Details for: MED12L

Gene ID: 116931

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: MED12L

Ensembl ID: ENSG00000144893

Description: mediator complex subunit 12L

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • choroid plexus epithelial cell CL0000706
    CSI 42.83
    rCSI 70.14%
    PRS 89.78
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 27.24
    rCSI 45.72%
    PRS 86.11
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 25.16
    rCSI 54.59%
    PRS 85.89
  • astrocyte of the cerebral cortex CL0002605
    CSI 24.29
    rCSI 54.45%
    PRS 86.02
  • ependymal cell CL0000065
    CSI 23.78
    rCSI 48.26%
    PRS 80.67
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 22.42
    rCSI 54.48%
    PRS 84.08
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 18.77
    rCSI 23.35%
    PRS 83.85
  • VIP GABAergic cortical interneuron CL4023016
    CSI 18.16
    rCSI 21.7%
    PRS 86.01
  • sncg GABAergic cortical interneuron CL4023015
    CSI 16.84
    rCSI 27.09%
    PRS 86.85
  • L6b glutamatergic cortical neuron CL4023038
    CSI 16.48
    rCSI 51.51%
    PRS 86.92
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 16.08
    rCSI 38.45%
    PRS 87.08
  • glioblast CL0000030
    CSI 16.04
    rCSI 25.58%
    PRS 88.98
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 15.78
    rCSI 49.36%
    PRS 88.41
  • neuron CL0000540
    CSI 14.72
    rCSI 39.19%
    PRS 84.87
  • hematopoietic precursor cell CL0008001
    CSI 14.23
    rCSI 14.64%
    PRS 97.51
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 13.99
    rCSI 50.34%
    PRS 84.33
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 13.23
    rCSI 15.28%
    PRS 88.69
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 13.18
    rCSI 43.31%
    PRS 85.93
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 13
    rCSI 22.96%
    PRS 85.37
  • vascular leptomeningeal cell CL4023051
    CSI 12.61
    rCSI 22.11%
    PRS 92.65
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 12.53
    rCSI 47.34%
    PRS 86.06
  • oligodendrocyte precursor cell CL0002453
    CSI 10.24
    rCSI 22.54%
    PRS 80.31
  • rod bipolar cell CL0000751
    CSI 10.07
    rCSI 18.09%
    PRS 90.97
  • inhibitory interneuron CL0000498
    CSI 10.03
    rCSI 23.16%
    PRS 88.18
  • sst GABAergic cortical interneuron CL4023017
    CSI 9.92
    rCSI 12.79%
    PRS 86.89
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 9.15
    rCSI 8.27%
    PRS 93.8
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 8.84
    rCSI 52.07%
    PRS 86.35
  • glutamatergic neuron CL0000679
    CSI 8.31
    rCSI 17.08%
    PRS 85.49
  • interneuron CL0000099
    CSI 8.24
    rCSI 16.54%
    PRS 90.73
  • amacrine cell CL0000561
    CSI 8.23
    rCSI 23.84%
    PRS 88.53
  • retinal bipolar neuron CL0000748
    CSI 8.21
    rCSI 15.38%
    PRS 88.87
  • Mueller cell CL0000636
    CSI 7.98
    rCSI 18.22%
    PRS 90.05
  • GABAergic amacrine cell CL4030027
    CSI 7.77
    rCSI 26.62%
    PRS 84.71
  • H2 horizontal cell CL0004218
    CSI 7.69
    rCSI 38.25%
    PRS 90.42
  • retina horizontal cell CL0000745
    CSI 7.53
    rCSI 11.48%
    PRS 92.25
  • glial cell CL0000125
    CSI 7.32
    rCSI 27.86%
    PRS 89.65
  • H1 horizontal cell CL0004217
