Details for: CCR4

Gene ID: 1233

Symbol: CCR4

Ensembl ID: ENSG00000183813

Description: C-C motif chemokine receptor 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 24.6874
    Cell Significance Index: -3.8400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 15.3365
    Cell Significance Index: -3.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 12.0613
    Cell Significance Index: -4.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.2094
    Cell Significance Index: 70.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.5749
    Cell Significance Index: 34.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.3706
    Cell Significance Index: 34.2600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7586
    Cell Significance Index: 22.2800
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.6373
    Cell Significance Index: 7.5100
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.4767
    Cell Significance Index: 4.7800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3972
    Cell Significance Index: 23.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3945
    Cell Significance Index: 39.0200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.3907
    Cell Significance Index: -1.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3154
    Cell Significance Index: 60.0300
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.2662
    Cell Significance Index: 2.7600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1599
    Cell Significance Index: 17.3900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1256
    Cell Significance Index: 5.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0724
    Cell Significance Index: 5.0100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0470
    Cell Significance Index: 32.5000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0135
    Cell Significance Index: 0.1700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0035
    Cell Significance Index: 0.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0003
    Cell Significance Index: -0.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0019
    Cell Significance Index: -0.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0020
    Cell Significance Index: -3.7300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0021
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0029
    Cell Significance Index: -1.3000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0030
    Cell Significance Index: -0.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0030
    Cell Significance Index: -5.4600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0037
    Cell Significance Index: -0.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0037
    Cell Significance Index: -5.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0041
    Cell Significance Index: -5.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0053
    Cell Significance Index: -0.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0054
    Cell Significance Index: -0.1900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0058
    Cell Significance Index: -0.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0061
    Cell Significance Index: -4.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0069
    Cell Significance Index: -3.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0071
    Cell Significance Index: -4.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0071
    Cell Significance Index: -5.3500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0076
    Cell Significance Index: -0.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0086
    Cell Significance Index: -4.8500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0100
    Cell Significance Index: -0.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0100
    Cell Significance Index: -4.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0119
    Cell Significance Index: -4.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0133
    Cell Significance Index: -3.8300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0142
    Cell Significance Index: -0.3800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0145
    Cell Significance Index: -0.2200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0146
    Cell Significance Index: -0.1400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0159
    Cell Significance Index: -0.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0166
    Cell Significance Index: -3.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0235
    Cell Significance Index: -4.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0240
    Cell Significance Index: -4.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0245
    Cell Significance Index: -4.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0296
    Cell Significance Index: -4.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0305
    Cell Significance Index: -4.4300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0306
    Cell Significance Index: -0.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0315
    Cell Significance Index: -3.8700
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0328
    Cell Significance Index: -0.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0336
    Cell Significance Index: -1.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0365
    Cell Significance Index: -4.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0427
    Cell Significance Index: -4.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0462
    Cell Significance Index: -5.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0465
    Cell Significance Index: -6.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0512
    Cell Significance Index: -3.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0542
    Cell Significance Index: -1.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0547
    Cell Significance Index: -3.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0559
    Cell Significance Index: -1.1900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0568
    Cell Significance Index: -0.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0621
    Cell Significance Index: -1.3000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0629
    Cell Significance Index: -0.9200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0722
    Cell Significance Index: -1.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0735
    Cell Significance Index: -3.8200
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0752
    Cell Significance Index: -0.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0756
    Cell Significance Index: -3.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0794
    Cell Significance Index: -5.3400
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0811
    Cell Significance Index: -0.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0812
    Cell Significance Index: -6.0600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0813
    Cell Significance Index: -1.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0848
    Cell Significance Index: -5.2100
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.0850
    Cell Significance Index: -1.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0852
    Cell Significance Index: -4.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0869
    Cell Significance Index: -4.0900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0872
    Cell Significance Index: -1.0300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0872
    Cell Significance Index: -1.0300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0882
    Cell Significance Index: -1.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0896
    Cell Significance Index: -5.7800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0903
    Cell Significance Index: -2.6600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0954
    Cell Significance Index: -1.5300
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0959
    Cell Significance Index: -0.6900
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0978
    Cell Significance Index: -1.3300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1005
    Cell Significance Index: -1.1500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1030
    Cell Significance Index: -3.6100
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1040
    Cell Significance Index: -1.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1047
    Cell Significance Index: -2.8500
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1092
    Cell Significance Index: -1.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1106
    Cell Significance Index: -4.8900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1140
    Cell Significance Index: -1.6000
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1156
    Cell Significance Index: -1.4800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1157
    Cell Significance Index: -1.4600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1177
    Cell Significance Index: -1.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Chemokine Receptor:** CCR4 is a C-C motif chemokine receptor, which means it is activated by C-C chemokines, a family of small cytokines that play a crucial role in the recruitment of immune cells to sites of inflammation. 2. **G-Protein Coupled Receptor:** CCR4 belongs to the GPCR family, which is characterized by its ability to activate G-proteins, leading to the modulation of various cellular processes. 3. **Highly Expressed in Immune Cells:** CCR4 is highly expressed in various immune cells, including granulocytes, monocytes, and T cells, highlighting its role in the regulation of immune responses. 4. **Involved in Cell Migration:** CCR4 is involved in the regulation of cell migration, including the migration of immune cells to sites of inflammation and the migration of neural cells during development. **Pathways and Functions:** 1. **Chemokine-Mediated Signaling:** CCR4 is activated by C-C chemokines, leading to the activation of downstream signaling pathways that modulate immune cell migration, proliferation, and survival. 2. **Calcium-Mediated Signaling:** CCR4 activates calcium-dependent signaling pathways, which are involved in the regulation of immune cell function and cell migration. 3. **Cell Chemotaxis:** CCR4 is involved in the regulation of cell chemotaxis, including the migration of immune cells to sites of inflammation. 4. **Homeostasis of Cell Number:** CCR4 is involved in the regulation of cell homeostasis, including the regulation of immune cell numbers and the maintenance of tissue architecture. **Clinical Significance:** 1. **Inflammatory Disorders:** CCR4 is involved in the regulation of inflammatory responses, making it a potential target for the treatment of inflammatory disorders, such as rheumatoid arthritis and asthma. 2. **Cancer:** CCR4 is overexpressed in various types of cancer, including breast cancer and lung cancer, highlighting its potential role in tumor progression and metastasis. 3. **Neurological Disorders:** CCR4 is involved in the regulation of neural cell migration and function, making it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Autoimmune Diseases:** CCR4 is involved in the regulation of immune cell function and cell migration, making it a potential target for the treatment of autoimmune diseases, such as multiple sclerosis and type 1 diabetes. In conclusion, the CCR4 gene is a crucial component of the immune system, playing a vital role in the regulation of immune responses and cell migration. Its involvement in various physiological and pathological processes highlights its potential as a therapeutic target for the treatment of inflammatory disorders, cancer, neurological disorders, and autoimmune diseases.

