Gene DPYD - ENSG00000188641 | NCBI Gene ID: 1806

Details for: DPYD

Gene ID: 1806

Symbol: DPYD

Ensembl ID: ENSG00000188641

Description: dihydropyrimidine dehydrogenase

Associated with

Metabolism
(R-HSA-1430728)
Metabolism of nucleotides
(R-HSA-15869)
Nucleotide catabolism
(R-HSA-8956319)
Pyrimidine catabolism
(R-HSA-73621)
4 iron, 4 sulfur cluster binding
(GO:0051539)
Beta-alanine biosynthetic process
(GO:0019483)
Cmp catabolic process
(GO:0006248)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dcmp catabolic process
(GO:0006249)
Dihydropyrimidine dehydrogenase (nadp+) activity
(GO:0017113)
Dump catabolic process
(GO:0046079)
Flavin adenine dinucleotide binding
(GO:0050660)
Metal ion binding
(GO:0046872)
Nadp binding
(GO:0050661)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Purine nucleobase catabolic process
(GO:0006145)
Pyrimidine nucleobase catabolic process
(GO:0006208)
Thymidine catabolic process
(GO:0006214)
Thymine catabolic process
(GO:0006210)
Ump catabolic process
(GO:0046050)
Uracil binding
(GO:0002058)
Uracil catabolic process
(GO:0006212)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hepatoblast (CL0005026)
Fold Change: 7.46
Marker Score: 24438
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 4.82
Marker Score: 2680
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 3.61
Marker Score: 8649
Cell Name: sympathetic neuron (CL0011103)
Fold Change: 3.52
Marker Score: 1163
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 3.41
Marker Score: 3862
Cell Name: mature microglial cell (CL0002629)
Fold Change: 3.39
Marker Score: 1226.5
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 3.38
Marker Score: 2226
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 3.35
Marker Score: 6449
Cell Name: cardiac neuron (CL0010022)
Fold Change: 3.19
Marker Score: 3975
Cell Name: contractile cell (CL0000183)
Fold Change: 3.12
Marker Score: 1688
Cell Name: skin fibroblast (CL0002620)
Fold Change: 3.1
Marker Score: 804
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 3.06
Marker Score: 12819
Cell Name: lactocyte (CL0002325)
Fold Change: 3.04
Marker Score: 48868
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 2.97
Marker Score: 8474
Cell Name: lung goblet cell (CL1000143)
Fold Change: 2.89
Marker Score: 831.5
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 2.84
Marker Score: 4764
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 2.68
Marker Score: 1861
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 2.66
Marker Score: 777
Cell Name: retinal cone cell (CL0000573)
Fold Change: 2.65
Marker Score: 7594
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.64
Marker Score: 5790.5
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2.6
Marker Score: 2987
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 2.47
Marker Score: 1441
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 2.42
Marker Score: 2146
Cell Name: fat cell (CL0000136)
Fold Change: 2.27
Marker Score: 1268
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.24
Marker Score: 1339
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 2.24
Marker Score: 2397.5
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 2.2
Marker Score: 49233
Cell Name: chromaffin cell (CL0000166)
Fold Change: 2.19
Marker Score: 3081
Cell Name: taste receptor cell (CL0000209)
Fold Change: 2.11
Marker Score: 1822
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 2.09
Marker Score: 1100
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.07
Marker Score: 115815
Cell Name: anterior lens cell (CL0002223)
Fold Change: 2.05
Marker Score: 2761
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.04
Marker Score: 125644
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1.97
Marker Score: 621
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.96
Marker Score: 20237
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.94
Marker Score: 18284
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.91
Marker Score: 18136
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.86
Marker Score: 15987
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.84
Marker Score: 1756
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.83
Marker Score: 9862
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.78
Marker Score: 454
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.78
Marker Score: 605
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 1.77
Marker Score: 7382
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.76
Marker Score: 664
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.74
Marker Score: 3388
Cell Name: podocyte (CL0000653)
Fold Change: 1.71
Marker Score: 633
Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.71
Marker Score: 640
Cell Name: lung macrophage (CL1001603)
Fold Change: 1.7
Marker Score: 1942
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.69
Marker Score: 33710
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.68
Marker Score: 10809
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.68
Marker Score: 610
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 1.68
Marker Score: 5624
Cell Name: neuron (CL0000540)
Fold Change: 1.66
Marker Score: 6778
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.66
Marker Score: 4162
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.62
Marker Score: 5756
Cell Name: CNS interneuron (CL0000402)
Fold Change: 1.61
Marker Score: 772
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.59
Marker Score: 10341
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.58
Marker Score: 6839
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.57
Marker Score: 2419
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 1.56
Marker Score: 1592
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.56
Marker Score: 3875
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.55
Marker Score: 499
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.51
Marker Score: 2197
Cell Name: renal principal cell (CL0005009)
Fold Change: 1.5
Marker Score: 1154
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 1.47
Marker Score: 389
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.44
Marker Score: 863
Cell Name: blood cell (CL0000081)
Fold Change: 1.39
Marker Score: 16214
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 1.38
Marker Score: 3331
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.35
Marker Score: 422
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.35
Marker Score: 10313
Cell Name: thymocyte (CL0000893)
Fold Change: 1.34
Marker Score: 1408
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.34
Marker Score: 2726
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.34
Marker Score: 1440
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.34
Marker Score: 3145
Cell Name: club cell (CL0000158)
Fold Change: 1.31
Marker Score: 1533
Cell Name: secretory cell (CL0000151)
Fold Change: 1.3
Marker Score: 2364
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.29
Marker Score: 20177
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.28
Marker Score: 1179
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.28
Marker Score: 4945
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 1.28
Marker Score: 351
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.27
Marker Score: 1268
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 1.25
Marker Score: 457
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.25
Marker Score: 731
Cell Name: Schwann cell (CL0002573)
Fold Change: 1.24
Marker Score: 431
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 1.24
Marker Score: 327
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 1.22
Marker Score: 1513
Cell Name: mesothelial cell (CL0000077)
Fold Change: 1.18
Marker Score: 472
Cell Name: classical monocyte (CL0000860)
Fold Change: 1.17
Marker Score: 4874
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.17
Marker Score: 1244
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.17
Marker Score: 44364
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.16
Marker Score: 1648
Cell Name: melanocyte (CL0000148)
Fold Change: 1.15
Marker Score: 464
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.14
Marker Score: 565
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 1.14
Marker Score: 410
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.12
Marker Score: 1182
Cell Name: macrophage (CL0000235)
Fold Change: 1.12
Marker Score: 1244
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.11
Marker Score: 1347
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 1.1
Marker Score: 777
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.09
Marker Score: 528
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 1.09
Marker Score: 540.5

