Details for: ACTA2
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 5.84
Marker Score: 7,606 - Cell Name: contractile cell (CL0000183)
Fold Change: 4.73
Marker Score: 2,562 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 3.95
Marker Score: 3,764 - Cell Name: supporting cell (CL0000630)
Fold Change: 3.68
Marker Score: 6,911 - Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 3.59
Marker Score: 2,553 - Cell Name: smooth muscle cell (CL0000192)
Fold Change: 3.07
Marker Score: 2,018 - Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 3.02
Marker Score: 1,144 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.9
Marker Score: 6,362 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 2.89
Marker Score: 913 - Cell Name: decidual cell (CL2000002)
Fold Change: 2.82
Marker Score: 12,179 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 2.72
Marker Score: 6,405 - Cell Name: muscle cell (CL0000187)
Fold Change: 2.56
Marker Score: 726 - Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 2.39
Marker Score: 3,292 - Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 2.31
Marker Score: 11,364 - Cell Name: myofibroblast cell (CL0000186)
Fold Change: 2.26
Marker Score: 2,795 - Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 2.25
Marker Score: 660 - Cell Name: mesodermal cell (CL0000222)
Fold Change: 2
Marker Score: 26,415 - Cell Name: pericyte (CL0000669)
Fold Change: 1.85
Marker Score: 1,083 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.82
Marker Score: 462 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.72
Marker Score: 7,219 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.63
Marker Score: 18,374 - Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 1.62
Marker Score: 425 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.56
Marker Score: 5,788 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.54
Marker Score: 3,078 - Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.53
Marker Score: 3,997 - Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168,657 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.46
Marker Score: 2,805 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.45
Marker Score: 5,157 - Cell Name: enteric neuron (CL0007011)
Fold Change: 1.44
Marker Score: 766 - Cell Name: theca cell (CL0000503)
Fold Change: 1.43
Marker Score: 1,022 - Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 1.4
Marker Score: 486 - Cell Name: neural crest cell (CL0011012)
Fold Change: 1.34
Marker Score: 1,437 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.34
Marker Score: 2,200 - Cell Name: fibroblast (CL0000057)
Fold Change: 1.31
Marker Score: 1,270 - Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 1.24
Marker Score: 441 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 1.24
Marker Score: 1,058 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.12
Marker Score: 7,304 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.1
Marker Score: 1,264 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 1.01
Marker Score: 262 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,754 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47,978 - Cell Name: fibrocyte (CL0000135)
Fold Change: 0.99
Marker Score: 307 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,400 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.95
Marker Score: 1,465 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,404 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.94
Marker Score: 486 - Cell Name: bronchial smooth muscle cell (CL0002598)
Fold Change: 0.93
Marker Score: 264 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.93
Marker Score: 441 - Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 0.93
Marker Score: 388 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.93
Marker Score: 297 - Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 0.92
Marker Score: 303 - Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.91
Marker Score: 203 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,719 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.89
Marker Score: 1,510 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.89
Marker Score: 357 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.89
Marker Score: 282 - Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.89
Marker Score: 408 - Cell Name: smooth muscle cell of small intestine (CL1000275)
Fold Change: 0.89
Marker Score: 232 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.87
Marker Score: 450 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,252 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.87
Marker Score: 4,940 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 311 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.78
Marker Score: 1,590 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.78
Marker Score: 4,691 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.78
Marker Score: 1,832 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.78
Marker Score: 371 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1,255 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 588 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.76
Marker Score: 457 - Cell Name: brush cell (CL0002204)
Fold Change: 0.74
Marker Score: 671 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.73
Marker Score: 378 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.73
Marker Score: 235 - Cell Name: germ cell (CL0000586)
Fold Change: 0.7
Marker Score: 1,223 - Cell Name: Leydig cell (CL0000178)
Fold Change: 0.7
Marker Score: 754 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.69
Marker Score: 865 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.69
Marker Score: 2,874 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 173 - Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.66
Marker Score: 622 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.65
Marker Score: 204 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.65
Marker Score: 1,595 - Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 0.64
Marker Score: 486 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.64
Marker Score: 165 - Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.63
Marker Score: 395 - Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.62
Marker Score: 356 - Cell Name: myometrial cell (CL0002366)
Fold Change: 0.61
Marker Score: 175 - Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.61
Marker Score: 382 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.6
Marker Score: 1,023 - Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.6
Marker Score: 272 - Cell Name: ventricular cardiac muscle cell (CL2000046)
Fold Change: 0.59
Marker Score: 246 - Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 0.59
Marker Score: 327 - Cell Name: mesangial cell (CL0000650)
Fold Change: 0.59
Marker Score: 709 - Cell Name: myoepithelial cell (CL0000185)
Fold Change: 0.59
Marker Score: 164 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.58
Marker Score: 19,852 - Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 0.58
Marker Score: 273 - Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.58
Marker Score: 130 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 441 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.55
Marker Score: 208 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.54
Marker Score: 393 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.54
Marker Score: 8,455 - Cell Name: kidney cell (CL1000497)
Fold Change: 0.52
Marker Score: 349
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 891602321
Symbol: ACTA_HUMAN
Name: Actin, aortic smooth muscle
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2701935
Title: The nucleotide sequence of a human smooth muscle alpha-actin (aortic type) cDNA.