Genular Protein ID: 2026356885

Symbol: CCR4_HUMAN

Name: C-C chemokine receptor type 4

UniProtKB Accession Codes:

P51679 Q9ULY6 Q9ULY7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 10 Ensembl 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7642634

Title: Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line.

PubMed ID: 7642634

DOI: 10.1074/jbc.270.33.19495

PubMed ID: 11196669

Title: New variations of human CC-chemokine receptors CCR3 and CCR4.

PubMed ID: 11196669

DOI: 10.1038/sj.gene.6363638

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9169480

Title: The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4.

PubMed ID: 9169480

DOI: 10.1074/jbc.272.23.15036

PubMed ID: 9430724

Title: Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4.

PubMed ID: 9430724

DOI: 10.1074/jbc.273.3.1764

PubMed ID: 10466728

Title: The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells.

PubMed ID: 10466728

DOI: 10.1038/23495

PubMed ID: 10754297

Title: Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309.

PubMed ID: 10754297

DOI: 10.4049/jimmunol.164.8.4048

PubMed ID: 16137713

Title: Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4).

PubMed ID: 16137713

DOI: 10.1016/j.lfs.2005.05.070

Sequence Information:

  • Length: 360
  • Mass: 41403
  • Checksum: 51EBE12AD1FAFABF
  • Sequence:
    • MNPTDIADTT LDESIYSNYY LYESIPKPCT KEGIKAFGEL FLPPLYSLVF VFGLLGNSVV 
VLVLFKYKRL RSMTDVYLLN LAISDLLFVF SLPFWGYYAA DQWVFGLGLC KMISWMYLVG 
FYSGIFFVML MSIDRYLAIV HAVFSLRART LTYGVITSLA TWSVAVFASL PGFLFSTCYT 
ERNHTYCKTK YSLNSTTWKV LSSLEINILG LVIPLGIMLF CYSMIIRTLQ HCKNEKKNKA 
VKMIFAVVVL FLGFWTPYNI VLFLETLVEL EVLQDCTFER YLDYAIQATE TLAFVHCCLN 
PIIYFFLGEK FRKYILQLFK TCRGLFVLCQ YCGLLQIYSA DTPSSSYTQS TMDHDLHDAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.