Details for: DLEU2

Gene ID: 8847

Symbol: DLEU2

Ensembl ID: ENSG00000231607

Description: deleted in lymphocytic leukemia 2

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 123.2095
    Cell Significance Index: -58.1700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 103.2592
    Cell Significance Index: -53.1200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.4229
    Cell Significance Index: -54.7100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.5176
    Cell Significance Index: -44.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 6.2158
    Cell Significance Index: 348.8000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 3.7260
    Cell Significance Index: 72.7200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 3.4936
    Cell Significance Index: 59.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.3920
    Cell Significance Index: 87.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.9017
    Cell Significance Index: 575.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.4500
    Cell Significance Index: 150.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.3174
    Cell Significance Index: 177.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9554
    Cell Significance Index: 392.2500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.9364
    Cell Significance Index: 85.6500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.8822
    Cell Significance Index: 45.1400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.8215
    Cell Significance Index: 68.9800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.7410
    Cell Significance Index: 42.4800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.2813
    Cell Significance Index: 32.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9330
    Cell Significance Index: 334.6500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.8851
    Cell Significance Index: 12.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7789
    Cell Significance Index: 77.0500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6746
    Cell Significance Index: 609.1400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5241
    Cell Significance Index: 35.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.4906
    Cell Significance Index: 71.3100
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.4763
    Cell Significance Index: 6.6900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.4673
    Cell Significance Index: 23.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4501
    Cell Significance Index: 28.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4494
    Cell Significance Index: 73.1000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.3973
    Cell Significance Index: 6.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3437
    Cell Significance Index: 9.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2364
    Cell Significance Index: 6.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2356
    Cell Significance Index: 27.7900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2303
    Cell Significance Index: 25.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2133
    Cell Significance Index: 38.4600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1721
    Cell Significance Index: 1.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1431
    Cell Significance Index: 17.6000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1185
    Cell Significance Index: 161.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1094
    Cell Significance Index: 2.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0998
    Cell Significance Index: 187.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0626
    Cell Significance Index: 96.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0582
    Cell Significance Index: 16.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0555
    Cell Significance Index: 25.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0229
    Cell Significance Index: 42.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0172
    Cell Significance Index: -9.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0187
    Cell Significance Index: -11.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0305
    Cell Significance Index: -5.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0415
    Cell Significance Index: -4.8400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0502
    Cell Significance Index: -37.1900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0657
    Cell Significance Index: -29.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0664
    Cell Significance Index: -48.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0707
    Cell Significance Index: -39.8900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0776
    Cell Significance Index: -58.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0838
    Cell Significance Index: -3.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1094
    Cell Significance Index: -68.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1490
    Cell Significance Index: -9.6200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1673
    Cell Significance Index: -5.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1929
    Cell Significance Index: -13.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2543
    Cell Significance Index: -34.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2790
    Cell Significance Index: -58.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3016
    Cell Significance Index: -14.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3024
    Cell Significance Index: -30.8900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3030
    Cell Significance Index: -8.0900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3057
    Cell Significance Index: -4.3900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3211
    Cell Significance Index: -4.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3244
    Cell Significance Index: -41.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3480
    Cell Significance Index: -59.4200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3704
    Cell Significance Index: -3.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3907
    Cell Significance Index: -50.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4173
    Cell Significance Index: -47.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4534
    Cell Significance Index: -27.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4571
    Cell Significance Index: -47.5900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4699
    Cell Significance Index: -7.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5226
    Cell Significance Index: -27.1500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.5615
    Cell Significance Index: -6.0200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5847
    Cell Significance Index: -6.9700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6016
    Cell Significance Index: -8.8800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6194
    Cell Significance Index: -49.0600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.6361
    Cell Significance Index: -6.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6616
    Cell Significance Index: -21.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6918
    Cell Significance Index: -51.5600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.6949
    Cell Significance Index: -8.7500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7369
    Cell Significance Index: -21.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.8113
    Cell Significance Index: -57.3800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.9299
    Cell Significance Index: -13.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.9424
    Cell Significance Index: -20.0700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.9688
    Cell Significance Index: -16.7500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.9912
    Cell Significance Index: -12.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.0586
    Cell Significance Index: -55.5800
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -1.0880
    Cell Significance Index: -7.9100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.0985
    Cell Significance Index: -21.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.1271
    Cell Significance Index: -36.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.1305
    Cell Significance Index: -52.7100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.1472
    Cell Significance Index: -39.8700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.1822
    Cell Significance Index: -25.0900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1884
    Cell Significance Index: -37.8500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -1.2415
    Cell Significance Index: -15.9200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.2704
    Cell Significance Index: -34.5800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.3008
    Cell Significance Index: -45.5700
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -1.3344
    Cell Significance Index: -12.1300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.3364
    Cell Significance Index: -49.0600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.4104
    Cell Significance Index: -44.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DLEU2 is a non-coding RNA gene, which means it does not encode a protein. Instead, it regulates gene expression through microRNA (miRNA) and long non-coding RNA (lncRNA) pathways. DLEU2 is highly expressed in cells of the central nervous system, including photoreceptor cells, microglial cells, and oligodendrocytes. It is also found in fibroblasts of cardiac tissue, kidney interstitial fibroblasts, hepatoblasts, and other cell types. The expression of DLEU2 is tightly regulated, and its dysregulation has been implicated in various diseases, including cancer, autoimmune disorders, and neurological conditions. **Pathways and Functions:** The DLEU2 gene is involved in several key pathways that regulate cell differentiation, survival, and immune function. One of the primary functions of DLEU2 is to modulate the expression of genes involved in cell differentiation and survival. DLEU2 acts as a tumor suppressor by inhibiting the expression of oncogenes and promoting the expression of tumor suppressor genes. Additionally, DLEU2 is involved in the regulation of immune responses, particularly in the context of cancer and autoimmune diseases. It modulates the expression of miRNAs and lncRNAs that regulate immune cell function, including the activity of T cells and dendritic cells. **Clinical Significance:** The dysregulation of DLEU2 has been implicated in various diseases, including cancer, autoimmune disorders, and neurological conditions. In cancer, DLEU2 is often downregulated in tumor cells, leading to the loss of tumor suppressor function and contributing to tumorigenesis. In autoimmune diseases, DLEU2 dysregulation has been linked to the abnormal activation of immune cells, leading to tissue damage and inflammation. In neurological conditions, DLEU2 dysregulation has been implicated in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Understanding the role of DLEU2 in these diseases has significant implications for the development of novel therapeutic strategies, including the use of miRNAs and lncRNAs as therapeutic agents. In conclusion, DLEU2 is a critical gene that regulates cell differentiation, survival, and immune function. Its dysregulation has been implicated in various diseases, including cancer, autoimmune disorders, and neurological conditions. Further research is needed to fully elucidate the role of DLEU2 in these diseases and to develop novel therapeutic strategies that target this gene.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.