Details for: DXO

Gene ID: 1797

Symbol: DXO

Ensembl ID: ENSG00000204348

Description: decapping exoribonuclease

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 71.4262
    Cell Significance Index: -11.1100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 39.3072
    Cell Significance Index: -9.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 27.3552
    Cell Significance Index: -12.9200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 26.8303
    Cell Significance Index: -10.9000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.5319
    Cell Significance Index: -11.0100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.5624
    Cell Significance Index: -11.7900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.9476
    Cell Significance Index: -10.5800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.6180
    Cell Significance Index: 59.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.0537
    Cell Significance Index: -12.0500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.8032
    Cell Significance Index: -8.6100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.4895
    Cell Significance Index: -3.2600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.4517
    Cell Significance Index: 23.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8775
    Cell Significance Index: 792.3500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7763
    Cell Significance Index: 46.6100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7178
    Cell Significance Index: 78.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6527
    Cell Significance Index: 64.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5959
    Cell Significance Index: 96.9300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5507
    Cell Significance Index: 14.9900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4579
    Cell Significance Index: 9.9200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4467
    Cell Significance Index: 12.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4032
    Cell Significance Index: 76.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3772
    Cell Significance Index: 26.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2970
    Cell Significance Index: 4.9700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.2876
    Cell Significance Index: 8.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2748
    Cell Significance Index: 37.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2660
    Cell Significance Index: 13.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2253
    Cell Significance Index: 11.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2190
    Cell Significance Index: 13.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2069
    Cell Significance Index: 9.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1990
    Cell Significance Index: 9.2800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1957
    Cell Significance Index: 6.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1907
    Cell Significance Index: 12.3100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1856
    Cell Significance Index: 2.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1855
    Cell Significance Index: 8.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1854
    Cell Significance Index: 21.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1708
    Cell Significance Index: 2.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1624
    Cell Significance Index: 3.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1579
    Cell Significance Index: 86.2500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1554
    Cell Significance Index: 1.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1471
    Cell Significance Index: 10.9600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1434
    Cell Significance Index: 3.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1367
    Cell Significance Index: 3.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1300
    Cell Significance Index: 57.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1243
    Cell Significance Index: 22.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1037
    Cell Significance Index: 12.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1015
    Cell Significance Index: 13.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0984
    Cell Significance Index: 12.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0956
    Cell Significance Index: 19.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0727
    Cell Significance Index: 5.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0595
    Cell Significance Index: 11.8000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0585
    Cell Significance Index: 2.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0488
    Cell Significance Index: 1.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0453
    Cell Significance Index: 16.2600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0445
    Cell Significance Index: 2.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0243
    Cell Significance Index: 16.8000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0176
    Cell Significance Index: 0.8900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0128
    Cell Significance Index: 0.2200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0119
    Cell Significance Index: 0.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0117
    Cell Significance Index: 2.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0054
    Cell Significance Index: 3.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0050
    Cell Significance Index: 9.4900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0036
    Cell Significance Index: -6.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0040
    Cell Significance Index: -2.9100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0042
    Cell Significance Index: -3.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0046
    Cell Significance Index: -7.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0089
    Cell Significance Index: -12.0500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0113
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0124
    Cell Significance Index: -9.1900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0141
    Cell Significance Index: -0.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0166
    Cell Significance Index: -7.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0173
    Cell Significance Index: -9.7600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0176
    Cell Significance Index: -0.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0178
    Cell Significance Index: -1.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0237
    Cell Significance Index: -14.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0285
    Cell Significance Index: -3.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0360
    Cell Significance Index: -5.2400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0367
    Cell Significance Index: -0.3800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0413
    Cell Significance Index: -0.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0428
    Cell Significance Index: -12.3200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0509
    Cell Significance Index: -1.3000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0560
    Cell Significance Index: -2.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0617
    Cell Significance Index: -12.9900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0690
    Cell Significance Index: -0.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0719
    Cell Significance Index: -5.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0746
    Cell Significance Index: -8.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1005
    Cell Significance Index: -5.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1049
    Cell Significance Index: -2.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1116
    Cell Significance Index: -11.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1165
    Cell Significance Index: -3.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1170
    Cell Significance Index: -3.1300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1259
    Cell Significance Index: -1.0700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1262
    Cell Significance Index: -1.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1285
    Cell Significance Index: -10.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1290
    Cell Significance Index: -3.7900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1638
    Cell Significance Index: -1.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1990
    Cell Significance Index: -12.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2075
    Cell Significance Index: -9.1800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2420
    Cell Significance Index: -5.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2452
    Cell Significance Index: -8.5900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2531
    Cell Significance Index: -9.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The DXO gene exhibits the following key characteristics: * **5'-3' exonuclease activity**: DXO possesses the ability to degrade RNA from the 5' to 3' end, allowing for the precise regulation of mRNA stability and translation. * **NAD-cap dependent activity**: DXO requires NAD+ (nicotinamide adenine dinucleotide) as a cofactor to perform its decapping function, highlighting the intricate relationship between RNA metabolism and redox balance. * **Widespread tissue expression**: DXO is significantly expressed in various cell types, including immune cells, epithelial cells, and stem cells, suggesting a conserved role in tissue development and maintenance. * **Regulation of gene expression**: By controlling mRNA stability and translation, DXO plays a critical role in modulating gene expression and responding to cellular stress and environmental cues. **Pathways and Functions:** DXO is involved in several key pathways and processes, including: * **RNA catabolic process**: DXO participates in the degradation of mRNA, thereby regulating gene expression and maintaining cellular homeostasis. * **NAD-cap decapping**: DXO-dependent decapping of mRNA requires NAD+ as a cofactor, highlighting the importance of redox balance in RNA metabolism. * **Nuclear-transcribed mRNA catabolic process**: DXO regulates the degradation of nuclear-transcribed mRNA, ensuring the proper termination of transcription and translation. * **RNA destabilization**: DXO contributes to the destabilization of specific mRNAs, allowing for the regulation of gene expression in response to cellular stress and environmental cues. **Clinical Significance:** Dysregulation of the DXO gene has been implicated in various diseases, including: * **Cancer**: Altered DXO expression has been observed in various types of cancer, suggesting a potential role in tumorigenesis and metastasis. * **Neurodegenerative disorders**: DXO dysfunction has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's, highlighting the importance of RNA metabolism in maintaining neuronal health. * **Immune system dysregulation**: DXO expression is critical for the regulation of immune responses, and dysregulation of this gene may contribute to immune system dysfunction and autoimmune diseases. In conclusion, the DXO gene plays a vital role in regulating RNA metabolism and maintaining cellular homeostasis. Further research is needed to fully elucidate the mechanisms by which DXO functions and to explore its potential as a therapeutic target in various diseases.

