Details for: DDX6

Gene ID: 1656

Symbol: DDX6

Ensembl ID: ENSG00000110367

Description: DEAD-box helicase 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 3.94
    Marker Score: 16431
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.89
    Marker Score: 2452
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.7
    Marker Score: 2664
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.54
    Marker Score: 134171
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.51
    Marker Score: 5271
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.49
    Marker Score: 7869.5
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.46
    Marker Score: 1063
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.42
    Marker Score: 3341
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.4
    Marker Score: 5268.5
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.38
    Marker Score: 6678
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.28
    Marker Score: 2435
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.27
    Marker Score: 1370
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.23
    Marker Score: 9351
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.2
    Marker Score: 2056
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.14
    Marker Score: 2256
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.13
    Marker Score: 754
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.06
    Marker Score: 8567
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.04
    Marker Score: 20718
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.95
    Marker Score: 975
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.94
    Marker Score: 22537
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.89
    Marker Score: 2044
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.88
    Marker Score: 2159
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.86
    Marker Score: 1027
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.85
    Marker Score: 70265
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.85
    Marker Score: 608
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.84
    Marker Score: 1028
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.84
    Marker Score: 1394
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.83
    Marker Score: 36339
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.83
    Marker Score: 637
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.82
    Marker Score: 1103
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.81
    Marker Score: 7009
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.8
    Marker Score: 26955
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.8
    Marker Score: 908
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.79
    Marker Score: 1732
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.79
    Marker Score: 523
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.78
    Marker Score: 551
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.77
    Marker Score: 2602
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.77
    Marker Score: 422
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.76
    Marker Score: 6823
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.76
    Marker Score: 4297
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.76
    Marker Score: 1897
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.75
    Marker Score: 17370
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.75
    Marker Score: 2109
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.73
    Marker Score: 106485
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.72
    Marker Score: 3080
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.72
    Marker Score: 698
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.72
    Marker Score: 13159
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.71
    Marker Score: 1506
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.71
    Marker Score: 63254
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.71
    Marker Score: 1345.5
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.71
    Marker Score: 615
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.7
    Marker Score: 1157
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.68
    Marker Score: 837
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.68
    Marker Score: 1272
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.68
    Marker Score: 37539
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.68
    Marker Score: 2253
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.66
    Marker Score: 56524
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.66
    Marker Score: 437
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.66
    Marker Score: 1128
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.65
    Marker Score: 673
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.65
    Marker Score: 6829
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.64
    Marker Score: 15452
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.64
    Marker Score: 518
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.63
    Marker Score: 3185
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.62
    Marker Score: 15388
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.61
    Marker Score: 1518
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.61
    Marker Score: 13849
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.61
    Marker Score: 2013
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.61
    Marker Score: 2364
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.6
    Marker Score: 593
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.6
    Marker Score: 554
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.6
    Marker Score: 556
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.6
    Marker Score: 1992
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.59
    Marker Score: 1727
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.58
    Marker Score: 1154
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.58
    Marker Score: 552
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.58
    Marker Score: 456
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.58
    Marker Score: 1914
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.58
    Marker Score: 1116
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.58
    Marker Score: 33642
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.58
    Marker Score: 462
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.57
    Marker Score: 916
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.56
    Marker Score: 962
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.56
    Marker Score: 3556
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.56
    Marker Score: 1391
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.56
    Marker Score: 7207
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.55
    Marker Score: 1306.5
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.55
    Marker Score: 753
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.55
    Marker Score: 1420
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.55
    Marker Score: 460.5
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 1.54
    Marker Score: 453
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.54
    Marker Score: 4246
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.53
    Marker Score: 1358
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.51
    Marker Score: 1665
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.51
    Marker Score: 1233
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.5
    Marker Score: 898
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.5
    Marker Score: 454
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.5
    Marker Score: 2877
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.49
    Marker Score: 342
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.49
    Marker Score: 367

