Details for: DLEU2

Gene ID: 8847

Symbol: DLEU2

Ensembl ID: ENSG00000231607

Description: deleted in lymphocytic leukemia 2

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DLEU2 is a non-coding RNA gene, which means it does not encode a protein. Instead, it regulates gene expression through microRNA (miRNA) and long non-coding RNA (lncRNA) pathways. DLEU2 is highly expressed in cells of the central nervous system, including photoreceptor cells, microglial cells, and oligodendrocytes. It is also found in fibroblasts of cardiac tissue, kidney interstitial fibroblasts, hepatoblasts, and other cell types. The expression of DLEU2 is tightly regulated, and its dysregulation has been implicated in various diseases, including cancer, autoimmune disorders, and neurological conditions. **Pathways and Functions:** The DLEU2 gene is involved in several key pathways that regulate cell differentiation, survival, and immune function. One of the primary functions of DLEU2 is to modulate the expression of genes involved in cell differentiation and survival. DLEU2 acts as a tumor suppressor by inhibiting the expression of oncogenes and promoting the expression of tumor suppressor genes. Additionally, DLEU2 is involved in the regulation of immune responses, particularly in the context of cancer and autoimmune diseases. It modulates the expression of miRNAs and lncRNAs that regulate immune cell function, including the activity of T cells and dendritic cells. **Clinical Significance:** The dysregulation of DLEU2 has been implicated in various diseases, including cancer, autoimmune disorders, and neurological conditions. In cancer, DLEU2 is often downregulated in tumor cells, leading to the loss of tumor suppressor function and contributing to tumorigenesis. In autoimmune diseases, DLEU2 dysregulation has been linked to the abnormal activation of immune cells, leading to tissue damage and inflammation. In neurological conditions, DLEU2 dysregulation has been implicated in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Understanding the role of DLEU2 in these diseases has significant implications for the development of novel therapeutic strategies, including the use of miRNAs and lncRNAs as therapeutic agents. In conclusion, DLEU2 is a critical gene that regulates cell differentiation, survival, and immune function. Its dysregulation has been implicated in various diseases, including cancer, autoimmune disorders, and neurological conditions. Further research is needed to fully elucidate the role of DLEU2 in these diseases and to develop novel therapeutic strategies that target this gene.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.