Hover over a box to see details here...

**Key characteristics:** * DPYD is a multi-functional enzyme with activity in both the nucleus and cytoplasm. * It is a flavoprotein with a conserved active site. * It is expressed in a wide range of cell types, including hepatocytes, fibroblasts, and immune cells. **Pathways and functions:** * DPYD is involved in the metabolism of purines and pyrimidines, including the degradation of thymine, uracil, and cytidine. * It is also involved in the biosynthesis of pyrimidine nucleotides from deoxycytidine and deoxyguanosine. * It plays a role in the regulation of cell growth, differentiation, and apoptosis. * DPYD is also involved in the detoxification of reactive oxygen species. **Clinical significance:** * Mutations in DPYD have been linked to several human diseases, including cancer and neurodegenerative disorders. * Studies of DPYD have implications for the development of new therapeutic strategies for these diseases. **Additional information:** * DPYD is a highly regulated enzyme that is tightly controlled by various factors, including the cellular environment and the presence of allosteric regulators. * It is a well-studied enzyme that has been extensively characterized in both mammalian and yeast systems.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Dihydrothymine dehydrogenase

Genular Protein ID: 13778501

Symbol: DPYD_HUMAN

Name: Dihydrothymine dehydrogenase

UniProtKB Accession Codes:

Q12882 A2RRQ2 A2RRQ3 A8K5A2 A8MWG9 B1AN21 E9PFN1 Q16694 Q16761 Q32NB0 Q96HL6 Q96TH1

Database IDs:

Citations:

PubMed ID: 8083224

Title: cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria.

PubMed ID: 8083224

DOI: 10.1016/s0021-9258(17)31638-1

PubMed ID: 9135003

Title: Structural organization of the human dihydropyrimidine dehydrogenase gene.

PubMed ID: 9135003

PubMed ID: 9464498

Title: Suicidal inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil derived from the antiviral, sorivudine.

PubMed ID: 9464498

DOI: 10.1016/s0304-3835(97)00377-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8892022

Title: A point mutation in an invariant splice donor site leads to exon skipping in two unrelated Dutch patients with dihydropyrimidine dehydrogenase deficiency.

PubMed ID: 8892022

DOI: 10.1007/bf01799841

PubMed ID: 9170156

Title: Lack of correlation between phenotype and genotype for the polymorphically expressed dihydropyrimidine dehydrogenase in a family of Pakistani origin.

PubMed ID: 9170156

DOI: 10.1097/00008571-199704000-00012

PubMed ID: 1512248

Title: Purification and characterization of dihydropyrimidine dehydrogenase from human liver.

PubMed ID: 1512248

DOI: 10.1016/s0021-9258(18)41899-6

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9439663

Title: Dihydropyrimidine dehydrogenase (DPD) deficiency: identification and expression of missense mutations C29R, R886H and R235W.

