Details for: DHX8

Gene ID: 1659

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: DHX8

Ensembl ID: ENSG00000067596

Description: DEAH-box helicase 8

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • intermediate monocyte CL0002393
    CSI 8.52
    rCSI 12.86%
    PRS 81.55
  • ionocyte CL0005006
    CSI 6.38
    rCSI 6.84%
    PRS 76.95
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 5.64
    rCSI 5.09%
    PRS 73.83
  • astrocyte of the cerebral cortex CL0002605
    CSI 5.34
    rCSI 11.98%
    PRS 58.14
  • lung ciliated cell CL1000271
    CSI 4.61
    rCSI 5.34%
    PRS 67.69
  • lung macrophage CL1001603
    CSI 4.13
    rCSI 9.22%
    PRS 83.58
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 3.52
    rCSI 2.68%
    PRS 88.35
  • mature B cell CL0000785
    CSI 3.28
    rCSI 2.85%
    PRS 85.75
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 3.25
    rCSI 2.34%
    PRS 88.65
  • VIP GABAergic cortical interneuron CL4023016
    CSI 3.08
    rCSI 3.67%
    PRS 57.39
  • pulmonary ionocyte CL0017000
    CSI 3
    rCSI 3.65%
    PRS 82.88
  • double negative thymocyte CL0002489
    CSI 3
    rCSI 2.08%
    PRS 87.17
  • multi-ciliated epithelial cell CL0005012
    CSI 2.99
    rCSI 2.98%
    PRS 69.72
  • amacrine cell CL0000561
    CSI 2.88
    rCSI 8.34%
    PRS 65.07
  • squamous epithelial cell CL0000076
    CSI 2.85
    rCSI 6.77%
    PRS 77.23
  • naive T cell CL0000898
    CSI 2.83
    rCSI 1.97%
    PRS 89.8
  • cardiac endothelial cell CL0010008
    CSI 2.78
    rCSI 11.21%
    PRS 75.44
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 2.73
    rCSI 1.61%
    PRS 91.14
  • neural crest cell CL0011012
    CSI 2.66
    rCSI 2.1%
    PRS 63.94
  • kidney connecting tubule epithelial cell CL1000768
    CSI 2.65
    rCSI 6.72%
    PRS 66
  • CD4-positive helper T cell CL0000492
    CSI 2.62
    rCSI 1.98%
    PRS 88.21
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 2.48
    rCSI 4.39%
    PRS 56.62
  • melanocyte CL0000148
    CSI 2.47
    rCSI 1.83%
    PRS 69
  • nasal mucosa goblet cell CL0002480
    CSI 2.46
    rCSI 2.85%
    PRS 80.74
  • secretory cell CL0000151
    CSI 2.41
    rCSI 2.51%
    PRS 75.59
  • T follicular helper cell CL0002038
    CSI 2.37
    rCSI 1.77%
    PRS 88.83
  • precursor B cell CL0000817
    CSI 2.33
    rCSI 2.05%
    PRS 83.77
  • group 3 innate lymphoid cell CL0001071
    CSI 2.33
    rCSI 1.75%
    PRS 81.95
  • epithelial cell of lung CL0000082
    CSI 2.25
    rCSI 1.87%
    PRS 76.58
  • direct pathway medium spiny neuron CL4023026
    CSI 2.2
    rCSI 52.6%
    PRS 55.98
  • duct epithelial cell CL0000068
    CSI 2.19
    rCSI 3.2%
    PRS 81
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.13
    rCSI 51.33%
    PRS 56.56
  • Mueller cell CL0000636
    CSI 2.1
    rCSI 4.79%
    PRS 67.2
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 2.07
    rCSI 2.04%
    PRS 89.62
  • plasmacytoid dendritic cell, human CL0001058
    CSI 2.06
    rCSI 1.44%
    PRS 79.36
  • myeloid leukocyte CL0000766
    CSI 2.03
    rCSI 1.87%
    PRS 77.63
  • alpha-beta T cell CL0000789
    CSI 2
    rCSI 2.35%
    PRS 89.87
  • retinal bipolar neuron CL0000748
    CSI 1.92
    rCSI 3.6%
    PRS 63.89
  • perivascular cell CL4033054
    CSI 1.92
    rCSI 2.62%
    PRS 80.69
  • ciliated epithelial cell CL0000067
    CSI 1.89
    rCSI 1.66%
    PRS 64.66
  • goblet cell CL0000160
    CSI 1.89
    rCSI 1.78%
