Details for: RPL23

Gene ID: 9349

Symbol: RPL23

Ensembl ID: ENSG00000125691

Description: ribosomal protein L23

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 5.79
    Marker Score: 3,264
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 5.27
    Marker Score: 25,867
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 5.16
    Marker Score: 4,038
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 5.16
    Marker Score: 7,939
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 4.96
    Marker Score: 1,829
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 4.88
    Marker Score: 2,518
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.7
    Marker Score: 46,547
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.53
    Marker Score: 154,220
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 4.51
    Marker Score: 2,317
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 4.5
    Marker Score: 60,398
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 4.48
    Marker Score: 2,391
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 4.46
    Marker Score: 2,871
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.45
    Marker Score: 5,795
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 4.4
    Marker Score: 3,195
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.38
    Marker Score: 3,138
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 4.35
    Marker Score: 22,877
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.3
    Marker Score: 3,843
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.24
    Marker Score: 2,581
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.19
    Marker Score: 55,313
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.18
    Marker Score: 11,539
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 4.17
    Marker Score: 3,150
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.13
    Marker Score: 10,086
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 4.06
    Marker Score: 4,333
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.06
    Marker Score: 969
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.05
    Marker Score: 9,219
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 4
    Marker Score: 8,390
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 3.99
    Marker Score: 2,815
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.95
    Marker Score: 3,366
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.94
    Marker Score: 3,886
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 3.94
    Marker Score: 23,955
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 3.93
    Marker Score: 1,277
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.92
    Marker Score: 11,444
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3.92
    Marker Score: 207,282
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 3.88
    Marker Score: 2,272
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 3.83
    Marker Score: 2,911
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 3.82
    Marker Score: 6,558
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.82
    Marker Score: 24,887
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.79
    Marker Score: 7,121
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.69
    Marker Score: 1,216
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 3.68
    Marker Score: 15,353
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.68
    Marker Score: 205,751
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.67
    Marker Score: 2,075
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.67
    Marker Score: 42,667
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 3.66
    Marker Score: 1,575
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.57
    Marker Score: 3,963
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.55
    Marker Score: 11,216
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.54
    Marker Score: 3,695
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.54
    Marker Score: 2,777
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.53
    Marker Score: 1,584
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.52
    Marker Score: 22,909
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 3.52
    Marker Score: 1,607
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 3.52
    Marker Score: 806
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.5
    Marker Score: 3,118
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.49
    Marker Score: 7,930
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.48
    Marker Score: 1,270
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.48
    Marker Score: 2,632
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 3.47
    Marker Score: 1,445
  • Cell Name: club cell (CL0000158)
    Fold Change: 3.45
    Marker Score: 4,024
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.44
    Marker Score: 1,896
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 3.43
    Marker Score: 975
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.42
    Marker Score: 12,141
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.41
    Marker Score: 26,639
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.41
    Marker Score: 3,899
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.4
    Marker Score: 9,551
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.4
    Marker Score: 14,596
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.4
    Marker Score: 2,864
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.4
    Marker Score: 1,614
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.4
    Marker Score: 5,403
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.39
    Marker Score: 3,651
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.39
    Marker Score: 117,339
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 3.39
    Marker Score: 2,885
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.38
    Marker Score: 6,753
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 3.37
    Marker Score: 887
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.36
    Marker Score: 3,141
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.35
    Marker Score: 4,610
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.35
    Marker Score: 1,395
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 3.34
    Marker Score: 2,888
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.33
    Marker Score: 1,069
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 3.33
    Marker Score: 4,835
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 3.33
    Marker Score: 2,189
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.32
    Marker Score: 8,697
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 3.32
    Marker Score: 8,269
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 3.32
    Marker Score: 2,233
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 3.32
    Marker Score: 934
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.31
    Marker Score: 943
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 3.3
    Marker Score: 667
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 3.3
    Marker Score: 7,975
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.29
    Marker Score: 872
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 3.29
    Marker Score: 873
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 3.28
    Marker Score: 897
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 3.28
    Marker Score: 1,310
  • Cell Name: mesothelial fibroblast (CL4023054)
    Fold Change: 3.28
    Marker Score: 969
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.27
    Marker Score: 3,273
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.27
    Marker Score: 12,601
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.26
    Marker Score: 2,571
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.26
    Marker Score: 1,630
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.26
    Marker Score: 8,742
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.26
    Marker Score: 2,874
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 3.26
    Marker Score: 2,042
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 3.25
    Marker Score: 1,099

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPL23 is a 17-kDa protein that belongs to the ribosomal protein L family, which makes up a significant portion of the 60S large ribosomal subunit. The 60S subunit is responsible for decoding mRNA and assembling amino acids into polypeptide chains during translation elongation. RPL23 is highly conserved across species, suggesting its essential role in the translation process. **Pathways and Functions** RPL23 is involved in various cellular pathways, including: 1. **Translation elongation**: RPL23 plays a crucial role in the translation elongation process, where it helps to assemble amino acids into polypeptide chains. 2. **Cell growth and proliferation**: RPL23 is involved in regulating cell growth and proliferation by controlling the translation of essential mRNAs. 3. **Response to stress**: RPL23 is activated in response to cellular stress, allowing cells to adapt and survive. 4. **Regulation of gene expression**: RPL23 can regulate the expression of certain genes by controlling the translation of specific mRNAs. 5. **Signaling pathways**: RPL23 is involved in signaling pathways, including the regulation of the G1 to G0 transition and the response to amino acid deficiency. **Clinical Significance** Dysregulation of RPL23 has been implicated in various diseases, including: 1. **Cancer**: Overexpression of RPL23 has been observed in certain types of cancer, suggesting its potential role in tumorigenesis. 2. **Neurological disorders**: RPL23 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it may play a role in regulating protein synthesis and aggregation. 3. **Infectious diseases**: RPL23 has been identified as a target for antiviral therapy, as it is involved in the translation of viral mRNAs. 4. **Metabolic disorders**: RPL23 has been implicated in metabolic disorders, such as diabetes, where it may play a role in regulating glucose metabolism. In conclusion, RPL23 is a critical component of the 60S large ribosomal subunit, playing a vital role in translation elongation, cell growth, and response to stress. Its dysregulation has been implicated in various diseases, highlighting the importance of RPL23 in maintaining cellular homeostasis. Further research is necessary to fully understand the mechanisms by which RPL23 regulates cellular processes and its role in disease.

Genular Protein ID: 4073683486

Symbol: RL23_HUMAN

Name: 60S ribosomal protein L17

UniProtKB Accession Codes:

P62829 P23131 P24048 Q29246 Q3SWV7 Q6P5S1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 7 EMDB 44 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 81 PDBsum 77 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1861993

Title: cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17.

PubMed ID: 1861993

DOI: 10.1093/nar/19.14.4001

PubMed ID: 1874450

Title: Isolation and analysis of a human cDNA highly homologous to the yeast gene encoding L17A ribosomal protein.

PubMed ID: 1874450

DOI: 10.1016/0378-1119(91)90091-o

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 140
  • Mass: 14865
  • Checksum: 807E14139B2EB0B5
  • Sequence:
    • MSKRGRGGSS GAKFRISLGL PVGAVINCAD NTGAKNLYII SVKGIKGRLN RLPAAGVGDM 
VMATVKKGKP ELRKKVHPAV VIRQRKSYRR KDGVFLYFED NAGVIVNNKG EMKGSAITGP 
VAKECADLWP RIASNAGSIA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.