Genular Protein ID: 3456401345

Symbol: DXO_HUMAN

Name: N/A

UniProtKB Accession Codes:

O77932 A2CER3 B0UZ80 O15004 O78127 O78128 Q5ST60 Q6IPZ2 Q9NPK4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 38 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 18 ExpressionAtlas 1 GO 16 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 Rhea 24 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9799600

Title: Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA.

PubMed ID: 9799600

DOI: 10.1006/geno.1998.5499

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10686478

Title: Organizations and gene duplications of the human and mouse MHC complement gene clusters.

PubMed ID: 10686478

DOI: 10.1159/000019119

PubMed ID: 21750099

Title: Unraveling regulation and new components of human P-bodies through a protein interaction framework and experimental validation.

PubMed ID: 21750099

DOI: 10.1261/rna.2789611

PubMed ID: 28283058

Title: 5' end nicotinamide adenine dinucleotide cap in human cells promotes RNA decay through DXO-mediated deNADding.

PubMed ID: 28283058

DOI: 10.1016/j.cell.2017.02.019

PubMed ID: 29601584

Title: 2'-O-methylation of the mRNA cap protects RNAs from decapping and degradation by DXO.

PubMed ID: 29601584

DOI: 10.1371/journal.pone.0193804

PubMed ID: 31101919

Title: Structural and mechanistic basis of mammalian Nudt12 RNA deNADding.

PubMed ID: 31101919

DOI: 10.1038/s41589-019-0293-7

PubMed ID: 32374864

Title: DXO/Rai1 enzymes remove 5'-end FAD and dephospho-CoA caps on RNAs.

PubMed ID: 32374864

DOI: 10.1093/nar/gkaa297

Sequence Information:

  • Length: 396
  • Mass: 44929
  • Checksum: 17C8119037EB6892
  • Sequence:
    • MDPRGTKRGA EKTEVAEPRN KLPRPAPSLP TDPALYSGPF PFYRRPSELG CFSLDAQRQY 
HGDARALRYY SPPPTNGPGP NFDLRDGYPD RYQPRDEEVQ ERLDHLLCWL LEHRGRLEGG 
PGWLAEAIVT WRGHLTKLLT TPYERQEGWQ LAASRFQGTL YLSEVETPNA RAQRLARPPL 
LRELMYMGYK FEQYMCADKP GSSPDPSGEV NTNVAFCSVL RSRLGSHPLL FSGEVDCTDP 
QAPSTQPPTC YVELKTSKEM HSPGQWRSFY RHKLLKWWAQ SFLPGVPNVV AGFRNPDGFV 
SSLKTFPTMK MFEYVRNDRD GWNPSVCMNF CAAFLSFAQS TVVQDDPRLV HLFSWEPGGP 
VTVSVHQDAP YAFLPIWYVE AMTQDLPSPP KTPSPK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.