    CSI 7.14
    rCSI 28.27%
    PRS 89.93
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 7.08
    rCSI 12.86%
    PRS 90.42
  • neural cell CL0002319
    CSI 6.76
    rCSI 25.5%
    PRS 83.68
  • cerebral cortex neuron CL0010012
    CSI 6.75
    rCSI 27.52%
    PRS 88.96
  • macroglial cell CL0000126
    CSI 6.45
    rCSI 16.58%
    PRS 91.34
  • central nervous system neuron CL2000029
    CSI 5.99
    rCSI 44.06%
    PRS 89.22
  • glycinergic amacrine cell CL4030028
    CSI 5.98
    rCSI 15.58%
    PRS 89.79
  • hematopoietic stem cell CL0000037
    CSI 5.92
    rCSI 3.94%
    PRS 95.49
  • mature astrocyte CL0002627
    CSI 5.87
    rCSI 24.95%
    PRS 89.73
  • starburst amacrine cell CL0004232
    CSI 5.8
    rCSI 48.86%
    PRS 83.08
  • central nervous system macrophage CL0000878
    CSI 5.8
    rCSI 19.21%
    PRS 95.72
  • Bergmann glial cell CL0000644
    CSI 5.62
    rCSI 7.69%
    PRS 89.13
  • hematopoietic multipotent progenitor cell CL0000837
    CSI 5.45
    rCSI 13.11%
    PRS 98.17
  • cerebellar granule cell CL0001031
    CSI 5.44
    rCSI 7.99%
    PRS 91.16
  • retinal ganglion cell CL0000740
    CSI 5.08
    rCSI 11.22%
    PRS 87.2
  • neural crest cell CL0011012
    CSI 4.91
    rCSI 3.88%
    PRS 90.15
  • medium spiny neuron CL1001474
    CSI 4.41
    rCSI 38.01%
    PRS 88.86
  • neural progenitor cell CL0011020
    CSI 4.26
    rCSI 18.74%
    PRS 85.96
  • dopaminergic neuron CL0000700
    CSI 3.97
    rCSI 22.43%
    PRS 86.73
  • cerebral cortex endothelial cell CL1001602
    CSI 3.75
    rCSI 6.48%
    PRS 91.37
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 3.46
    rCSI 4.18%
    PRS 97.49
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 3.21
    rCSI 3.89%
    PRS 77.74
  • GABAergic neuron CL0000617
    CSI 3.18
    rCSI 10.65%
    PRS 84.42
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 2.9
    rCSI 7.5%
    PRS 93.08
  • cerebellar neuron CL1001611
    CSI 2.86
    rCSI 25.21%
    PRS 85.11
  • serotonergic neuron CL0000850
    CSI 2.65
    rCSI 11.83%
    PRS 82.98
  • basket cell CL0000118
    CSI 2.31
    rCSI 14.48%
    PRS 78.61
  • germinal center B cell CL0000844
    CSI 2.29
    rCSI 6.83%
    PRS 96.17
  • OFFx cell CL4033036
    CSI 2.22
    rCSI 10.44%
    PRS 85.93
  • direct pathway medium spiny neuron CL4023026
    CSI 2.19
    rCSI 52.32%
    PRS 83.77
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.16
    rCSI 52.15%
    PRS 83.66
  • diffuse bipolar 6 cell CL4033032
    CSI 1.92
    rCSI 10.08%
    PRS 86.32
  • placental villous trophoblast CL2000060
    CSI 1.64
    rCSI 2.54%
    PRS 93.13
  • diffuse bipolar 3b cell CL4033030
    CSI 1.57
    rCSI 10.42%
    PRS 89.39
  • flat midget bipolar cell CL4033033
    CSI 1.44
    rCSI 10.3%
    PRS 86.59
  • diffuse bipolar 2 cell CL4033028
    CSI 1.09
    rCSI 8.44%
    PRS 88.25
  • megakaryocyte CL0000556
    CSI 1.07
    rCSI 4.65%
    PRS 94.49
  • ON midget ganglion cell CL4033046
    CSI 1.02
    rCSI 20.82%
    PRS 88
  • OFF midget ganglion cell CL4033047
    CSI 0.78
    rCSI 15.78%
    PRS 88.45
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 0.43
    rCSI 4.6%
    PRS 91.61
  • megakaryocyte progenitor cell CL0000553
    CSI 0.34
    rCSI 6.22%
    PRS 98.84

