Details for: DMWD

Gene ID: 1762

Symbol: DMWD

Ensembl ID: ENSG00000185800

Description: DM1 locus, WD repeat containing

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 108.2643
    Cell Significance Index: -16.8400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 68.5608
    Cell Significance Index: -17.3900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 37.5008
    Cell Significance Index: -17.7100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 36.1840
    Cell Significance Index: -14.7000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.3549
    Cell Significance Index: -14.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.9827
    Cell Significance Index: -17.2400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.4785
    Cell Significance Index: -17.3600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.6688
    Cell Significance Index: -14.3400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.3968
    Cell Significance Index: -17.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9769
    Cell Significance Index: 113.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.7191
    Cell Significance Index: 15.7500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7150
    Cell Significance Index: 645.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7016
    Cell Significance Index: 140.7400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.6214
    Cell Significance Index: 5.2200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5834
    Cell Significance Index: 35.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5617
    Cell Significance Index: 15.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5450
    Cell Significance Index: 59.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5383
    Cell Significance Index: 27.9700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5333
    Cell Significance Index: 33.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5318
    Cell Significance Index: 73.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4563
    Cell Significance Index: 74.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3645
    Cell Significance Index: 27.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3467
    Cell Significance Index: 124.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2819
    Cell Significance Index: 19.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2334
    Cell Significance Index: 10.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2313
    Cell Significance Index: 5.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2294
    Cell Significance Index: 125.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2152
    Cell Significance Index: 38.8000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1978
    Cell Significance Index: 10.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1961
    Cell Significance Index: 5.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1942
    Cell Significance Index: 23.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1937
    Cell Significance Index: 6.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1764
    Cell Significance Index: 4.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1728
    Cell Significance Index: 8.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1574
    Cell Significance Index: 11.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1529
    Cell Significance Index: 29.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1386
    Cell Significance Index: 6.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1085
    Cell Significance Index: 4.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1022
    Cell Significance Index: 45.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0968
    Cell Significance Index: 3.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0945
    Cell Significance Index: 5.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0835
    Cell Significance Index: 10.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0817
    Cell Significance Index: 2.1900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0809
    Cell Significance Index: 2.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0743
    Cell Significance Index: 7.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0611
    Cell Significance Index: 7.8300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0568
    Cell Significance Index: 2.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0529
    Cell Significance Index: 2.9700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0496
    Cell Significance Index: 34.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0489
    Cell Significance Index: 2.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0230
    Cell Significance Index: 4.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0074
    Cell Significance Index: 0.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0022
    Cell Significance Index: -0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0062
    Cell Significance Index: -11.6900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0067
    Cell Significance Index: -4.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0078
    Cell Significance Index: -14.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0103
    Cell Significance Index: -15.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0130
    Cell Significance Index: -17.6700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0152
    Cell Significance Index: -11.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0152
    Cell Significance Index: -11.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0218
    Cell Significance Index: -13.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0220
    Cell Significance Index: -2.6000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0268
    Cell Significance Index: -0.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0283
    Cell Significance Index: -15.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0290
    Cell Significance Index: -13.1600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0317
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0326
    Cell Significance Index: -20.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0370
    Cell Significance Index: -0.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0429
    Cell Significance Index: -7.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0502
    Cell Significance Index: -3.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0513
    Cell Significance Index: -14.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0545
    Cell Significance Index: -1.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0745
    Cell Significance Index: -7.6100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0776
    Cell Significance Index: -1.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0778
    Cell Significance Index: -8.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0806
    Cell Significance Index: -11.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0872
    Cell Significance Index: -18.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0955
    Cell Significance Index: -2.5500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1510
    Cell Significance Index: -3.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1668
    Cell Significance Index: -17.3700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1730
    Cell Significance Index: -2.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1786
    Cell Significance Index: -11.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1802
    Cell Significance Index: -14.2700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2014
    Cell Significance Index: -4.6500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2015
    Cell Significance Index: -3.5600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2102
    Cell Significance Index: -5.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2122
    Cell Significance Index: -5.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2396
    Cell Significance Index: -16.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2654
    Cell Significance Index: -16.2700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2693
    Cell Significance Index: -3.2100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2907
    Cell Significance Index: -6.1700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2910
    Cell Significance Index: -8.5700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3179
    Cell Significance Index: -10.1300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3185
    Cell Significance Index: -4.8000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3187
    Cell Significance Index: -6.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3203
    Cell Significance Index: -10.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3245
    Cell Significance Index: -10.6300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3657
    Cell Significance Index: -12.8100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3879
    Cell Significance Index: -14.2400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3907
    Cell Significance Index: -4.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DMWD is a WD repeat containing gene, characterized by the presence of WD repeat domains, which are known to play a crucial role in protein-protein interactions. The gene is significantly expressed in various cell types, including mesangial cells, pancreatic A cells, cardiac muscle myoblasts, and dopaminergic neurons. This widespread expression suggests that DMWD may be involved in multiple cellular processes, including cell signaling, regulation, and maintenance. **Pathways and Functions:** DMWD is implicated in various cellular pathways, including: 1. **Deubiquitinase activity:** DMWD is a deubiquitinase activator, which suggests that it plays a role in the regulation of protein ubiquitination. Deubiquitinases are enzymes that remove ubiquitin from proteins, and their dysregulation has been linked to various human diseases, including cancer and neurodegenerative disorders. 2. **Protein binding:** DMWD is involved in protein binding, which is essential for the regulation of various cellular processes, including cell signaling and gene expression. The gene's ability to bind to multiple proteins suggests that it may play a key role in the regulation of complex cellular networks. 3. **Cellular compartmentalization:** DMWD is localized to specific cellular compartments, including the cytoplasm, nucleus, and perikaryon. This compartmentalization suggests that DMWD may play a role in the regulation of cellular processes that occur within these compartments. **Clinical Significance:** The clinical significance of DMWD is an area of active research. While the gene's involvement in multiple cellular pathways and its potential implications in human diseases make it an attractive subject for further investigation, more studies are needed to elucidate the gene's role in human disease. DMWD has been implicated in various diseases, including: 1. **Myotonic dystrophy:** DMWD has been identified as a potential contributor to myotonic dystrophy, a genetic disorder characterized by muscle wasting and weakness. 2. **Neurodegenerative disorders:** DMWD has been implicated in the regulation of protein ubiquitination, which is essential for the clearance of toxic proteins in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer:** DMWD has been shown to play a role in the regulation of protein ubiquitination, which is essential for the maintenance of genome stability and the prevention of cancer. In conclusion, DMWD is a WD repeat containing gene that is involved in multiple cellular pathways, including deubiquitinase activity, protein binding, and cellular compartmentalization. The gene's widespread expression profile and its potential implications in human diseases make it an attractive subject for further investigation. Further studies are needed to elucidate the gene's role in human disease and to explore its potential as a therapeutic target for the treatment of various diseases.

