Details for: DOCK1

Gene ID: 1793

Symbol: DOCK1

Ensembl ID: ENSG00000150760

Description: dedicator of cytokinesis 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 382.5254
    Cell Significance Index: -59.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 230.4614
    Cell Significance Index: -58.4600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 122.5332
    Cell Significance Index: -49.7800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 52.0559
    Cell Significance Index: -49.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 48.2499
    Cell Significance Index: -59.4900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 26.0945
    Cell Significance Index: -57.1100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.1417
    Cell Significance Index: -59.7500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 7.5124
    Cell Significance Index: 66.6900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 6.2159
    Cell Significance Index: 89.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 5.5778
    Cell Significance Index: 155.8800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 4.5032
    Cell Significance Index: 87.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.7801
    Cell Significance Index: 212.1200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 3.1720
    Cell Significance Index: 19.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.4817
    Cell Significance Index: 492.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.8318
    Cell Significance Index: 45.7900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.4311
    Cell Significance Index: 30.5900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 1.4049
    Cell Significance Index: 19.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3549
    Cell Significance Index: 1223.3800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.1221
    Cell Significance Index: 58.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9710
    Cell Significance Index: 27.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9028
    Cell Significance Index: 69.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8858
    Cell Significance Index: 40.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.8365
    Cell Significance Index: 42.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8071
    Cell Significance Index: 99.2400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.8023
    Cell Significance Index: 13.2200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.7883
    Cell Significance Index: 11.3200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7447
    Cell Significance Index: 81.0000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5369
    Cell Significance Index: 32.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4608
    Cell Significance Index: 83.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.4512
    Cell Significance Index: 694.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3507
    Cell Significance Index: 34.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3238
    Cell Significance Index: 15.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2984
    Cell Significance Index: 561.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2779
    Cell Significance Index: 38.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2653
    Cell Significance Index: 489.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2569
    Cell Significance Index: 29.9400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2282
    Cell Significance Index: 157.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2257
    Cell Significance Index: 143.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1735
    Cell Significance Index: 94.7700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1688
    Cell Significance Index: 1.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1569
    Cell Significance Index: 71.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1475
    Cell Significance Index: 200.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1293
    Cell Significance Index: 6.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1137
    Cell Significance Index: 50.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1123
    Cell Significance Index: 40.2800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0972
    Cell Significance Index: 18.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0613
    Cell Significance Index: 2.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0194
    Cell Significance Index: -0.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0310
    Cell Significance Index: -22.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0396
    Cell Significance Index: -24.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0459
    Cell Significance Index: -33.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0542
    Cell Significance Index: -8.8200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0768
    Cell Significance Index: -58.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0818
    Cell Significance Index: -13.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0885
    Cell Significance Index: -49.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1000
    Cell Significance Index: -20.0600
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.1284
    Cell Significance Index: -1.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1524
    Cell Significance Index: -22.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1799
    Cell Significance Index: -51.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1983
    Cell Significance Index: -22.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2050
    Cell Significance Index: -43.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2061
    Cell Significance Index: -10.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2173
    Cell Significance Index: -22.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2859
    Cell Significance Index: -36.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3401
    Cell Significance Index: -43.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3701