    PRS 75.11
  • pro-B cell CL0000826
    CSI 1.89
    rCSI 1.56%
    PRS 78.47
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 1.88
    rCSI 4.91%
    PRS 76.7
  • promyelocyte CL0000836
    CSI 1.88
    rCSI 2.71%
    PRS 82.9
  • hepatocyte CL0000182
    CSI 1.87
    rCSI 3.35%
    PRS 75.3
  • choroid plexus epithelial cell CL0000706
    CSI 1.82
    rCSI 2.98%
    PRS 65.24
  • interneuron CL0000099
    CSI 1.78
    rCSI 3.58%
    PRS 65.64
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 1.78
    rCSI 2.34%
    PRS 87.24
  • common myeloid progenitor CL0000049
    CSI 1.76
    rCSI 1.42%
    PRS 78.29
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 1.71
    rCSI 1.98%
    PRS 68.07
  • cerebral cortex endothelial cell CL1001602
    CSI 1.7
    rCSI 2.95%
    PRS 66.9
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 1.64
    rCSI 2.05%
    PRS 55.36
  • retinal rod cell CL0000604
    CSI 1.64
    rCSI 2.88%
    PRS 71.93
  • vascular leptomeningeal cell CL4023051
    CSI 1.64
    rCSI 2.87%
    PRS 69.05
  • respiratory hillock cell CL4030023
    CSI 1.63
    rCSI 2.9%
    PRS 85.5
  • Kupffer cell CL0000091
    CSI 1.62
    rCSI 3.72%
    PRS 76.87
  • granulocyte monocyte progenitor cell CL0000557
    CSI 1.61
    rCSI 1.39%
    PRS 80.37
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 1.57
    rCSI 1.21%
    PRS 78.25
  • sst GABAergic cortical interneuron CL4023017
    CSI 1.55
    rCSI 2%
    PRS 58.68
  • stem cell CL0000034
    CSI 1.55
    rCSI 1.49%
    PRS 68.64
  • parietal epithelial cell CL1000452
    CSI 1.52
    rCSI 4.07%
    PRS 67.15
  • extravillous trophoblast CL0008036
    CSI 1.5
    rCSI 1.85%
    PRS 73.73
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 1.49
    rCSI 1.78%
    PRS 91.12
  • regular ventricular cardiac myocyte CL0002131
    CSI 1.48
    rCSI 9.24%
    PRS 67.42
  • placental villous trophoblast CL2000060
    CSI 1.47
    rCSI 2.27%
    PRS 75.17
  • promonocyte CL0000559
    CSI 1.42
    rCSI 2.44%
    PRS 83.02
  • basal cell CL0000646
    CSI 1.38
    rCSI 1.85%
    PRS 74.99
  • BEST4+ enteroycte CL4030026
    CSI 1.37
    rCSI 1.71%
    PRS 77.32
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 1.37
    rCSI 2.3%
    PRS 57.43
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 1.35
    rCSI 6.77%
    PRS 87.74
  • common dendritic progenitor CL0001029
    CSI 1.31
    rCSI 1.65%
    PRS 85.23
  • cardiac muscle cell CL0000746
    CSI 1.28
    rCSI 1.84%
    PRS 65.48
  • blood vessel smooth muscle cell CL0019018
    CSI 1.26
    rCSI 10.27%
    PRS 69.5
  • sncg GABAergic cortical interneuron CL4023015
    CSI 0.98
    rCSI 1.58%
    PRS 59.16
  • neural progenitor cell CL0011020
    CSI 0.86
    rCSI 3.77%
    PRS 64.52
  • retinal cone cell CL0000573
    CSI 0.77
    rCSI 1.25%
    PRS 65.77
  • L6b glutamatergic cortical neuron CL4023038
    CSI 0.77
    rCSI 2.4%
    PRS 59.17
  • retinal ganglion cell CL0000740
    CSI 0.71
    rCSI 1.57%
    PRS 61.47
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 0.63
    rCSI 1.53%
    PRS 55.48
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 0.62
    rCSI 2.34%
    PRS 57.83
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 0.45
    rCSI 1.62%
    PRS 55.43
  • central nervous system neuron CL2000029
    CSI 0.33
    rCSI 2.44%
    PRS 62.9
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 0.3
    rCSI 1.78%
    PRS 58.28

