Details for: DECR1

Gene ID: 1666

Symbol: DECR1

Ensembl ID: ENSG00000104325

Description: 2,4-dienoyl-CoA reductase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 277.0898
    Cell Significance Index: -43.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 170.2390
    Cell Significance Index: -43.1800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 123.2225
    Cell Significance Index: -50.0600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 117.0035
    Cell Significance Index: -55.2400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 106.0343
    Cell Significance Index: -54.5400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 82.3818
    Cell Significance Index: -55.2800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 52.7472
    Cell Significance Index: -50.3600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 41.6965
    Cell Significance Index: -51.4100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.7567
    Cell Significance Index: -42.2100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.9228
    Cell Significance Index: -54.9400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.3324
    Cell Significance Index: -40.9500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.1905
    Cell Significance Index: -26.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.4326
    Cell Significance Index: 400.0300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.5471
    Cell Significance Index: 23.4600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.4262
    Cell Significance Index: 40.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.3351
    Cell Significance Index: 179.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.0610
    Cell Significance Index: 55.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.7469
    Cell Significance Index: 284.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.5817
    Cell Significance Index: 30.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5201
    Cell Significance Index: 274.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3802
    Cell Significance Index: 71.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3083
    Cell Significance Index: 17.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3012
    Cell Significance Index: 160.0000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2614
    Cell Significance Index: 173.2200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.2544
    Cell Significance Index: 36.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2403
    Cell Significance Index: 246.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9930
    Cell Significance Index: 199.1900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9852
    Cell Significance Index: 68.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9058
    Cell Significance Index: 58.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8161
    Cell Significance Index: 38.0500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.8128
    Cell Significance Index: 12.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8110
    Cell Significance Index: 442.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7613
    Cell Significance Index: 336.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6709
    Cell Significance Index: 47.4500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.5995
    Cell Significance Index: 6.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5620
    Cell Significance Index: 31.5400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.5599
    Cell Significance Index: 7.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5171
    Cell Significance Index: 60.9800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5090
    Cell Significance Index: 65.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4955
    Cell Significance Index: 36.9300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4811
    Cell Significance Index: 10.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4292
    Cell Significance Index: 28.8600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3345
    Cell Significance Index: 43.2100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3316
    Cell Significance Index: 7.6600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2949
    Cell Significance Index: 5.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2622
    Cell Significance Index: 49.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2591
    Cell Significance Index: 11.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2318
    Cell Significance Index: 6.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2065
    Cell Significance Index: 7.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1800
    Cell Significance Index: 17.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1303
    Cell Significance Index: 245.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1226
    Cell Significance Index: 5.7600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1017
    Cell Significance Index: 74.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1005
    Cell Significance Index: 69.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0906
    Cell Significance Index: 41.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0763
    Cell Significance Index: 48.4300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0625
    Cell Significance Index: 1.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0611
    Cell Significance Index: 112.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0579
    Cell Significance Index: 2.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0574
    Cell Significance Index: 9.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0481
    Cell Significance Index: 74.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0311
    Cell Significance Index: 42.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0248
    Cell Significance Index: 8.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0024
    Cell Significance Index: 0.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0031
    Cell Significance Index: -0.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0119
    Cell Significance Index: -0.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0142
    Cell Significance Index: -10.7600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0390
    Cell Significance Index: -35.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0475
    Cell Significance Index: -4.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0636
    Cell Significance Index: -47.1000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0881
    Cell Significance Index: -1.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0896
    Cell Significance Index: -50.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0921
    Cell Significance Index: -5.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0989
    Cell Significance Index: -61.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1595
    Cell Significance Index: -45.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1803
    Cell Significance Index: -14.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1855
    Cell Significance Index: -26.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1877
    Cell Significance Index: -5.2500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1985
    Cell Significance Index: -2.9300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2271
    Cell Significance Index: -7.8900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2379
    Cell Significance Index: -6.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2665
    Cell Significance Index: -30.5300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2813
    Cell Significance Index: -59.2400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3351
    Cell Significance Index: -8.5600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3573
    Cell Significance Index: -38.8600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3622
    Cell Significance Index: -9.3100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3726
    Cell Significance Index: -5.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3790
    Cell Significance Index: -8.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4123
    Cell Significance Index: -42.9300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4393
    Cell Significance Index: -22.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4586
    Cell Significance Index: -24.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6325
    Cell Significance Index: -10.8400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.7189
    Cell Significance Index: -5.7400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.7276
    Cell Significance Index: -7.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.7346
    Cell Significance Index: -19.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7550
    Cell Significance Index: -46.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7947
    Cell Significance Index: -50.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8016
    Cell Significance Index: -20.0400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.8515
    Cell Significance Index: -8.8200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.9260
    Cell Significance Index: -13.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DECR1 is a mitochondrial enzyme that catalyzes the reduction of 2,4-dienoyl-CoA, a key intermediate in fatty acid beta-oxidation. This reaction is essential for the breakdown of fatty acids into acetyl-CoA, which can then be used to produce energy, synthesize fatty acids, or participate in various cellular processes. DECR1 is a member of the FAD-dependent reductase family and is characterized by its ability to bind NADPH and FAD. The enzyme is highly expressed in various tissues, including the heart, liver, and adipose tissue, where it plays a critical role in regulating fatty acid metabolism. **Pathways and Functions:** DECR1 is involved in several key pathways, including: 1. **Fatty acid beta-oxidation**: DECR1 catalyzes the reduction of 2,4-dienoyl-CoA, which is a crucial step in the breakdown of fatty acids into acetyl-CoA. 2. **Mitochondrial fatty acid beta-oxidation**: DECR1 is essential for the regulation of fatty acid metabolism in the mitochondria, where it plays a critical role in the production of energy. 3. **Thermogenesis**: DECR1 has been implicated in the regulation of thermogenesis, a process by which the body generates heat in response to cold exposure. 4. **Lipid metabolism**: DECR1 is involved in the regulation of lipid metabolism, including the synthesis and breakdown of fatty acids. **Clinical Significance:** Dysregulation of DECR1 has been implicated in various diseases, including: 1. **Metabolic disorders**: DECR1 has been linked to metabolic disorders, such as obesity, type 2 diabetes, and dyslipidemia. 2. **Cardiovascular disease**: DECR1 has been implicated in the development of cardiovascular disease, including atherosclerosis and heart failure. 3. **Thermoregulation disorders**: DECR1 has been linked to thermoregulation disorders, including hypothyroidism and anorexia nervosa. 4. **Cancer**: DECR1 has been implicated in the regulation of cancer cell metabolism, including the growth and proliferation of cancer cells. In conclusion, DECR1 is a crucial enzyme involved in the regulation of fatty acid metabolism, particularly in the context of mitochondrial fatty acid beta-oxidation. Its dysregulation has been implicated in various diseases, highlighting the importance of DECR1 in human health. Further studies are needed to fully elucidate the role of DECR1 in human disease and to develop novel therapeutic strategies targeting this enzyme.