Genular Protein ID: 3715007890

Symbol: DMWD_HUMAN

Name: Dystrophia myotonica WD repeat-containing protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 7905855

Title: Genomic organization and transcriptional units at the myotonic dystrophy locus.

PubMed ID: 7905855

DOI: 10.1016/s0888-7543(05)80372-6

PubMed ID: 8499920

Title: Structure and genomic sequence of the myotonic dystrophy (DM kinase) gene.

PubMed ID: 8499920

DOI: 10.1093/hmg/2.3.299

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 33844468

Title: The dystrophia myotonica WD repeat-containing protein DMWD and WDR20 differentially regulate USP12 deubiquitinase.

PubMed ID: 33844468

DOI: 10.1111/febs.15875

Sequence Information:

  • Length: 674
  • Mass: 70438
  • Checksum: DC93F6930915E928
  • Sequence:
  • MAAGGAEGGS GPGAAMGDCA EIKSQFRTRE GFYKLLPGDG AARRSGPASA QTPVPPQPPQ 
    PPPGPASASG PGAAGPASSP PPAGPGPGPA LPAVRLSLVR LGEPDSAGAG EPPATPAGLG 
    SGGDRVCFNL GRELYFYPGC CRRGSQRSID LNKPIDKRIY KGTQPTCHDF NQFTAATETI 
    SLLVGFSAGQ VQYLDLIKKD TSKLFNEERL IDKTKVTYLK WLPESESLFL ASHASGHLYL 
    YNVSHPCASA PPQYSLLKQG EGFSVYAAKS KAPRNPLAKW AVGEGPLNEF AFSPDGRHLA 
    CVSQDGCLRV FHFDSMLLRG LMKSYFGGLL CVCWSPDGRY VVTGGEDDLV TVWSFTEGRV 
    VARGHGHKSW VNAVAFDPYT TRAEEAATAA GADGERSGEE EEEEPEAAGT GSAGGAPLSP 
    LPKAGSITYR FGSAGQDTQF CLWDLTEDVL YPHPPLARTR TLPGTPGTTP PAASSSRGGE 
    PGPGPLPRSL SRSNSLPHPA GGGKAGGPGV AAEPGTPFSI GRFATLTLQE RRDRGAEKEH 
    KRYHSLGNIS RGGSGGSGSG GEKPSGPVPR SRLDPAKVLG TALCPRIHEV PLLEPLVCKK 
    IAQERLTVLL FLEDCIITAC QEGLICTWAR PGKAFTDEET EAQTGEGSWP RSPSKSVVEG 
    ISSQPGNSPS GTVV

Genular Protein ID: 3444908183

Symbol: Q8WUW6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 334
  • Mass: 34742
  • Checksum: 1D4050B2A901CCD7
  • Sequence:
  • MLLRGLMKSY FGGLLCVCWS PDGRYVVTGG EDDLVTVWSF TEGRVVARGH GHKSWVNAVA 
    FDPYTTRAEE AATAAGADGE RSGEEEEEEP EAAGTGSAGG APLSPLPKAG SITYRFGSAG 
    QDTQFCLWDL TEDVLYPHPP LARTRTLPGT PGTTPPAASS SRGGEPGPGP LPRSLSRSNS 
    LPHPAGGGKA GGPGVAAEPG TPFSIGRFAT LTLQERRDRG AEKEHKRYHS LGNISRGGSG 
    GSGSGGEKPS GPVPRSRLDP AKVLGTALCP RIHEVPLLEP LVCKKIAQER LTVLLFLEDC 
    IITACQEGLI CTWARPGKAG ISSQPGNSPS GTVV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.