PubMed ID: 2701935
PubMed ID: 2295650
Title: Structure of the human smooth muscle alpha-actin gene. Analysis of a cDNA and 5' upstream region.
PubMed ID: 2295650
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 6330528
Title: Structure of a human smooth muscle actin gene (aortic type) with a unique intron site.
PubMed ID: 6330528
PubMed ID: 2612915
Title: Structure of 3'-downstream segment of the human smooth muscle (aortic-type) alpha-actin-encoding gene and isolation of the specific DNA probe.
PubMed ID: 2612915
PubMed ID: 16548883
Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.
PubMed ID: 16548883
PubMed ID: 19015515
Title: Connecting actin monomers by iso-peptide bond is a toxicity mechanism of the Vibrio cholerae MARTX toxin.
PubMed ID: 19015515
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 26228148
Title: ACD toxin-produced actin oligomers poison formin-controlled actin polymerization.
PubMed ID: 26228148
PubMed ID: 30626964
Title: SETD3 is an actin histidine methyltransferase that prevents primary dystocia.
PubMed ID: 30626964
PubMed ID: 17994018
Title: Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections.
PubMed ID: 17994018
DOI: 10.1038/ng.2007.6
PubMed ID: 19409525
Title: Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease.
PubMed ID: 19409525
PubMed ID: 19639654
Title: Mutation of ACTA2 gene as an important cause of familial and nonfamilial nonsyndromatic thoracic aortic aneurysm and/or dissection (TAAD).
PubMed ID: 19639654
DOI: 10.1002/humu.21081
PubMed ID: 20734336
Title: De novo ACTA2 mutation causes a novel syndrome of multisystemic smooth muscle dysfunction.
PubMed ID: 20734336
DOI: 10.1002/ajmg.a.33657
PubMed ID: 20970362
Title: Analysis of ACTA2 in European Moyamoya disease patients.
PubMed ID: 20970362
PubMed ID: 27481187
Title: Visceral myopathy: Clinical and molecular survey of a cohort of seven new patients and state of the art of overlapping phenotypes.
PubMed ID: 27481187
DOI: 10.1002/ajmg.a.37857
Sequence Information:
- Length: 377
- Mass: 42009
- Checksum: 2D0543262DB35CA5
- Sequence:
MCEEEDSTAL VCDNGSGLCK AGFAGDDAPR AVFPSIVGRP RHQGVMVGMG QKDSYVGDEA QSKRGILTLK YPIEHGIITN WDDMEKIWHH SFYNELRVAP EEHPTLLTEA PLNPKANREK MTQIMFETFN VPAMYVAIQA VLSLYASGRT TGIVLDSGDG VTHNVPIYEG YALPHAIMRL DLAGRDLTDY LMKILTERGY SFVTTAEREI VRDIKEKLCY VALDFENEMA TAASSSSLEK SYELPDGQVI TIGNERFRCP ETLFQPSFIG MESAGIHETT YNSIMKCDID IRKDLYANNV LSGGTTMYPG IADRMQKEIT ALAPSTMKIK IIAPPERKYS VWIGGSILAS LSTFQQMWIS KQEYDEAGPS IVHRKCF
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.