Details for: SLC26A2

Gene ID: 1836

Symbol: SLC26A2

Ensembl ID: ENSG00000155850

Description: solute carrier family 26 member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 125.4298
    Cell Significance Index: -19.5100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 71.2023
    Cell Significance Index: -18.0600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 46.4710
    Cell Significance Index: -21.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 45.1931
    Cell Significance Index: -18.3600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 32.8305
    Cell Significance Index: -22.0300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.2722
    Cell Significance Index: -18.4000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.0265
    Cell Significance Index: -19.7600
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 11.3620
    Cell Significance Index: 8.1200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 9.0245
    Cell Significance Index: 241.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 8.5190
    Cell Significance Index: 386.1400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.7906
    Cell Significance Index: -20.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 7.6138
    Cell Significance Index: 203.3000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.0760
    Cell Significance Index: -20.0300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.4406
    Cell Significance Index: -7.5300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 3.0587
    Cell Significance Index: 65.3800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.7638
    Cell Significance Index: 40.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.7257
    Cell Significance Index: 80.4600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.6505
    Cell Significance Index: 19.6800
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 1.2624
    Cell Significance Index: 8.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.2425
    Cell Significance Index: 78.3100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.1057
    Cell Significance Index: 15.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6820
    Cell Significance Index: 372.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6598
    Cell Significance Index: 595.7200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6052
    Cell Significance Index: 98.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5971
    Cell Significance Index: 107.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5927
    Cell Significance Index: 58.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5533
    Cell Significance Index: 68.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4689
    Cell Significance Index: 13.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4476
    Cell Significance Index: 23.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4219
    Cell Significance Index: 11.7900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3999
    Cell Significance Index: 76.1000
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 0.3732
    Cell Significance Index: 5.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3720
    Cell Significance Index: 51.0800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3671
    Cell Significance Index: 25.3900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.3236
    Cell Significance Index: 4.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3183
    Cell Significance Index: 6.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2943
    Cell Significance Index: 34.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2908
    Cell Significance Index: 13.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2335
    Cell Significance Index: 6.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2049
    Cell Significance Index: 40.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1969
    Cell Significance Index: 39.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1966
    Cell Significance Index: 86.9100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.1654
    Cell Significance Index: 3.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1328
    Cell Significance Index: 17.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1176
    Cell Significance Index: 42.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0998
    Cell Significance Index: 3.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0720
    Cell Significance Index: 1.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0480
    Cell Significance Index: 6.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0424
    Cell Significance Index: 1.4900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0334
    Cell Significance Index: 0.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0251
    Cell Significance Index: 4.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0239
    Cell Significance Index: 1.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0124
    Cell Significance Index: 23.2800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0108
    Cell Significance Index: 7.5000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0090
    Cell Significance Index: 0.1400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0037
    Cell Significance Index: 0.0300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0033
    Cell Significance Index: 0.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0060
    Cell Significance Index: -11.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0060
    Cell Significance Index: -9.3100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0072
    Cell Significance Index: -4.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0091
    Cell Significance Index: -6.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0092
    Cell Significance Index: -5.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0108
    Cell Significance Index: -0.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0112
    Cell Significance Index: -15.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0162
    Cell Significance Index: -9.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0181
    Cell Significance Index: -13.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0194
    Cell Significance Index: -14.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0241
    Cell Significance Index: -10.9600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0274
    Cell Significance Index: -0.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0373
    Cell Significance Index: -2.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0415
    Cell Significance Index: -2.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0471
    Cell Significance Index: -6.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0492
    Cell Significance Index: -14.1700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0493
    Cell Significance Index: -0.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0501
    Cell Significance Index: -10.5500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0574
    Cell Significance Index: -4.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0618
    Cell Significance Index: -6.3100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0740
    Cell Significance Index: -1.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0885
    Cell Significance Index: -10.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0898
    Cell Significance Index: -4.6800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0993
    Cell Significance Index: -0.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1328
    Cell Significance Index: -15.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1514
    Cell Significance Index: -11.2800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1644
    Cell Significance Index: -18.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1758
    Cell Significance Index: -9.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1784
    Cell Significance Index: -7.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1868
    Cell Significance Index: -6.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1874
    Cell Significance Index: -19.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1968
    Cell Significance Index: -21.4100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1981
    Cell Significance Index: -7.5000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2025
    Cell Significance Index: -3.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2048
    Cell Significance Index: -12.5900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2108
    Cell Significance Index: -10.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2314
    Cell Significance Index: -15.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2421
    Cell Significance Index: -14.8400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2535
    Cell Significance Index: -20.0800
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.2548
    Cell Significance Index: -2.4200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2632
    Cell Significance Index: -2.7300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2669
    Cell Significance Index: -5.2100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2746
    Cell Significance Index: -3.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The SLC26A2 gene is a member of the solute carrier family 26 (SLC26) and is primarily expressed in the apical plasma membrane of various epithelial cells. The SLC26A2 protein is a multifunctional anion exchanger that can transport a wide range of anions, including bicarbonate, chloride, sulfate, and inorganic cations. The protein has been shown to utilize secondary active transport mechanisms, which rely on the concentration gradient of a co-transported molecule to drive the transport of the anion. **Pathways and Functions** The SLC26A2 protein is involved in multiple cellular pathways, including: 1. **Bicarbonate Transport**: The SLC26A2 protein plays a crucial role in the regulation of bicarbonate transport in various tissues, including the colon and placenta. 2. **Chloride Transport**: The protein is also involved in chloride transport, which is essential for maintaining proper ion balance and fluid homeostasis in the body. 3. **Sulfate Transport**: The SLC26A2 protein is a sulfate transporter that is involved in the transport of sulfate across cell membranes. 4. **Glycosaminoglycan Metabolism**: The protein is also implicated in the metabolism of glycosaminoglycans, which are important components of the extracellular matrix. 5. **Oxalate Transport**: The SLC26A2 protein has been shown to transport oxalate, a compound that is involved in the development of kidney stones. **Clinical Significance** Mutations in the SLC26A2 gene have been associated with several diseases, including: 1. **Chondrodysplasias**: Mutations in the SLC26A2 gene have been linked to various forms of chondrodysplasias, a group of disorders characterized by abnormal bone development. 2. **Disorders of Glycosylation**: The SLC26A2 protein is also involved in glycosylation, a process that is essential for the proper functioning of proteins. Mutations in the gene have been associated with disorders of glycosylation, including congenital disorders of glycosylation. 3. **Metabolic Disorders**: The SLC26A2 protein is also involved in the regulation of metabolism, particularly in the transport of sulfate and oxalate. Mutations in the gene have been associated with metabolic disorders, including kidney stone disease. In conclusion, the SLC26A2 gene is a multifunctional anion exchanger that plays a crucial role in various cellular pathways, including bicarbonate transport, chloride transport, and sulfate transport. Mutations in this gene have been associated with several diseases, including chondrodysplasias, disorders of glycosylation, and metabolic disorders. Further research is needed to fully understand the implications of this gene in human health and disease.

