Details for: DIAPH1

Gene ID: 1729

Symbol: DIAPH1

Ensembl ID: ENSG00000131504

Description: diaphanous related formin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 261.9174
    Cell Significance Index: -40.7400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 154.2717
    Cell Significance Index: -39.1300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 100.6998
    Cell Significance Index: -40.9100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 87.8136
    Cell Significance Index: -45.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 43.1582
    Cell Significance Index: -41.2100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.8269
    Cell Significance Index: -42.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.8981
    Cell Significance Index: -39.9100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.6362
    Cell Significance Index: -35.7400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.0389
    Cell Significance Index: -43.5600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.2291
    Cell Significance Index: -18.0100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 6.5902
    Cell Significance Index: 169.4000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 4.6755
    Cell Significance Index: 114.0800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.4875
    Cell Significance Index: 172.0300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 2.1190
    Cell Significance Index: 34.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.1081
    Cell Significance Index: 56.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9001
    Cell Significance Index: 51.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8389
    Cell Significance Index: 364.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.6499
    Cell Significance Index: 126.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.5713
    Cell Significance Index: 101.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5577
    Cell Significance Index: 312.4800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.4265
    Cell Significance Index: 24.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2925
    Cell Significance Index: 140.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2279
    Cell Significance Index: 199.7100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.1925
    Cell Significance Index: 22.0400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.9904
    Cell Significance Index: 14.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8320
    Cell Significance Index: 18.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8236
    Cell Significance Index: 23.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7944
    Cell Significance Index: 22.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7649
    Cell Significance Index: 274.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7414
    Cell Significance Index: 133.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7310
    Cell Significance Index: 34.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7241
    Cell Significance Index: 89.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6027
    Cell Significance Index: 114.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4934
    Cell Significance Index: 25.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4778
    Cell Significance Index: 12.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4697
    Cell Significance Index: 256.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4424
    Cell Significance Index: 19.5700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4275
    Cell Significance Index: 16.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4196
    Cell Significance Index: 19.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4040
    Cell Significance Index: 47.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3884
    Cell Significance Index: 23.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3854
    Cell Significance Index: 11.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3754
    Cell Significance Index: 27.9800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3601
    Cell Significance Index: 249.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2601
    Cell Significance Index: 115.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.2102
    Cell Significance Index: 131.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1930
    Cell Significance Index: 19.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1897
    Cell Significance Index: 24.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1471
    Cell Significance Index: 6.8600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1418
    Cell Significance Index: 1.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1376
    Cell Significance Index: 23.5000
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.1090
    Cell Significance Index: 1.1000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0922
    Cell Significance Index: 1.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0777
    Cell Significance Index: 5.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0586
    Cell Significance Index: 3.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0559
    Cell Significance Index: 105.2000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0548
    Cell Significance Index: 3.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0531
    Cell Significance Index: 33.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0438
    Cell Significance Index: 1.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0415
    Cell Significance Index: 63.9500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0398
    Cell Significance Index: 73.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0265
    Cell Significance Index: 3.6400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0147
    Cell Significance Index: 0.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0006
    Cell Significance Index: -0.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0070
    Cell Significance Index: -9.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0128
    Cell Significance Index: -9.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0239
    Cell Significance Index: -18.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0356
    Cell Significance Index: -20.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0376
    Cell Significance Index: -5.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0509
    Cell Significance Index: -23.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0525
    Cell Significance Index: -5.3600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0697
    Cell Significance Index: -1.4900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1159
    Cell Significance Index: -0.7000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1170
    Cell Significance Index: -24.6400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1276
    Cell Significance Index: -14.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1328
    Cell Significance Index: -38.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1561
    Cell Significance Index: -2.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1618
    Cell Significance Index: -11.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1876
    Cell Significance Index: -24.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1966
    Cell Significance Index: -22.5200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2392
    Cell Significance Index: -3.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2591
    Cell Significance Index: -30.2000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3233
    Cell Significance Index: -7.4700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3275
    Cell Significance Index: -8.7800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3285
    Cell Significance Index: -5.6300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3615
    Cell Significance Index: -37.6400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3702
    Cell Significance Index: -5.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3827
    Cell Significance Index: -19.9400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3946
    Cell Significance Index: -9.8700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3964
    Cell Significance Index: -8.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4145
    Cell Significance Index: -13.2800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4153
    Cell Significance Index: -9.9600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4675
    Cell Significance Index: -13.3400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4869
    Cell Significance Index: -8.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4923
    Cell Significance Index: -38.9900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5168
    Cell Significance Index: -7.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6143
    Cell Significance Index: -17.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6497
    Cell Significance Index: -39.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6516
    Cell Significance Index: -34.2100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7015
    Cell Significance Index: -17.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Formin Family Member:** DIAPH1 belongs to the formin family, which is characterized by its ability to nucleate actin filaments and regulate actin cytoskeleton dynamics. 2. **Significant Expression:** DIAPH1 is expressed in a wide range of cell types, including skeletal muscle fibers, immune cells, and epithelial cells, highlighting its broad functional significance. 3. **Actin Cytoskeleton Regulation:** DIAPH1 is involved in regulating actin filament polymerization, organization, and dynamics, which are critical for various cellular processes. 4. **Interactions with Signaling Pathways:** DIAPH1 interacts with various signaling pathways, including those mediated by ErbB2, Rho GTPases, and receptor tyrosine kinases, which underscores its role in regulating cellular behavior. **Pathways and Functions:** 1. **Actin Cytoskeleton Organization:** DIAPH1 regulates actin filament organization and dynamics, which is essential for maintaining cellular shape, migration, and division. 2. **Immune Response:** DIAPH1 is involved in regulating immune cell function, including neutrophil degranulation, immune system development, and innate immune response. 3. **Cell Migration:** DIAPH1 plays a crucial role in regulating cell migration, which is essential for various physiological and pathological processes. 4. **Signaling Pathway Regulation:** DIAPH1 interacts with various signaling pathways, including those mediated by ErbB2, Rho GTPases, and receptor tyrosine kinases, which regulates cellular behavior and response to stimuli. **Clinical Significance:** 1. **Immune System Disorders:** Alterations in DIAPH1 expression or function may contribute to immune system disorders, including autoimmune diseases and cancer. 2. **Cancer Progression:** DIAPH1's role in regulating cell migration and invasion makes it a potential target for cancer therapy. 3. **Neurological Disorders:** DIAPH1's involvement in regulating actin cytoskeleton dynamics may contribute to neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Regenerative Medicine:** DIAPH1's role in regulating cell migration and differentiation makes it a potential target for regenerative medicine therapies. In conclusion, DIAPH1 is a complex gene that plays a critical role in regulating actin cytoskeleton dynamics and immune response. Its interactions with various signaling pathways underscore its significance in maintaining cellular homeostasis and function. Further research is needed to fully elucidate the functional significance of DIAPH1 and its potential applications in disease prevention and treatment.