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [MED12L](/details-gene/116931), or Mediator Complex Subunit 12L, is a protein-coding gene located on chromosome 3q25.1. As its name suggests, it functions as a component of the Mediator complex, a critical coactivator essential for the regulation of transcription by RNA polymerase II ([GO:0016592](https://www.ebi.ac.uk/QuickGO/term/GO:0016592), [GO:0045944](https://www.ebi.ac.uk/QuickGO/term/GO:0045944)). **Overall**, expression data reveals that [MED12L](/details-gene/116931) is a highly significant gene within the central nervous system, showing prominent expression in specialized epithelial cells such as [choroid plexus epithelial cell](/details-cell/CL0000706) and a diverse array of both glutamatergic and GABAergic [neurons](/details-cell/CL0000540). Its role in transcription, coupled with its expression landscape, is consistent with its clinical association with intellectual disability, as mutations in the gene have been linked to defects in transcriptional regulation ([Link](https://doi.org/10.1038/s41436-019-0557-3)). ## Cellular Roles and Expression Landscape The expression profile of [MED12L](/details-gene/116931) highlights its fundamental importance in the cellular architecture and function of the brain. The gene's highest significance index (**Overall** CSI: 42.83) is observed in the [choroid plexus epithelial cell](/details-cell/CL0000706), the specialized cell type responsible for producing cerebrospinal fluid, suggesting a critical role in maintaining brain homeostasis. Beyond this, [MED12L](/details-gene/116931) demonstrates broad and significant expression across a wide spectrum of neuronal subtypes. It is a key marker in both inhibitory and excitatory neurons, including [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011) (CSI: 27.24) and [L2/3 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4030059) (CSI: 25.16). Its high significance extends to glial cells, such as [astrocyte of the cerebral cortex](/details-cell/CL0002605) (CSI: 24.29), and other specialized epithelial-like cells lining the brain's ventricles, like the [ependymal cell](/details-cell/CL0000065) (CSI: 23.78). This widespread expression across multiple major cell lineages within the CNS underscores its foundational role in neural tissue development and maintenance. Interestingly, the gene also shows significance in [glioblast](/details-cell/CL0000030) (CSI: 16.04), indicating a potential role in the pathophysiology of this brain malignancy. Furthermore, its expression in [hematopoietic precursor cell](/details-cell/CL0008001) suggests its functions may not be exclusively restricted to the nervous system, possibly extending to developmental processes in other lineages. ## Pathways and Molecular Function Functionally, [MED12L](/details-gene/116931) is integral to the process of gene transcription. As a subunit of the Mediator complex, it acts as a transcriptional coactivator ([GO:0003713](https://www.ebi.ac.uk/QuickGO/term/GO:0003713)), bridging DNA-bound transcription factors with the RNA polymerase II machinery to initiate and regulate gene expression. This role in the [positive regulation of transcription by RNA polymerase II](/details-go/GO0045944) ([GO:0045944](https://www.ebi.ac.uk/QuickGO/term/GO:0045944)) is fundamental to cellular function and differentiation, which aligns with its widespread importance in the highly complex and diverse cellular environment of the brain. Molecular annotation also indicates that the MED12L protein is involved in protein-protein interactions, including [beta-catenin binding](/details-go/GO0008013) ([GO:0008013](https://www.ebi.ac.uk/QuickGO/term/GO:0008013)). This link to beta-catenin suggests a potential role in modulating the Wnt signaling pathway, a critical pathway for neurodevelopment, cell fate determination, and tissue patterning. ## Research Directions The available data points to several compelling avenues for future research into the function of [MED12L](/details-gene/116931), particularly concerning its roles in neurodevelopment and disease. **Proposed Testable Hypotheses:** 1. Given that mutations in [MED12L](/details-gene/116931) are associated with intellectual disability ([Link](https://doi.org/10.1038/s41436-019-0557-3)) and its high expression across diverse neuronal subtypes, it is hypothesized that [MED12L](/details-gene/116931) orchestrates specific transcriptional programs essential for the terminal differentiation, migration, or synaptic integration of cortical neurons. Its disruption would therefore lead to improper cortical circuit formation. 2. The exceptionally high significance of [MED12L](/details-gene/116931) in [choroid plexus epithelial cell](/details-cell/CL0000706) suggests a specialized function. We hypothesize that [MED12L](/details-gene/116931) is a master regulator of genes controlling cerebrospinal fluid (CSF) production and the integrity of the blood-CSF barrier. Consequently, pathogenic variants in [MED12L](/details-gene/116931) could cause neurodevelopmental disorders by altering the composition and homeostatic balance of the CSF environment. 3. The significant expression of [MED12L](/details-gene/116931) in [glioblast](/details-cell/CL0000030) suggests a potential role in brain cancer. It is hypothesized that [MED12L](/details-gene/116931) is co-opted in glioblastoma to drive the expression of oncogenic programs that promote tumor cell proliferation, survival, and resistance to therapy. **Proposed Experimental Approach:** To test hypothesis #2, one could utilize human pluripotent stem cell-derived brain organoids that develop choroid plexus-like structures. Using CRISPR-Cas9-mediated knockdown or knockout of [MED12L](/details-gene/116931) in these organoids, researchers could assess the impact on choroid plexus development and function. Single-cell RNA sequencing would reveal the downstream transcriptional targets of [MED12L](/details-gene/116931] and identify dysregulated pathways related to ion transport, protein secretion, and barrier function. Furthermore, functional assays, such as measuring the secretion of key CSF proteins into the culture medium and testing the barrier integrity with fluorescently-labeled dextrans, would provide direct evidence of a functional deficit. **Therapeutic Potential:** As a core component of the transcriptional machinery, [MED12L](/details-gene/116931) presents a challenging therapeutic target due to the high risk of off-target effects. Global inhibition would likely be cytotoxic. However, in the context of glioblastoma, where its activity might be aberrantly directed, [MED12L](/details-gene/116931) could represent a potential target for inhibition. A therapeutic strategy might involve developing small molecules that specifically disrupt the interaction of MED12L with oncogenic transcription factors unique to the tumor cells, thereby selectively blocking cancer-promoting gene expression while sparing its essential functions in healthy cells. This approach would require a deep understanding of the specific protein-protein interactions that drive malignancy.

