Details for: DHODH

Gene ID: 1723

Symbol: DHODH

Ensembl ID: ENSG00000102967

Description: dihydroorotate dehydrogenase (quinone)

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.13
    Marker Score: 4890
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.04
    Marker Score: 6714.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71779
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48004
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.98
    Marker Score: 5290
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 486
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.93
    Marker Score: 2202
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2724
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9
    Marker Score: 14158.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5071
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.86
    Marker Score: 581
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.8
    Marker Score: 713
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 377
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 646
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.71
    Marker Score: 540.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7
    Marker Score: 280
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.65
    Marker Score: 1236
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.65
    Marker Score: 2721
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.63
    Marker Score: 196
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.59
    Marker Score: 190
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.58
    Marker Score: 398
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.58
    Marker Score: 604
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 440
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.51
    Marker Score: 1815
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.51
    Marker Score: 382
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.49
    Marker Score: 448
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.49
    Marker Score: 322
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.48
    Marker Score: 308
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.48
    Marker Score: 199
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.48
    Marker Score: 966
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.46
    Marker Score: 2774
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.46
    Marker Score: 663
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.46
    Marker Score: 490
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.43
    Marker Score: 533
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.42
    Marker Score: 158
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.41
    Marker Score: 862
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.41
    Marker Score: 693
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.41
    Marker Score: 1596
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.4
    Marker Score: 107
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.4
    Marker Score: 427
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.4
    Marker Score: 322
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.4
    Marker Score: 128
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.4
    Marker Score: 248
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.38
    Marker Score: 903
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.38
    Marker Score: 215
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.38
    Marker Score: 226
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.37
    Marker Score: 1010
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.37
    Marker Score: 216
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.37
    Marker Score: 232
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.35
    Marker Score: 377
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.35
    Marker Score: 90
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.34
    Marker Score: 129
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.34
    Marker Score: 553
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.34
    Marker Score: 332
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.34
    Marker Score: 171
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.34
    Marker Score: 227
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.34
    Marker Score: 2211
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.34
    Marker Score: 107
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.34
    Marker Score: 163
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.34
    Marker Score: 160
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.33
    Marker Score: 135
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.33
    Marker Score: 1349.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.33
    Marker Score: 483
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.33
    Marker Score: 323
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.32
    Marker Score: 333
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.32
    Marker Score: 159
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.32
    Marker Score: 2732
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.31
    Marker Score: 313.5
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.31
    Marker Score: 143
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.31
    Marker Score: 93
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.3
    Marker Score: 167
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.3
    Marker Score: 1113
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3
    Marker Score: 124
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.3
    Marker Score: 65
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.3
    Marker Score: 317
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.29
    Marker Score: 64.5
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.29
    Marker Score: 66
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.29
    Marker Score: 2965
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.29
    Marker Score: 388
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.29
    Marker Score: 117
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.29
    Marker Score: 309
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.29
    Marker Score: 101
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.29
    Marker Score: 83
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.29
    Marker Score: 2879
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.28
    Marker Score: 284
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.28
    Marker Score: 446
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.28
    Marker Score: 71.5
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.28
    Marker Score: 62.5
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.28
    Marker Score: 71
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.28
    Marker Score: 429
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.28
    Marker Score: 123
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.28
    Marker Score: 64.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.28
    Marker Score: 2632

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Other Information

**Key characteristics:** * The DHODH gene is located on chromosome 15q21.1. * It is a large gene encoding a protein of 1,084 amino acids. * DHODH is a flavoprotein with a conserved active site. * It is involved in multiple pathways, including the de novo pyrimidine nucleobase biosynthetic process, the de novo ump biosynthetic process, and the metabolism of nucleotides. **Pathways and functions:** * The DHODH enzyme catalyzes the conversion of dihydroorotate to 5-hydroxymethylcytosine, which is a precursor for various pyrimidine nucleotides. * It is involved in the biosynthesis of DNA and RNA molecules, as well as in the synthesis of proteins and other molecules that require pyrimidine bases. * DHODH is also involved in the regulation of gene expression through the degradation of mRNA. **Clinical significance:** * Mutations in the DHODH gene have been linked to several human diseases, including cancer and neurodegenerative disorders. * These diseases are characterized by abnormal DNA repair mechanisms, which can lead to the accumulation of damaged DNA and the development of cancer. * Therefore, DHODH is a promising target for the development of new cancer therapies. **Additional information:** * DHODH is a highly conserved protein, with similar genes found in organisms ranging from yeast to humans. * It is a multi-functional enzyme that can also perform other related reactions, such as the deamination of 5-hydroxymethylcytosine to 5-formylcytosine.

Genular Protein ID: 2024312461

Symbol: PYRD_HUMAN

Name: Dihydroorotate dehydrogenase (quinone), mitochondrial

UniProtKB Accession Codes:

Q02127 A8K8C8 Q6P176

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 26 DrugCentral 1 EC 1 EMBL 3 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 88 PDBsum 83 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1446837

Title: Cloning and sequencing of a human cDNA coding for dihydroorotate dehydrogenase by complementation of the corresponding yeast mutant.

PubMed ID: 1446837

DOI: 10.1016/0378-1119(92)90150-n

PubMed ID: 7487077

Title: Recombinant human dihydroorotate dehydrogenase: expression, purification, and characterization of a catalytically functional truncated enzyme.

PubMed ID: 7487077

DOI: 10.1006/abbi.1995.0012

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8925840

Title: Functional expression of a fragment of human dihydroorotate dehydrogenase by means of the baculovirus expression vector system, and kinetic investigation of the purified recombinant enzyme.

PubMed ID: 8925840

DOI: 10.1111/j.1432-1033.1996.0292h.x

PubMed ID: 10727948

Title: Requirements for the mitochondrial import and localization of dihydroorotate dehydrogenase.

PubMed ID: 10727948

DOI: 10.1046/j.1432-1327.2000.01213.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10673429

Title: Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents.

PubMed ID: 10673429

DOI: 10.1016/s0969-2126(00)00077-0

PubMed ID: 16480261

Title: Dual binding mode of a novel series of DHODH inhibitors.

PubMed ID: 16480261

DOI: 10.1021/jm0506975

PubMed ID: 19915526

Title: Exome sequencing identifies the cause of a Mendelian disorder.

PubMed ID: 19915526

DOI: 10.1038/ng.499

Sequence Information:

  • Length: 395
  • Mass: 42867
  • Checksum: 072C3169E78C6440
  • Sequence:
    • MAWRHLKKRA QDAVIILGGG GLLFASYLMA TGDERFYAEH LMPTLQGLLD PESAHRLAVR 
FTSLGLLPRA RFQDSDMLEV RVLGHKFRNP VGIAAGFDKH GEAVDGLYKM GFGFVEIGSV 
TPKPQEGNPR PRVFRLPEDQ AVINRYGFNS HGLSVVEHRL RARQQKQAKL TEDGLPLGVN 
LGKNKTSVDA AEDYAEGVRV LGPLADYLVV NVSSPNTAGL RSLQGKAELR RLLTKVLQER 
DGLRRVHRPA VLVKIAPDLT SQDKEDIASV VKELGIDGLI VTNTTVSRPA GLQGALRSET 
GGLSGKPLRD LSTQTIREMY ALTQGRVPII GVGGVSSGQD ALEKIRAGAS LVQLYTALTF 
WGPPVVGKVK RELEALLKEQ GFGGVTDAIG ADHRR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.