Details for: DEFA3

Gene ID: 1668

Symbol: DEFA3

Ensembl ID: ENSG00000239839

Description: defensin alpha 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.65
    Marker Score: 712
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.25
    Marker Score: 697
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.23
    Marker Score: 609
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7692
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.11
    Marker Score: 572
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.06
    Marker Score: 2698
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 799
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71832
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48057.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5357
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.66
    Marker Score: 329
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.6
    Marker Score: 449
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 472
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.58
    Marker Score: 320
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.52
    Marker Score: 344
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.38
    Marker Score: 101
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.25
    Marker Score: 272
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.25
    Marker Score: 161
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.24
    Marker Score: 113
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.24
    Marker Score: 84
  • Cell Name: immature neutrophil (CL0000776)
    Fold Change: 0.24
    Marker Score: 80
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.23
    Marker Score: 146
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.23
    Marker Score: 138
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.19
    Marker Score: 103.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.19
    Marker Score: 119
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.17
    Marker Score: 171
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.17
    Marker Score: 174
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 0.16
    Marker Score: 122
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.16
    Marker Score: 70
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.15
    Marker Score: 63
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.15
    Marker Score: 62
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.15
    Marker Score: 53
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.15
    Marker Score: 77
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.13
    Marker Score: 59
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.12
    Marker Score: 54
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.12
    Marker Score: 52
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.12
    Marker Score: 180
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.12
    Marker Score: 64.5
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.11
    Marker Score: 108
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.11
    Marker Score: 39
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1
    Marker Score: 57
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.1
    Marker Score: 49
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.1
    Marker Score: 50
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.09
    Marker Score: 100
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.08
    Marker Score: 29
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.08
    Marker Score: 83
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.07
    Marker Score: 56
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 65
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.07
    Marker Score: 53
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.07
    Marker Score: 64
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.06
    Marker Score: 56
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.06
    Marker Score: 35
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.05
    Marker Score: 222.5
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.05
    Marker Score: 46
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.05
    Marker Score: 35
  • Cell Name: endosteal cell (CL0002157)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.05
    Marker Score: 105
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.05
    Marker Score: 45
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.05
    Marker Score: 34
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.05
    Marker Score: 11
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.04
    Marker Score: 69
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.04
    Marker Score: 104
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.04
    Marker Score: 35
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: 0.04
    Marker Score: 13

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Other Information

**Key characteristics:** * The DEFA3 gene is located on chromosome 19p13.1. * It is a large gene with a length of approximately 34.5 kb. * DEFA3 contains a single open reading frame that encodes a protein of 341 amino acids. * The protein is a defensin-related protein that is similar to defensins A and C. **Pathways and functions:** * DEFA3 is involved in the innate immune response and is a key regulator of the inflammatory response. * It is expressed in high levels in myeloid cells, including neutrophils, macrophages, and dendritic cells. * In myeloid cells, DEFA3 is involved in the activation of the innate immune response and the production of inflammatory cytokines. * DEFA3 also plays a role in the regulation of the adaptive immune response. * It is expressed in epithelial cells in the gut, where it helps to protect the body from infection. * DEFA3 is also expressed in neurons and glial cells in the brain, where it plays a role in the immune response to pathogens. **Clinical significance:** * Mutations in the DEFA3 gene have been linked to a number of human diseases, including sepsis, meningitis, and tuberculosis. * These mutations can lead to the production of defective defensins, which can damage tissues and organs. * As a result, DEFA3 is a promising target for the treatment of infectious diseases. **Additional information:** * DEFA3 is a member of the defensin family of antimicrobial peptides. * Defensins are a family of proteins that are produced by epithelial cells and macrophages to protect the body from infection. * They are characterized by their ability to kill pathogens and to disrupt the integrity of the plasma membrane of invading microorganisms.

Genular Protein ID: 3306464183

Symbol: DEF3_HUMAN

Name: Neutrophil defensin 3

UniProtKB Accession Codes:

P59666 P11479 Q14125

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 6 PIR 1 PIRSF 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3174637

Title: Isolation and characterization of human defensin cDNA clones.

PubMed ID: 3174637

DOI: 10.1073/pnas.85.19.7327

PubMed ID: 2918759

Title: Differentiation stage-specific expression of a gene during granulopoiesis.

PubMed ID: 2918759

PubMed ID: 8477861

Title: The structure of neutrophil defensin genes.

PubMed ID: 8477861

DOI: 10.1016/0014-5793(93)80122-b

PubMed ID: 8325384

Title:

PubMed ID: 8325384

DOI: 10.1016/0014-5793(93)81813-f

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 4056036

Title: Primary structures of three human neutrophil defensins.

PubMed ID: 4056036

DOI: 10.1172/jci112121

PubMed ID: 2917986

Title: Determination of the disulfide array in the human defensin HNP-2. A covalently cyclized peptide.

PubMed ID: 2917986

DOI: 10.1016/s0021-9258(19)84952-9

PubMed ID: 1339298

Title: Posttranslational processing of defensins in immature human myeloid cells.

PubMed ID: 1339298

PubMed ID: 15616305

Title: Antibacterial activity and specificity of the six human alpha-defensins.

PubMed ID: 15616305

DOI: 10.1128/aac.49.1.269-275.2005

PubMed ID: 15772169

Title: Human alpha-defensins neutralize anthrax lethal toxin and protect against its fatal consequences.

PubMed ID: 15772169

DOI: 10.1073/pnas.0500508102

PubMed ID: 17142766

Title: Human alpha- and beta-defensins block multiple steps in herpes simplex virus infection.

PubMed ID: 17142766

DOI: 10.4049/jimmunol.177.12.8658

PubMed ID: 18435932

Title: Human alpha-defensins inhibit Clostridium difficile toxin B.

PubMed ID: 18435932

DOI: 10.1053/j.gastro.2008.03.008

PubMed ID: 25963798

Title: alpha-Defensins partially protect human neutrophils against Panton-Valentine leukocidin produced by Staphylococcus aureus.

PubMed ID: 25963798

DOI: 10.1111/lam.12438

PubMed ID: 29282039

Title: Plasma levels of alarmin HNPs 1-3 associate with lung dysfunction after cardiac surgery in children.

PubMed ID: 29282039

DOI: 10.1186/s12890-017-0558-4

PubMed ID: 2006422

Title: Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization.

PubMed ID: 2006422

DOI: 10.1126/science.2006422

PubMed ID: 15894545

Title: Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids.

PubMed ID: 15894545

DOI: 10.1074/jbc.m503084200

PubMed ID: 17452329

Title: Toward understanding the cationicity of defensins. Arg and Lys versus their noncoded analogs.

PubMed ID: 17452329

DOI: 10.1074/jbc.m611003200

Sequence Information:

  • Length: 94
  • Mass: 10245
  • Checksum: 0E0F8E957376C6AF
  • Sequence:
    • MRTLAILAAI LLVALQAQAE PLQARADEVA AAPEQIAADI PEVVVSLAWD ESLAPKHPGS 
RKNMDCYCRI PACIAGERRY GTCIYQGRLW AFCC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.