Details for: DHX15

Gene ID: 1665

Symbol: DHX15

Ensembl ID: ENSG00000109606

Description: DEAH-box helicase 15

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 333.4721
    Cell Significance Index: -51.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 212.7002
    Cell Significance Index: -53.9500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 131.0676
    Cell Significance Index: -61.8800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 128.5639
    Cell Significance Index: -52.2300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 114.8556
    Cell Significance Index: -59.0800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 92.2026
    Cell Significance Index: -61.8700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 54.7582
    Cell Significance Index: -52.2800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 47.4672
    Cell Significance Index: -58.5300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.5834
    Cell Significance Index: -55.1400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.1709
    Cell Significance Index: -59.8700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.7817
    Cell Significance Index: -42.3300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.8524
    Cell Significance Index: -25.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.0687
    Cell Significance Index: 81.9400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.2083
    Cell Significance Index: 30.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.9080
    Cell Significance Index: 107.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6470
    Cell Significance Index: 326.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4833
    Cell Significance Index: 297.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.3640
    Cell Significance Index: 38.1200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3072
    Cell Significance Index: 78.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2605
    Cell Significance Index: 57.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2306
    Cell Significance Index: 35.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1484
    Cell Significance Index: 141.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0285
    Cell Significance Index: 185.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9769
    Cell Significance Index: 26.5900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8956
    Cell Significance Index: 808.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8888
    Cell Significance Index: 485.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7539
    Cell Significance Index: 270.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7416
    Cell Significance Index: 51.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7414
    Cell Significance Index: 87.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7273
    Cell Significance Index: 321.5500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7219
    Cell Significance Index: 117.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7212
    Cell Significance Index: 37.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6970
    Cell Significance Index: 53.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6089
    Cell Significance Index: 83.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6068
    Cell Significance Index: 28.5200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6014
    Cell Significance Index: 17.2400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5407
    Cell Significance Index: 18.7900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5307
    Cell Significance Index: 367.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5267
    Cell Significance Index: 11.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3084
    Cell Significance Index: 20.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2892
    Cell Significance Index: 20.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2165
    Cell Significance Index: 13.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2087
    Cell Significance Index: 13.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2001
    Cell Significance Index: 7.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1997
    Cell Significance Index: 25.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1772
    Cell Significance Index: 13.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1748
    Cell Significance Index: 17.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1720
    Cell Significance Index: 29.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1594
    Cell Significance Index: 20.4300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1544
    Cell Significance Index: 3.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1059
    Cell Significance Index: 199.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1010
    Cell Significance Index: 4.7100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0899
    Cell Significance Index: 57.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0729
    Cell Significance Index: 1.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0610
    Cell Significance Index: 1.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0526
    Cell Significance Index: 23.8800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0439
    Cell Significance Index: 8.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0296
    Cell Significance Index: 45.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0248
    Cell Significance Index: 45.7200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0123
    Cell Significance Index: 0.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0046
    Cell Significance Index: 6.2100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0029
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0169
    Cell Significance Index: -12.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0192
    Cell Significance Index: -11.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0252
    Cell Significance Index: -3.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0306
    Cell Significance Index: -22.4100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0315
    Cell Significance Index: -0.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0367
    Cell Significance Index: -27.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0632
    Cell Significance Index: -35.6600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0764
    Cell Significance Index: -1.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1129
    Cell Significance Index: -11.5300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1273
    Cell Significance Index: -2.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1537
    Cell Significance Index: -32.3800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1723
    Cell Significance Index: -7.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1786
    Cell Significance Index: -51.3800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1815
    Cell Significance Index: -2.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1986
    Cell Significance Index: -12.5200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2084
    Cell Significance Index: -7.8900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2135
    Cell Significance Index: -1.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2816
    Cell Significance Index: -32.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3327
    Cell Significance Index: -17.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3559
    Cell Significance Index: -41.4800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3597
    Cell Significance Index: -7.6600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3746
    Cell Significance Index: -3.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3859
    Cell Significance Index: -12.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4296
    Cell Significance Index: -44.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4877
    Cell Significance Index: -12.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5485
    Cell Significance Index: -28.5700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6401
    Cell Significance Index: -7.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6447
    Cell Significance Index: -51.0600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.6788
    Cell Significance Index: -7.3800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6941
    Cell Significance Index: -10.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8160
    Cell Significance Index: -50.0300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.8329
    Cell Significance Index: -11.9600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8461
    Cell Significance Index: -21.6200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.8703
    Cell Significance Index: -25.5600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.8823
    Cell Significance Index: -7.1900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.8859
    Cell Significance Index: -21.2500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.9020
    Cell Significance Index: -25.7400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.9439
    Cell Significance Index: -13.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** DHX15 is a 3' to 5' exonuclease that exhibits ATP-dependent helicase activity, allowing it to unwind double-stranded RNA (dsRNA) and single-stranded RNA (ssRNA) structures. This ability is essential for the recognition and processing of viral RNA, which is often in the form of dsRNA. The gene's expression is tightly regulated, and its levels are elevated in response to viral infections, suggesting a role in the innate immune response. The DHX15 protein is a hexameric complex, consisting of six subunits that interact with each other to form a helicase core. This structure allows for efficient unwinding of RNA molecules and the recognition of specific viral RNA sequences. The protein's ability to bind dsRNA and ssRNA structures is mediated by specific motifs, which are essential for its function. **Pathways and Functions** DHX15 is involved in various cellular pathways, including: 1. **Antiviral Innate Immune Response**: DHX15 plays a critical role in the recognition and processing of viral RNA, which triggers the activation of downstream signaling pathways that lead to the production of type I interferons and the induction of immune responses. 2. **RNA Metabolism**: DHX15 is involved in the processing of capped intron-containing pre-mRNAs, which is essential for the regulation of gene expression. 3. **Nuclear Organization**: The DHX15 protein contributes to the organization of the nucleus by interacting with various nuclear components, including chromatin and the nucleolus. 4. **Signal Transduction**: DHX15 is involved in the regulation of canonical NF-κB signaling pathways, which are essential for the induction of immune responses and the regulation of gene expression. **Clinical Significance** The DHX15 gene has been implicated in various diseases, including: 1. **Viral Infections**: Mutations in the DHX15 gene have been associated with increased susceptibility to viral infections, such as HIV-1 and influenza virus. 2. **Cancer**: Elevated expression of DHX15 has been observed in various types of cancer, including breast cancer and lung cancer. 3. **Neurological Disorders**: DHX15 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Huntington's disease. In conclusion, the DHX15 gene plays a critical role in the innate immune response against viral infections and is involved in various cellular processes, including RNA metabolism, nuclear organization, and signal transduction pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the function and regulation of this gene.

