Details for: DHX15

Gene ID: 1665

Symbol: DHX15

Ensembl ID: ENSG00000109606

Description: DEAH-box helicase 15

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.93
    Marker Score: 2060
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.85
    Marker Score: 1950
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.77
    Marker Score: 60345
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.67
    Marker Score: 1440
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.63
    Marker Score: 3412
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.63
    Marker Score: 3583
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.62
    Marker Score: 2383
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.56
    Marker Score: 2264
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.56
    Marker Score: 1678
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.55
    Marker Score: 1644
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.52
    Marker Score: 13061
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.52
    Marker Score: 4121
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.51
    Marker Score: 92927
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.51
    Marker Score: 1599
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.5
    Marker Score: 2550.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.5
    Marker Score: 895
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.5
    Marker Score: 1933
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.49
    Marker Score: 14190
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.49
    Marker Score: 55049
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.48
    Marker Score: 56072
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.45
    Marker Score: 1553
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.45
    Marker Score: 1668
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.45
    Marker Score: 967
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.44
    Marker Score: 2070
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.44
    Marker Score: 49771
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.43
    Marker Score: 1435
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.41
    Marker Score: 3381
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.41
    Marker Score: 5550
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.41
    Marker Score: 1555
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.4
    Marker Score: 1590
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.4
    Marker Score: 13177
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.4
    Marker Score: 24811
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.4
    Marker Score: 408
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.39
    Marker Score: 767
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.39
    Marker Score: 866
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.39
    Marker Score: 5641
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.39
    Marker Score: 3712.5
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.38
    Marker Score: 1300
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.38
    Marker Score: 1730
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.38
    Marker Score: 323
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.38
    Marker Score: 1482
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.36
    Marker Score: 5649
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.36
    Marker Score: 661
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.36
    Marker Score: 5660
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.36
    Marker Score: 3694
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.35
    Marker Score: 1243
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.35
    Marker Score: 1066
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.34
    Marker Score: 5621
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.34
    Marker Score: 781
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.34
    Marker Score: 501
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.34
    Marker Score: 5578
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.34
    Marker Score: 8531
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.33
    Marker Score: 452
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.33
    Marker Score: 2047
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.33
    Marker Score: 6513
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.33
    Marker Score: 5126
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.33
    Marker Score: 3236.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.32
    Marker Score: 26351
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.32
    Marker Score: 3921
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.31
    Marker Score: 415
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.31
    Marker Score: 1389
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.3
    Marker Score: 27762
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.29
    Marker Score: 753
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.29
    Marker Score: 993.5
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.29
    Marker Score: 308
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.29
    Marker Score: 8372
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.28
    Marker Score: 4750
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.28
    Marker Score: 1327
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.27
    Marker Score: 1484
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.27
    Marker Score: 1289
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.26
    Marker Score: 512
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.26
    Marker Score: 467
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.26
    Marker Score: 9681
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.26
    Marker Score: 514
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.25
    Marker Score: 1087
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.25
    Marker Score: 910
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.25
    Marker Score: 2402
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.24
    Marker Score: 2816
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.24
    Marker Score: 1756
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.24
    Marker Score: 782
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.24
    Marker Score: 12757
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.23
    Marker Score: 1444
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.23
    Marker Score: 19786
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.23
    Marker Score: 427
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.23
    Marker Score: 2914
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.21
    Marker Score: 811
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.21
    Marker Score: 1612
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.21
    Marker Score: 1217
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.21
    Marker Score: 18115
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.2
    Marker Score: 1147
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.2
    Marker Score: 15814
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.2
    Marker Score: 418
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.2
    Marker Score: 1074
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.2
    Marker Score: 817
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.2
    Marker Score: 2815
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.19
    Marker Score: 893.5
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.19
    Marker Score: 3737
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.19
    Marker Score: 590
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.19
    Marker Score: 625
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.18
    Marker Score: 803

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - DHX15 is a helicase that is capable of hydrolyzing RNA molecules. - It is a member of the DEAD (deadenylation, RNA binding, and exorcising) family of RNA helicases. - DHX15 is found in both free and protein-bound forms. - It is involved in a variety of cellular processes, including gene expression, DNA repair, and RNA splicing. **Pathways and functions:** DHX15 plays a role in the regulation of gene expression through RNA helicase activity. It is involved in the processing of capped intron-containing pre-mRNA, the initiation of mRNA splicing, and the regulation of the expression of genes involved in muscle development and function. **Clinical significance:** Mutations in DHX15 have been linked to a number of human diseases, including cancer, cardiovascular disease, and metabolic disorders. These mutations can disrupt the normal function of DHX15, leading to the development of these diseases. **Additional information:** - DHX15 is a highly conserved protein, with a similar gene found in humans, mice, and flies. - It is a member of the DHX family of RNA helicases, which are characterized by their ability to recognize and bind to RNA molecules. - DHX15 is a key regulator of gene expression in a variety of cell types.