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [DHX8](/details-gene/1659) is a protein-coding gene that encodes DEAH-box helicase 8, an ATP-dependent RNA helicase. As a core component of the spliceosome, [DHX8](/details-gene/1659) plays a fundamental role in post-transcriptional gene regulation. Its primary function involves the processing of pre-mRNA, specifically facilitating the catalytic step 2 of splicing and the subsequent release of mature mRNA from the spliceosomal complex for nuclear export ([Link](https://pubmed.ncbi.nlm.nih.gov/8608946/)). Consistent with this essential housekeeping function, [DHX8](/details-gene/1659) shows significant expression across a wide range of functionally diverse and transcriptionally active cell types, including immune cells like the [intermediate monocyte](/details-cell/CL0002393), specialized epithelial cells such as the [ionocyte](/details-cell/CL0005006), and hematopoietic progenitors. ## Cellular Roles and Expression Landscape The expression profile of [DHX8](/details-gene/1659) suggests it is a crucial "workhorse" gene in cells with high metabolic and transcriptional demands, rather than a specific lineage marker. - **Immune System:** **Overall**, [DHX8](/details-gene/1659) shows high significance in both myeloid and lymphoid lineages. Its top rank in [intermediate monocyte](/details-cell/CL0002393) (CSI: 8.52) and notable expression in [lung macrophage](/details-cell/CL1001603) suggest a key role in the innate immune system. Furthermore, its expression in adaptive immune cells, including [effector CD8-positive, alpha-beta T cell](/details-cell/CL0001050), [mature B cell](/details-cell/CL0000785), and [CD4-positive, alpha-beta memory T cell](/details-cell/CL0000897), indicates its continuous importance during lymphocyte activation and differentiation, processes that require rapid and extensive alterations to the transcriptome. - **Specialized and Progenitor Cells:** The gene is highly significant in [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050), highlighting its importance in hematopoiesis where precise gene regulation via splicing is critical for cell fate decisions. Its prominence in highly specialized cells like [ionocyte](/details-cell/CL0005006), [lung ciliated cell](/details-cell/CL1000271), and [astrocyte of the cerebral cortex](/details-cell/CL0002605) further underscores its role in maintaining the complex transcriptomes required for specialized cellular functions. This broad but significant expression pattern across diverse, active cell types is consistent with the indispensable nature of the splicing machinery for eukaryotic life. ## Pathways and Molecular Function [DHX8](/details-gene/1659) functions as an ATP-dependent RNA helicase, a role supported by its molecular function annotations including [ATP binding](/details-go/GO0005524), [ATP hydrolysis activity](/details-go/GO0016887), and [RNA helicase activity](/details-go/GO0003724). Its primary biological process is [mRNA splicing, via spliceosome](/details-go/GO0000398), a key step in the [Metabolism of RNA](/details-reactome/R-HSA-8953854). As a structural constituent of the [spliceosomal complex](/details-go/GO0005681), [DHX8](/details-gene/1659) is localized to the [nucleus](/details-go/GO0005634). It has been identified as a critical component of the [catalytic step 2 spliceosome](/details-go/GO0071013), where it is thought to use the energy from ATP hydrolysis to remodel the spliceosome's structure. This action is crucial for releasing the ligated exons (the mature mRNA) and the excised intron lariat, thereby finalizing the splicing reaction and preparing the mRNA for export ([Link](https://pubmed.ncbi.nlm.nih.gov/8608946/), [Link](https://pubmed.ncbi.nlm.nih.gov/28076346/)). Some evidence also suggests an interaction with proteins involved in sister chromatid cohesion, hinting at potential roles in cell cycle regulation ([Link](https://pubmed.ncbi.nlm.nih.gov/28062851/)). ## Research Directions The ubiquitous and essential nature of [DHX8](/details-gene/1659) in RNA splicing provides a foundation for several research avenues, particularly concerning cell-specific regulation and disease. **Proposed Hypotheses:** 1. **Regulation of Immune Cell Fate by Splicing Fidelity:** Given its high expression in diverse immune cells, [DHX8](/details-gene/1659) may be a critical regulator of the alternative splicing programs that define immune cell phenotypes. It is hypothesized that reduced [DHX8](/details-gene/1659) activity in T cells or monocytes would not cause general cell death but would specifically impair their differentiation into effector or memory subtypes by disrupting the production of key splice isoforms required for these specialized functions. 2. **A Role in Proliferation and Malignancy:** The high expression in [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050) and its reported link to sister chromatid cohesion ([Link](https://pubmed.ncbi.nlm.nih.gov/28062851/)) suggest a role beyond canonical splicing. It is hypothesized that [DHX8](/details-gene/1659) is essential for the proliferation of hematopoietic progenitors, and its overexpression or mutation could contribute to hematological malignancies by altering the splicing of cell cycle regulators or directly impacting chromosome segregation. **Experimental Approach:** To test the first hypothesis regarding the role of [DHX8](/details-gene/1659) in T cell differentiation, one could utilize primary human CD4+ T cells. An shRNA or CRISPR-interference (CRISPRi) system could be used to achieve partial knockdown of [DHX8](/details-gene/1659), avoiding the lethality of a full knockout. These knockdown cells, alongside controls, would be subjected to established in vitro differentiation protocols for Th1, Th2, and Th17 lineages. The impact on differentiation could be assessed by measuring lineage-specific cytokine production (via ELISA or intracellular flow cytometry) and master transcription factor expression (e.g., T-bet, GATA3, RORγt). Deep RNA-sequencing of these populations would then be performed to identify specific alternative splicing events that are dependent on [DHX8](/details-gene/1659) levels and correlate with failed differentiation. **Therapeutic Potential:** As a core component of the essential splicing machinery, systemic targeting of [DHX8](/details-gene/1659) would likely result in high toxicity. However, the phenomenon of "splicing addiction," where certain cancer cells are uniquely vulnerable to the inhibition of spliceosome components, makes [DHX8](/details-gene/1659) a potential therapeutic target. A therapeutic strategy would involve the **inhibition** of its helicase activity. Given its intracellular, nuclear localization, small molecule inhibitors would be the required modality. Such a drug could have efficacy in specific hematological malignancies or solid tumors that have been shown to be hypersensitive to perturbations in the splicing machinery.

