Details for: DOCK2

Gene ID: 1794

Symbol: DOCK2

Ensembl ID: ENSG00000134516

Description: dedicator of cytokinesis 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 105.3713
    Cell Significance Index: -16.3900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 46.4484
    Cell Significance Index: -18.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 45.4575
    Cell Significance Index: -11.5300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 38.7939
    Cell Significance Index: -19.9600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.1992
    Cell Significance Index: -19.2900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.2770
    Cell Significance Index: -16.3700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.4288
    Cell Significance Index: -14.0700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.1668
    Cell Significance Index: -16.5200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.7823
    Cell Significance Index: -17.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.2600
    Cell Significance Index: -16.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 3.8079
    Cell Significance Index: 121.9600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.2794
    Cell Significance Index: 42.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.8890
    Cell Significance Index: 40.9300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.2001
    Cell Significance Index: 141.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9888
    Cell Significance Index: 188.1800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8239
    Cell Significance Index: 81.5100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.8224
    Cell Significance Index: 22.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6533
    Cell Significance Index: 589.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5951
    Cell Significance Index: 38.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5315
    Cell Significance Index: 32.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3836
    Cell Significance Index: 62.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3790
    Cell Significance Index: 11.1300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.3030
    Cell Significance Index: 2.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2855
    Cell Significance Index: 19.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2838
    Cell Significance Index: 56.9300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2655
    Cell Significance Index: 28.8800
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.2318
    Cell Significance Index: 1.4800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1288
    Cell Significance Index: 3.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1137
    Cell Significance Index: 209.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1087
    Cell Significance Index: 21.5800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0957
    Cell Significance Index: 0.9600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0510
    Cell Significance Index: 95.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0434
    Cell Significance Index: 66.7400
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.0023
    Cell Significance Index: 0.0200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0036
    Cell Significance Index: -0.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0067
    Cell Significance Index: -9.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0076
    Cell Significance Index: -2.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0083
    Cell Significance Index: -0.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0154
    Cell Significance Index: -0.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0162
    Cell Significance Index: -0.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0212
    Cell Significance Index: -16.0700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0216
    Cell Significance Index: -1.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0235
    Cell Significance Index: -17.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0237
    Cell Significance Index: -15.0700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0251
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0287
    Cell Significance Index: -17.9400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0296
    Cell Significance Index: -0.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0304
    Cell Significance Index: -16.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0318
    Cell Significance Index: -17.9300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0326
    Cell Significance Index: -14.8100
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0387
    Cell Significance Index: -0.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0451
    Cell Significance Index: -12.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0454
    Cell Significance Index: -2.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0554
    Cell Significance Index: -3.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0588
    Cell Significance Index: -4.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0705
    Cell Significance Index: -7.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0727
    Cell Significance Index: -13.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0787
    Cell Significance Index: -11.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0805
    Cell Significance Index: -13.7400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0840
    Cell Significance Index: -1.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0848
    Cell Significance Index: -17.8700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1048
    Cell Significance Index: -14.4000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1055
    Cell Significance Index: -2.7000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1114
    Cell Significance Index: -6.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1335
    Cell Significance Index: -16.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1346
