Details for: DECR1

Gene ID: 1666

Symbol: DECR1

Ensembl ID: ENSG00000104325

Description: 2,4-dienoyl-CoA reductase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.91
    Marker Score: 64945
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.54
    Marker Score: 2647
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.14
    Marker Score: 1194.5
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.08
    Marker Score: 53321
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.08
    Marker Score: 9978
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.05
    Marker Score: 5172
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.02
    Marker Score: 1076.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.01
    Marker Score: 8678
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.98
    Marker Score: 4170
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.97
    Marker Score: 3269
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.96
    Marker Score: 2084
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.95
    Marker Score: 16783
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.94
    Marker Score: 5198
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.93
    Marker Score: 937
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.93
    Marker Score: 34188
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.92
    Marker Score: 40891
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.91
    Marker Score: 22203
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.91
    Marker Score: 2057.5
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.88
    Marker Score: 2342.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.86
    Marker Score: 6587
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.83
    Marker Score: 5739
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.82
    Marker Score: 3985.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.81
    Marker Score: 2667
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.76
    Marker Score: 4191
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.72
    Marker Score: 10969.5
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.69
    Marker Score: 2398
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 1.69
    Marker Score: 700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.67
    Marker Score: 9878
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.66
    Marker Score: 546
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.66
    Marker Score: 61132.5
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.65
    Marker Score: 1199
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.64
    Marker Score: 5840
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.64
    Marker Score: 2526
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.64
    Marker Score: 6705
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.63
    Marker Score: 2173.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.63
    Marker Score: 21457
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.61
    Marker Score: 2801
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.6
    Marker Score: 1612
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.6
    Marker Score: 1871.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.6
    Marker Score: 840
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.59
    Marker Score: 2257
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.58
    Marker Score: 1373
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.58
    Marker Score: 88185
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.56
    Marker Score: 649.5
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.55
    Marker Score: 1061
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.55
    Marker Score: 3027
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.55
    Marker Score: 1639
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.55
    Marker Score: 2226
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.55
    Marker Score: 1420
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.53
    Marker Score: 432.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.52
    Marker Score: 11877.5
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.5
    Marker Score: 1523
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.5
    Marker Score: 998
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.49
    Marker Score: 2303
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.49
    Marker Score: 1552
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 1.49
    Marker Score: 744
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.48
    Marker Score: 354
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.48
    Marker Score: 11003
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.46
    Marker Score: 6125.5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.46
    Marker Score: 2661
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.44
    Marker Score: 1683
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.44
    Marker Score: 6217
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.44
    Marker Score: 9244
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.44
    Marker Score: 585
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.43
    Marker Score: 281
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.43
    Marker Score: 1197
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.43
    Marker Score: 2534
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.43
    Marker Score: 16093.5
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.42
    Marker Score: 334
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.42
    Marker Score: 3871
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.42
    Marker Score: 5893
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.42
    Marker Score: 1417.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.41
    Marker Score: 14323.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.41
    Marker Score: 13987.5
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.41
    Marker Score: 407
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.41
    Marker Score: 7557.5
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.4
    Marker Score: 1926
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.4
    Marker Score: 1319
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.39
    Marker Score: 3464.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.38
    Marker Score: 444
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.38
    Marker Score: 559
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.38
    Marker Score: 758
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.38
    Marker Score: 708
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.37
    Marker Score: 477
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.37
    Marker Score: 971
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.36
    Marker Score: 513
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.35
    Marker Score: 434
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.34
    Marker Score: 1298
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.34
    Marker Score: 2199.5
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.34
    Marker Score: 1011
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.33
    Marker Score: 3222
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.33
    Marker Score: 499
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.33
    Marker Score: 1353.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.33
    Marker Score: 3039
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.32
    Marker Score: 290
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.32
    Marker Score: 1180
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.32
    Marker Score: 2761
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.32
    Marker Score: 2542
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.32
    Marker Score: 497
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.32
    Marker Score: 4878

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Other Information

## Summary The DECR1 gene encodes a protein that is involved in the metabolism of fatty acids. It is expressed in a variety of cell types, including cardiac myocytes, erythroid progenitor cells, fat cells, macrophages, enterocytes, kidney cells, and decidual cells. ## Key characteristics * DECR1 is a protein that is involved in the regulation of fatty acid metabolism. * It is a key enzyme in the beta-oxidation of fatty acids, which is a process that is essential for the production of energy and building blocks for cells. * DECR1 is also involved in the regulation of mitochondrial fatty acid beta-oxidation, a process that is important for the production of energy in mitochondria. ## Pathways and functions * DECR1 is involved in the following pathways and functions: * 2,4-dienoyl-CoA reductase (nadph) activity * Catalytic complex * Cytosol * Fatty acid beta-oxidation * Fatty acid metabolism * Identical protein binding * Metabolism * Metabolism of lipids * Mitochondrial fatty acid beta-oxidation * Mitochondrial matrix * Mitochondrion * Nadph binding * Nucleoplasm * Nucleus * Positive regulation of cold-induced thermogenesis ## Clinical significance * Mutations in the DECR1 gene have been linked to a number of human diseases, including obesity, type 2 diabetes, and cardiovascular disease. * DECR1 is a potential target for the treatment of these diseases.

Genular Protein ID: 506722900

Symbol: DECR_HUMAN

Name: 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial

UniProtKB Accession Codes:

Q16698 B7Z6B8 Q2M304 Q93085

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 CarbonylDB 1 ChEBI 20 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 2 EMBL 16 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 3 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7818482

Title: Isolation and characterization of cDNA for human 120 kDa mitochondrial 2,4-dienoyl-coenzyme A reductase.

PubMed ID: 7818482

DOI: 10.1042/bj3040787

PubMed ID: 9403065

Title: Molecular cloning and characterization of the human mitochondrial 2,4-dienoyl-CoA reductase gene (DECR).

PubMed ID: 9403065

DOI: 10.1006/geno.1997.5004

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24847004

Title: Mitochondrial NADP(H) deficiency due to a mutation in NADK2 causes dienoyl-CoA reductase deficiency with hyperlysinemia.

PubMed ID: 24847004

DOI: 10.1093/hmg/ddu218

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 15531764

Title: Structure and reactivity of human mitochondrial 2,4-dienoyl-CoA reductase: enzyme-ligand interactions in a distinctive short-chain reductase active site.

PubMed ID: 15531764

DOI: 10.1074/jbc.m411069200

Sequence Information:

  • Length: 335
  • Mass: 36068
  • Checksum: F04E72AACB718430
  • Sequence:
    • MKLPARVFFT LGSRLPCGLA PRRFFSYGTK ILYQNTEALQ SKFFSPLQKA MLPPNSFQGK 
VAFITGGGTG LGKGMTTLLS SLGAQCVIAS RKMDVLKATA EQISSQTGNK VHAIQCDVRD 
PDMVQNTVSE LIKVAGHPNI VINNAAGNFI SPTERLSPNA WKTITDIVLN GTAFVTLEIG 
KQLIKAQKGA AFLSITTIYA ETGSGFVVPS ASAKAGVEAM SKSLAAEWGK YGMRFNVIQP 
GPIKTKGAFS RLDPTGTFEK EMIGRIPCGR LGTVEELANL AAFLCSDYAS WINGAVIKFD 
GGEEVLISGE FNDLRKVTKE QWDTIEELIR KTKGS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.