Genular Protein ID: 1082928059

Symbol: DHX8_HUMAN

Name: ATP-dependent RNA helicase DHX8

UniProtKB Accession Codes:

Q14562

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CORUM 1 CTD 1 ChEBI 6 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 1 EMDB 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PIR 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SMART 4 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7935475

Title: Identification of a putative RNA helicase (HRH1), a human homolog of yeast Prp22.

PubMed ID: 7935475

DOI: 10.1128/mcb.14.11.7611-7620.1994

PubMed ID: 8608946

Title: A human RNA helicase-like protein, HRH1, facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome.

PubMed ID: 8608946

DOI: 10.1101/gad.10.8.997

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 16820410

Title: Novel function of beta-arrestin2 in the nucleus of mature spermatozoa.

PubMed ID: 16820410

DOI: 10.1242/jcs.03046

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28062851

Title: Human cactin interacts with DHX8 and SRRM2 to assure efficient pre-mRNA splicing and sister chromatid cohesion.

PubMed ID: 28062851

DOI: 10.1242/jcs.194068

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31256877

Title: Paralog studies augment gene discovery: DDX and DHX genes.

PubMed ID: 31256877

DOI: 10.1016/j.ajhg.2019.06.001

PubMed ID: 23096351

Title: Structural analysis of the C-terminal domain of the spliceosomal helicase Prp22.

PubMed ID: 23096351

DOI: 10.1515/hsz-2012-0158

PubMed ID: 28502770

Title: An Atomic Structure of the Human Spliceosome.

