Details for: SLC26A2

Gene ID: 1836

Symbol: SLC26A2

Ensembl ID: ENSG00000155850

Description: solute carrier family 26 member 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.88
    Marker Score: 68829
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.41
    Marker Score: 10702
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 2.1
    Marker Score: 1722
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.09
    Marker Score: 5136
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.06
    Marker Score: 8089
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1992
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.93
    Marker Score: 951
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.85
    Marker Score: 587
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.73
    Marker Score: 821
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.71
    Marker Score: 3899
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.6
    Marker Score: 1337
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.45
    Marker Score: 972
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.33
    Marker Score: 3381
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.2
    Marker Score: 359
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.17
    Marker Score: 1228
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.15
    Marker Score: 8529
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.14
    Marker Score: 1264
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.11
    Marker Score: 664
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.1
    Marker Score: 828
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.1
    Marker Score: 541
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.06
    Marker Score: 425
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.05
    Marker Score: 267
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.04
    Marker Score: 5014
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.04
    Marker Score: 486
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71736
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47959
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30397
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.96
    Marker Score: 8314
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2398
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 482
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5271
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.92
    Marker Score: 1487
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.91
    Marker Score: 1279
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2708
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.89
    Marker Score: 764
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.88
    Marker Score: 253
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5245
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.86
    Marker Score: 813
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.84
    Marker Score: 2397
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.84
    Marker Score: 29020
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.83
    Marker Score: 13063
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.83
    Marker Score: 897
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.83
    Marker Score: 1519
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.82
    Marker Score: 1189
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8
    Marker Score: 9015
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.79
    Marker Score: 1169
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.79
    Marker Score: 1381
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.79
    Marker Score: 1020
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 311
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.76
    Marker Score: 442
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.76
    Marker Score: 1802
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.75
    Marker Score: 313
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.75
    Marker Score: 1524
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.74
    Marker Score: 1148
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.74
    Marker Score: 749
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 469
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.73
    Marker Score: 1720
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 376
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.72
    Marker Score: 232
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.71
    Marker Score: 1032
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.69
    Marker Score: 1104
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.69
    Marker Score: 683
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2877
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.68
    Marker Score: 463
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 618
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.67
    Marker Score: 211
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.65
    Marker Score: 290
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.64
    Marker Score: 1280
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.64
    Marker Score: 509
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.63
    Marker Score: 418
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.63
    Marker Score: 145
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.63
    Marker Score: 437
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.62
    Marker Score: 2127
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.62
    Marker Score: 357
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.61
    Marker Score: 430
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.61
    Marker Score: 733
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.6
    Marker Score: 342
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.59
    Marker Score: 171
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.59
    Marker Score: 141
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.59
    Marker Score: 525
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.58
    Marker Score: 322
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.58
    Marker Score: 698
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.57
    Marker Score: 4940
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 237
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.57
    Marker Score: 155
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.54
    Marker Score: 497
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 430
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.54
    Marker Score: 142
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.52
    Marker Score: 136
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.52
    Marker Score: 331
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.52
    Marker Score: 128
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.51
    Marker Score: 234
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.51
    Marker Score: 253
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.51
    Marker Score: 568
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.51
    Marker Score: 3944
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.5
    Marker Score: 166

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * SLC26A2 is a member of the SLC26 family of solute carriers, which are responsible for the transport of inorganic and organic anions across cell membranes. * It is a multi-subunit protein that is composed of four transmembrane domains, each of which is responsible for a specific transport function. * SLC26A2 is expressed in high levels in the kidney, where it is involved in the reabsorption of hydrogen ions and the secretion of potassium ions. * It is also expressed in other tissues, such as the colon, where it is involved in the transport of hydrogen ions and the regulation of water balance. **Pathways and functions:** * SLC26A2 is involved in a variety of cellular processes, including: * The reabsorption of hydrogen ions in the kidney * The secretion of potassium ions in the kidney * The transport of small molecules and amino acids in the intestine * The regulation of water balance **Clinical significance:** * Mutations in SLC26A2 have been linked to a number of human diseases, including: * Chondrodysplasias * Diseases associated with glycosaminoglycan metabolism * Disorders of transmembrane transporters * Glycosaminoglycan metabolism disorders * Metabolic disorders * SLC26A2 inhibitors are being investigated as potential treatments for these diseases. **Additional information:** * SLC26A2 is a highly conserved protein that is found in organisms from yeast to humans. * It is a regulated protein that is controlled by a variety of factors, including the cellular oxygen tension and the presence of calcium ions. * SLC26A2 is a promising target for the treatment of human diseases.