    Cell Significance Index: -17.3900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1384
    Cell Significance Index: -2.8700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1463
    Cell Significance Index: -2.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1512
    Cell Significance Index: -15.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1564
    Cell Significance Index: -17.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1796
    Cell Significance Index: -8.4400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1827
    Cell Significance Index: -7.9500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1848
    Cell Significance Index: -23.6900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2342
    Cell Significance Index: -4.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2435
    Cell Significance Index: -18.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2859
    Cell Significance Index: -14.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2860
    Cell Significance Index: -16.0500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3009
    Cell Significance Index: -5.1100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3026
    Cell Significance Index: -4.5600
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.3098
    Cell Significance Index: -0.8300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3274
    Cell Significance Index: -4.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3342
    Cell Significance Index: -15.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3345
    Cell Significance Index: -17.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3441
    Cell Significance Index: -15.2200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3556
    Cell Significance Index: -2.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3586
    Cell Significance Index: -18.6800
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.3627
    Cell Significance Index: -2.6100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3636
    Cell Significance Index: -7.1900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3821
    Cell Significance Index: -7.4700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3861
    Cell Significance Index: -14.6200
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: -0.3998
    Cell Significance Index: -4.4800
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.4012
    Cell Significance Index: -4.1600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4042
    Cell Significance Index: -14.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4093
    Cell Significance Index: -13.4000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4184
    Cell Significance Index: -8.4000
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.4370
    Cell Significance Index: -4.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4426
    Cell Significance Index: -12.3700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4460
    Cell Significance Index: -11.9500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4498
    Cell Significance Index: -16.5100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4575
    Cell Significance Index: -14.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DOCK2 is a guanine nucleotide exchange factor (GEF) that activates the Rho GTPase family, including Rac1, Rac2, RhoA, and Rhog. This activation promotes actin cytoskeleton organization, cell migration, and intracellular signaling pathways. DOCK2's expression is regulated by various post-translational modifications, including phosphorylation and ubiquitination. DOCK2's interaction with other proteins, such as Nef and the HIV-1 Gag protein, modulates its activity and subcellular localization. **Pathways and Functions:** DOCK2's involvement in various signaling pathways highlights its complex functions in immune cell migration, signaling, and viral infection. Some of the key pathways and functions of DOCK2 include: 1. **Actin Cytoskeleton Organization:** DOCK2 regulates actin cytoskeleton organization by activating the Rho GTPase family, which in turn modulates actin polymerization and cell migration. 2. **Immune Cell Migration:** DOCK2 promotes immune cell migration by regulating the actin cytoskeleton and intracellular signaling pathways, such as the MAPK/ERK and PI3K/Akt pathways. 3. **Intracellular Signaling:** DOCK2 modulates intracellular signaling pathways, including the JAK/STAT and NF-κB pathways, which are involved in immune responses and inflammation. 4. **Viral Infection:** DOCK2's interaction with the HIV-1 Gag protein and Nef protein modulates its activity and subcellular localization, which in turn affects viral replication and disease pathogenesis. 5. **Cell Polarity:** DOCK2 regulates cell polarity by modulating the actin cytoskeleton and intracellular signaling pathways, which are essential for immune cell function and development. **Clinical Significance:** DOCK2's involvement in immune responses, viral infection, and disease pathogenesis highlights its importance as a therapeutic target for treating immune-related disorders and infections. Some potential clinical applications of DOCK2 include: 1. **Immunotherapy:** Targeting DOCK2 could lead to the development of novel immunotherapies for treating immune-related disorders, such as cancer and autoimmune diseases. 2. **Viral Infection:** DOCK2's interaction with viral proteins, such as the HIV-1 Gag protein and Nef protein, makes it a potential target for developing antiviral therapies. 3. **Inflammatory Diseases:** DOCK2's regulation of intracellular signaling pathways, such as the JAK/STAT and NF-κB pathways, makes it a potential target for developing novel treatments for inflammatory diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, DOCK2 is a multifunctional protein that plays a crucial role in various cellular processes, including immune cell migration, signaling, and viral infection. Its complex functions highlight its importance as a therapeutic target for treating immune-related disorders and infections.