PubMed ID: 28502770

DOI: 10.1016/j.cell.2017.04.033

PubMed ID: 28076346

Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

PubMed ID: 28076346

DOI: 10.1038/nature21079

Sequence Information:

  • Length: 1220
  • Mass: 139315
  • Checksum: 17C1602A73A0EF24
  • Sequence:
    • MAVAVAMAGA LIGSEPGPAE ELAKLEYLSL VSKVCTELDN HLGINDKDLA EFVISLAEKN 
TTFDTFKASL VKNGAEFTDS LISNLLRLIQ TMRPPAKPST SKDPVVKPKT EKEKLKELFP 
VLCQPDNPSV RTMLDEDDVK VAVDVLKELE ALMPSAAGQE KQRDAEHRDR TKKKKRSRSR 
DRNRDRDRDR ERNRDRDHKR RHRSRSRSRS RTRERNKVKS RYRSRSRSQS PPKDRKDRDK 
YGERNLDRWR DKHVDRPPPE EPTIGDIYNG KVTSIMQFGC FVQLEGLRKR WEGLVHISEL 
RREGRVANVA DVVSKGQRVK VKVLSFTGTK TSLSMKDVDQ ETGEDLNPNR RRNLVGETNE 
ETSMRNPDRP THLSLVSAPE VEDDSLERKR LTRISDPEKW EIKQMIAANV LSKEEFPDFD 
EETGILPKVD DEEDEDLEIE LVEEEPPFLR GHTKQSMDMS PIKIVKNPDG SLSQAAMMQS 
ALAKERRELK QAQREAEMDS IPMGLNKHWV DPLPDAEGRQ IAANMRGIGM MPNDIPEWKK 
HAFGGNKASY GKKTQMSILE QRESLPIYKL KEQLVQAVHD NQILIVIGET GSGKTTQITQ 
YLAEAGYTSR GKIGCTQPRR VAAMSVAKRV SEEFGCCLGQ EVGYTIRFED CTSPETVIKY 
MTDGMLLREC LIDPDLTQYA IIMLDEAHER TIHTDVLFGL LKKTVQKRQD MKLIVTSATL 
DAVKFSQYFY EAPIFTIPGR TYPVEILYTK EPETDYLDAS LITVMQIHLT EPPGDILVFL 
TGQEEIDTAC EILYERMKSL GPDVPELIIL PVYSALPSEM QTRIFDPAPP GSRKVVIATN 
IAETSLTIDG IYYVVDPGFV KQKVYNSKTG IDQLVVTPIS QAQAKQRAGR AGRTGPGKCY 
RLYTERAYRD EMLTTNVPEI QRTNLASTVL SLKAMGINDL LSFDFMDAPP METLITAMEQ 
LYTLGALDDE GLLTRLGRRM AEFPLEPMLC KMLIMSVHLG CSEEMLTIVS MLSVQNVFYR 
PKDKQALADQ KKAKFHQTEG DHLTLLAVYN SWKNNKFSNP WCYENFIQAR SLRRAQDIRK 
QMLGIMDRHK LDVVSCGKST VRVQKAICSG FFRNAAKKDP QEGYRTLIDQ QVVYIHPSSA 
LFNRQPEWVV YHELVLTTKE YMREVTTIDP RWLVEFAPAF FKVSDPTKLS KQKKQQRLEP 
LYNRYEEPNA WRISRAFRRR

Genular Protein ID: 3958580483

Symbol: B7Z8F4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z8F4

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 4 CTD 1 ChEBI 5 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 6 Gene3D 3 InterPro 13 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 7 PeptideAtlas 1 Pfam 6 RefSeq 1 Rhea 1 SAM 1 SMART 4 SUPFAM 2

Sequence Information:

  • Length: 1181
  • Mass: 133958
  • Checksum: 03D5FAE55ACDA917
  • Sequence:
    • MAVAVAMAGA LIGSEPGPAE ELAKLEYLSL VSKVCTELDN HLGINDKDLA EFVISLAEKN 
TTFDTFKASL VKNGAEFTDS LISNLLRLIQ TMRPPAKPST SKDPVVKPKT EKEKLKELFP 
VLCQPDNPSV RTMLDEDDVK VAVDVLKELE ALMPSAAGQE KQRDAEHRDR TKKKKRSRSR 
DRNRDRDRDR ERNRDRDHKR RHRSRSRSRS RTRERNKVKS RYRSRSRSQS PPKDRKDRDK 
YGERNLDRWR DKHVDRPPPE EPTIGDIYNG KVTSIMQFGC FVQLEGLRKR WEGLVHISEL 
RREGRVANVA DVVSKGQRVK VKVLSFTGTK TSLSMKDVDQ ETGEDLNPNR RRNLVGETNE 
ETSMRNPDRP THLSLVSAPE VEDDSLERKR LTRISDPEKW EIKQMIAANV LSKEEFPDFD 
EETGILPKVD DEEDEDLEIE LVEEEPPFLR GHTKQSMDMS PIKIVKNPDG SLSQAAMMQS 
ALAKERRELK QAQREAEMDS IPMGLNKHWV DPLPDAEGRQ IAANMRGIGM MPNDIPEWKK 
HAFGGNKASY GKKTQMSILG QRESLPIYKL KEQLVQAVHD NQILIVIGET GSGKTTQITQ 
YLAEAGYTSR GKIGCTQPRR VAAMSVAKRV SEEFGCCLGQ EVGYTIRFED CTSPETVIKY 
MTDGMLLREC LIDPDLTQYA IIMLDEAHER TIHTDVLFGL LKKTVQKRQD MKLIVTSATL 
DAVKFSQYFY EAPIFTIPGR TYPVEILYTK EPETDYLDAS LITVMQIHLT EPPGDILVFL 
TGREEIDTAC EILYERMKSL GPDVPELIIL PVYSALPSEM QTRIFDPAPP GSRKVVIATN 
IAETSLTIDG IYYVVDPGFV KQKVYNSKTG IDQLVVTPIS QAQAKQRAGR AGRTGPGKCY 
RLYTERAYRD EMLTTNVPEI QRTNLASTVL SLKAMGINDL LSFDFMDAPP METLITAMEQ 
LYTLGALDDE GLLTRLGRRM AEFPLEPMLC KMLIMSVHLG CSEEMLTIVS MLSVQNVFYR 
PKDKQALADQ KKAKFHQTEG DHLTLLAVYN SWKNNKFSNP WCYENFIQAR SLRRAQDIRK 
QMLGIMDRHK LDVVSCGKST VRVQKAICSG FFRNAAKKDP QEGYRTLIDQ QVVYIHPSSA 
LFNRQPECPK HFLPVVAVAV SLEQCLSKFE DLNKELGLVT C

Genular Protein ID: 1277769298

Symbol: K7END7_HUMAN

Name: N/A

UniProtKB Accession Codes:

K7END7

Database IDs:

ARBA 10 Antibodypedia 1 Bgee 1 CDD 4 CTD 1 ChEBI 5 ChiTaRS 1 EC 1 EMBL 4 Ensembl 2 GO 8 Gene3D 3 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 13 NCBI Taxonomy 1 PANTHER 2 PROSITE 7 PeptideAtlas 1 Pfam 6 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 1 SAM 1 SMART 4 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 1169
  • Mass: 132782
  • Checksum: F49874CD5F2E3D08
  • Sequence:
    • MAVAVAMAGA LIGSEPGPAE ELAKLEYLSL VSKVCTELDN HLGINDKDLA EFVISLAEKN 
TTFDTFKASL VKNGAEFTDS LISNLLRLIQ TMRPPAKPST SKDPVVKPKT EKEKLKELFP 
VLCQPDNPSV RTMLDEDDVK VAVDVLKELE ALMPSAAGQE KQRDAEHRDR TKKKKRSRSR 
DRNRDRDRDR ERNRDRDHKR RHRSRSRSRS RTRERNKVKS RYRSRSRSQS PPKDRKDRDK 
YGERNLDRWR DKHVDRPPPE EPTIGDIYNG KVTSIMQFGC FVQLEGLRKR WEGLVHISEL 
RREGRVANVA DVVSKGQRVK VKVLSFTGTK TSLSMKDVDQ ETGEDLNPNR RRNLVGETNE 
ETSMRNPDRP THLSLVSAPE VEDDSLERKR LTRISDPEKW EIKQMIAANV LSKEEFPDFD 
EETGILPKVD DEEDEDLEIE LVEEEPPFLR GHTKQSMDMS PIKIVKNPDG SLSQAAMMQS 
ALAKERRELK QAQREAEMDS IPMGLNKHWV DPLPDAEGRQ IAANMRGIGM MPNDIPEWKK 
HAFGGNKASY GKKTQMSILE QRESLPIYKL KEQLVQAVHD NQILIVIGET GSGKTTQITQ 
YLAEAGYTSR GKIGCTQPRR VAAMSVAKRV SEEFGCCLGQ EVGYTIRFED CTSPETVIKY 
MTDGMLLREC LIDPDLTQYA IIMLDEAHER TIHTDVLFGL LKKTVQKRQD MKLIVTSATL 
DAVKFSQYFY EAPIFTIPGR TYPVEILYTK EPETDYLDAS LITVMQIHLT EPPGDILVFL 
TGQEEIDTAC EILYERMKSL GPDVPELIIL PVYSALPSEM QTRIFDPAPP GSRKVVIATN 
IAETSLTIDG IYYVVDPGFV KQKVYNSKTG IDQLVVTPIS QAQAKQRAGR AGRTGPGKCY 
RLYTERAYRD EMLTTNVPEI QRTNLASTVL SLKAMGINDL LSFDFMDAPP METLITAMEQ 
LYTLGALDDE GLLTRLGRRM AEFPLEPMLC KMLIMSVHLG CSEEMLTIVS MLSVQNVFYR 
PKDKQALADQ KKAKFHQTEG DHLTLLAVYN SWKNNKFSNP WCYENFIQAR SLRRAQDIRK 
QMLGIMDRHK LDVVSCGKST VRVQKAICSG FFRNAAKKDP QEGYRTLIDQ QVVYIHPSSA 
LFNRQPEWDL YSRFSEWKSG TNCSSLSGT

