Details for: DIAPH1

Gene ID: 1729

Symbol: DIAPH1

Ensembl ID: ENSG00000131504

Description: diaphanous related formin 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.53
    Marker Score: 6,332
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.35
    Marker Score: 2,475
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.06
    Marker Score: 890
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.91
    Marker Score: 4,700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.87
    Marker Score: 1,272
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.85
    Marker Score: 2,048
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.79
    Marker Score: 99,885
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.74
    Marker Score: 919
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.71
    Marker Score: 4,256
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.68
    Marker Score: 17,023
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.64
    Marker Score: 1,436
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.62
    Marker Score: 1,748
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.61
    Marker Score: 4,513
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.61
    Marker Score: 5,075
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.6
    Marker Score: 6,512
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.56
    Marker Score: 1,545
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.54
    Marker Score: 2,238
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.54
    Marker Score: 767
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.53
    Marker Score: 1,179
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.53
    Marker Score: 1,114
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.52
    Marker Score: 57,607
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.52
    Marker Score: 15,657
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.52
    Marker Score: 2,145
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.51
    Marker Score: 436
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.5
    Marker Score: 7,379
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5
    Marker Score: 92,143
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.5
    Marker Score: 464
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.5
    Marker Score: 1,000
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.49
    Marker Score: 3,510
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.48
    Marker Score: 12,687
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.47
    Marker Score: 14,547
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.46
    Marker Score: 2,155
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.46
    Marker Score: 2,150
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.45
    Marker Score: 9,311
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 165,771
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.42
    Marker Score: 1,425
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.41
    Marker Score: 6,095
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.41
    Marker Score: 4,613
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.41
    Marker Score: 2,742
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.41
    Marker Score: 13,226
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.4
    Marker Score: 2,165
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.4
    Marker Score: 13,272
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.37
    Marker Score: 3,314
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.37
    Marker Score: 10,506
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.37
    Marker Score: 7,348
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.36
    Marker Score: 50,049
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.35
    Marker Score: 30,141
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.34
    Marker Score: 26,561
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.33
    Marker Score: 1,720
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.33
    Marker Score: 1,223
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.32
    Marker Score: 455
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.31
    Marker Score: 1,030
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.31
    Marker Score: 5,073
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.31
    Marker Score: 490
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.31
    Marker Score: 894
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.31
    Marker Score: 33,442
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.3
    Marker Score: 1,322
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.29
    Marker Score: 1,013
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.28
    Marker Score: 402
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.28
    Marker Score: 1,361
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.28
    Marker Score: 1,197
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.28
    Marker Score: 20,492
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.26
    Marker Score: 1,375
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.26
    Marker Score: 282
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.26
    Marker Score: 14,663
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.25
    Marker Score: 3,362
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.25
    Marker Score: 19,497
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.24
    Marker Score: 725
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.22
    Marker Score: 834
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.22
    Marker Score: 394
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.22
    Marker Score: 1,027
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.22
    Marker Score: 424
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.21
    Marker Score: 1,031
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.2
    Marker Score: 2,135
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.2
    Marker Score: 1,000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.2
    Marker Score: 430
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.19
    Marker Score: 1,389
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.18
    Marker Score: 283
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.18
    Marker Score: 430
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.18
    Marker Score: 2,885
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.18
    Marker Score: 7,563
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.18
    Marker Score: 1,197
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.18
    Marker Score: 1,225
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.18
    Marker Score: 283
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.16
    Marker Score: 954
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.16
    Marker Score: 227
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.16
    Marker Score: 7,386
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.16
    Marker Score: 564
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.15
    Marker Score: 689
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 1.15
    Marker Score: 348
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.15
    Marker Score: 253
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.15
    Marker Score: 719
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.15
    Marker Score: 283
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.14
    Marker Score: 4,720
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.14
    Marker Score: 1,142
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.14
    Marker Score: 247
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.13
    Marker Score: 287
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.12
    Marker Score: 636
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.12
    Marker Score: 1,544
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.11
    Marker Score: 454

