Details for: DHX8

Gene ID: 1659

Symbol: DHX8

Ensembl ID: ENSG00000067596

Description: DEAH-box helicase 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 162.2679
    Cell Significance Index: -25.2400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 101.2445
    Cell Significance Index: -25.6800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 68.9408
    Cell Significance Index: -28.4000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 56.9344
    Cell Significance Index: -23.1300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 50.8860
    Cell Significance Index: -26.1800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.3731
    Cell Significance Index: -23.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.6309
    Cell Significance Index: -26.6700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.3025
    Cell Significance Index: -24.9200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.7455
    Cell Significance Index: -23.7900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.8626
    Cell Significance Index: -27.0800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.0078
    Cell Significance Index: -10.9600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 4.8299
    Cell Significance Index: 79.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.8807
    Cell Significance Index: 25.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9835
    Cell Significance Index: 195.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9633
    Cell Significance Index: 104.7800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8774
    Cell Significance Index: 38.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8210
    Cell Significance Index: 31.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7907
    Cell Significance Index: 128.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6687
    Cell Significance Index: 134.1500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6449
    Cell Significance Index: 231.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5781
    Cell Significance Index: 104.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5009
    Cell Significance Index: 61.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3110
    Cell Significance Index: 17.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2940
    Cell Significance Index: 6.3700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2784
    Cell Significance Index: 8.0200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2708
    Cell Significance Index: 18.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2699
    Cell Significance Index: 14.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2486
    Cell Significance Index: 15.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2456
    Cell Significance Index: 6.8700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2388
    Cell Significance Index: 105.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2193
    Cell Significance Index: 16.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2136
    Cell Significance Index: 9.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1748
    Cell Significance Index: 24.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1648
    Cell Significance Index: 31.3700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1598
    Cell Significance Index: 110.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1566
    Cell Significance Index: 85.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1556
    Cell Significance Index: 10.4600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1495
    Cell Significance Index: 17.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1488
    Cell Significance Index: 14.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1165
    Cell Significance Index: 5.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0491
    Cell Significance Index: 92.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0477
    Cell Significance Index: 1.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0450
    Cell Significance Index: 2.1200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0357
    Cell Significance Index: 1.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0283
    Cell Significance Index: 38.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0267
    Cell Significance Index: 41.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0198
    Cell Significance Index: 1.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0194
    Cell Significance Index: 1.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0161
    Cell Significance Index: 10.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0111
    Cell Significance Index: 20.5600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0049
    Cell Significance Index: 0.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0012
    Cell Significance Index: 0.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0090
    Cell Significance Index: -8.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0176
    Cell Significance Index: -2.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0186
    Cell Significance Index: -13.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0271
    Cell Significance Index: -20.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0293
    Cell Significance Index: -21.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0318
    Cell Significance Index: -4.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0430
    Cell Significance Index: -3.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0456
    Cell Significance Index: -25.6900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0479
    Cell Significance Index: -29.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0600
    Cell Significance Index: -10.2500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0676
    Cell Significance Index: -1.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0773
    Cell Significance Index: -22.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0899
    Cell Significance Index: -10.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0943
    Cell Significance Index: -9.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0969
    Cell Significance Index: -12.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1023
    Cell Significance Index: -11.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1295
    Cell Significance Index: -9.6500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1351
    Cell Significance Index: -2.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1459
    Cell Significance Index: -30.7300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1714
    Cell Significance Index: -3.1700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2223
    Cell Significance Index: -2.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2272
    Cell Significance Index: -23.6600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2503
    Cell Significance Index: -2.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2645
    Cell Significance Index: -7.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2714
    Cell Significance Index: -7.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2951
    Cell Significance Index: -23.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3035
    Cell Significance Index: -18.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3111
    Cell Significance Index: -8.3400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3114
    Cell Significance Index: -4.7300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3187
    Cell Significance Index: -6.2200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3385
    Cell Significance Index: -9.6600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3446
    Cell Significance Index: -7.5500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3731
    Cell Significance Index: -19.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3758
    Cell Significance Index: -9.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3827
    Cell Significance Index: -6.4100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4007
    Cell Significance Index: -9.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4021
    Cell Significance Index: -12.8800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4248
    Cell Significance Index: -11.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4268
    Cell Significance Index: -10.6700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4680
    Cell Significance Index: -5.8100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5050
    Cell Significance Index: -17.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5127
    Cell Significance Index: -16.3300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5247
    Cell Significance Index: -17.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5271
    Cell Significance Index: -15.4800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5486
    Cell Significance Index: -16.1600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5802
    Cell Significance Index: -29.3200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5957
    Cell Significance Index: -15.9400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5975
    Cell Significance Index: -20.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RNA Binding and Helicase Activity:** DHX8 exhibits high affinity for RNA, enabling it to bind and unwind double-stranded RNA (dsRNA) structures. This activity is essential for the catalytic step of the spliceosome, where DHX8 facilitates the removal of introns and the joining of exons. 2. **ATP-Dependent:** DHX8's helicase activity is dependent on the hydrolysis of ATP, which provides the energy required for RNA unwinding and processing. 3. **Spliceosome Involvement:** DHX8 is a key component of the spliceosome, a complex that assembles on pre-mRNA to facilitate the removal of introns and the joining of exons. 4. **Neuronal Expression:** DHX8 is significantly expressed in various neuronal populations, including corticothalamic-projecting glutamatergic cortical neurons and GABAergic cortical interneurons. **Pathways and Functions:** 1. **RNA Splicing:** DHX8 plays a crucial role in the catalytic step of the spliceosome, facilitating the removal of introns and the joining of exons to form mature mRNA. 2. **Metabolism of RNA:** DHX8 is involved in the processing of capped intron-containing pre-mRNA, which is essential for the production of functional mRNA. 3. **Cell Signaling:** DHX8 has been implicated in cell signaling pathways, including those involved in the regulation of gene expression and cellular response to stress. 4. **Neurological Function:** DHX8's expression in specific neuronal populations suggests its involvement in neurological function, including the regulation of neuronal excitability and synaptic plasticity. **Clinical Significance:** Dysregulation of DHX8 has been implicated in various neurological disorders, including: 1. **Spliceosome-Related Disorders:** Mutations in the DHX8 gene have been associated with spliceosome-related disorders, such as myasthenia gravis and frontotemporal dementia. 2. **Autism Spectrum Disorder:** Studies have suggested that DHX8 may play a role in the regulation of gene expression in autism spectrum disorder (ASD), a neurodevelopmental disorder characterized by impaired social communication and repetitive behaviors. 3. **Neurodegenerative Diseases:** DHX8's involvement in RNA processing and cell signaling pathways suggests its potential role in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, DHX8 is a critical component of the spliceosome, facilitating the processing and splicing of RNA molecules. Its expression in specific neuronal populations and its involvement in neurological disorders highlight the importance of further research into the role of DHX8 in RNA processing and its implications for neurological function.