    Cell Significance Index: -37.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4133
    Cell Significance Index: -18.2800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4575
    Cell Significance Index: -9.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4818
    Cell Significance Index: -10.2600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4858
    Cell Significance Index: -55.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4927
    Cell Significance Index: -30.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4964
    Cell Significance Index: -58.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5131
    Cell Significance Index: -16.4400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5570
    Cell Significance Index: -9.6300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.5700
    Cell Significance Index: -5.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5733
    Cell Significance Index: -21.7100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6171
    Cell Significance Index: -8.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6180
    Cell Significance Index: -46.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6379
    Cell Significance Index: -50.5300
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.6383
    Cell Significance Index: -9.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6651
    Cell Significance Index: -47.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6953
    Cell Significance Index: -46.7500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7568
    Cell Significance Index: -20.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7606
    Cell Significance Index: -46.6300
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.8034
    Cell Significance Index: -8.0400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.8083
    Cell Significance Index: -11.9300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.8236
    Cell Significance Index: -8.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.8331
    Cell Significance Index: -53.7500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.9065
    Cell Significance Index: -15.2700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9556
    Cell Significance Index: -60.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.9925
    Cell Significance Index: -16.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0634
    Cell Significance Index: -28.5000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.1217
    Cell Significance Index: -16.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.1714
    Cell Significance Index: -33.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.1892
    Cell Significance Index: -62.4400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.2392
    Cell Significance Index: -17.6400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -1.2428
    Cell Significance Index: -15.6500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.2901
    Cell Significance Index: -11.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.3333
    Cell Significance Index: -46.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DOCK1 is a cytoplasmic protein that belongs to the DOCK family of GEFs. It is characterized by its ability to exchange GDP for GTP, activating small GTPases such as Rac1, Rac2, and Rhog, which are essential for cell migration, cytoskeleton reorganization, and phagocytosis. DOCK1 is highly expressed in various cell types, including immune cells, epithelial cells, and neurons. **Pathways and Functions:** DOCK1 is involved in multiple signaling pathways, including: 1. **Cell Migration:** DOCK1 regulates cell migration by activating Rac1 and Rhog, which are essential for the formation of the actin cytoskeleton and cell adhesion. 2. **Phagocytosis:** DOCK1 facilitates phagocytosis by regulating the activity of small GTPases involved in the formation of the phagocytic cup. 3. **Immune Response:** DOCK1 is essential for the regulation of immune responses, including the activation of immune cells and the production of cytokines. 4. **Neuronal Development:** DOCK1 plays a role in neuronal development and axon guidance, regulating the formation of the axon and the guidance of neurons. **Clinical Significance:** DOCK1 has been implicated in various diseases, including: 1. **Cancer:** DOCK1 overexpression has been observed in several types of cancer, including breast, lung, and colon cancer, suggesting its potential as a therapeutic target. 2. **Immune Disorders:** DOCK1 mutations have been associated with immune disorders, such as immunodeficiency and autoimmune diseases. 3. **Neurological Disorders:** DOCK1 has been implicated in neurological disorders, including Parkinson's disease and Alzheimer's disease. 4. **Infectious Diseases:** DOCK1 plays a role in the regulation of immune responses to infectious diseases, including Leishmania and malaria. **Conclusion:** DOCK1 is a multifunctional protein that plays a crucial role in various cellular processes, including cell migration, phagocytosis, and immune response. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target. Further research is needed to fully elucidate the mechanisms of DOCK1 and its role in human disease. **Recommendations:** 1. Further studies are needed to elucidate the mechanisms of DOCK1 and its role in human disease. 2. DOCK1 should be investigated as a potential therapeutic target for various diseases, including cancer, immune disorders, and neurological disorders. 3. The role of DOCK1 in infectious diseases should be further studied to develop effective treatments for these conditions. **Limitations:** 1. Further studies are needed to fully elucidate the mechanisms of DOCK1 and its role in human disease. 2. The role of DOCK1 in various diseases is not fully understood, and more research is needed to confirm its involvement in these conditions. **Future Directions:** 1. Further studies are needed to elucidate the mechanisms of DOCK1 and its role in human disease. 2. The development of therapeutic strategies targeting DOCK1 should be pursued to treat various diseases. 3. The role of DOCK1 in infectious diseases should be further studied to develop effective treatments for these conditions.

