Details for: DMWD

Gene ID: 1762

Symbol: DMWD

Ensembl ID: ENSG00000185800

Description: DM1 locus, WD repeat containing

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 2.22
    Marker Score: 2678.5
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.18
    Marker Score: 1160
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.12
    Marker Score: 17478
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.1
    Marker Score: 11380
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71771
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47995.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.95
    Marker Score: 8169.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.95
    Marker Score: 1465
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.94
    Marker Score: 20116
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.93
    Marker Score: 57042
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.92
    Marker Score: 1605
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.92
    Marker Score: 8627
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5217
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2720
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.89
    Marker Score: 8425
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5260
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.84
    Marker Score: 317
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.83
    Marker Score: 716
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.81
    Marker Score: 3130
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.78
    Marker Score: 26346
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.77
    Marker Score: 1464
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.75
    Marker Score: 327
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.75
    Marker Score: 27486
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.73
    Marker Score: 27553
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 290.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 553.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.72
    Marker Score: 8128
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.71
    Marker Score: 369
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.71
    Marker Score: 793
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2961
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.7
    Marker Score: 2604
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.67
    Marker Score: 5171
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 615
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.67
    Marker Score: 13251
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.67
    Marker Score: 2757
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.66
    Marker Score: 979
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.65
    Marker Score: 310
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.64
    Marker Score: 9535
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.62
    Marker Score: 1455.5
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.61
    Marker Score: 1502
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.61
    Marker Score: 648
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.61
    Marker Score: 1237
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6
    Marker Score: 1270
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.6
    Marker Score: 5220
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.6
    Marker Score: 289
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.59
    Marker Score: 609
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.58
    Marker Score: 621
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.58
    Marker Score: 622
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.57
    Marker Score: 539.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.57
    Marker Score: 19362
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.56
    Marker Score: 1284
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.56
    Marker Score: 996.5
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.56
    Marker Score: 1046
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.56
    Marker Score: 128
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.55
    Marker Score: 355
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.55
    Marker Score: 172
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.54
    Marker Score: 617
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 427
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.51
    Marker Score: 321.5
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.51
    Marker Score: 2483.5
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.51
    Marker Score: 5083
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.5
    Marker Score: 1173
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.48
    Marker Score: 275
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.48
    Marker Score: 137
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.48
    Marker Score: 1832
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.47
    Marker Score: 283
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.47
    Marker Score: 929
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.45
    Marker Score: 15647
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.45
    Marker Score: 298
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.45
    Marker Score: 134
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.45
    Marker Score: 148
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.45
    Marker Score: 304
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.44
    Marker Score: 264
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.44
    Marker Score: 2374
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.44
    Marker Score: 309
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.44
    Marker Score: 674
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.44
    Marker Score: 2593
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.44
    Marker Score: 3284
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.43
    Marker Score: 2282
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 388
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.43
    Marker Score: 104
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.43
    Marker Score: 161
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.43
    Marker Score: 1448
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.43
    Marker Score: 138
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.43
    Marker Score: 282
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.43
    Marker Score: 144
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.42
    Marker Score: 151
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.42
    Marker Score: 614
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.42
    Marker Score: 186
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.42
    Marker Score: 2714
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.42
    Marker Score: 126
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.41
    Marker Score: 595

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - The DMWD gene is located on chromosome 15q26.1. - It contains a WD repeat of 130 nucleotides. - The gene is alternatively spliced, resulting in two main transcript variants. - The full-length DMWD protein is a transmembrane protein that belongs to the WD repeat expansion protein family. **Pathways and functions:** - DMWD is involved in the regulation of cell growth, differentiation, and apoptosis. - It is a key regulator of mesangial cell migration and survival. - It is also involved in the development and survival of neurons. - DMWD has been linked to the pathogenesis of several neurological disorders, including amyotrophic lateral sclerosis and schizophrenia. **Clinical significance:** - Mutations in the DMWD gene have been linked to several human diseases, including amyotrophic lateral sclerosis, schizophrenia, and autism. - DMWD is a promising target for the treatment of these disorders. - Research efforts are focused on developing drugs that can inhibit the activity of DMWD to slow or prevent neurodegenerative diseases.