Genular Protein ID: 1082928059

Symbol: DHX8_HUMAN

Name: ATP-dependent RNA helicase DHX8

UniProtKB Accession Codes:

Q14562

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CORUM 1 CTD 1 ChEBI 6 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 1 EMDB 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PIR 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SMART 4 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7935475

Title: Identification of a putative RNA helicase (HRH1), a human homolog of yeast Prp22.

PubMed ID: 7935475

DOI: 10.1128/mcb.14.11.7611-7620.1994

PubMed ID: 8608946

Title: A human RNA helicase-like protein, HRH1, facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome.

PubMed ID: 8608946

DOI: 10.1101/gad.10.8.997

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 16820410

Title: Novel function of beta-arrestin2 in the nucleus of mature spermatozoa.

PubMed ID: 16820410

DOI: 10.1242/jcs.03046

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28062851

Title: Human cactin interacts with DHX8 and SRRM2 to assure efficient pre-mRNA splicing and sister chromatid cohesion.

PubMed ID: 28062851

DOI: 10.1242/jcs.194068

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31256877

Title: Paralog studies augment gene discovery: DDX and DHX genes.

PubMed ID: 31256877

DOI: 10.1016/j.ajhg.2019.06.001

PubMed ID: 23096351

Title: Structural analysis of the C-terminal domain of the spliceosomal helicase Prp22.

PubMed ID: 23096351

DOI: 10.1515/hsz-2012-0158

PubMed ID: 28502770

Title: An Atomic Structure of the Human Spliceosome.