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Formin Family Member:** DIAPH1 belongs to the formin family, which is characterized by its ability to nucleate actin filaments and regulate actin cytoskeleton dynamics. 2. **Significant Expression:** DIAPH1 is expressed in a wide range of cell types, including skeletal muscle fibers, immune cells, and epithelial cells, highlighting its broad functional significance. 3. **Actin Cytoskeleton Regulation:** DIAPH1 is involved in regulating actin filament polymerization, organization, and dynamics, which are critical for various cellular processes. 4. **Interactions with Signaling Pathways:** DIAPH1 interacts with various signaling pathways, including those mediated by ErbB2, Rho GTPases, and receptor tyrosine kinases, which underscores its role in regulating cellular behavior. **Pathways and Functions:** 1. **Actin Cytoskeleton Organization:** DIAPH1 regulates actin filament organization and dynamics, which is essential for maintaining cellular shape, migration, and division. 2. **Immune Response:** DIAPH1 is involved in regulating immune cell function, including neutrophil degranulation, immune system development, and innate immune response. 3. **Cell Migration:** DIAPH1 plays a crucial role in regulating cell migration, which is essential for various physiological and pathological processes. 4. **Signaling Pathway Regulation:** DIAPH1 interacts with various signaling pathways, including those mediated by ErbB2, Rho GTPases, and receptor tyrosine kinases, which regulates cellular behavior and response to stimuli. **Clinical Significance:** 1. **Immune System Disorders:** Alterations in DIAPH1 expression or function may contribute to immune system disorders, including autoimmune diseases and cancer. 2. **Cancer Progression:** DIAPH1's role in regulating cell migration and invasion makes it a potential target for cancer therapy. 3. **Neurological Disorders:** DIAPH1's involvement in regulating actin cytoskeleton dynamics may contribute to neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Regenerative Medicine:** DIAPH1's role in regulating cell migration and differentiation makes it a potential target for regenerative medicine therapies. In conclusion, DIAPH1 is a complex gene that plays a critical role in regulating actin cytoskeleton dynamics and immune response. Its interactions with various signaling pathways underscore its significance in maintaining cellular homeostasis and function. Further research is needed to fully elucidate the functional significance of DIAPH1 and its potential applications in disease prevention and treatment.

Genular Protein ID: 1070128448

Symbol: DIAP1_HUMAN

Name: Protein diaphanous homolog 1

UniProtKB Accession Codes:

O60610 A6NF18 B7ZKW2 E9PEZ2 Q17RN4 Q59FH8 Q9UC76

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 25 Gene3D 6 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 8 RefSeq 2 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9360932

Title: Nonsyndromic deafness DFNA1 associated with mutation of a human homolog of the Drosophila gene diaphanous.

PubMed ID: 9360932

DOI: 10.1126/science.278.5341.1315

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16887337

Title: HAN11 binds mDia1 and controls GLI1 transcriptional activity.

PubMed ID: 16887337

DOI: 10.1016/j.jdermsci.2006.06.001

PubMed ID: 7737110

Title: The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins.

PubMed ID: 7737110

DOI: 10.1002/j.1460-2075.1995.tb07146.x

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20937854

Title: ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.

PubMed ID: 20937854

DOI: 10.1073/pnas.1000975107

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21834987

Title: Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration.

PubMed ID: 21834987

DOI: 10.1186/1741-7007-9-54

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23325789

Title: cAMP-stimulated phosphorylation of diaphanous 1 regulates protein stability and interaction with binding partners in adrenocortical cells.

PubMed ID: 23325789

DOI: 10.1091/mbc.e12-08-0597

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26463574

Title: Novel loss-of-function variants in DIAPH1 associated with syndromic microcephaly, blindness, and early onset seizures.

PubMed ID: 26463574

DOI: 10.1002/ajmg.a.37422

PubMed ID: 24781755

Title: Homozygous loss of DIAPH1 is a novel cause of microcephaly in humans.

PubMed ID: 24781755

DOI: 10.1038/ejhg.2014.82

PubMed ID: 26912466

Title: A gain-of-function variant in DIAPH1 causes dominant macrothrombocytopenia and hearing loss.

PubMed ID: 26912466

DOI: 10.1182/blood-2015-10-675629

PubMed ID: 27808407

Title: Extension of the clinical and molecular phenotype of DIAPH1-associated autosomal dominant hearing loss (DFNA1).

PubMed ID: 27808407

DOI: 10.1111/cge.12915

PubMed ID: 22938506

Title: Targeted massive parallel sequencing: the effective detection of novel causative mutations associated with hearing loss in small families.

PubMed ID: 22938506

DOI: 10.1186/1750-1172-7-60

Sequence Information:

  • Length: 1272
  • Mass: 141347
  • Checksum: 9C8273DE4748564F
  • Sequence:
    • MEPPGGSLGP GRGTRDKKKG RSPDELPSAG GDGGKSKKFT LKRLMADELE RFTSMRIKKE 
KEKPNSAHRN SSASYGDDPT AQSLQDVSDE QVLVLFEQML LDMNLNEEKQ QPLREKDIII 
KREMVSQYLY TSKAGMSQKE SSKSAMMYIQ ELRSGLRDMP LLSCLESLRV SLNNNPVSWV 
QTFGAEGLAS LLDILKRLHD EKEETAGSYD SRNKHEIIRC LKAFMNNKFG IKTMLETEEG 
ILLLVRAMDP AVPNMMIDAA KLLSALCILP QPEDMNERVL EAMTERAEMD EVERFQPLLD 
GLKSGTTIAL KVGCLQLINA LITPAEELDF RVHIRSELMR LGLHQVLQDL REIENEDMRV 
QLNVFDEQGE EDSYDLKGRL DDIRMEMDDF NEVFQILLNT VKDSKAEPHF LSILQHLLLV 
RNDYEARPQY YKLIEECISQ IVLHKNGADP DFKCRHLQIE IEGLIDQMID KTKVEKSEAK 
AAELEKKLDS ELTARHELQV EMKKMESDFE QKLQDLQGEK DALHSEKQQI ATEKQDLEAE 
VSQLTGEVAK LTKELEDAKK EMASLSAAAI TVPPSVPSRA PVPPAPPLPG DSGTIIPPPP 
APGDSTTPPP PPPPPPPPPP LPGGVCISSP PSLPGGTAIS PPPPLSGDAT IPPPPPLPEG 
VGIPSPSSLP GGTAIPPPPP LPGSARIPPP PPPLPGSAGI PPPPPPLPGE AGMPPPPPPL 
PGGPGIPPPP PFPGGPGIPP PPPGMGMPPP PPFGFGVPAA PVLPFGLTPK KLYKPEVQLR 
RPNWSKLVAE DLSQDCFWTK VKEDRFENNE LFAKLTLTFS AQTKTSKAKK DQEGGEEKKS 
VQKKKVKELK VLDSKTAQNL SIFLGSFRMP YQEIKNVILE VNEAVLTESM IQNLIKQMPE 
PEQLKMLSEL KDEYDDLAES EQFGVVMGTV PRLRPRLNAI LFKLQFSEQV ENIKPEIVSV 
TAACEELRKS ESFSNLLEIT LLVGNYMNAG SRNAGAFGFN ISFLCKLRDT KSTDQKMTLL 
HFLAELCEND YPDVLKFPDE LAHVEKASRV SAENLQKNLD QMKKQISDVE RDVQNFPAAT 
DEKDKFVEKM TSFVKDAQEQ YNKLRMMHSN METLYKELGE YFLFDPKKLS VEEFFMDLHN 
FRNMFLQAVK ENQKRRETEE KMRRAKLAKE KAEKERLEKQ QKREQLIDMN AEGDETGVMD 
SLLEALQSGA AFRRKRGPRQ ANRKAGCAVT SLLASELTKD DAMAAVPAKV SKNSETFPTI 
LEEAKELVGR AS

Genular Protein ID: 619352636

Symbol: A0A2R8Y5N1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A2R8Y5N1

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 6 GeneTree 1 HGNC 1 InterPro 9 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 PeptideAtlas 1 Pfam 4 Proteomes 2 RefSeq 1 SAM 2 SMART 3 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.M111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 1250
  • Mass: 139413
  • Checksum: 87CE7CCB054D2A72
  • Sequence:
    • MEPPGGSLGP GRGTRDKKKG RSPDELPSAG GDGGKSKKFT LKRLMADELE RFTSMRIKKE 
KEKPNSAHRN SSASYGDDPT AQSLQDVSDE QVLVLFEQML LDMNLNEEKQ QPLREKDIII 
KREMVSQYLY TSKAGMSQKE SSKSAMMYIQ ELRSGLRDMP LLSCLESLRV SLNNNPVSWV 
QTFGAEGLAS LLDILKRLHD EKEETAGSYD SRNKHEIIRC LKAFMNNKFG IKTMLETEEG 
ILLLVRAMDP AVPNMMIDAA KLLSALCILP QPEDMNERVL EAMTERAEMD EVERFQPLLD 
GLKSGTTIAL KVGCLQLINA LITPAEELDF RVHIRSELMR LGLHQVLQDL REIENEDMRV 
QLNVFDEQGE EDSYDLKGRL DDIRMEMDDF NEVFQILLNT VKDSKAEPHF LSILQHLLLV 
RNDYEARPQY YKLIEECISQ IVLHKNGADP DFKCRHLQIE IEGLIDQMID KTKVEKSEAK 
AAELEKKLDS ELTARHELQV EMKKMESDFE QKLQDLQGEK DALHSEKQQI ATEKQDLEAE 
VSQLTGEVAK LTKELEDAKK EMASLSAAAI TVPPSVPSRA PVPPAPPLPG DSGTIIPPPP 
APGDSTTPPP PPPPPPPPPP LPGGVCISSP PSLPGGTAIS PPPPLSGDAT IPPPPPLPEG 
VGIPSPSSLP GGTAIPPPPP LPGSARIPPP PPPLPGSAGI PPPPPPLPGE AGMPPPPPPL 
PGGPGIPPPP PFPGGPGIPP PPPGMGMPPP PPFGFGVPAA PVLPFGLTPK KLYKPEVQLR 
RPNWSKLVAE DLSQDCFWTK VKEDRFENNE LFAKLTLTFS AQTKTSKAKK DQEGGEEKKS 
VQKKKVKELK VLDSKTAQNL SIFLGSFRMP YQEIKNVILE VNEAVLTESM IQNLIKQMPE 
PEQLKMLSEL KDEYDDLAES EQFGVVMGTV PRLRPRLNAI LFKLQFSEQV ENIKPEIVSV 
TAACEELRKS ESFSNLLEIT LLVGNYMNAG SRNAGAFGFN ISFLCKLRDT KSTDQKMTLL 
HFLAELCEND YPDVLKFPDE LAHVEKASRV SAENLQKNLD QMKKQISDVE RDVQNFPAAT 
DEKDKFVEKM TSFVKDAQEQ YNKLRMMHSN METLYKELGE YFLFDPKKLS VEEFFMDLHN 
FRNMFLQAVK ENQKRRETEE KMRRAKLAKE KAEKERLEKQ QKREQLIDMN AEGDETGVMD 
SLLEALQSGA AFRRKRGPRQ DNLLCPWEVE EEEETFKLPT GRPGVQSHLC