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Other Information

**Key characteristics:** * DDX6 is a protein of the DEAD-box family of RNA helicases. * It is expressed in a variety of cell types, including neurons, immune cells, and stem cells. * It is a highly conserved protein with a conserved DEAD-box domain. * It forms a complex with other proteins, including B2R858. **Pathways and functions:** * DDX6 is involved in a variety of cellular processes, including: * mRNA decay * Stem cell maintenance * Viral rna genome packaging * Neuronal differentiation * Negative regulation of translation * Protein binding * It plays a critical role in the regulation of gene expression by controlling the stability and translation of mRNA. **Clinical significance:** * Mutations in DDX6 have been linked to a number of human diseases, including: * Neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease) * Cancer * Immune disorders **Conclusion:** DDX6 is a key regulator of gene expression that plays a critical role in maintaining cellular homeostasis and preventing the accumulation of damaged or unnecessary mRNA. Its dysfunction can lead to a variety of diseases, highlighting its importance in human health.

Genular Protein ID: 2198663365

Symbol: DDX6_HUMAN

Name: ATP-dependent RNA helicase p54

UniProtKB Accession Codes:

P26196 Q5D048

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 3 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 9 PIR 1 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1579499

Title: Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3.

PubMed ID: 1579499

DOI: 10.1093/nar/20.8.1967

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1394235

Title: The RCK gene associated with t(11;14) translocation is distinct from the MLL/ALL-1 gene with t(4;11) and t(11;19) translocations.

PubMed ID: 1394235

PubMed ID: 16364915

Title: Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping.

PubMed ID: 16364915

DOI: 10.1016/j.molcel.2005.10.031

PubMed ID: 16699599

Title: Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies.

PubMed ID: 16699599

DOI: 10.1371/journal.ppat.0020041

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 20616046

Title: LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing.

PubMed ID: 20616046

DOI: 10.1073/pnas.0914987107

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22915799

Title: HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies.

PubMed ID: 22915799

DOI: 10.1128/jvi.00595-12

PubMed ID: 23209657

Title: Ataxin-2-like is a regulator of stress granules and processing bodies.

PubMed ID: 23209657

DOI: 10.1371/journal.pone.0050134

PubMed ID: 23125361

Title: The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function.

PubMed ID: 23125361

DOI: 10.1093/nar/gks1032

PubMed ID: 26184334

Title: Comprehensive protein interactome analysis of a key RNA helicase: detection of novel stress granule proteins.

PubMed ID: 26184334

DOI: 10.3390/biom5031441

PubMed ID: 26027925

Title: The eIF4E-Binding protein 4E-T is a component of the mRNA decay machinery that bridges the 5' and 3' termini of target mRNAs.

PubMed ID: 26027925

DOI: 10.1016/j.celrep.2015.04.065

PubMed ID: 25995375

Title: P-body assembly requires DDX6 repression complexes rather than decay or Ataxin2/2L complexes.

PubMed ID: 25995375

DOI: 10.1091/mbc.e15-03-0136

PubMed ID: 26098573

Title: A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy.

PubMed ID: 26098573

DOI: 10.1038/ncb3189

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27342281

Title: The DDX6-4E-T interaction mediates translational repression and P-body assembly.

PubMed ID: 27342281

DOI: 10.1093/nar/gkw565

PubMed ID: 28216671

Title: Dual mechanisms regulate the nucleocytoplasmic localization of human DDX6.

PubMed ID: 28216671

DOI: 10.1038/srep42853

PubMed ID: 30258011

Title: Rotavirus Induces Formation of Remodeled Stress Granules and P Bodies and Their Sequestration in Viroplasms To Promote Progeny Virus Production.

PubMed ID: 30258011

DOI: 10.1128/jvi.01363-18

PubMed ID: 31422817

Title: Rare de novo missense variants in RNA helicase DDX6 cause intellectual disability and dysmorphic features and lead to P-body defects and RNA dysregulation.