Genular Protein ID: 2244913661

Symbol: DOCK2_HUMAN

Name: Dedicator of cytokinesis protein 2

UniProtKB Accession Codes:

Q92608 Q2M3I0 Q96AK7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 4 EMDB 2 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 15 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 7 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9039502

Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

PubMed ID: 9039502

DOI: 10.1093/dnares/3.5.321

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10559471

Title: Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins.

PubMed ID: 10559471

DOI: 10.1016/s0167-4889(99)00133-0

PubMed ID: 12393632

Title: DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines.

PubMed ID: 12393632

DOI: 10.1182/blood-2001-11-0032

PubMed ID: 12176041

Title: DOCK2 mediates T cell receptor-induced activation of Rac2 and IL-2 transcription.

PubMed ID: 12176041

DOI: 10.1016/s0006-291x(02)00931-2

PubMed ID: 12432077

Title: Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.

PubMed ID: 12432077

DOI: 10.1242/jcs.00219

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26083206

Title: Inherited DOCK2 deficiency in patients with early-onset invasive infections.

PubMed ID: 26083206

DOI: 10.1056/nejmoa1413462

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 21613211

Title: Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis (DOCK) nucleotide exchange factors.

PubMed ID: 21613211

DOI: 10.1074/jbc.m111.236455

Sequence Information:

  • Length: 1830
  • Mass: 211948
  • Checksum: 18568D3322DAA92A
  • Sequence:
    • MAPWRKADKE RHGVAIYNFQ GSGAPQLSLQ IGDVVRIQET CGDWYRGYLI KHKMLQGIFP 
KSFIHIKEVT VEKRRNTENI IPAEIPLAQE VTTTLWEWGS IWKQLYVASK KERFLQVQSM 
MYDLMEWRSQ LLSGTLPKDE LKELKQKVTS KIDYGNKILE LDLIVRDEDG NILDPDNTSV 
ISLFHAHEEA TDKITERIKE EMSKDQPDYA MYSRISSSPT HSLYVFVRNF VCRIGEDAEL 
FMSLYDPNKQ TVISENYLVR WGSRGFPKEI EMLNNLKVVF TDLGNKDLNR DKIYLICQIV 
RVGKMDLKDT GAKKCTQGLR RPFGVAVMDI TDIIKGKAES DEEKQHFIPF HPVTAENDFL 
HSLLGKVIAS KGDSGGQGLW VTMKMLVGDI IQIRKDYPHL VDRTTVVARK LGFPEIIMPG 
DVRNDIYITL LQGDFDKYNK TTQRNVEVIM CVCAEDGKTL PNAICVGAGD KPMNEYRSVV 
YYQVKQPRWM ETVKVAVPIE DMQRIHLRFM FRHRSSLESK DKGEKNFAMS YVKLMKEDGT 
TLHDGFHDLV VLKGDSKKME DASAYLTLPS YRHHVENKGA TLSRSSSSVG GLSVSSRDVF 
SISTLVCSTK LTQNVGLLGL LKWRMKPQLL QENLEKLKIV DGEEVVKFLQ DTLDALFNIM 
MEHSQSDEYD ILVFDALIYI IGLIADRKFQ HFNTVLEAYI QQHFSATLAY KKLMTVLKTY 
LDTSSRGEQC EPILRTLKAL EYVFKFIVRS RTLFSQLYEG KEQMEFEESM RRLFESINNL 
MKSQYKTTIL LQVAALKYIP SVLHDVEMVF DAKLLSQLLY EFYTCIPPVK LQKQKVQSMN 
EIVQSNLFKK QECRDILLPV ITKELKELLE QKDDMQHQVL ERKYCVELLN SILEVLSYQD 
AAFTYHHIQE IMVQLLRTVN RTVITMGRDH ILISHFVACM TAILNQMGDQ HYSFYIETFQ 
TSSELVDFLM ETFIMFKDLI GKNVYPGDWM AMSMVQNRVF LRAINKFAET MNQKFLEHTN 
FEFQLWNNYF HLAVAFITQD SLQLEQFSHA KYNKILNKYG DMRRLIGFSI RDMWYKLGQN 
KICFIPGMVG PILEMTLIPE AELRKATIPI FFDMMLCEYQ RSGDFKKFEN EIILKLDHEV 
EGGRGDEQYM QLLESILMEC AAEHPTIAKS VENFVNLVKG LLEKLLDYRG VMTDESKDNR 
MSCTVNLLNF YKDNNREEMY IRYLYKLRDL HLDCDNYTEA AYTLLLHTWL LKWSDEQCAS 
QVMQTGQQHP QTHRQLKETL YETIIGYFDK GKMWEEAISL CKELAEQYEM EIFDYELLSQ 
NLIQQAKFYE SIMKILRPKP DYFAVGYYGQ GFPSFLRNKV FIYRGKEYER REDFQMQLMT 
QFPNAEKMNT TSAPGDDVKN APGQYIQCFT VQPVLDEHPR FKNKPVPDQI INFYKSNYVQ 
RFHYSRPVRR GTVDPENEFA SMWIERTSFV TAYKLPGILR WFEVVHMSQT TISPLENAIE 
TMSTANEKIL MMINQYQSDE TLPINPLSML LNGIVDPAVM GGFAKYEKAF FTEEYVRDHP 
EDQDKLTHLK DLIAWQIPFL GAGIKIHEKR VSDNLRPFHD RMEECFKNLK MKVEKEYGVR 
EMPDFDDRRV GRPRSMLRSY RQMSIISLAS MNSDCSTPSK PTSESFDLEL ASPKTPRVEQ 
EEPISPGSTL PEVKLRRSKK RTKRSSVVFA DEKAAAESDL KRLSRKHEFM SDTNLSEHAA 
IPLKASVLSQ MSFASQSMPT IPALALSVAG IPGLDEANTS PRLSQTFLQL SDGDKKTLTR 
KKVNQFFKTM LASKSAEEGK QIPDSLSTDL

