Details for: DPYD
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hepatoblast (CL0005026)
Fold Change: 7.46
Marker Score: 24,438 - Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 4.82
Marker Score: 2,680 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 3.61
Marker Score: 8,649 - Cell Name: sympathetic neuron (CL0011103)
Fold Change: 3.52
Marker Score: 1,163 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 3.41
Marker Score: 3,862 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 3.39
Marker Score: 1,227 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 3.38
Marker Score: 2,226 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 3.35
Marker Score: 6,449 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 3.19
Marker Score: 3,975 - Cell Name: contractile cell (CL0000183)
Fold Change: 3.12
Marker Score: 1,688 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 3.1
Marker Score: 804 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 3.06
Marker Score: 12,819 - Cell Name: lactocyte (CL0002325)
Fold Change: 3.04
Marker Score: 48,868 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 2.97
Marker Score: 8,474 - Cell Name: lung goblet cell (CL1000143)
Fold Change: 2.89
Marker Score: 832 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 2.84
Marker Score: 4,764 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 2.68
Marker Score: 1,861 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 2.66
Marker Score: 777 - Cell Name: retinal cone cell (CL0000573)
Fold Change: 2.65
Marker Score: 7,594 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.64
Marker Score: 5,791 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2.6
Marker Score: 2,987 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 2.47
Marker Score: 1,441 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 2.42
Marker Score: 2,146 - Cell Name: fat cell (CL0000136)
Fold Change: 2.27
Marker Score: 1,268 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.24
Marker Score: 1,339 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 2.24
Marker Score: 2,398 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 2.2
Marker Score: 49,233 - Cell Name: chromaffin cell (CL0000166)
Fold Change: 2.19
Marker Score: 3,081 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 2.11
Marker Score: 1,822 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 2.09
Marker Score: 1,100 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.07
Marker Score: 115,815 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 2.05
Marker Score: 2,761 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.04
Marker Score: 125,644 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1.97
Marker Score: 621 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.96
Marker Score: 20,237 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.94
Marker Score: 18,284 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.91
Marker Score: 18,136 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.86
Marker Score: 15,987 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.84
Marker Score: 1,756 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.83
Marker Score: 9,862 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.78
Marker Score: 454 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.78
Marker Score: 605 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 1.77
Marker Score: 7,382 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.76
Marker Score: 664 - Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.74
Marker Score: 3,388 - Cell Name: podocyte (CL0000653)
Fold Change: 1.71
Marker Score: 633 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.71
Marker Score: 640 - Cell Name: lung macrophage (CL1001603)
Fold Change: 1.7
Marker Score: 1,942 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.69
Marker Score: 33,710 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.68
Marker Score: 10,809 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.68
Marker Score: 610 - Cell Name: neuronal brush cell (CL0000555)
Fold Change: 1.68
Marker Score: 5,624 - Cell Name: neuron (CL0000540)
Fold Change: 1.66
Marker Score: 6,778 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.66
Marker Score: 4,162 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.62
Marker Score: 5,756 - Cell Name: CNS interneuron (CL0000402)
Fold Change: 1.61
Marker Score: 772 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.59
Marker Score: 10,341 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.58
Marker Score: 6,839 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.57
Marker Score: 2,419 - Cell Name: dendritic cell, human (CL0001056)
Fold Change: 1.56
Marker Score: 1,592 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.56
Marker Score: 3,875 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.55
Marker Score: 499 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.51
Marker Score: 2,197 - Cell Name: renal principal cell (CL0005009)
Fold Change: 1.5
Marker Score: 1,154 - Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 1.47
Marker Score: 389 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.44
Marker Score: 863 - Cell Name: blood cell (CL0000081)
Fold Change: 1.39
Marker Score: 16,214 - Cell Name: non-classical monocyte (CL0000875)
Fold Change: 1.38
Marker Score: 3,331 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.35
Marker Score: 422 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.35
Marker Score: 10,313 - Cell Name: thymocyte (CL0000893)
Fold Change: 1.34
Marker Score: 1,408 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.34
Marker Score: 2,726 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.34
Marker Score: 1,440 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.34
Marker Score: 3,145 - Cell Name: club cell (CL0000158)
Fold Change: 1.31
Marker Score: 1,533 - Cell Name: secretory cell (CL0000151)
Fold Change: 1.3
Marker Score: 2,364 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.29
Marker Score: 20,177 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.28
Marker Score: 1,179 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.28
Marker Score: 4,945 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 1.28
Marker Score: 351 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.27
Marker Score: 1,268 - Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 1.25
Marker Score: 457 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.25
Marker Score: 731 - Cell Name: Schwann cell (CL0002573)
Fold Change: 1.24
Marker Score: 431 - Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 1.24
Marker Score: 327 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 1.22
Marker Score: 1,513 - Cell Name: mesothelial cell (CL0000077)
Fold Change: 1.18
Marker Score: 472 - Cell Name: classical monocyte (CL0000860)
Fold Change: 1.17
Marker Score: 4,874 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.17
Marker Score: 1,244 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.17
Marker Score: 44,364 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.16
Marker Score: 1,648 - Cell Name: melanocyte (CL0000148)
Fold Change: 1.15
Marker Score: 464 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.14
Marker Score: 565 - Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 1.14
Marker Score: 410 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.12
Marker Score: 1,182 - Cell Name: macrophage (CL0000235)
Fold Change: 1.12
Marker Score: 1,244 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.11
Marker Score: 1,347 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 1.1
Marker Score: 777 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.09
Marker Score: 528 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 1.09
Marker Score: 541
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 13778501
Symbol: DPYD_HUMAN
Name: Dihydrothymine dehydrogenase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8083224
Title: cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria.