Genular Protein ID: 506722900

Symbol: DECR_HUMAN

Name: 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial

UniProtKB Accession Codes:

Q16698 B7Z6B8 Q2M304 Q93085

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 CarbonylDB 1 ChEBI 20 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 2 EMBL 16 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 3 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7818482

Title: Isolation and characterization of cDNA for human 120 kDa mitochondrial 2,4-dienoyl-coenzyme A reductase.

PubMed ID: 7818482

DOI: 10.1042/bj3040787

PubMed ID: 9403065

Title: Molecular cloning and characterization of the human mitochondrial 2,4-dienoyl-CoA reductase gene (DECR).

PubMed ID: 9403065

DOI: 10.1006/geno.1997.5004

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24847004

Title: Mitochondrial NADP(H) deficiency due to a mutation in NADK2 causes dienoyl-CoA reductase deficiency with hyperlysinemia.

PubMed ID: 24847004

DOI: 10.1093/hmg/ddu218

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 15531764

Title: Structure and reactivity of human mitochondrial 2,4-dienoyl-CoA reductase: enzyme-ligand interactions in a distinctive short-chain reductase active site.

PubMed ID: 15531764

DOI: 10.1074/jbc.m411069200

Sequence Information:

  • Length: 335
  • Mass: 36068
  • Checksum: F04E72AACB718430
  • Sequence:
    • MKLPARVFFT LGSRLPCGLA PRRFFSYGTK ILYQNTEALQ SKFFSPLQKA MLPPNSFQGK 
VAFITGGGTG LGKGMTTLLS SLGAQCVIAS RKMDVLKATA EQISSQTGNK VHAIQCDVRD 
PDMVQNTVSE LIKVAGHPNI VINNAAGNFI SPTERLSPNA WKTITDIVLN GTAFVTLEIG 
KQLIKAQKGA AFLSITTIYA ETGSGFVVPS ASAKAGVEAM SKSLAAEWGK YGMRFNVIQP 
GPIKTKGAFS RLDPTGTFEK EMIGRIPCGR LGTVEELANL AAFLCSDYAS WINGAVIKFD 
GGEEVLISGE FNDLRKVTKE QWDTIEELIR KTKGS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.