PubMed ID: 28502770

DOI: 10.1016/j.cell.2017.04.033

PubMed ID: 28076346

Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

PubMed ID: 28076346

DOI: 10.1038/nature21079

Sequence Information:

  • Length: 1220
  • Mass: 139315
  • Checksum: 17C1602A73A0EF24
  • Sequence:
    • MAVAVAMAGA LIGSEPGPAE ELAKLEYLSL VSKVCTELDN HLGINDKDLA EFVISLAEKN 
TTFDTFKASL VKNGAEFTDS LISNLLRLIQ TMRPPAKPST SKDPVVKPKT EKEKLKELFP 
VLCQPDNPSV RTMLDEDDVK VAVDVLKELE ALMPSAAGQE KQRDAEHRDR TKKKKRSRSR 
DRNRDRDRDR ERNRDRDHKR RHRSRSRSRS RTRERNKVKS RYRSRSRSQS PPKDRKDRDK 
YGERNLDRWR DKHVDRPPPE EPTIGDIYNG KVTSIMQFGC FVQLEGLRKR WEGLVHISEL 
RREGRVANVA DVVSKGQRVK VKVLSFTGTK TSLSMKDVDQ ETGEDLNPNR RRNLVGETNE 
ETSMRNPDRP THLSLVSAPE VEDDSLERKR LTRISDPEKW EIKQMIAANV LSKEEFPDFD 
EETGILPKVD DEEDEDLEIE LVEEEPPFLR GHTKQSMDMS PIKIVKNPDG SLSQAAMMQS 
ALAKERRELK QAQREAEMDS IPMGLNKHWV DPLPDAEGRQ IAANMRGIGM MPNDIPEWKK 
HAFGGNKASY GKKTQMSILE QRESLPIYKL KEQLVQAVHD NQILIVIGET GSGKTTQITQ 
YLAEAGYTSR GKIGCTQPRR VAAMSVAKRV SEEFGCCLGQ EVGYTIRFED CTSPETVIKY 
MTDGMLLREC LIDPDLTQYA IIMLDEAHER TIHTDVLFGL LKKTVQKRQD MKLIVTSATL 
DAVKFSQYFY EAPIFTIPGR TYPVEILYTK EPETDYLDAS LITVMQIHLT EPPGDILVFL 
TGQEEIDTAC EILYERMKSL GPDVPELIIL PVYSALPSEM QTRIFDPAPP GSRKVVIATN 
IAETSLTIDG IYYVVDPGFV KQKVYNSKTG IDQLVVTPIS QAQAKQRAGR AGRTGPGKCY 
RLYTERAYRD EMLTTNVPEI QRTNLASTVL SLKAMGINDL LSFDFMDAPP METLITAMEQ 
LYTLGALDDE GLLTRLGRRM AEFPLEPMLC KMLIMSVHLG CSEEMLTIVS MLSVQNVFYR 
PKDKQALADQ KKAKFHQTEG DHLTLLAVYN SWKNNKFSNP WCYENFIQAR SLRRAQDIRK 
QMLGIMDRHK LDVVSCGKST VRVQKAICSG FFRNAAKKDP QEGYRTLIDQ QVVYIHPSSA 
LFNRQPEWVV YHELVLTTKE YMREVTTIDP RWLVEFAPAF FKVSDPTKLS KQKKQQRLEP 
LYNRYEEPNA WRISRAFRRR

Genular Protein ID: 3958580483

Symbol: B7Z8F4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z8F4

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 4 CTD 1 ChEBI 5 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 6 Gene3D 3 InterPro 13 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 7 PeptideAtlas 1 Pfam 6 RefSeq 1 Rhea 1 SAM 1 SMART 4 SUPFAM 2

Sequence Information:

  • Length: 1181
  • Mass: 133958
  • Checksum: 03D5FAE55ACDA917
  • Sequence:
    • MAVAVAMAGA LIGSEPGPAE ELAKLEYLSL VSKVCTELDN HLGINDKDLA EFVISLAEKN 
TTFDTFKASL VKNGAEFTDS LISNLLRLIQ TMRPPAKPST SKDPVVKPKT EKEKLKELFP 
VLCQPDNPSV RTMLDEDDVK VAVDVLKELE ALMPSAAGQE KQRDAEHRDR TKKKKRSRSR 
DRNRDRDRDR ERNRDRDHKR RHRSRSRSRS RTRERNKVKS RYRSRSRSQS PPKDRKDRDK 
YGERNLDRWR DKHVDRPPPE EPTIGDIYNG KVTSIMQFGC FVQLEGLRKR WEGLVHISEL 
RREGRVANVA DVVSKGQRVK VKVLSFTGTK TSLSMKDVDQ ETGEDLNPNR RRNLVGETNE 
ETSMRNPDRP THLSLVSAPE VEDDSLERKR LTRISDPEKW EIKQMIAANV LSKEEFPDFD 
EETGILPKVD DEEDEDLEIE LVEEEPPFLR GHTKQSMDMS PIKIVKNPDG SLSQAAMMQS 
ALAKERRELK QAQREAEMDS IPMGLNKHWV DPLPDAEGRQ IAANMRGIGM MPNDIPEWKK 
HAFGGNKASY GKKTQMSILG QRESLPIYKL KEQLVQAVHD NQILIVIGET GSGKTTQITQ 
YLAEAGYTSR GKIGCTQPRR VAAMSVAKRV SEEFGCCLGQ EVGYTIRFED CTSPETVIKY 
MTDGMLLREC LIDPDLTQYA IIMLDEAHER TIHTDVLFGL LKKTVQKRQD MKLIVTSATL 
DAVKFSQYFY EAPIFTIPGR TYPVEILYTK EPETDYLDAS LITVMQIHLT EPPGDILVFL 
TGREEIDTAC EILYERMKSL GPDVPELIIL PVYSALPSEM QTRIFDPAPP GSRKVVIATN 
IAETSLTIDG IYYVVDPGFV KQKVYNSKTG IDQLVVTPIS QAQAKQRAGR AGRTGPGKCY 
RLYTERAYRD EMLTTNVPEI QRTNLASTVL SLKAMGINDL LSFDFMDAPP METLITAMEQ 
LYTLGALDDE GLLTRLGRRM AEFPLEPMLC KMLIMSVHLG CSEEMLTIVS MLSVQNVFYR 
PKDKQALADQ KKAKFHQTEG DHLTLLAVYN SWKNNKFSNP WCYENFIQAR SLRRAQDIRK 
QMLGIMDRHK LDVVSCGKST VRVQKAICSG FFRNAAKKDP QEGYRTLIDQ QVVYIHPSSA 
LFNRQPECPK HFLPVVAVAV SLEQCLSKFE DLNKELGLVT C

Genular Protein ID: 1277769298

Symbol: K7END7_HUMAN

Name: N/A

UniProtKB Accession Codes:

K7END7

Database IDs:

ARBA 10 Antibodypedia 1 Bgee 1 CDD 4 CTD 1 ChEBI 5 ChiTaRS 1 EC 1 EMBL 4 Ensembl 2 GO 8 Gene3D 3 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 13 NCBI Taxonomy 1 PANTHER 2 PROSITE 7 PeptideAtlas 1 Pfam 6 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 1 SAM 1 SMART 4 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 1169
  • Mass: 132782
  • Checksum: F49874CD5F2E3D08
  • Sequence:
    • MAVAVAMAGA LIGSEPGPAE ELAKLEYLSL VSKVCTELDN HLGINDKDLA EFVISLAEKN 
TTFDTFKASL VKNGAEFTDS LISNLLRLIQ TMRPPAKPST SKDPVVKPKT EKEKLKELFP 
VLCQPDNPSV RTMLDEDDVK VAVDVLKELE ALMPSAAGQE KQRDAEHRDR TKKKKRSRSR 
DRNRDRDRDR ERNRDRDHKR RHRSRSRSRS RTRERNKVKS RYRSRSRSQS PPKDRKDRDK 
YGERNLDRWR DKHVDRPPPE EPTIGDIYNG KVTSIMQFGC FVQLEGLRKR WEGLVHISEL 
RREGRVANVA DVVSKGQRVK VKVLSFTGTK TSLSMKDVDQ ETGEDLNPNR RRNLVGETNE 
ETSMRNPDRP THLSLVSAPE VEDDSLERKR LTRISDPEKW EIKQMIAANV LSKEEFPDFD 
EETGILPKVD DEEDEDLEIE LVEEEPPFLR GHTKQSMDMS PIKIVKNPDG SLSQAAMMQS 
ALAKERRELK QAQREAEMDS IPMGLNKHWV DPLPDAEGRQ IAANMRGIGM MPNDIPEWKK 
HAFGGNKASY GKKTQMSILE QRESLPIYKL KEQLVQAVHD NQILIVIGET GSGKTTQITQ 
YLAEAGYTSR GKIGCTQPRR VAAMSVAKRV SEEFGCCLGQ EVGYTIRFED CTSPETVIKY 
MTDGMLLREC LIDPDLTQYA IIMLDEAHER TIHTDVLFGL LKKTVQKRQD MKLIVTSATL 
DAVKFSQYFY EAPIFTIPGR TYPVEILYTK EPETDYLDAS LITVMQIHLT EPPGDILVFL 
TGQEEIDTAC EILYERMKSL GPDVPELIIL PVYSALPSEM QTRIFDPAPP GSRKVVIATN 
IAETSLTIDG IYYVVDPGFV KQKVYNSKTG IDQLVVTPIS QAQAKQRAGR AGRTGPGKCY 
RLYTERAYRD EMLTTNVPEI QRTNLASTVL SLKAMGINDL LSFDFMDAPP METLITAMEQ 
LYTLGALDDE GLLTRLGRRM AEFPLEPMLC KMLIMSVHLG CSEEMLTIVS MLSVQNVFYR 
PKDKQALADQ KKAKFHQTEG DHLTLLAVYN SWKNNKFSNP WCYENFIQAR SLRRAQDIRK 
QMLGIMDRHK LDVVSCGKST VRVQKAICSG FFRNAAKKDP QEGYRTLIDQ QVVYIHPSSA 
LFNRQPEWDL YSRFSEWKSG TNCSSLSGT