Genular Protein ID: 1070128448

Symbol: DIAP1_HUMAN

Name: Protein diaphanous homolog 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9360932

Title: Nonsyndromic deafness DFNA1 associated with mutation of a human homolog of the Drosophila gene diaphanous.

PubMed ID: 9360932

DOI: 10.1126/science.278.5341.1315

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16887337

Title: HAN11 binds mDia1 and controls GLI1 transcriptional activity.

PubMed ID: 16887337

DOI: 10.1016/j.jdermsci.2006.06.001

PubMed ID: 7737110

Title: The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins.

PubMed ID: 7737110

DOI: 10.1002/j.1460-2075.1995.tb07146.x

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20937854

Title: ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.

PubMed ID: 20937854

DOI: 10.1073/pnas.1000975107

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21834987

Title: Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration.

PubMed ID: 21834987

DOI: 10.1186/1741-7007-9-54

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23325789

Title: cAMP-stimulated phosphorylation of diaphanous 1 regulates protein stability and interaction with binding partners in adrenocortical cells.

PubMed ID: 23325789

DOI: 10.1091/mbc.e12-08-0597

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26463574

Title: Novel loss-of-function variants in DIAPH1 associated with syndromic microcephaly, blindness, and early onset seizures.

PubMed ID: 26463574

DOI: 10.1002/ajmg.a.37422

PubMed ID: 24781755

Title: Homozygous loss of DIAPH1 is a novel cause of microcephaly in humans.

PubMed ID: 24781755

DOI: 10.1038/ejhg.2014.82

PubMed ID: 26912466

Title: A gain-of-function variant in DIAPH1 causes dominant macrothrombocytopenia and hearing loss.

PubMed ID: 26912466

DOI: 10.1182/blood-2015-10-675629

PubMed ID: 27808407

Title: Extension of the clinical and molecular phenotype of DIAPH1-associated autosomal dominant hearing loss (DFNA1).

PubMed ID: 27808407

DOI: 10.1111/cge.12915

PubMed ID: 22938506

Title: Targeted massive parallel sequencing: the effective detection of novel causative mutations associated with hearing loss in small families.