Genular Protein ID: 926818648

Symbol: Q5XG91_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5XG91

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 2 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 SAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 617
  • Mass: 71419
  • Checksum: 31CC6C0FE1AEDEF7
  • Sequence:
    • NNREEMYIRY LYKLRDLHLD CDNYTEAAYT LLLHTWLLKW SDEQCASQVM QTGQQHPQTH 
RQLKETLYET IIGYFDKGKM WEEAISLCKE LAEQYEMEIF DYELLSQNLI QQAKFYESIM 
KILRPKPDYF AVGYYGQGFP SFLRNKVFIY RGKEYERRED FQMQLMTQFP NAEKMNTTSA 
PGDDVKNAPG QYIQCFTVQP VLDEHPRFKN KPVPDQIINF YKSNYVQRFH YSRPVRRGTV 
DPENEFASMW IERTSFVTAY KLPGILRWFE VVHMSQTTIS PLENAIETMS TANEKILMMI 
NQYQSDETLP INPLSMLLNG IVDPAVMGGF AKYEKAFFTE EYVRDHPEDQ DKLTHLKDLI 
AWQIPFLGAG IKIHEKRVSD NLRPFHDRME ECFKNLKMKV EKEYGVREMP DFDDRRVGRP 
RSMLRSYRQM SIISLASMNS DCSTPSKPTS ESFDLELASP KTPRVEQEEP ISPGSTLPEV 
KLRRSKKRTK RSSVVFADEK AAAESDLKRL SRKHEFMSDT NLSEHAAIPL KASVLSQMSF 
ASQSMPTIPA LALSVAGIPG LDEANTSPRL SQTFLQLSDG DKKTLTRKKV NQFFKTMLAS 
KSAEEGKQIP DSLSTDL

Genular Protein ID: 335637459

Symbol: H0YB76_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0YB76

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChiTaRS 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 3 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 7 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 2 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 957
  • Mass: 110151
  • Checksum: 5F5FAD8EF3D308D6
  • Sequence:
    • MAPWRKADKE RHGVAIYNFQ GSGAPQLSLQ IGDVVRIQET CGDWYRGYLI KHKMLQGIFP 
KSFIHIKEVT VEKRRNTENI IPAEIPLAQE VTTTLWEWGS IWKQLYVASK KERFLQVQSM 
MYDLMEWRSQ LLSGTLPKDE LKELKQKVTS KIDYGNKILE LDLIVRDEDG NILDPDNTSV 
ISLFHAHEEA TDKITERIKE EMSKDQPDYA MYSRISSSPT HSLYVFVRNF VCRIGEDAEL 
FMSLYDPNKQ TVISENYLVR WGSRGFPKEI EMLNNLKVVF TDLGNKDLNR DKIYLICQIV 
RVGKMDLKDT GAKKCTQGLR RPFGVAVMDI TDIIKGKAES DEEKQHFIPF HPVTAENDFL 
HSLLGKVIAS KGDSGGQGLW VTMKMLVGDI IQIRKDYPHL VDRTTVVARK LGFPEIIMPG 
DVRNDIYITL LQGDFDKYNK TTQRNVEVIM CVCAEDGKTL PNAICVGAGD KPMNEYRSVV 
YYQVKQPRWM ETVKVAVPIE DMQRIHLRFM FRHRSSLESK DKGEKNFAMS YVKLMKEDGT 
TLHDGFHDLV VLKGDSKKME DASAYLTLPS YRHHVENKGA TLSRSSSSVG GLSVSSRDVF 
SISTLVCSTK LTQNVGLLGL LKWRMKPQLL QENLEKLKIV DGEEVVKFLQ DTLDALFNIM 
MEHSQSDEYD ILVFDALIYI IGLIADRKFQ HFNTVLEAYI QQHFSATLAY KKLMTVLKTY 
LDTSSRGEQC EPILRTLKAL EYVFKFIVRS RTLFSQLYEG KEQMEFEESM RRLFESINNL 
MKSQYKTTIL LQVAALKYIP SVLHDVEMVF DAKLLSQLLY EFYTCIPPVK LQKQKVQSMN 
EIVQSNLFKK QECRDILLPV ITKELKELLE QKDDMQHQVL ERKYCVELLN SILEVLSYQD 
AAFTYHHIQE IMVQLLRTVN RTVITMGRDH ILIDAADDRT EPIGCYGVLN VIVSAKG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.