PubMed ID: 9439663

DOI: 10.1007/s004390050637

PubMed ID: 9266349

Title: Identification of novel point mutations in the dihydropyrimidine dehydrogenase gene.

PubMed ID: 9266349

DOI: 10.1023/a:1005357307122

PubMed ID: 9472650

Title: Dihydropyrimidine dehydrogenase pharmacogenetics in patients with colorectal cancer.

PubMed ID: 9472650

DOI: 10.1038/bjc.1998.79

PubMed ID: 9723824

Title: Dihydropyrimidine dehydrogenase pharmacogenetics in Caucasian subjects.

PubMed ID: 9723824

DOI: 10.1046/j.1365-2125.1998.00751.x

PubMed ID: 18987736

Title: DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.

PubMed ID: 18987736

DOI: 10.1038/nature07485

Sequence Information:

Length: 1025
Mass: 111401
Checksum: 0201943955AB2C21
Sequence:

MAPVLSKDSA DIESILALNP RTQTHATLCS TSAKKLDKKH WKRNPDKNCF NCEKLENNFD 
DIKHTTLGER GALREAMRCL KCADAPCQKS CPTNLDIKSF ITSIANKNYY GAAKMIFSDN 
PLGLTCGMVC PTSDLCVGGC NLYATEEGPI NIGGLQQFAT EVFKAMSIPQ IRNPSLPPPE 
KMSEAYSAKI ALFGAGPASI SCASFLARLG YSDITIFEKQ EYVGGLSTSE IPQFRLPYDV 
VNFEIELMKD LGVKIICGKS LSVNEMTLST LKEKGYKAAF IGIGLPEPNK DAIFQGLTQD 
QGFYTSKDFL PLVAKGSKAG MCACHSPLPS IRGVVIVLGA GDTAFDCATS ALRCGARRVF 
IVFRKGFVNI RAVPEEMELA KEEKCEFLPF LSPRKVIVKG GRIVAMQFVR TEQDETGKWN 
EDEDQMVHLK ADVVISAFGS VLSDPKVKEA LSPIKFNRWG LPEVDPETMQ TSEAWVFAGG 
DVVGLANTTV ESVNDGKQAS WYIHKYVQSQ YGASVSAKPE LPLFYTPIDL VDISVEMAGL 
KFINPFGLAS ATPATSTSMI RRAFEAGWGF ALTKTFSLDK DIVTNVSPRI IRGTTSGPMY 
GPGQSSFLNI ELISEKTAAY WCQSVTELKA DFPDNIVIAS IMCSYNKNDW TELAKKSEDS 
GADALELNLS CPHGMGERGM GLACGQDPEL VRNICRWVRQ AVQIPFFAKL TPNVTDIVSI 
ARAAKEGGAN GVTATNTVSG LMGLKSDGTP WPAVGIAKRT TYGGVSGTAI RPIALRAVTS 
IARALPGFPI LATGGIDSAE SGLQFLHSGA SVLQVCSAIQ NQDFTVIEDY CTGLKALLYL 
KSIEELQDWD GQSPATVSHQ KGKPVPRIAE LMDKKLPSFG PYLEQRKKII AENKIRLKEQ 
NVAFSPLKRN CFIPKRPIPT IKDVIGKALQ YLGTFGELSN VEQVVAMIDE EMCINCGKCY 
MTCNDSGYQA IQFDPETHLP TITDTCTGCT LCLSVCPIVD CIKMVSRTTP YEPKRGVPLS 
VNPVC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: DPYD

Associated with

Cells (max top 100)

Other Information

cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria. PubMed ID: 8083224

Structural organization of the human dihydropyrimidine dehydrogenase gene. PubMed ID: 9135003

Suicidal inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil derived from the antiviral, sorivudine. PubMed ID: 9464498

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A point mutation in an invariant splice donor site leads to exon skipping in two unrelated Dutch patients with dihydropyrimidine dehydrogenase deficiency. PubMed ID: 8892022

Lack of correlation between phenotype and genotype for the polymorphically expressed dihydropyrimidine dehydrogenase in a family of Pakistani origin. PubMed ID: 9170156

Purification and characterization of dihydropyrimidine dehydrogenase from human liver. PubMed ID: 1512248

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Dihydropyrimidine dehydrogenase (DPD) deficiency: identification and expression of missense mutations C29R, R886H and R235W. PubMed ID: 9439663

Identification of novel point mutations in the dihydropyrimidine dehydrogenase gene. PubMed ID: 9266349

Dihydropyrimidine dehydrogenase pharmacogenetics in patients with colorectal cancer. PubMed ID: 9472650

Dihydropyrimidine dehydrogenase pharmacogenetics in Caucasian subjects. PubMed ID: 9723824

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. PubMed ID: 18987736