Details for: DHX15
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 333.4721
Cell Significance Index: -51.8700 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 212.7002
Cell Significance Index: -53.9500 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 131.0676
Cell Significance Index: -61.8800 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 128.5639
Cell Significance Index: -52.2300 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 114.8556
Cell Significance Index: -59.0800 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 92.2026
Cell Significance Index: -61.8700 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 54.7582
Cell Significance Index: -52.2800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 47.4672
Cell Significance Index: -58.5300 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 20.5834
Cell Significance Index: -55.1400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 15.1709
Cell Significance Index: -59.8700 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 13.7817
Cell Significance Index: -42.3300 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 11.8524
Cell Significance Index: -25.9400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 3.0687
Cell Significance Index: 81.9400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.2083
Cell Significance Index: 30.1300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.9080
Cell Significance Index: 107.0700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.6470
Cell Significance Index: 326.8600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.4833
Cell Significance Index: 297.5500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.3640
Cell Significance Index: 38.1200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.3072
Cell Significance Index: 78.4800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.2605
Cell Significance Index: 57.1400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.2306
Cell Significance Index: 35.4600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.1484
Cell Significance Index: 141.2100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.0285
Cell Significance Index: 185.4000 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.9769
Cell Significance Index: 26.5900 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8956
Cell Significance Index: 808.6400 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.8888
Cell Significance Index: 485.4000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.7539
Cell Significance Index: 270.4200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.7416
Cell Significance Index: 51.2900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.7414
Cell Significance Index: 87.4400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.7273
Cell Significance Index: 321.5500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7219
Cell Significance Index: 117.4100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.7212
Cell Significance Index: 37.4700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.6970
Cell Significance Index: 53.4900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.6089
Cell Significance Index: 83.6200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.6068
Cell Significance Index: 28.5200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.6014
Cell Significance Index: 17.2400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.5407
Cell Significance Index: 18.7900 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.5307
Cell Significance Index: 367.0900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5267
Cell Significance Index: 11.4100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.3084
Cell Significance Index: 20.7400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.2892
Cell Significance Index: 20.4500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.2165
Cell Significance Index: 13.3100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2087
Cell Significance Index: 13.4700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2001
Cell Significance Index: 7.0300 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.1997
Cell Significance Index: 25.8000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.1772
Cell Significance Index: 13.2100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1748
Cell Significance Index: 17.2900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1720
Cell Significance Index: 29.3700 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1594
Cell Significance Index: 20.4300 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.1544
Cell Significance Index: 3.9700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1059
Cell Significance Index: 199.3200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1010
Cell Significance Index: 4.7100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0899
Cell Significance Index: 57.1100 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0729
Cell Significance Index: 1.9200 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0610
Cell Significance Index: 1.6400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0526
Cell Significance Index: 23.8800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0439
Cell Significance Index: 8.3500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0296
Cell Significance Index: 45.6100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0248
Cell Significance Index: 45.7200 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.0123
Cell Significance Index: 0.2400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0046
Cell Significance Index: 6.2100 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0029
Cell Significance Index: -0.3400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0169
Cell Significance Index: -12.5300 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0192
Cell Significance Index: -11.9600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0252
Cell Significance Index: -3.6600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0306
Cell Significance Index: -22.4100 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0315
Cell Significance Index: -0.5400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0367
Cell Significance Index: -27.8000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0632
Cell Significance Index: -35.6600 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0764
Cell Significance Index: -1.6000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1129
Cell Significance Index: -11.5300 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1273
Cell Significance Index: -2.1300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1537
Cell Significance Index: -32.3800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1723
Cell Significance Index: -7.6200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1786
Cell Significance Index: -51.3800 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.1815
Cell Significance Index: -2.6100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1986
Cell Significance Index: -12.5200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2084
Cell Significance Index: -7.8900 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2135
Cell Significance Index: -1.2900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2816
Cell Significance Index: -32.2600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3327
Cell Significance Index: -17.4700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3559
Cell Significance Index: -41.4800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3597
Cell Significance Index: -7.6600 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.3746
Cell Significance Index: -3.4500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3859
Cell Significance Index: -12.3600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4296
Cell Significance Index: -44.7300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.4877
Cell Significance Index: -12.1900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.5485
Cell Significance Index: -28.5700 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.6401
Cell Significance Index: -7.6300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6447
Cell Significance Index: -51.0600 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.6788
Cell Significance Index: -7.3800 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.6941
Cell Significance Index: -10.4000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8160
Cell Significance Index: -50.0300 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.8329
Cell Significance Index: -11.9600 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.8461
Cell Significance Index: -21.6200 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.8703
Cell Significance Index: -25.5600 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.8823
Cell Significance Index: -7.1900 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.8859
Cell Significance Index: -21.2500 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.9020
Cell Significance Index: -25.7400 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.9439
Cell Significance Index: -13.9400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3750770924
Symbol: DHX15_HUMAN
Name: ATP-dependent RNA helicase #46
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9388478
Title: Cloning and characterization of a putative human RNA helicase gene of the DEAH-box protein family.