Genular Protein ID: 2413123117

Symbol: MD12L_HUMAN

Name: Mediator of RNA polymerase II transcription subunit 12-like protein

UniProtKB Accession Codes:

Q86YW9 Q96PC7 Q96PC8 Q9H9M5 Q9HCD7 Q9UI69

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 RefSeq 2 SMART 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11524702

Title: Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3.

PubMed ID: 11524702

DOI: 10.1086/323610

PubMed ID: 10997877

Title: Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10997877

DOI: 10.1093/dnares/7.4.271

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11483580

Title: Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs.

PubMed ID: 11483580

DOI: 10.1101/gr.175501

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 31155615

Title: Variants in MED12L, encoding a subunit of the mediator kinase module, are responsible for intellectual disability associated with transcriptional defect.

PubMed ID: 31155615

DOI: 10.1038/s41436-019-0557-3

PubMed ID: 37883018

Title: Two epilepsy-associated variants in KCNA2 (KV 1.2) at position H310 oppositely affect channel functional expression.

PubMed ID: 37883018

DOI: 10.1113/jp285052

Sequence Information:

  • Length: 2145
  • Mass: 240120
  • Checksum: 578F84E1C76004C9
  • Sequence:
    • MAAFGLLSYE QRPLKRPRLG PPDVYPQDPK QKEDELTAVN VKQGFNNQPA FTGDEHGSAR 
NIVINPSKIG AYFSSILAEK LKLNTFQDTG KKKPQVNAKD NYWLVTARSQ SAIHSWFSDL 
AGNKPLSILA KKVPILSKKE DVFAYLAKYS VPMVRATWLI KMTCAYYSAI SEAKIKKRQA 
PDPNLEWTQI STRYLREQLA KISDFYHMAS STGDGPVPVP PEVEQAMKQW EYNEKLAFHM 
FQEGMLEKHE YLTWILDVLE KIRPMDDDLL KLLLPLMLQY SDEFVQSAYL SRRLAYFCAR 
RLSLLLSDSP NLLAAHSPHM MIGPNNSSIG APSPGPPGPG MSPVQLAFSD FLSCAQHGPL 
VYGLSCMLQT VTLCCPSALV WNYSTNENKS ANPGSPLDLL QVAPSSLPMP GGNTAFNQQV 
RARIYEVEQQ IKQRGRAVEV RWSFDKCQES TAGVTISRVL HTLEVLDRHC FDRTDSSNSM 
ETLYHKIFWA NQNKDNQEVA PNDEAVVTLL CEWAVSCKRS GKHRAMAVAK LLEKRQAEIE 
AERCGESEVL DEKESISSSS LAGSSLPVFQ NVLLRFLDTQ APSLSDPNSE CEKVEFVNLV 
LLFCEFIRHD VFSHDAYMCT LISRGDLSVT ASTRPRSPVG ENADEHYSKD HDVKMEIFSP 
MPGESCENAN TSLGRRMSVN CEKLVKREKP RELIFPSNYD LLRHLQYATH FPIPLDESSS 
HECNQRTILL YGVGKERDEA RHQLKKITKD ILKILNKKST TETGVGDEGQ KARKNKQETF 
PTLETVFTKL QLLSYFDQHQ VTSQISNNVL EQITSFASGT SYHLPLAHHI QLIFDLMEPA 
LNINGLIDFA IQLLNELSVV EAELLLKSSS LAGSYTTGLC VCIVAVLRRY HSCLILNPDQ 