Genular Protein ID: 3750770924

Symbol: DHX15_HUMAN

Name: ATP-dependent RNA helicase #46

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9388478

Title: Cloning and characterization of a putative human RNA helicase gene of the DEAH-box protein family.

PubMed ID: 9388478

DOI: 10.1006/bbrc.1997.7585

PubMed ID: 12458796

Title: The human La (SS-B) autoantigen interacts with DDX15/hPrp43, a putative DEAH-box RNA helicase.

PubMed ID: 12458796

DOI: 10.1017/s1355838202021076

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15146077

Title: The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.

PubMed ID: 15146077

DOI: 10.1261/rna.7320604

PubMed ID: 19432882

Title: Involvement of G-patch domain containing 2 overexpression in breast carcinogenesis.

PubMed ID: 19432882

DOI: 10.1111/j.1349-7006.2009.01185.x

PubMed ID: 19103666

Title: Isolation and characterization of post-splicing lariat-intron complexes.

PubMed ID: 19103666

DOI: 10.1093/nar/gkn1002

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22002106

Title: Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization.

PubMed ID: 22002106

DOI: 10.1074/mcp.m111.013680

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24990078

Title: DHX15 senses double-stranded RNA in myeloid dendritic cells.

PubMed ID: 24990078

DOI: 10.4049/jimmunol.1303322

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24782566

Title: The DEAH-box RNA helicase DHX15 activates NF-kappaB and MAPK signaling downstream of MAVS during antiviral responses.

PubMed ID: 24782566

DOI: 10.1126/scisignal.2004841

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 34161762

Title: DHX15 is required to control RNA virus-induced intestinal inflammation.

PubMed ID: 34161762

DOI: 10.1016/j.celrep.2021.109205

PubMed ID: 28580923

Title: The crystal structure of human DEAH-box RNA helicase 15 reveals a domain organization of the mammalian DEAH/RHA family.

PubMed ID: 28580923

DOI: 10.1107/s2053230x17007336

PubMed ID: 30728453

Title: Structures of the human spliceosomes before and after release of the ligated exon.

PubMed ID: 30728453

DOI: 10.1038/s41422-019-0143-x

PubMed ID: 32179686

Title: Structural basis for DEAH-helicase activation by G-patch proteins.

PubMed ID: 32179686

DOI: 10.1073/pnas.1913880117

Sequence Information:

  • Length: 795
  • Mass: 90933
  • Checksum: 9A21FBE0051CCAA9
  • Sequence:
  • MSKRHRLDLG EDYPSGKKRA GTDGKDRDRD RDREDRSKDR DRERDRGDRE REREKEKEKE 
    LRASTNAMLI SAGLPPLKAS HSAHSTHSAH STHSTHSAHS THAGHAGHTS LPQCINPFTN 
    LPHTPRYYDI LKKRLQLPVW EYKDRFTDIL VRHQSFVLVG ETGSGKTTQI PQWCVEYMRS 
    LPGPKRGVAC TQPRRVAAMS VAQRVADEMD VMLGQEVGYS IRFEDCSSAK TILKYMTDGM 
    LLREAMNDPL LERYGVIILD EAHERTLATD ILMGVLKEVV RQRSDLKVIV MSATLDAGKF 
    QIYFDNCPLL TIPGRTHPVE IFYTPEPERD YLEAAIRTVI QIHMCEEEEG DLLLFLTGQE 
    EIDEACKRIK REVDDLGPEV GDIKIIPLYS TLPPQQQQRI FEPPPPKKQN GAIGRKVVVS 
    TNIAETSLTI DGVVFVIDPG FAKQKVYNPR IRVESLLVTA ISKASAQQRA GRAGRTRPGK 
    CFRLYTEKAY KTEMQDNTYP EILRSNLGSV VLQLKKLGID DLVHFDFMDP PAPETLMRAL 
    ELLNYLAALN DDGDLTELGS MMAEFPLDPQ LAKMVIASCD YNCSNEVLSI TAMLSVPQCF 
    VRPTEAKKAA DEAKMRFAHI DGDHLTLLNV YHAFKQNHES VQWCYDNFIN YRSLMSADNV 
    RQQLSRIMDR FNLPRRSTDF TSRDYYINIR KALVTGYFMQ VAHLERTGHY LTVKDNQVVQ 
    LHPSTVLDHK PEWVLYNEFV LTTKNYIRTC TDIKPEWLVK IAPQYYDMSN FPQCEAKRQL 
    DRIIAKLQSK EYSQY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.