Genular Protein ID: 317807082

Symbol: S26A2_HUMAN

Name: Sulfate transporter

UniProtKB Accession Codes:

P50443 A8K2U3 B2R6J1 Q6N051

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 9 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 6 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7923357

Title: The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping.

PubMed ID: 7923357

DOI: 10.1016/0092-8674(94)90281-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 8528239

Title: Achondrogenesis type IB is caused by mutations in the diastrophic dysplasia sulphate transporter gene.

PubMed ID: 8528239

DOI: 10.1038/ng0196-100

PubMed ID: 8571951

Title: Atelosteogenesis type II is caused by mutations in the diastrophic dysplasia sulfate-transporter gene (DTDST): evidence for a phenotypic series involving three chondrodysplasias.

PubMed ID: 8571951

PubMed ID: 10466420

Title: Homozygosity for a novel DTDST mutation in a child with a 'broad bone-platyspondylic' variant of diastrophic dysplasia.

PubMed ID: 10466420

DOI: 10.1034/j.1399-0004.1999.560110.x

PubMed ID: 12966518

Title: Autosomal recessive multiple epiphyseal dysplasia with homozygosity for C653S in the DTDST gene: double-layer patella as a reliable sign.

PubMed ID: 12966518

DOI: 10.1002/ajmg.a.20282

PubMed ID: 11448940

Title: Mutations in the diastrophic dysplasia sulfate transporter (DTDST) gene: correlation between sulfate transport activity and chondrodysplasia phenotype.

PubMed ID: 11448940

DOI: 10.1093/hmg/10.14.1485

PubMed ID: 15294877

Title: Functional expression and cellular distribution of diastrophic dysplasia sulfate transporter (DTDST) gene mutations in HEK cells.

PubMed ID: 15294877

DOI: 10.1093/hmg/ddh242

PubMed ID: 20219950

Title: Regulated transport of sulfate and oxalate by SLC26A2/DTDST.

PubMed ID: 20219950

DOI: 10.1152/ajpcell.00004.2010

PubMed ID: 21922596

Title: Pseudoachondroplasia and multiple epiphyseal dysplasia: A 7-year comprehensive analysis of the known disease genes identify novel and recurrent mutations and provides an accurate assessment of their relative contribution.

PubMed ID: 21922596

DOI: 10.1002/humu.21611

Sequence Information:

  • Length: 739
  • Mass: 81662
  • Checksum: 577984D0E973087F
  • Sequence:
    • MSSESKEQHN VSPRDSAEGN DSYPSGIHLE LQRESSTDFK QFETNDQCRP YHRILIERQE 
KSDTNFKEFV IKKLQKNCQC SPAKAKNMIL GFLPVLQWLP KYDLKKNILG DVMSGLIVGI 
LLVPQSIAYS LLAGQEPVYG LYTSFFASII YFLLGTSRHI SVGIFGVLCL MIGETVDREL 
QKAGYDNAHS APSLGMVSNG STLLNHTSDR ICDKSCYAIM VGSTVTFIAG VYQVAMGFFQ 
VGFVSVYLSD ALLSGFVTGA SFTILTSQAK YLLGLNLPRT NGVGSLITTW IHVFRNIHKT 
NLCDLITSLL CLLVLLPTKE LNEHFKSKLK APIPIELVVV VAATLASHFG KLHENYNSSI 
AGHIPTGFMP PKVPEWNLIP SVAVDAIAIS IIGFAITVSL SEMFAKKHGY TVKANQEMYA 
IGFCNIIPSF FHCFTTSAAL AKTLVKESTG CHTQLSGVVT ALVLLLVLLV IAPLFYSLQK 
SVLGVITIVN LRGALRKFRD LPKMWSISRM DTVIWFVTML SSALLSTEIG LLVGVCFSIF 
CVILRTQKPK SSLLGLVEES EVFESVSAYK NLQIKPGIKI FRFVAPLYYI NKECFKSALY 
KQTVNPILIK VAWKKAAKRK IKEKVVTLGG IQDEMSVQLS HDPLELHTIV IDCSAIQFLD 
TAGIHTLKEV RRDYEAIGIQ VLLAQCNPTV RDSLTNGEYC KKEEENLLFY SVYEAMAFAE 
VSKNQKGVCV PNGLSLSSD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.