Genular Protein ID: 3750770924

Symbol: DHX15_HUMAN

Name: ATP-dependent RNA helicase #46

UniProtKB Accession Codes:

O43143 Q9NQT7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 EMDB 1 EPD 1 Ensembl 1 GO 22 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 5 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SAM 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9388478

Title: Cloning and characterization of a putative human RNA helicase gene of the DEAH-box protein family.

PubMed ID: 9388478

DOI: 10.1006/bbrc.1997.7585

PubMed ID: 12458796

Title: The human La (SS-B) autoantigen interacts with DDX15/hPrp43, a putative DEAH-box RNA helicase.

PubMed ID: 12458796

DOI: 10.1017/s1355838202021076

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15146077

Title: The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.

PubMed ID: 15146077

DOI: 10.1261/rna.7320604

PubMed ID: 19432882

Title: Involvement of G-patch domain containing 2 overexpression in breast carcinogenesis.

PubMed ID: 19432882

DOI: 10.1111/j.1349-7006.2009.01185.x

PubMed ID: 19103666

Title: Isolation and characterization of post-splicing lariat-intron complexes.

PubMed ID: 19103666

DOI: 10.1093/nar/gkn1002

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22002106

Title: Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization.

PubMed ID: 22002106

DOI: 10.1074/mcp.m111.013680

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24990078

Title: DHX15 senses double-stranded RNA in myeloid dendritic cells.

PubMed ID: 24990078

DOI: 10.4049/jimmunol.1303322

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24782566

Title: The DEAH-box RNA helicase DHX15 activates NF-kappaB and MAPK signaling downstream of MAVS during antiviral responses.

PubMed ID: 24782566

DOI: 10.1126/scisignal.2004841

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 34161762

Title: DHX15 is required to control RNA virus-induced intestinal inflammation.

PubMed ID: 34161762

DOI: 10.1016/j.celrep.2021.109205

PubMed ID: 28580923

Title: The crystal structure of human DEAH-box RNA helicase 15 reveals a domain organization of the mammalian DEAH/RHA family.

PubMed ID: 28580923

DOI: 10.1107/s2053230x17007336

PubMed ID: 30728453

Title: Structures of the human spliceosomes before and after release of the ligated exon.

PubMed ID: 30728453

DOI: 10.1038/s41422-019-0143-x

PubMed ID: 32179686

Title: Structural basis for DEAH-helicase activation by G-patch proteins.

PubMed ID: 32179686

DOI: 10.1073/pnas.1913880117

Sequence Information:

  • Length: 795
  • Mass: 90933
  • Checksum: 9A21FBE0051CCAA9
  • Sequence:
    • MSKRHRLDLG EDYPSGKKRA GTDGKDRDRD RDREDRSKDR DRERDRGDRE REREKEKEKE 
LRASTNAMLI SAGLPPLKAS HSAHSTHSAH STHSTHSAHS THAGHAGHTS LPQCINPFTN 
LPHTPRYYDI LKKRLQLPVW EYKDRFTDIL VRHQSFVLVG ETGSGKTTQI PQWCVEYMRS 
LPGPKRGVAC TQPRRVAAMS VAQRVADEMD VMLGQEVGYS IRFEDCSSAK TILKYMTDGM 
LLREAMNDPL LERYGVIILD EAHERTLATD ILMGVLKEVV RQRSDLKVIV MSATLDAGKF 
QIYFDNCPLL TIPGRTHPVE IFYTPEPERD YLEAAIRTVI QIHMCEEEEG DLLLFLTGQE 
EIDEACKRIK REVDDLGPEV GDIKIIPLYS TLPPQQQQRI FEPPPPKKQN GAIGRKVVVS 
TNIAETSLTI DGVVFVIDPG FAKQKVYNPR IRVESLLVTA ISKASAQQRA GRAGRTRPGK 
CFRLYTEKAY KTEMQDNTYP EILRSNLGSV VLQLKKLGID DLVHFDFMDP PAPETLMRAL 
ELLNYLAALN DDGDLTELGS MMAEFPLDPQ LAKMVIASCD YNCSNEVLSI TAMLSVPQCF 
VRPTEAKKAA DEAKMRFAHI DGDHLTLLNV YHAFKQNHES VQWCYDNFIN YRSLMSADNV 
RQQLSRIMDR FNLPRRSTDF TSRDYYINIR KALVTGYFMQ VAHLERTGHY LTVKDNQVVQ 
LHPSTVLDHK PEWVLYNEFV LTTKNYIRTC TDIKPEWLVK IAPQYYDMSN FPQCEAKRQL 
DRIIAKLQSK EYSQY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.