PubMed ID: 8083224
PubMed ID: 9135003
Title: Structural organization of the human dihydropyrimidine dehydrogenase gene.
PubMed ID: 9135003
PubMed ID: 9464498
Title: Suicidal inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil derived from the antiviral, sorivudine.
PubMed ID: 9464498
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8892022
Title: A point mutation in an invariant splice donor site leads to exon skipping in two unrelated Dutch patients with dihydropyrimidine dehydrogenase deficiency.
PubMed ID: 8892022
DOI: 10.1007/bf01799841
PubMed ID: 9170156
Title: Lack of correlation between phenotype and genotype for the polymorphically expressed dihydropyrimidine dehydrogenase in a family of Pakistani origin.
PubMed ID: 9170156
PubMed ID: 1512248
Title: Purification and characterization of dihydropyrimidine dehydrogenase from human liver.
PubMed ID: 1512248
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 9439663
Title: Dihydropyrimidine dehydrogenase (DPD) deficiency: identification and expression of missense mutations C29R, R886H and R235W.
PubMed ID: 9439663
PubMed ID: 9266349
Title: Identification of novel point mutations in the dihydropyrimidine dehydrogenase gene.
PubMed ID: 9266349
PubMed ID: 9472650
Title: Dihydropyrimidine dehydrogenase pharmacogenetics in patients with colorectal cancer.
PubMed ID: 9472650
DOI: 10.1038/bjc.1998.79
PubMed ID: 9723824
Title: Dihydropyrimidine dehydrogenase pharmacogenetics in Caucasian subjects.
PubMed ID: 9723824
PubMed ID: 18987736
Title: DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.
PubMed ID: 18987736
DOI: 10.1038/nature07485
Sequence Information:
- Length: 1025
- Mass: 111401
- Checksum: 0201943955AB2C21
- Sequence:
MAPVLSKDSA DIESILALNP RTQTHATLCS TSAKKLDKKH WKRNPDKNCF NCEKLENNFD DIKHTTLGER GALREAMRCL KCADAPCQKS CPTNLDIKSF ITSIANKNYY GAAKMIFSDN PLGLTCGMVC PTSDLCVGGC NLYATEEGPI NIGGLQQFAT EVFKAMSIPQ IRNPSLPPPE KMSEAYSAKI ALFGAGPASI SCASFLARLG YSDITIFEKQ EYVGGLSTSE IPQFRLPYDV VNFEIELMKD LGVKIICGKS LSVNEMTLST LKEKGYKAAF IGIGLPEPNK DAIFQGLTQD QGFYTSKDFL PLVAKGSKAG MCACHSPLPS IRGVVIVLGA GDTAFDCATS ALRCGARRVF IVFRKGFVNI RAVPEEMELA KEEKCEFLPF LSPRKVIVKG GRIVAMQFVR TEQDETGKWN EDEDQMVHLK ADVVISAFGS VLSDPKVKEA LSPIKFNRWG LPEVDPETMQ TSEAWVFAGG DVVGLANTTV ESVNDGKQAS WYIHKYVQSQ YGASVSAKPE LPLFYTPIDL VDISVEMAGL KFINPFGLAS ATPATSTSMI RRAFEAGWGF ALTKTFSLDK DIVTNVSPRI IRGTTSGPMY GPGQSSFLNI ELISEKTAAY WCQSVTELKA DFPDNIVIAS IMCSYNKNDW TELAKKSEDS GADALELNLS CPHGMGERGM GLACGQDPEL VRNICRWVRQ AVQIPFFAKL TPNVTDIVSI ARAAKEGGAN GVTATNTVSG LMGLKSDGTP WPAVGIAKRT TYGGVSGTAI RPIALRAVTS IARALPGFPI LATGGIDSAE SGLQFLHSGA SVLQVCSAIQ NQDFTVIEDY CTGLKALLYL KSIEELQDWD GQSPATVSHQ KGKPVPRIAE LMDKKLPSFG PYLEQRKKII AENKIRLKEQ NVAFSPLKRN CFIPKRPIPT IKDVIGKALQ YLGTFGELSN VEQVVAMIDE EMCINCGKCY MTCNDSGYQA IQFDPETHLP TITDTCTGCT LCLSVCPIVD CIKMVSRTTP YEPKRGVPLS VNPVC
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.