Gene CCR4 - ENSG00000183813 | NCBI Gene ID: 1233

Details for: CCR4

Gene ID: 1233

Symbol: CCR4

Ensembl ID: ENSG00000183813

Description: C-C motif chemokine receptor 4

Associated with

Chemokine receptors bind chemokines
(R-HSA-380108)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (i) signalling events
(R-HSA-418594)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Peptide ligand-binding receptors
(R-HSA-375276)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
C-c chemokine binding
(GO:0019957)
C-c chemokine receptor activity
(GO:0016493)
Calcium-mediated signaling
(GO:0019722)
Cell chemotaxis
(GO:0060326)
Chemokine-mediated signaling pathway
(GO:0070098)
Chemokine receptor activity
(GO:0004950)
Chemotaxis
(GO:0006935)
External side of plasma membrane
(GO:0009897)
G protein-coupled receptor signaling pathway
(GO:0007186)
Homeostasis of number of cells
(GO:0048872)
Immune response
(GO:0006955)
Inflammatory response
(GO:0006954)
Interneuron migration
(GO:1904936)
Neuronal cell body
(GO:0043025)
Plasma membrane
(GO:0005886)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of positive chemotaxis
(GO:0050927)
Protein binding
(GO:0005515)
Response to bacterium
(GO:0009617)
Tolerance induction
(GO:0002507)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 2.09
Marker Score: 2105
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1172
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.42
Marker Score: 1413
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.38
Marker Score: 873
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.27
Marker Score: 858
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.18
Marker Score: 488
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4819
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.05
Marker Score: 799
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71832
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48057
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 510
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30409
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 463
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5349
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 374
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2741
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 326
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.89
Marker Score: 407
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5292
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1265
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 710
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 397
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.73
Marker Score: 1388
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.73
Marker Score: 436
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 463
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 179
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 0.67
Marker Score: 485
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.61
Marker Score: 406
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.61
Marker Score: 3872
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.6
Marker Score: 1226
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.58
Marker Score: 454
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.57
Marker Score: 420
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.57
Marker Score: 452
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 148
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.55
Marker Score: 8625
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 174
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 0.49
Marker Score: 150
Cell Name: regulatory T cell (CL0000815)
Fold Change: 0.46
Marker Score: 512
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 0.45
Marker Score: 1950
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 0.44
Marker Score: 411
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.4
Marker Score: 169
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.4
Marker Score: 383
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.39
Marker Score: 20603
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.37
Marker Score: 400
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 0.35
Marker Score: 604
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.34
Marker Score: 964
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.31
Marker Score: 95
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.3
Marker Score: 299
Cell Name: mature T cell (CL0002419)
Fold Change: 0.28
Marker Score: 2787
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.27
Marker Score: 296
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.25
Marker Score: 124
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 0.25
Marker Score: 86
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.24
Marker Score: 477
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.24
Marker Score: 115
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.24
Marker Score: 180.5
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.24
Marker Score: 134
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 0.23
Marker Score: 104
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 74
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 0.21
Marker Score: 139
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.19
Marker Score: 273
Cell Name: naive T cell (CL0000898)
Fold Change: 0.19
Marker Score: 120
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.18
Marker Score: 150
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.17
Marker Score: 103
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 42
Cell Name: leukocyte (CL0000738)
Fold Change: 0.17
Marker Score: 97
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.16
Marker Score: 100
Cell Name: Unknown (CL0000548)
Fold Change: 0.15
Marker Score: 112
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.15
Marker Score: 90
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.15
Marker Score: 101
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.15
Marker Score: 65
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.14
Marker Score: 122
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.14
Marker Score: 65
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.13
Marker Score: 303
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.13
Marker Score: 113
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.13
Marker Score: 65
Cell Name: platelet (CL0000233)
Fold Change: 0.12
Marker Score: 54
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.12
Marker Score: 244
Cell Name: blood cell (CL0000081)
Fold Change: 0.11
Marker Score: 1307
Cell Name: plasma cell (CL0000786)
Fold Change: 0.11
Marker Score: 125
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.11
Marker Score: 76
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.11
Marker Score: 107
Cell Name: memory T cell (CL0000813)
Fold Change: 0.11
Marker Score: 46
Cell Name: mast cell (CL0000097)
Fold Change: 0.11
Marker Score: 62
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.11
Marker Score: 59
Cell Name: T follicular regulatory cell (CL0009113)
Fold Change: 0.1
Marker Score: 28
Cell Name: macrophage (CL0000235)
Fold Change: 0.1
Marker Score: 114
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.1
Marker Score: 143
Cell Name: group 2 innate lymphoid cell (CL0001069)
Fold Change: 0.1
Marker Score: 33
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.09
Marker Score: 73
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.09
Marker Score: 33
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.09
Marker Score: 51
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.09
Marker Score: 54
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.09
Marker Score: 17
Cell Name: T-helper 1 cell (CL0000545)
Fold Change: 0.08
Marker Score: 33
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.08
Marker Score: 4652.5
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 0.08
Marker Score: 200.5
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 0.08
Marker Score: 34
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 0.08
Marker Score: 18