TAQVFEGLCG VVKHVVNPSE CSSPERCILA YLYDLYVSCS HLRSKFGDLF SSACSKVKQT 
IYNNVMPANS NLRWDPDFMM DFIENPSARS INYSMLGKIL SDNAANRYSF VCNTLMNVCM 
GHQDAGRIND IANFSSELTA CCTVLSSEWL GVLKALCCSS NHVWGFNDVL CTVDVSDLSF 
HDSLATFIAI LIARQCFSLE DVVQHVALPS LLAAACGDAD AEPGARMTCR LLLHLFRAPQ 
ACFLPQATGK PFPGIRSSCD RHLLAAAHNS IEVGAVFAVL KAIMMLGDAK IGNNSVSSLK 
NDDFTMRGLR CDGNADDIWT ASQNPKSCGK SISIETANLR EYARYVLRTI CQQEWVGEHC 
LKEPERLCTD KELILDPVLS NMQAQKLLQL ICYPHGIKEC TEGDNLQRQH IKRILQNLEQ 
WTLRQSWLEL QLMIKQCLKD PGSGSVAEMN NLLDNIAKAT IEVFQQSADL NNSSNSGMSL 
FNPNSIGSAD TSSTRQNGIK TFLSSSERRG VWLVAPLIAR LPTSVQGRVL KAAGEELEKG 
QHLGSSSKKE RDRQKQKSMS LLSQQPFLSL VLTCLKGQDE QREGLLTSLQ NQVNQILSNW 
REERYQDDIK ARQMMHEALQ LRLNLVGGMF DTVQRSTQWT TDWALLLLQI ITSGTVDMHT 
NNELFTTVLD MLGVLINGTL ASDLSNASPG GSEENKRAYM NLVKKLKKEL GDKRSESIDK 
VRQLLPLPKQ TCDVITCEPM GSLIDTKGNK IAGFDSIDKK QGLQVSTKQK VSPWDLFEGQ 
KNPAPLSWAW FGTVRVDRRV IKYEEQHHLL LYHTHPMPKP RSYYLQPLPL PPEEEEEEPT 
SPVSQEPERK SAELSDQGKT TTDEEKKTKG RKRKTKSSSR VDEYPQSNIY RVPPNYSPIS 
SQMMHHPQST LWGYNLVGQP QQPGFFLQNQ SLTPGGSRLD PAGSFVPTNT KQALSNMLQR 
RSGAMMQPPS LHAITSQQQL IQMKLLQQQQ QQRLLRQAQT RPFQQGQPGD QAALFAAQAR 
PSPQLPQYPG LQQAQTMPQG YTMYGTQMPL QQTSQQQAGS VVLSPSYNSR AYPAAHSNPV 
LMERLRQIQQ QPSGYVQQQA SPYLQPLTGS QRLNHQALQQ SPLVGGGIDA VLTSAHPNLP 
SVPLPQDPMR PRQPQVRQQQ RLLQMQQPQQ PQPQQPPQPQ QSSQSQSQTL GLQAMQPQQP 
LFPRQGLQQT QQQQQTAALV RQLQKQLSSN QPQQGVTPYG HPSHF

Genular Protein ID: 2940431332

Symbol: B3KXY0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KXY0

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 580
  • Mass: 65376
  • Checksum: 391E47DDEA3DDB53
  • Sequence:
    • MMLGDAKIGN NSVSSLKNDD FTMRGLQCDG NADDIWTASQ NPKSCGKSIS IETANLREYA 
RYVLRTICQQ EWVGEHCLKE PERLCTDKEL ILDPVLSNMQ AQKLLQLICY PHGIKECTEG 
DNLQRQHIKR ILQNLEQWTL RQSWLELQLM IKQCLKDPGS GSVAEMNNLL DNIAKATIEV 
FQQSADLNNS SNSGMSLFNP NSIGSADTSS TRQNGIKTFL SSSERRGVWL VAPLIARLPT 
SVQGRVLKAA GEELEKGQHL GSSSKKERDR QKQKSMSLLS QQPFLSLVLT CLKGQDEQRE 
GLLTSLQNQV NQILSNWREE RYQDDIKARQ MMHEALQLRL NLVGGMFDTV QRSTQWTTDW 
ALLLLQIITS GTVDMHTNNE LFTTVLDMLG VLINGTLASD LSNASPGGSE ENKRAYMNLV 
KKLKKELGDK RSESIDKVRQ LLPLPKQTCD VITCEPMGSL IDTKGNKIAG FDSIDKKQGL 
QVSTKQKVSP WDLFEGQKNP APLSWAWFGT VRVDRRVIKY EEQHHLLLYH THPMPKPRSY 
YLQPLPLPPE EEEEEPTSPV SQEPERKSAE LSDQGKTTTD