PubMed ID: 22938506

DOI: 10.1186/1750-1172-7-60

Sequence Information:

  • Length: 1272
  • Mass: 141347
  • Checksum: 9C8273DE4748564F
  • Sequence:
  • MEPPGGSLGP GRGTRDKKKG RSPDELPSAG GDGGKSKKFT LKRLMADELE RFTSMRIKKE 
    KEKPNSAHRN SSASYGDDPT AQSLQDVSDE QVLVLFEQML LDMNLNEEKQ QPLREKDIII 
    KREMVSQYLY TSKAGMSQKE SSKSAMMYIQ ELRSGLRDMP LLSCLESLRV SLNNNPVSWV 
    QTFGAEGLAS LLDILKRLHD EKEETAGSYD SRNKHEIIRC LKAFMNNKFG IKTMLETEEG 
    ILLLVRAMDP AVPNMMIDAA KLLSALCILP QPEDMNERVL EAMTERAEMD EVERFQPLLD 
    GLKSGTTIAL KVGCLQLINA LITPAEELDF RVHIRSELMR LGLHQVLQDL REIENEDMRV 
    QLNVFDEQGE EDSYDLKGRL DDIRMEMDDF NEVFQILLNT VKDSKAEPHF LSILQHLLLV 
    RNDYEARPQY YKLIEECISQ IVLHKNGADP DFKCRHLQIE IEGLIDQMID KTKVEKSEAK 
    AAELEKKLDS ELTARHELQV EMKKMESDFE QKLQDLQGEK DALHSEKQQI ATEKQDLEAE 
    VSQLTGEVAK LTKELEDAKK EMASLSAAAI TVPPSVPSRA PVPPAPPLPG DSGTIIPPPP 
    APGDSTTPPP PPPPPPPPPP LPGGVCISSP PSLPGGTAIS PPPPLSGDAT IPPPPPLPEG 
    VGIPSPSSLP GGTAIPPPPP LPGSARIPPP PPPLPGSAGI PPPPPPLPGE AGMPPPPPPL 
    PGGPGIPPPP PFPGGPGIPP PPPGMGMPPP PPFGFGVPAA PVLPFGLTPK KLYKPEVQLR 
    RPNWSKLVAE DLSQDCFWTK VKEDRFENNE LFAKLTLTFS AQTKTSKAKK DQEGGEEKKS 
    VQKKKVKELK VLDSKTAQNL SIFLGSFRMP YQEIKNVILE VNEAVLTESM IQNLIKQMPE 
    PEQLKMLSEL KDEYDDLAES EQFGVVMGTV PRLRPRLNAI LFKLQFSEQV ENIKPEIVSV 
    TAACEELRKS ESFSNLLEIT LLVGNYMNAG SRNAGAFGFN ISFLCKLRDT KSTDQKMTLL 
    HFLAELCEND YPDVLKFPDE LAHVEKASRV SAENLQKNLD QMKKQISDVE RDVQNFPAAT 
    DEKDKFVEKM TSFVKDAQEQ YNKLRMMHSN METLYKELGE YFLFDPKKLS VEEFFMDLHN 
    FRNMFLQAVK ENQKRRETEE KMRRAKLAKE KAEKERLEKQ QKREQLIDMN AEGDETGVMD 
    SLLEALQSGA AFRRKRGPRQ ANRKAGCAVT SLLASELTKD DAMAAVPAKV SKNSETFPTI 
    LEEAKELVGR AS

Genular Protein ID: 1921248832

Symbol: Q6URC4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 1272
  • Mass: 141303
  • Checksum: 86334CCF67A77DA2
  • Sequence:
  • MEPPGGSLGP GRGTRDKKKG RSPDELPSAG GDGGKSKKFT LKRLMADELE RFTSMRIKKE 
    KEKPNSAHRN SSASYGDDPT AQSLQDVSDE QVLVLFEQML LDMNLNEEKQ QPLREKDIII 
    KREMVSQYLY TSKAGMSQKE SSKSAMMYIQ ELRSGLRDMP LLSCLESLRV SLNNNPVSWV 
    QTFGAEGLAS LLDILKRLHD EKEETAGSYD SRNKHEIIRC LKAFMNNKFG IKTMLETEEG 
    ILLLVRAMDP AVPNMMIDAA KLLSALCILP QPEDMNERVL EAMTERAEMD EVERFQPLLD 
    GLKSGTTIAL KVGCLQLINA LITPAEELDF RVHIRSELMR LGLHQVLQDL REIENEDMRV 
    QLNVFDEQGE EDSYDLKGRL DDIRMEMDDF NEVFQILLNT VKDSKAEPHF LSILQHLLLV 
    RNDYEARPQY YKLIEECISQ IVLHKNGADP DFKCRHLQIE IEGLIDQMID KTKVEKSEAK 
    AAELGKKLDS ELTARHELQV EMKKMESDFE QKLQDLQGEK DALHSEKQQI ATEKQDLEAE 
    VSQLTGEVAK LTKELEDAKK EMASLSAAAI TVPPSVPSRA PVPPAPPLPG DSGTIIPPPP 
    APGDSTTPPP PPPPPPPPPP LPGGVCISSP PSLPGGTAIS PPPPLSGDAT IPPPPPLPEG 
    VGIPSPSSLP GGTAIPPPPP LPGSARIPPP PPPLPGSAGI PPPPPPLPGE AGMPPPPPPL 
    PGGPGIPPPP PFPGGPGIPP PPPGMGMPPP PPFGFGVPAA PVLPFGLTPK KLYKPEVQLR 
    RPNWSKLVAE DLSQDCFWTK VKEDRFENNE LFAKLTLTFS AQTKTSKAKK DQEGGEEKKS 
    VQKKKVKELK VLDSKTAQNL SIFLGSFRMP YQEIKNVILE VNEAVLTESM IQNLIKQMPE 
    PEQLKMLSEL KDEYDDLAES EQFGVVMGTV PRLRPRLNAI LFKLQFSEQV ENIKPEIVSV 
    TAACEELRKS ESFSNLLEIT LLVGNYMNAG SRNAGAFGFN ISFLCKLRDT KSTDQKMTLL 
    HFLAELCEND YPDVLKFPDE LAHVEKASRV SAENLQKNLD QMKKRISDVE RDVQNFPAAT 
    DEKDKFVEKM TSFVKDAQEQ YNKLRMMHSN METLYKELGE YFLFDPKKLS VEEFFMDLHN 
    FRNMFLQAVK ENQKRRETEE KMRRAKLAKE KAEKERLEKQ QKREQLIDMN AEGDETGVMD 
    SLLEALQSGA AFRRKRGPRQ ANRKAGCAVT SLLASELTKD DAMAAVPAKV SKNSETFPTI 
    LEEAKELVGR AS

