Index: -27.9100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.2087
    Cell Significance Index: -21.9900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.4378
    Cell Significance Index: -29.3500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.2479
    Cell Significance Index: -19.1900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.0339
    Cell Significance Index: -6.6400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.9176
    Cell Significance Index: 201.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.3644
    Cell Significance Index: 275.5400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.7303
    Cell Significance Index: 103.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1490
    Cell Significance Index: 52.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9455
    Cell Significance Index: 25.7400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.9364
    Cell Significance Index: 10.1800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9039
    Cell Significance Index: 31.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8652
    Cell Significance Index: 18.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8350
    Cell Significance Index: 38.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8048
    Cell Significance Index: 153.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7098
    Cell Significance Index: 36.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6648
    Cell Significance Index: 41.9000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6105
    Cell Significance Index: 43.1800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5686
    Cell Significance Index: 14.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5672
    Cell Significance Index: 250.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5415
    Cell Significance Index: 40.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5201
    Cell Significance Index: 27.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5004
    Cell Significance Index: 23.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4954
    Cell Significance Index: 68.0300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4525
    Cell Significance Index: 6.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4483
    Cell Significance Index: 244.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4363
    Cell Significance Index: 78.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4291
    Cell Significance Index: 55.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4122
    Cell Significance Index: 372.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3978
    Cell Significance Index: 11.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3804
    Cell Significance Index: 46.7800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3739
    Cell Significance Index: 2.9900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3730
    Cell Significance Index: 8.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3309
    Cell Significance Index: 8.8400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2550
    Cell Significance Index: 30.0700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2428
    Cell Significance Index: 31.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2289
    Cell Significance Index: 14.7700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.2052
    Cell Significance Index: 2.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1703
    Cell Significance Index: 34.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1627
    Cell Significance Index: 32.2900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1508
    Cell Significance Index: 14.9200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1153
    Cell Significance Index: 1.3100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1074
    Cell Significance Index: 74.2800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1040
    Cell Significance Index: 1.2400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0713
    Cell Significance Index: 1.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0573
    Cell Significance Index: 1.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0414
    Cell Significance Index: 14.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0387
    Cell Significance Index: 1.2400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0229
    Cell Significance Index: 0.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0178
    Cell Significance Index: 13.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0053
    Cell Significance Index: -0.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0053
    Cell Significance Index: -10.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0077
    Cell Significance Index: -5.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0151
    Cell Significance Index: -2.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0178
    Cell Significance Index: -1.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0178
    Cell Significance Index: -32.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0211
    Cell Significance Index: -32.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0233
    Cell Significance Index: -31.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0288
    Cell Significance Index: -21.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0329
    Cell Significance Index: -20.8800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0416
    Cell Significance Index: -0.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0427
    Cell Significance Index: -24.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0507
    Cell Significance Index: -23.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0536
    Cell Significance Index: -33.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0728
    Cell Significance Index: -20.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0981
    Cell Significance Index: -2.0900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0982
    Cell Significance Index: -2.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1196
    Cell Significance Index: -13.7100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1434
    Cell Significance Index: -4.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1447
    Cell Significance Index: -11.1100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1457
    Cell Significance Index: -0.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1601
    Cell Significance Index: -33.7300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1603
    Cell Significance Index: -4.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1686
    Cell Significance Index: -24.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1708
    Cell Significance Index: -2.3300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1926
    Cell Significance Index: -4.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2140
    Cell Significance Index: -5.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2242
    Cell Significance Index: -12.5800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2391
    Cell Significance Index: -1.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2447
    Cell Significance Index: -15.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2653
    Cell Significance Index: -7.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2784
    Cell Significance Index: -22.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2785
    Cell Significance Index: -29.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3011
    Cell Significance Index: -5.1600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3201
    Cell Significance Index: -4.1000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3242
    Cell Significance Index: -9.5500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3323
    Cell Significance Index: -3.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3580
    Cell Significance Index: -24.0700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3625
    Cell Significance Index: -6.7000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3837
    Cell Significance Index: -2.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3929
    Cell Significance Index: -24.0900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4236
    Cell Significance Index: -4.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4260
    Cell Significance Index: -22.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TMEM11 is a transmembrane protein with 11 transmembrane domains, which are crucial for its function and localization within the cell. It is primarily expressed in various cell types, including pancreatic acinar cells, placental villous trophoblasts, and erythroid progenitor cells. The protein's expression pattern suggests its involvement in specific cellular processes, such as energy metabolism and cellular differentiation. **Pathways and Functions:** TMEM11 is implicated in several critical pathways, including: 1. **Mitochondrial Biogenesis:** TMEM11 is essential for the regulation of mitochondrial biogenesis, which is the process by which mitochondria are synthesized and assembled. This process is crucial for maintaining cellular energy homeostasis. 2. **Cristae Formation:** TMEM11 plays a key role in the formation of cristae, the infoldings of the mitochondrial inner membrane that increase the surface area for energy production. 3. **Organelle Biogenesis and Maintenance:** TMEM11 is involved in the biogenesis and maintenance of other organelles, such as the endoplasmic reticulum and the Golgi apparatus. 4. **Protein Binding:** TMEM11 interacts with various proteins, including those involved in mitochondrial function, cellular signaling, and protein degradation. **Clinical Significance:** TMEM11's role in mitochondrial biogenesis and cristae formation makes it an important protein in the context of various diseases, including: 1. **Mitochondrial Diseases:** Mutations in TMEM11 have been associated with mitochondrial diseases, such as mitochondrial myopathies and lactic acidosis. 2. **Cancer:** TMEM11's involvement in cellular metabolism and energy production suggests its potential role in cancer development and progression. 3. **Neurological Disorders:** TMEM11's expression in neurons and its involvement in mitochondrial biogenesis make it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, TMEM11 is a complex transmembrane protein that plays a critical role in various cellular processes, including mitochondrial biogenesis, cristae formation, and organelle biogenesis. Its involvement in these processes makes it an important protein in the context of various diseases, and further research is needed to fully elucidate its functions and clinical significance.

Genular Protein ID: 2359361751

Symbol: TMM11_HUMAN

Name: Transmembrane protein 11, mitochondrial

UniProtKB Accession Codes:

P17152 Q53YB2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 GO 5 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2110658

Title: Nucleotide sequence of a cDNA encoding a protein with primary structural similarity to G-protein coupled receptors.

PubMed ID: 2110658

DOI: 10.1093/nar/18.7.1896

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21274005

Title: Inner-membrane proteins PMI/TMEM11 regulate mitochondrial morphogenesis independently of the DRP1/MFN fission/fusion pathways.

PubMed ID: 21274005

DOI: 10.1038/embor.2010.214

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25997101

Title: QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology.

PubMed ID: 25997101

DOI: 10.7554/elife.06265

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 192
  • Mass: 21541
  • Checksum: FE46BACEBF5ACD1D
  • Sequence:
    • MAAWGRRRLG PGSSGGSARE RVSLSATDCY IVHEIYNGEN AQDQFEYELE QALEAQYKYI 
VIEPTRIGDE TARWITVGNC LHKTAVLAGT ACLFTPLALP LDYSHYISLP AGVLSLACCT 
LYGISWQFDP CCKYQVEYDA YKLSRLPLHT LTSSTPVVLV RKDDLHRKRL HNTIALAALV 
YCVKKIYELY AV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.