Genular Protein ID: 1566377129

Symbol: DOCK1_HUMAN

Name: Dedicator of cytokinesis protein 1

UniProtKB Accession Codes:

Q14185 A9Z1Z5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 16 KEGG 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 9 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8657152

Title: DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane.

PubMed ID: 8657152

DOI: 10.1128/mcb.16.4.1770

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 8662907

Title: Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins.

PubMed ID: 8662907

DOI: 10.1074/jbc.271.24.14468

PubMed ID: 9808620

Title: Activation of Rac1 by a Crk SH3-binding protein, DOCK180.

PubMed ID: 9808620

DOI: 10.1101/gad.12.21.3331

PubMed ID: 11240126

Title: Identification and kinetic analysis of the interaction between Nck-2 and DOCK180.

PubMed ID: 11240126

DOI: 10.1016/s0014-5793(01)02195-0

PubMed ID: 11171081

Title: Membrane recruitment of DOCK180 by binding to PtdIns(3,4,5)P3.

PubMed ID: 11171081

DOI: 10.1042/0264-6021:3540073

PubMed ID: 12134158

Title: Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex.

PubMed ID: 12134158

DOI: 10.1038/ncb824

PubMed ID: 12432077

Title: Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.

PubMed ID: 12432077

DOI: 10.1242/jcs.00219

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19004829

Title: DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV.

PubMed ID: 19004829

DOI: 10.1074/jbc.m808010200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1865
  • Mass: 215346
  • Checksum: 940C5AFD047EBEDE
  • Sequence:
    • MTRWVPTKRE EKYGVAFYNY DARGADELSL QIGDTVHILE TYEGWYRGYT LRKKSKKGIF 
PASYIHLKEA IVEGKGQHET VIPGDLPLIQ EVTTTLREWS TIWRQLYVQD NREMFRSVRH 
MIYDLIEWRS QILSGTLPQD ELKELKKKVT AKIDYGNRIL DLDLVVRDED GNILDPELTS 