Genular Protein ID: 619352636

Symbol: A0A2R8Y5N1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.M111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 1250
  • Mass: 139413
  • Checksum: 87CE7CCB054D2A72
  • Sequence:
  • MEPPGGSLGP GRGTRDKKKG RSPDELPSAG GDGGKSKKFT LKRLMADELE RFTSMRIKKE 
    KEKPNSAHRN SSASYGDDPT AQSLQDVSDE QVLVLFEQML LDMNLNEEKQ QPLREKDIII 
    KREMVSQYLY TSKAGMSQKE SSKSAMMYIQ ELRSGLRDMP LLSCLESLRV SLNNNPVSWV 
    QTFGAEGLAS LLDILKRLHD EKEETAGSYD SRNKHEIIRC LKAFMNNKFG IKTMLETEEG 
    ILLLVRAMDP AVPNMMIDAA KLLSALCILP QPEDMNERVL EAMTERAEMD EVERFQPLLD 
    GLKSGTTIAL KVGCLQLINA LITPAEELDF RVHIRSELMR LGLHQVLQDL REIENEDMRV 
    QLNVFDEQGE EDSYDLKGRL DDIRMEMDDF NEVFQILLNT VKDSKAEPHF LSILQHLLLV 
    RNDYEARPQY YKLIEECISQ IVLHKNGADP DFKCRHLQIE IEGLIDQMID KTKVEKSEAK 
    AAELEKKLDS ELTARHELQV EMKKMESDFE QKLQDLQGEK DALHSEKQQI ATEKQDLEAE 
    VSQLTGEVAK LTKELEDAKK EMASLSAAAI TVPPSVPSRA PVPPAPPLPG DSGTIIPPPP 
    APGDSTTPPP PPPPPPPPPP LPGGVCISSP PSLPGGTAIS PPPPLSGDAT IPPPPPLPEG 
    VGIPSPSSLP GGTAIPPPPP LPGSARIPPP PPPLPGSAGI PPPPPPLPGE AGMPPPPPPL 
    PGGPGIPPPP PFPGGPGIPP PPPGMGMPPP PPFGFGVPAA PVLPFGLTPK KLYKPEVQLR 
    RPNWSKLVAE DLSQDCFWTK VKEDRFENNE LFAKLTLTFS AQTKTSKAKK DQEGGEEKKS 
    VQKKKVKELK VLDSKTAQNL SIFLGSFRMP YQEIKNVILE VNEAVLTESM IQNLIKQMPE 
    PEQLKMLSEL KDEYDDLAES EQFGVVMGTV PRLRPRLNAI LFKLQFSEQV ENIKPEIVSV 
    TAACEELRKS ESFSNLLEIT LLVGNYMNAG SRNAGAFGFN ISFLCKLRDT KSTDQKMTLL 
    HFLAELCEND YPDVLKFPDE LAHVEKASRV SAENLQKNLD QMKKQISDVE RDVQNFPAAT 
    DEKDKFVEKM TSFVKDAQEQ YNKLRMMHSN METLYKELGE YFLFDPKKLS VEEFFMDLHN 
    FRNMFLQAVK ENQKRRETEE KMRRAKLAKE KAEKERLEKQ QKREQLIDMN AEGDETGVMD 
    SLLEALQSGA AFRRKRGPRQ DNLLCPWEVE EEEETFKLPT GRPGVQSHLC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.