Genular Protein ID: 2744188024

Symbol: Q05CV4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q05CV4

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 IntAct 1 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 RefSeq 2 SAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 119
  • Mass: 12928
  • Checksum: 1FA8D1BCA91576BE
  • Sequence:
    • MAVAVAMAGA LIGSEPGPAE ELAKLEYLSL VSKVCTELDN HLGINDKDLA EFVISLAEKN 
TTFDTFKASL VKNGAEFTDS LISNLLRLIQ TMRPPAKPST SKDPVVKPKT EKKKKKKKK

Genular Protein ID: 289618056

Symbol: Q86YB2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86YB2

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 4 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 6 Gene3D 3 IntAct 1 InterPro 13 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 7 PeptideAtlas 1 Pfam 6 RefSeq 1 Rhea 1 SAM 1 SMART 4 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1220
  • Mass: 139315
  • Checksum: E33F8A6BC9A0F485
  • Sequence:
    • MAVAVAMAGA LIGSEPGPAE ELAKLEYLSL VSKVCTELDN HLGINDKDLA EFVISLAEKN 
TTFDTFKASL VKNGAEFTDS LISNLLRLIQ TMRPPAKPST SKDPVVKPKT EKEKLKELFP 
VLCQPDNPSV RTMLDEDDVK VAVDVLKELE ALMPSAAGQE KQRDAEHRDR TKKKKRSRSR 
DRNRDRDRDR ERNRDRDHKR RHRSRSRSRS RTRERNKVKS RYRSRSRSQS PPKDRKDRDK 
YGERNLDRWR DKHVDRPPPE EPTIGDIYNG KVTSIMQFGC FVQLEGLRKR WEGLVHISEL 
RREGRVANVA DVVSKGQRVK VKVLSFTGTK TSLSMKDVDQ ETGEDLNPNR RRNLVGETNE 
ETSMRNPDRP THLSLVSAPE VEDDSLERKR LTRISDPEKW EIKQMIAANV LSKEEFPDFD 
EETGILPKVD DEEDEDLEIE LVEEEPPFLR GHTKQSMDMS PIKIVKNPDG SLSQAAMMQS 
ALAKERRELK QAQREAEMDS IPMGLNKHWV DPLPDAEGRQ IAANMRGIGM MPNDIPEWKK 
HAFGGNKASY GKKTQMSILE QRESLPIYKL KEQLVQAVHD NQILIVIGET GSGKTTQITQ 
YLAEAGYTSR GKIGCTQPRR VAAMSVAKRV SEEFGCCLGQ EVGYTIRFED CTSPETVIKY 
MTDGMLLREC LIDPDLTQYA IIMLDEAHER TIHTDVLFGL LKKTVQKRQD MKLIVTSATL 
DAVKFSQYFY EAPIFTIPGR TYPVEILYTK EPETDYLDAS LITVMQIHLT EPPGDILVFL 
TGQEEIDTAC EILYERMKSL GPDVPELIIL PVYSALPSEM QTRIFDPAPP GSRKVVIATN 
IAETSLTIDG IYYVVDPGFV KQKVYNSKTG IDQLVVTPIS QAQAKQRAGR AGRTGPGKCY 
RLYTERAYRD EMLTTNVPEI QRTNLASTVL SLKAMGINDL LSFDFMDAPP METLITAMEQ 
LYTLGALDDE GLLTRLGRRM AEFPLEPMLC KMLIMSVHLG CSEEMLTIVS MLSVQNVFYR 
PKDKQALADQ KKAKFHQTEG DHLTLLAVYN SWKNNKFSNP WCYENFIKAR SLRRAQDIRK 
QMLGIMDRHK LDVVSCGKST VRVQKAICSG FFRNAAKKDP QEGYRTLIDQ QVVYIHPSSA 
LFNRQPEWVV YHELVLTTKE YMREVTTIDP RWLVEFAPAF FKVSDPTKLS KQKKQQRLEP 
LYNRYEEPNA WRISRAFRRR