Genular Protein ID: 2744188024

Symbol: Q05CV4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q05CV4

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 IntAct 1 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 RefSeq 2 SAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 119
  • Mass: 12928
  • Checksum: 1FA8D1BCA91576BE
  • Sequence:
    • MAVAVAMAGA LIGSEPGPAE ELAKLEYLSL VSKVCTELDN HLGINDKDLA EFVISLAEKN 
TTFDTFKASL VKNGAEFTDS LISNLLRLIQ TMRPPAKPST SKDPVVKPKT EKKKKKKKK

Genular Protein ID: 289618056

Symbol: Q86YB2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86YB2

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 4 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 6 Gene3D 3 IntAct 1 InterPro 13 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 7 PeptideAtlas 1 Pfam 6 RefSeq 1 Rhea 1 SAM 1 SMART 4 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1220
  • Mass: 139315
  • Checksum: E33F8A6BC9A0F485
  • Sequence:
    • MAVAVAMAGA LIGSEPGPAE ELAKLEYLSL VSKVCTELDN HLGINDKDLA EFVISLAEKN 
TTFDTFKASL VKNGAEFTDS LISNLLRLIQ TMRPPAKPST SKDPVVKPKT EKEKLKELFP 
VLCQPDNPSV RTMLDEDDVK VAVDVLKELE ALMPSAAGQE KQRDAEHRDR TKKKKRSRSR 
DRNRDRDRDR ERNRDRDHKR RHRSRSRSRS RTRERNKVKS RYRSRSRSQS PPKDRKDRDK 
YGERNLDRWR DKHVDRPPPE EPTIGDIYNG KVTSIMQFGC FVQLEGLRKR WEGLVHISEL 
RREGRVANVA DVVSKGQRVK VKVLSFTGTK TSLSMKDVDQ ETGEDLNPNR RRNLVGETNE 
ETSMRNPDRP THLSLVSAPE VEDDSLERKR LTRISDPEKW EIKQMIAANV LSKEEFPDFD 
EETGILPKVD DEEDEDLEIE LVEEEPPFLR GHTKQSMDMS PIKIVKNPDG SLSQAAMMQS 
ALAKERRELK QAQREAEMDS IPMGLNKHWV DPLPDAEGRQ IAANMRGIGM MPNDIPEWKK 
HAFGGNKASY GKKTQMSILE QRESLPIYKL KEQLVQAVHD NQILIVIGET GSGKTTQITQ 
YLAEAGYTSR GKIGCTQPRR VAAMSVAKRV SEEFGCCLGQ EVGYTIRFED CTSPETVIKY 
MTDGMLLREC LIDPDLTQYA IIMLDEAHER TIHTDVLFGL LKKTVQKRQD MKLIVTSATL 
DAVKFSQYFY EAPIFTIPGR TYPVEILYTK EPETDYLDAS LITVMQIHLT EPPGDILVFL 
TGQEEIDTAC EILYERMKSL GPDVPELIIL PVYSALPSEM QTRIFDPAPP GSRKVVIATN 
IAETSLTIDG IYYVVDPGFV KQKVYNSKTG IDQLVVTPIS QAQAKQRAGR AGRTGPGKCY 
RLYTERAYRD EMLTTNVPEI QRTNLASTVL SLKAMGINDL LSFDFMDAPP METLITAMEQ 
LYTLGALDDE GLLTRLGRRM AEFPLEPMLC KMLIMSVHLG CSEEMLTIVS MLSVQNVFYR 
PKDKQALADQ KKAKFHQTEG DHLTLLAVYN SWKNNKFSNP WCYENFIKAR SLRRAQDIRK 
QMLGIMDRHK LDVVSCGKST VRVQKAICSG FFRNAAKKDP QEGYRTLIDQ QVVYIHPSSA 
LFNRQPEWVV YHELVLTTKE YMREVTTIDP RWLVEFAPAF FKVSDPTKLS KQKKQQRLEP 
LYNRYEEPNA WRISRAFRRR