Genular Protein ID: 3715007890

Symbol: DMWD_HUMAN

Name: Dystrophia myotonica WD repeat-containing protein

UniProtKB Accession Codes:

Q09019

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 7905855

Title: Genomic organization and transcriptional units at the myotonic dystrophy locus.

PubMed ID: 7905855

DOI: 10.1016/s0888-7543(05)80372-6

PubMed ID: 8499920

Title: Structure and genomic sequence of the myotonic dystrophy (DM kinase) gene.

PubMed ID: 8499920

DOI: 10.1093/hmg/2.3.299

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 33844468

Title: The dystrophia myotonica WD repeat-containing protein DMWD and WDR20 differentially regulate USP12 deubiquitinase.

PubMed ID: 33844468

DOI: 10.1111/febs.15875

Sequence Information:

  • Length: 674
  • Mass: 70438
  • Checksum: DC93F6930915E928
  • Sequence:
    • MAAGGAEGGS GPGAAMGDCA EIKSQFRTRE GFYKLLPGDG AARRSGPASA QTPVPPQPPQ 
PPPGPASASG PGAAGPASSP PPAGPGPGPA LPAVRLSLVR LGEPDSAGAG EPPATPAGLG 
SGGDRVCFNL GRELYFYPGC CRRGSQRSID LNKPIDKRIY KGTQPTCHDF NQFTAATETI 
SLLVGFSAGQ VQYLDLIKKD TSKLFNEERL IDKTKVTYLK WLPESESLFL ASHASGHLYL 
YNVSHPCASA PPQYSLLKQG EGFSVYAAKS KAPRNPLAKW AVGEGPLNEF AFSPDGRHLA 
CVSQDGCLRV FHFDSMLLRG LMKSYFGGLL CVCWSPDGRY VVTGGEDDLV TVWSFTEGRV 
VARGHGHKSW VNAVAFDPYT TRAEEAATAA GADGERSGEE EEEEPEAAGT GSAGGAPLSP 
LPKAGSITYR FGSAGQDTQF CLWDLTEDVL YPHPPLARTR TLPGTPGTTP PAASSSRGGE 
PGPGPLPRSL SRSNSLPHPA GGGKAGGPGV AAEPGTPFSI GRFATLTLQE RRDRGAEKEH 
KRYHSLGNIS RGGSGGSGSG GEKPSGPVPR SRLDPAKVLG TALCPRIHEV PLLEPLVCKK 
IAQERLTVLL FLEDCIITAC QEGLICTWAR PGKAFTDEET EAQTGEGSWP RSPSKSVVEG 
ISSQPGNSPS GTVV

Genular Protein ID: 3444908183

Symbol: Q8WUW6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8WUW6

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 4 Gene3D 1 GenomeRNAi 1 IntAct 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 334
  • Mass: 34742
  • Checksum: 1D4050B2A901CCD7
  • Sequence:
    • MLLRGLMKSY FGGLLCVCWS PDGRYVVTGG EDDLVTVWSF TEGRVVARGH GHKSWVNAVA 
FDPYTTRAEE AATAAGADGE RSGEEEEEEP EAAGTGSAGG APLSPLPKAG SITYRFGSAG 
QDTQFCLWDL TEDVLYPHPP LARTRTLPGT PGTTPPAASS SRGGEPGPGP LPRSLSRSNS 
LPHPAGGGKA GGPGVAAEPG TPFSIGRFAT LTLQERRDRG AEKEHKRYHS LGNISRGGSG 
GSGSGGEKPS GPVPRSRLDP AKVLGTALCP RIHEVPLLEP LVCKKIAQER LTVLLFLEDC 
IITACQEGLI CTWARPGKAG ISSQPGNSPS GTVV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.