PubMed ID: 31422817

DOI: 10.1016/j.ajhg.2019.07.010

PubMed ID: 31439631

Title: Molecular basis for GIGYF-Me31B complex assembly in 4EHP-mediated translational repression.

PubMed ID: 31439631

DOI: 10.1101/gad.329219.119

PubMed ID: 32354837

Title: 4E-T-bound mRNAs are stored in a silenced and deadenylated form.

PubMed ID: 32354837

DOI: 10.1101/gad.336073.119

PubMed ID: 14684915

Title: Crystallization and X-ray analysis of the N-terminal core domain of a tumour-associated human DEAD-box RNA helicase, rck/p54.

PubMed ID: 14684915

DOI: 10.1107/s0907444903024223

PubMed ID: 19285948

Title: Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B.

PubMed ID: 19285948

DOI: 10.1016/j.molcel.2009.02.014

PubMed ID: 26489469

Title: Structure of a human 4E-T/DDX6/CNOT1 complex reveals the different interplay of DDX6-binding proteins with the CCR4-NOT complex.

PubMed ID: 26489469

DOI: 10.1016/j.celrep.2015.09.033

PubMed ID: 29510985

Title: Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes.

PubMed ID: 29510985

DOI: 10.15252/embj.201797869

Sequence Information:

  • Length: 483
  • Mass: 54417
  • Checksum: F802C642861793FB
  • Sequence:
    • MSTARTENPV IMGLSSQNGQ LRGPVKPTGG PGGGGTQTQQ QMNQLKNTNT INNGTQQQAQ 
SMTTTIKPGD DWKKTLKLPP KDLRIKTSDV TSTKGNEFED YCLKRELLMG IFEMGWEKPS 
PIQEESIPIA LSGRDILARA KNGTGKSGAY LIPLLERLDL KKDNIQAMVI VPTRELALQV 
SQICIQVSKH MGGAKVMATT GGTNLRDDIM RLDDTVHVVI ATPGRILDLI KKGVAKVDHV 
QMIVLDEADK LLSQDFVQIM EDIILTLPKN RQILLYSATF PLSVQKFMNS HLQKPYEINL 
MEELTLKGVT QYYAYVTERQ KVHCLNTLFS RLQINQSIIF CNSSQRVELL AKKISQLGYS 
CFYIHAKMRQ EHRNRVFHDF RNGLCRNLVC TDLFTRGIDI QAVNVVINFD FPKLAETYLH 
RIGRSGRFGH LGLAINLITY DDRFNLKSIE EQLGTEIKPI PSNIDKSLYV AEYHSEPVED 
EKP

Genular Protein ID: 2970205627

Symbol: B2R858_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R858

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 1 GenomeRNAi 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 472
  • Mass: 53216
  • Checksum: 83AC5228E102ED04
  • Sequence:
    • MGLSSQNGQL RGPVKPTGGP GGGGTQTQQQ MNQLKNTNTI NNGTQQQAQS MTTTIKPGDD 
WKKTLKLPPK DLRIKTSDVT STKGNEFEDY CLKRELLMGI FEMGWEKPSP IQEESIPIAL 
SGRDILARAK NGTGKSGAYL IPLLERLDLK KDNIQAMVIV PTRELALQVS QICIQVSKHM 
GGAKVMATTG GTNLRDDIMR LDDTVHVVIA TPGRILDLIK KGVAKVDHVQ MIVLDEADKL 
LSQDFVQIME DIILTLPKNR QILLYSATFP LSVQKFMNSH LQKPYEINLM EELTLKGVTQ 
YYAYVTERQK VHCLNTLFSR LQINQSIIFC NSSQRVELLA KKISQLGYSC FYIHAKMRQE 
HRNRVFHDFR NGLCRNLVCT DLFTRGIDIQ AVNVVINFDF PKLAETYLHR IGRSGRFGHL 
GLAINLITYD DRFNLKSIEE QLGTEIKPIP SNIDKSLYVA EYHSEPVEDE KP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.