TISLFRAHEI ASKQVEERLQ EEKSQKQNID INRQAKFAAT PSLALFVNLK NVVCKIGEDA 
EVLMSLYDPV ESKFISENYL VRWSSSGLPK DIDRLHNLRA VFTDLGSKDL KREKISFVCQ 
IVRVGRMELR DNNTRKLTSG LRRPFGVAVM DVTDIINGKV DDEDKQHFIP FQPVAGENDF 
LQTVINKVIA AKEVNHKGQG LWVTLKLLPG DIHQIRKEFP HLVDRTTAVA RKTGFPEIIM 
PGDVRNDIYV TLVQGDFDKG SKTTAKNVEV TVSVYDEDGK RLEHVIFPGA GDEAISEYKS 
VIYYQVKQPR WFETVKVAIP IEDVNRSHLR FTFRHRSSQD SKDKSEKIFA LAFVKLMRYD 
GTTLRDGEHD LIVYKAEAKK LEDAATYLSL PSTKAELEEK GHSATGKSMQ SLGSCTISKD 
SFQISTLVCS TKLTQNVDLL GLLKWRSNTS LLQQNLRQLM KVDGGEVVKF LQDTLDALFN 
IMMENSESET FDTLVFDALV FIIGLIADRK FQHFNPVLET YIKKHFSATL AYTKLTKVLK 
NYVDGAEKPG VNEQLYKAMK ALESIFKFIV RSRILFNQLY ENKGEADFVE SLLQLFRSIN 
DMMSSMSDQT VRVKGAALKY LPTIVNDVKL VFDPKELSKM FTEFILNVPM GLLTIQKLYC 
LIEIVHSDLF TQHDCREILL PMMTDQLKYH LERQEDLEAC CQLLSHILEV LYRKDVGPTQ 
RHVQIIMEKL LRTVNRTVIS MGRDSELIGN FVACMTAILR QMEDYHYAHL IKTFGKMRTD 
VVDFLMETFI MFKNLIGKNV YPFDWVIMNM VQNKVFLRAI NQYADMLNKK FLDQANFELQ 
LWNNYFHLAV AFLTQESLQL ENFSSAKRAK ILNKYGDMRR QIGFEIRDMW YNLGQHKIKF 
IPEMVGPILE MTLIPETELR KATIPIFFDM MQCEFHSTRS FQMFENEIIT KLDHEVEGGR 
GDEQYKVLFD KILLEHCRKH KYLAKTGETF VKLVVRLMER LLDYRTIMHD ENKENRMSCT 
VNVLNFYKEI EREEMYIRYL YKLCDLHKEC DNYTEAAYTL LLHAKLLKWS EDVCVAHLTQ 
RDGYQATTQG QLKEQLYQEI IHYFDKGKMW EEAIALGKEL AEQYENEMFD YEQLSELLKK 
QAQFYENIVK VIRPKPDYFA VGYYGQGFPT FLRGKVFIYR GKEYERREDF EARLLTQFPN 
AEKMKTTSPP GDDIKNSPGQ YIQCFTVKPK LDLPPKFHRP VSEQIVSFYR VNEVQRFEYS 
RPIRKGEKNP DNEFANMWIE RTIYTTAYKL PGILRWFEVK SVFMVEISPL ENAIETMQLT 
NDKINSMVQQ HLDDPSLPIN PLSMLLNGIV DPAVMGGFAN YEKAFFTDRY LQEHPEAHEK 
IEKLKDLIAW QIPFLAEGIR IHGDKVTEAL RPFHERMEAC FKQLKEKVEK EYGVRIMPSS 
LDDRRGSRPR SMVRSFTMPS SSRPLSVASV SSLSSDSTPS RPGSDGFALE PLLPKKMHSR 
SQDKLDKDDL EKEKKDKKKE KRNSKHQEIF EKEFKPTDIS LQQSEAVILS ETISPLRPQR 
PKSQVMNVIG SERRFSVSPS SPSSQQTPPP VTPRAKLSFS MQSSLELNGM TGADVADVPP 
PLPLKGSVAD YGNLMENQDL LGSPTPPPPP PHQRHLPPPL PSKTPPPPPP KTTRKQASVD 
SGIVQ