PubMed ID: 9388478
PubMed ID: 12458796
Title: The human La (SS-B) autoantigen interacts with DDX15/hPrp43, a putative DEAH-box RNA helicase.
PubMed ID: 12458796
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14654843
Title: Proteomic characterization of the human centrosome by protein correlation profiling.
PubMed ID: 14654843
DOI: 10.1038/nature02166
PubMed ID: 15146077
Title: The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.
PubMed ID: 15146077
DOI: 10.1261/rna.7320604
PubMed ID: 19432882
Title: Involvement of G-patch domain containing 2 overexpression in breast carcinogenesis.
PubMed ID: 19432882
PubMed ID: 19103666
Title: Isolation and characterization of post-splicing lariat-intron complexes.
PubMed ID: 19103666
DOI: 10.1093/nar/gkn1002
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22002106
Title: Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization.
PubMed ID: 22002106
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24990078
Title: DHX15 senses double-stranded RNA in myeloid dendritic cells.
PubMed ID: 24990078
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24782566
Title: The DEAH-box RNA helicase DHX15 activates NF-kappaB and MAPK signaling downstream of MAVS during antiviral responses.
PubMed ID: 24782566
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 34161762
Title: DHX15 is required to control RNA virus-induced intestinal inflammation.
PubMed ID: 34161762
PubMed ID: 28580923
Title: The crystal structure of human DEAH-box RNA helicase 15 reveals a domain organization of the mammalian DEAH/RHA family.
PubMed ID: 28580923
PubMed ID: 30728453
Title: Structures of the human spliceosomes before and after release of the ligated exon.
PubMed ID: 30728453
PubMed ID: 32179686
Title: Structural basis for DEAH-helicase activation by G-patch proteins.
PubMed ID: 32179686
Sequence Information:
- Length: 795
- Mass: 90933
- Checksum: 9A21FBE0051CCAA9
- Sequence:
MSKRHRLDLG EDYPSGKKRA GTDGKDRDRD RDREDRSKDR DRERDRGDRE REREKEKEKE LRASTNAMLI SAGLPPLKAS HSAHSTHSAH STHSTHSAHS THAGHAGHTS LPQCINPFTN LPHTPRYYDI LKKRLQLPVW EYKDRFTDIL VRHQSFVLVG ETGSGKTTQI PQWCVEYMRS LPGPKRGVAC TQPRRVAAMS VAQRVADEMD VMLGQEVGYS IRFEDCSSAK TILKYMTDGM LLREAMNDPL LERYGVIILD EAHERTLATD ILMGVLKEVV RQRSDLKVIV MSATLDAGKF QIYFDNCPLL TIPGRTHPVE IFYTPEPERD YLEAAIRTVI QIHMCEEEEG DLLLFLTGQE EIDEACKRIK REVDDLGPEV GDIKIIPLYS TLPPQQQQRI FEPPPPKKQN GAIGRKVVVS TNIAETSLTI DGVVFVIDPG FAKQKVYNPR IRVESLLVTA ISKASAQQRA GRAGRTRPGK CFRLYTEKAY KTEMQDNTYP EILRSNLGSV VLQLKKLGID DLVHFDFMDP PAPETLMRAL ELLNYLAALN DDGDLTELGS MMAEFPLDPQ LAKMVIASCD YNCSNEVLSI TAMLSVPQCF VRPTEAKKAA DEAKMRFAHI DGDHLTLLNV YHAFKQNHES VQWCYDNFIN YRSLMSADNV RQQLSRIMDR FNLPRRSTDF TSRDYYINIR KALVTGYFMQ VAHLERTGHY LTVKDNQVVQ LHPSTVLDHK PEWVLYNEFV LTTKNYIRTC TDIKPEWLVK IAPQYYDMSN FPQCEAKRQL DRIIAKLQSK EYSQY
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.