Genular Protein ID: 3222476249

Symbol: F5H658_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5H658

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 4 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 3 GeneTree 1 HGNC 1 InterPro 13 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 7 PeptideAtlas 2 Pfam 6 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 1 SAM 1 SMART 4 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 1181
  • Mass: 134002
  • Checksum: E0318218E0D34D5A
  • Sequence:
    • MAVAVAMAGA LIGSEPGPAE ELAKLEYLSL VSKVCTELDN HLGINDKDLA EFVISLAEKN 
TTFDTFKASL VKNGAEFTDS LISNLLRLIQ TMRPPAKPST SKDPVVKPKT EKEKLKELFP 
VLCQPDNPSV RTMLDEDDVK VAVDVLKELE ALMPSAAGQE KQRDAEHRDR TKKKKRSRSR 
DRNRDRDRDR ERNRDRDHKR RHRSRSRSRS RTRERNKVKS RYRSRSRSQS PPKDRKDRDK 
YGERNLDRWR DKHVDRPPPE EPTIGDIYNG KVTSIMQFGC FVQLEGLRKR WEGLVHISEL 
RREGRVANVA DVVSKGQRVK VKVLSFTGTK TSLSMKDVDQ ETGEDLNPNR RRNLVGETNE 
ETSMRNPDRP THLSLVSAPE VEDDSLERKR LTRISDPEKW EIKQMIAANV LSKEEFPDFD 
EETGILPKVD DEEDEDLEIE LVEEEPPFLR GHTKQSMDMS PIKIVKNPDG SLSQAAMMQS 
ALAKERRELK QAQREAEMDS IPMGLNKHWV DPLPDAEGRQ IAANMRGIGM MPNDIPEWKK 
HAFGGNKASY GKKTQMSILE QRESLPIYKL KEQLVQAVHD NQILIVIGET GSGKTTQITQ 
YLAEAGYTSR GKIGCTQPRR VAAMSVAKRV SEEFGCCLGQ EVGYTIRFED CTSPETVIKY 
MTDGMLLREC LIDPDLTQYA IIMLDEAHER TIHTDVLFGL LKKTVQKRQD MKLIVTSATL 
DAVKFSQYFY EAPIFTIPGR TYPVEILYTK EPETDYLDAS LITVMQIHLT EPPGDILVFL 
TGQEEIDTAC EILYERMKSL GPDVPELIIL PVYSALPSEM QTRIFDPAPP GSRKVVIATN 
IAETSLTIDG IYYVVDPGFV KQKVYNSKTG IDQLVVTPIS QAQAKQRAGR AGRTGPGKCY 
RLYTERAYRD EMLTTNVPEI QRTNLASTVL SLKAMGINDL LSFDFMDAPP METLITAMEQ 
LYTLGALDDE GLLTRLGRRM AEFPLEPMLC KMLIMSVHLG CSEEMLTIVS MLSVQNVFYR 
PKDKQALADQ KKAKFHQTEG DHLTLLAVYN SWKNNKFSNP WCYENFIQAR SLRRAQDIRK 
QMLGIMDRHK LDVVSCGKST VRVQKAICSG FFRNAAKKDP QEGYRTLIDQ QVVYIHPSSA 
LFNRQPECPK HFLPVVAVAV SLEQCLSKFE DLNKELGLVT C