Genular Protein ID: 3138519469

Symbol: A0A2X0U2H5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A2X0U2H5

Database IDs:

ARBA 4 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 5 InterPro 16 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 6 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 2

Sequence Information:

  • Length: 1865
  • Mass: 215376
  • Checksum: 840D5AFD047EBEDE
  • Sequence:
    • MTRWVPTKRE EKYGVAFYNY DARGADELSL QIGDTVHILE TYEGWYRGYT LRKKSKKGIF 
PASYIHLKEA IVEGKGQHET VIPGDLPLIQ EVTTTLREWS TIWRQLYVQD NREMFRSVRH 
MIYDLIEWRS QILSGTLPQD ELKELKKKVT AKIDYGNRIL DLDLVVRDED GNILDPELTS 
TISLFRAHEI ASKQVEERLQ EEKSQKQNID INRQAKFAAT PSLALFVNLK NVVCKIGEDA 
EVLMSLYDPV ESKFISENYL VRWSSSGLPK DIDRLHNLRA VFTDLGSKDL KREKISFVCQ 
IVRVGRMELR DNNTRKLTSG LRRPFGVAVM DVTDIINGKV DDEDKQHFIP FQPVAGENDF 
LQTVINKVIA AKEVNHKGQG LWVTLKLLPG DIHQIRKEFP HLVDRTTAVA RKTGFPEIIM 
PGDVRNDIYV TLVQGDFDKG SKTTAKNVEV TVSVYDEDGK RLEHVIFPGA GDEAISEYKS 
VIYYQVKQPR WFETVKVAIP IEDVNRSHLR FTFRHRSSQD SKDKSEKIFA LAFVKLMRYD 
GTTLRDGEHD LIVYKAEAKK LEDAATYLSL PSTKAELEEK GHSATGKSMQ SLGSCTISKD 
SFQISTLVCS TKLTQNVDLL GLLKWRSNTS LLQQNLRQLM KVDGGEVVKF LQDTLDALFN 
IMMENSESET FDTLVFDALV FIIGLIADRK FQHFNPVLET YIKKHFSATL AYTKLTKVLK 
NYVDGAEKPG VNEQLYKAMK ALESIFKFIV RSRILFNQLY ENKGEADFVE SLLQLFRSIN 
DMMSSMSDQT VRVKGAALKY LPTIVNDVKL VFDPKELSKM FTEFILNVPM GLLTIQKLYC 
LIEIVHSDLF TQHDCREILL PMMTDQLKYH LERQEDLEAC CQLLSHILEV LYRKDVGPTQ 
RHVQIIMEKL LRTVNRTVIS MGRDSELIGN FVACMTAILR QMEDYHYAHL IKTFGKMRTD 
VVDFLMETFI MFKNLIGKNV YPFDWVIMNM VQNKVFLRAI NQYADMLNKK FLDQANFELQ 
LWNNYFHLAV AFLTQESLQL ENFSSAKRAK ILNKYGDMRR QIGFEIRDMW YNLGQHKIKF 
IPEMVGPILE MTLIPETELR KATIPIFFDM MQCEFHSTRS FQMFENEIIT KLDHEVEGGR 
GDEQYKVLFD KILLEHCRKH KYLAKTGETF VKLVVRLMER LLDYRTIMHD ENKENRMSCT 
VNVLNFYKEI EREEMYIRYL YKLCDLHKEC DNYTEAAYTL LLHAKLLKWS EDVCVAHLTQ 
RDGYQATTQG QLKEQLYQEI IHYFDKGKMW EEAIALGKEL AEQYENEMFD YEQLSELLKK 
QAQFYENIVK VIRPKPDYFA VGYYGQGFPT FLRGKVFIYR GKEYERREDF EARLLTQFPN 
AEKMKTTSPP GDDIKNSPGQ YIQCFTVKPK LDLPPKFHRP VSEQIVSFYR VNEVQRFEYS 
RPIRKGEKNP DNEFANMWIE RTIYTTAYKL PGILRWFEVK SVFMVEISPL ENAIETMQLT 
NDKINSMVQQ HLDDPSLPIN PLSMLLNGIV DPAVMGGFAN YEKAFFTDRY LQEHPEAHEK 
IEKLKDLIAW QIPFLAEGIR IHGDKVTEAL RPFHERMEAC FKQLKEKVEK EYGVRIMPSS 
LDDRRGSRPR SMVRSFTMPS SSRPLSVASV SSLSSDSTPS RPGSDGFALE PLLPKKMHSR 
SQDKLDKDDL EKEKKDKKKE KRNSKHQEIF EKEFKPTDIS LQQSEAVILS ETISPLRPQR 
PKSQVMNVIG SERRFSVSPS SPSSQQTPPP VTPRAKLSFS MQSSLELNGM TGADVADVPP 
PLPLKGSVAD YGNLMENQDL LGSPTPPPPP PHQRHLPPPL PSKTPPPPPP KTTRKQTSVD 
SGIVQ

Genular Protein ID: 1000778939

Symbol: B2RUU3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RUU3

Database IDs:

ARBA 4 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 5 InterPro 16 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 6 RefSeq 2 SAM 2 SMART 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1865
  • Mass: 215377
  • Checksum: 8DBC33E2226EF4E8
  • Sequence:
    • MTRWVPTKRE EKYGVAFYNY DARGADELSL QIGDTVHILE TYEGWYRGYT LRKKSKKGIF 
PASYIHLKEA IVEGKGQHET VIPGDLPLIQ EVTTTLREWS TIWRQLYVQD NREMFRSVRH 
MIYDLIEWRS QILSGTLPQD ELKELKKKVT AKIDYGNRIL DLDLVVRDED GNILDPELTS 
TISLFRAHEI ASKQVEERLQ EEKSQKQNID INRQAKFAAT PSLALFVNLK NVVCKIGEDA 
EVLMSLYDPV ESKFISENYL VRWSSSGLPK DIDRLHNLRA VFTDLGSKDL KREKISFVCQ 
IVRVGRMELR DNNTRKLTSG LRRPFGVAVM DVTDIINGKV DDEDKQHFIP FQPVAGENDF 
LQTVINKVIA AKEVNHKGQG LWVTLKLLPG DIHQIRKEFP HLVDRTTAVA RKTGFPEIIM 
PGDVRNDIYV TLVQGDFDKG SKTTAKNVEV TVSVYDEDGK RLEHVIFPGA GDEAISEYKS 
VIYYQVKQPR WFETVKVAIP IEDVNRSHLR FTFRHRSSQD SKDKSEKIFA LAFVKLMRYD 
GTTLRDGEHD LIVYKAEAKK LEDAATYLSL PSTKAELEEK GHSATGKSMQ SLGSCTISKD 
SFQISTLVCS TKLTQNVDLL GLLKWRSNTS LLQQNLRQLM KVDGGEVVKF LQDTLDALFN 
IMMENSESET FDTLVFDALV FIIGLIADRK FQHFNPVLET YIKKHFSATL AYTKLTKVLK 
NYVDGAEKPG VNEQLYKAMK ALESIFKFIV RSRILFNQLY ENKGEADFVE SLLQLFRSIN 
DMMSSMSDQT VRVKGAALKY LPTIVNDVKL VFDPKELSKM FTEFILNVPM GLLTIQKLYC 
LIEIVHSDLF TQHDCREILL PMMTDQLKYH LERQEDLEAC CQLLSHILEV LYRKDVGPTQ 
RHVQIIMEKL LRTVNRTVIS MGRDSELIGN FVACMTAILR QMEDYHYAHL IKTFGKMRTD 
VVDFLMETFI MFKNLIGKNV YPFDWVIMNM VQNKVFLRAI NQYADMLNKK FLDQANFELQ 
LWNNYFHLAV AFLTQESLQL ENFSSAKRAK ILNKYGDMRR QIGFEIRDMW YNLGQHKIKF 
IPEMVGPILE MTLIPETELR KATIPIFFDM MQCEFHSTRS FQMFENEIIT KLDHEVEGGR 
GDEQYKVLFD KILLEHCRKH KYLAKTGETF VKLVVRLMER LLDYRTIMHD ENKENRMSCT 
VNVLDFYKEI EREEMYIRYL YKLCDLHKEC DNYTEAAYTL LLHAKLLKWS EDVCVAHLTQ 
RDGYQATTQG QLKEQLYQEI IHYFDKGKMW EEAIALGKEL AEQYENEMFD YEQLSELLKK 
QAQFYENIVK VIRPKPDYFA VGYYGQGFPT FLRGKVFIYR GKEYERREDF EARLLTQFPN 
AEKMKTTSPP GDDIKNSPGQ YIQCFTVKPK LDLPPKFHRP VSEQIVSFYR VNEVQRFEYS 
RPIRKGEKNP DNEFANMWIE RTIYTTAYKL PGILRWFEVK SVFMVEISPL ENAIETMQLT 
NDKINSMVQQ HLDDPSLPIN PLSMLLNGIV DPAVMGGFAN YEKAFFTDRY LQEHPEAHEK 
IEKLKDLIAW QIPFLAEGIR IHGDKVTEAL RPFHERMEAC FKQLKEKVEK EYGVRIMPSS 
LDDRRGSRPR SMVRSFTMPS SSRPLSVASV SSLSSDSTPS RPGSDGFALE PLLPKKMHSR 
SQDKLDKDDL EKEKKDKKKE KRNSKHQEIF EKEFKPTDIS LQQSEAVILS ETISPLRPQR 
PKSQVMNVIG SERRFSVSPS SPSSQQTPPP VTPRAKLSFS MQSSLELNGM TGADVADVPP 
PLPLKGSVAD YGNLMENQDL LGSPTPPPPP PHQRHLPPPL PSKTPPPPPP KTTRKQTSVD 
SGIVQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.