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**Key characteristics:** *CCR4 is a member of the chemokine receptor family, which are a large group of cell surface receptors that are expressed on immune cells. *CCR4 is a G protein-coupled receptor that is expressed on a variety of cell types, including blood vessel endothelial cells, colon goblet cells, enterocytes, and immune cells. *CCR4 is a key regulator of inflammation and immune responses. It is expressed in high levels in inflammatory tissues and is involved in the recruitment of immune cells to sites of inflammation. *CCR4 is a positive regulator of cytosolic calcium ion concentration. This means that it can increase the concentration of calcium ions in the cytoplasm, which can lead to the activation of downstream signaling pathways. **Pathways and functions:** *CCR4 binds to the chemokine CXCL1, which is a cytokine that is produced by activated macrophages and dendritic cells. *When CCR4 binds to CXCL1, it activates the G protein-coupled receptor pathway. *The G protein-coupled receptor pathway is a signaling pathway that is involved in a variety of cellular processes, including inflammation and cell migration. *CCR4-mediated signaling can lead to the activation of the transcription factor NF-κB, which is a key regulator of inflammation. *NF-κB activation can lead to the production of inflammatory cytokines and chemokines, which can further amplify the inflammatory response. **Clinical significance:** *Mutations in the CCR4 gene have been linked to a number of inflammatory diseases, including rheumatoid arthritis, asthma, and inflammatory bowel disease. *CCR4 is a potential target for the treatment of inflammatory diseases. By blocking CCR4 signaling, it may be possible to reduce inflammation and pain.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

C-C chemokine receptor type 4

Genular Protein ID: 2026356885

Symbol: CCR4_HUMAN

Name: C-C chemokine receptor type 4

UniProtKB Accession Codes:

P51679 Q9ULY6 Q9ULY7

Database IDs:

Citations:

PubMed ID: 7642634

Title: Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line.

PubMed ID: 7642634

DOI: 10.1074/jbc.270.33.19495

PubMed ID: 11196669

Title: New variations of human CC-chemokine receptors CCR3 and CCR4.

PubMed ID: 11196669

DOI: 10.1038/sj.gene.6363638

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9169480

Title: The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4.

PubMed ID: 9169480

DOI: 10.1074/jbc.272.23.15036

PubMed ID: 9430724

Title: Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4.

PubMed ID: 9430724

DOI: 10.1074/jbc.273.3.1764

PubMed ID: 10466728

Title: The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells.

PubMed ID: 10466728

DOI: 10.1038/23495

PubMed ID: 10754297

Title: Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309.

PubMed ID: 10754297

DOI: 10.4049/jimmunol.164.8.4048

PubMed ID: 16137713

Title: Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4).

PubMed ID: 16137713

DOI: 10.1016/j.lfs.2005.05.070

Sequence Information:

Length: 360
Mass: 41403
Checksum: 51EBE12AD1FAFABF
Sequence:

MNPTDIADTT LDESIYSNYY LYESIPKPCT KEGIKAFGEL FLPPLYSLVF VFGLLGNSVV 
VLVLFKYKRL RSMTDVYLLN LAISDLLFVF SLPFWGYYAA DQWVFGLGLC KMISWMYLVG 
FYSGIFFVML MSIDRYLAIV HAVFSLRART LTYGVITSLA TWSVAVFASL PGFLFSTCYT 
ERNHTYCKTK YSLNSTTWKV LSSLEINILG LVIPLGIMLF CYSMIIRTLQ HCKNEKKNKA 
VKMIFAVVVL FLGFWTPYNI VLFLETLVEL EVLQDCTFER YLDYAIQATE TLAFVHCCLN 
PIIYFFLGEK FRKYILQLFK TCRGLFVLCQ YCGLLQIYSA DTPSSSYTQS TMDHDLHDAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CCR4

Associated with

Cells (max top 100)

Other Information

Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line. PubMed ID: 7642634

New variations of human CC-chemokine receptors CCR3 and CCR4. PubMed ID: 11196669

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4. PubMed ID: 9169480

Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. PubMed ID: 9430724

The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. PubMed ID: 10466728

Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309. PubMed ID: 10754297

Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4). PubMed ID: 16137713