Genular Protein ID: 1921248832

Symbol: Q6URC4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6URC4

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 6 Genevisible 1 GenomeRNAi 1 InterPro 9 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 SAM 2 SMART 3 SUPFAM 2

Sequence Information:

  • Length: 1272
  • Mass: 141303
  • Checksum: 86334CCF67A77DA2
  • Sequence:
    • MEPPGGSLGP GRGTRDKKKG RSPDELPSAG GDGGKSKKFT LKRLMADELE RFTSMRIKKE 
KEKPNSAHRN SSASYGDDPT AQSLQDVSDE QVLVLFEQML LDMNLNEEKQ QPLREKDIII 
KREMVSQYLY TSKAGMSQKE SSKSAMMYIQ ELRSGLRDMP LLSCLESLRV SLNNNPVSWV 
QTFGAEGLAS LLDILKRLHD EKEETAGSYD SRNKHEIIRC LKAFMNNKFG IKTMLETEEG 
ILLLVRAMDP AVPNMMIDAA KLLSALCILP QPEDMNERVL EAMTERAEMD EVERFQPLLD 
GLKSGTTIAL KVGCLQLINA LITPAEELDF RVHIRSELMR LGLHQVLQDL REIENEDMRV 
QLNVFDEQGE EDSYDLKGRL DDIRMEMDDF NEVFQILLNT VKDSKAEPHF LSILQHLLLV 
RNDYEARPQY YKLIEECISQ IVLHKNGADP DFKCRHLQIE IEGLIDQMID KTKVEKSEAK 
AAELGKKLDS ELTARHELQV EMKKMESDFE QKLQDLQGEK DALHSEKQQI ATEKQDLEAE 
VSQLTGEVAK LTKELEDAKK EMASLSAAAI TVPPSVPSRA PVPPAPPLPG DSGTIIPPPP 
APGDSTTPPP PPPPPPPPPP LPGGVCISSP PSLPGGTAIS PPPPLSGDAT IPPPPPLPEG 
VGIPSPSSLP GGTAIPPPPP LPGSARIPPP PPPLPGSAGI PPPPPPLPGE AGMPPPPPPL 
PGGPGIPPPP PFPGGPGIPP PPPGMGMPPP PPFGFGVPAA PVLPFGLTPK KLYKPEVQLR 
RPNWSKLVAE DLSQDCFWTK VKEDRFENNE LFAKLTLTFS AQTKTSKAKK DQEGGEEKKS 
VQKKKVKELK VLDSKTAQNL SIFLGSFRMP YQEIKNVILE VNEAVLTESM IQNLIKQMPE 
PEQLKMLSEL KDEYDDLAES EQFGVVMGTV PRLRPRLNAI LFKLQFSEQV ENIKPEIVSV 
TAACEELRKS ESFSNLLEIT LLVGNYMNAG SRNAGAFGFN ISFLCKLRDT KSTDQKMTLL 
HFLAELCEND YPDVLKFPDE LAHVEKASRV SAENLQKNLD QMKKRISDVE RDVQNFPAAT 
DEKDKFVEKM TSFVKDAQEQ YNKLRMMHSN METLYKELGE YFLFDPKKLS VEEFFMDLHN 
FRNMFLQAVK ENQKRRETEE KMRRAKLAKE KAEKERLEKQ QKREQLIDMN AEGDETGVMD 
SLLEALQSGA AFRRKRGPRQ ANRKAGCAVT SLLASELTKD DAMAAVPAKV SKNSETFPTI 
LEEAKELVGR AS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.