Genular Protein ID: 317807082

Symbol: S26A2_HUMAN

Name: Sulfate transporter

UniProtKB Accession Codes:

P50443 A8K2U3 B2R6J1 Q6N051

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 4 Ensembl 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 9 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 6 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7923357

Title: The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping.

PubMed ID: 7923357

DOI: 10.1016/0092-8674(94)90281-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 8528239

Title: Achondrogenesis type IB is caused by mutations in the diastrophic dysplasia sulphate transporter gene.

PubMed ID: 8528239

DOI: 10.1038/ng0196-100

PubMed ID: 8571951

Title: Atelosteogenesis type II is caused by mutations in the diastrophic dysplasia sulfate-transporter gene (DTDST): evidence for a phenotypic series involving three chondrodysplasias.

PubMed ID: 8571951

PubMed ID: 10466420

Title: Homozygosity for a novel DTDST mutation in a child with a 'broad bone-platyspondylic' variant of diastrophic dysplasia.

PubMed ID: 10466420

DOI: 10.1034/j.1399-0004.1999.560110.x

PubMed ID: 12966518

Title: Autosomal recessive multiple epiphyseal dysplasia with homozygosity for C653S in the DTDST gene: double-layer patella as a reliable sign.

PubMed ID: 12966518

DOI: 10.1002/ajmg.a.20282

PubMed ID: 11448940

Title: Mutations in the diastrophic dysplasia sulfate transporter (DTDST) gene: correlation between sulfate transport activity and chondrodysplasia phenotype.

PubMed ID: 11448940

DOI: 10.1093/hmg/10.14.1485

PubMed ID: 15294877

Title: Functional expression and cellular distribution of diastrophic dysplasia sulfate transporter (DTDST) gene mutations in HEK cells.

PubMed ID: 15294877

DOI: 10.1093/hmg/ddh242

PubMed ID: 20219950

Title: Regulated transport of sulfate and oxalate by SLC26A2/DTDST.

PubMed ID: 20219950

DOI: 10.1152/ajpcell.00004.2010

PubMed ID: 21922596

Title: Pseudoachondroplasia and multiple epiphyseal dysplasia: A 7-year comprehensive analysis of the known disease genes identify novel and recurrent mutations and provides an accurate assessment of their relative contribution.

PubMed ID: 21922596

DOI: 10.1002/humu.21611

Sequence Information:

  • Length: 739
  • Mass: 81662
  • Checksum: 577984D0E973087F
  • Sequence:
    • MSSESKEQHN VSPRDSAEGN DSYPSGIHLE LQRESSTDFK QFETNDQCRP YHRILIERQE 
KSDTNFKEFV IKKLQKNCQC SPAKAKNMIL GFLPVLQWLP KYDLKKNILG DVMSGLIVGI 
LLVPQSIAYS LLAGQEPVYG LYTSFFASII YFLLGTSRHI SVGIFGVLCL MIGETVDREL 
QKAGYDNAHS APSLGMVSNG STLLNHTSDR ICDKSCYAIM VGSTVTFIAG VYQVAMGFFQ 
VGFVSVYLSD ALLSGFVTGA SFTILTSQAK YLLGLNLPRT NGVGSLITTW IHVFRNIHKT 
NLCDLITSLL CLLVLLPTKE LNEHFKSKLK APIPIELVVV VAATLASHFG KLHENYNSSI 
AGHIPTGFMP PKVPEWNLIP SVAVDAIAIS IIGFAITVSL SEMFAKKHGY TVKANQEMYA 
IGFCNIIPSF FHCFTTSAAL AKTLVKESTG CHTQLSGVVT ALVLLLVLLV IAPLFYSLQK 
SVLGVITIVN LRGALRKFRD LPKMWSISRM DTVIWFVTML SSALLSTEIG LLVGVCFSIF 
CVILRTQKPK SSLLGLVEES EVFESVSAYK NLQIKPGIKI FRFVAPLYYI NKECFKSALY 
KQTVNPILIK VAWKKAAKRK IKEKVVTLGG IQDEMSVQLS HDPLELHTIV IDCSAIQFLD 
TAGIHTLKEV RRDYEAIGIQ VLLAQCNPTV RDSLTNGEYC KKEEENLLFY SVYEAMAFAE 
VSKNQKGVCV PNGLSLSSD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.