Genular Protein ID: 3222476249

Symbol: F5H658_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5H658

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 4 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 3 GeneTree 1 HGNC 1 InterPro 13 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 7 PeptideAtlas 2 Pfam 6 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 1 SAM 1 SMART 4 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 1181
  • Mass: 134002
  • Checksum: E0318218E0D34D5A
  • Sequence:
    • MAVAVAMAGA LIGSEPGPAE ELAKLEYLSL VSKVCTELDN HLGINDKDLA EFVISLAEKN 
TTFDTFKASL VKNGAEFTDS LISNLLRLIQ TMRPPAKPST SKDPVVKPKT EKEKLKELFP 
VLCQPDNPSV RTMLDEDDVK VAVDVLKELE ALMPSAAGQE KQRDAEHRDR TKKKKRSRSR 
DRNRDRDRDR ERNRDRDHKR RHRSRSRSRS RTRERNKVKS RYRSRSRSQS PPKDRKDRDK 
YGERNLDRWR DKHVDRPPPE EPTIGDIYNG KVTSIMQFGC FVQLEGLRKR WEGLVHISEL 
RREGRVANVA DVVSKGQRVK VKVLSFTGTK TSLSMKDVDQ ETGEDLNPNR RRNLVGETNE 
ETSMRNPDRP THLSLVSAPE VEDDSLERKR LTRISDPEKW EIKQMIAANV LSKEEFPDFD 
EETGILPKVD DEEDEDLEIE LVEEEPPFLR GHTKQSMDMS PIKIVKNPDG SLSQAAMMQS 
ALAKERRELK QAQREAEMDS IPMGLNKHWV DPLPDAEGRQ IAANMRGIGM MPNDIPEWKK 
HAFGGNKASY GKKTQMSILE QRESLPIYKL KEQLVQAVHD NQILIVIGET GSGKTTQITQ 
YLAEAGYTSR GKIGCTQPRR VAAMSVAKRV SEEFGCCLGQ EVGYTIRFED CTSPETVIKY 
MTDGMLLREC LIDPDLTQYA IIMLDEAHER TIHTDVLFGL LKKTVQKRQD MKLIVTSATL 
DAVKFSQYFY EAPIFTIPGR TYPVEILYTK EPETDYLDAS LITVMQIHLT EPPGDILVFL 
TGQEEIDTAC EILYERMKSL GPDVPELIIL PVYSALPSEM QTRIFDPAPP GSRKVVIATN 
IAETSLTIDG IYYVVDPGFV KQKVYNSKTG IDQLVVTPIS QAQAKQRAGR AGRTGPGKCY 
RLYTERAYRD EMLTTNVPEI QRTNLASTVL SLKAMGINDL LSFDFMDAPP METLITAMEQ 
LYTLGALDDE GLLTRLGRRM AEFPLEPMLC KMLIMSVHLG CSEEMLTIVS MLSVQNVFYR 
PKDKQALADQ KKAKFHQTEG DHLTLLAVYN SWKNNKFSNP WCYENFIQAR SLRRAQDIRK 
QMLGIMDRHK LDVVSCGKST VRVQKAICSG FFRNAAKKDP QEGYRTLIDQ QVVYIHPSSA 
LFNRQPECPK HFLPVVAVAV SLEQCLSKFE DLNKELGLVT C

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.