Details for: DUSP4

Gene ID: 1846

Symbol: DUSP4

Ensembl ID: ENSG00000120875

Description: dual specificity phosphatase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 157.8319
    Cell Significance Index: -24.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 96.4740
    Cell Significance Index: -24.4700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.9439
    Cell Significance Index: -24.5900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.1411
    Cell Significance Index: -19.1300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.3716
    Cell Significance Index: -19.5700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.2201
    Cell Significance Index: -24.5500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.3840
    Cell Significance Index: 26.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.7259
    Cell Significance Index: 193.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.6881
    Cell Significance Index: 125.8100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.3402
    Cell Significance Index: 39.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1955
    Cell Significance Index: 38.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.1907
    Cell Significance Index: 55.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1865
    Cell Significance Index: 32.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9830
    Cell Significance Index: 127.0000
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.6874
    Cell Significance Index: 11.8100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6769
    Cell Significance Index: 47.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6593
    Cell Significance Index: 13.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6525
    Cell Significance Index: 356.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6014
    Cell Significance Index: 543.0000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4937
    Cell Significance Index: 14.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4840
    Cell Significance Index: 16.8200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4659
    Cell Significance Index: 4.2900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.4609
    Cell Significance Index: 3.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4454
    Cell Significance Index: 44.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3497
    Cell Significance Index: 18.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3380
    Cell Significance Index: 54.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3022
    Cell Significance Index: 51.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2690
    Cell Significance Index: 33.0700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2685
    Cell Significance Index: 29.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2618
    Cell Significance Index: 47.2000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2501
    Cell Significance Index: 3.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2035
    Cell Significance Index: 38.7300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1240
    Cell Significance Index: 8.5800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1201
    Cell Significance Index: 7.2100
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.1172
    Cell Significance Index: 0.5100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0559
    Cell Significance Index: 38.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0452
    Cell Significance Index: 0.9800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0436
    Cell Significance Index: 5.1400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0346
    Cell Significance Index: 3.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0344
    Cell Significance Index: 0.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0228
    Cell Significance Index: 0.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0161
    Cell Significance Index: 7.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0083
    Cell Significance Index: 2.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0037
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0062
    Cell Significance Index: -4.5800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0098
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0104
    Cell Significance Index: -6.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0115
    Cell Significance Index: -21.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0117
    Cell Significance Index: -21.5700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0154
    Cell Significance Index: -23.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0221
    Cell Significance Index: -4.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0221
    Cell Significance Index: -30.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0239
    Cell Significance Index: -13.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0272
    Cell Significance Index: -20.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0312
    Cell Significance Index: -22.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0351
    Cell Significance Index: -22.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0398
    Cell Significance Index: -11.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0471
    Cell Significance Index: -2.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0557
    Cell Significance Index: -25.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0595
    Cell Significance Index: -6.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0634
    Cell Significance Index: -6.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0636
    Cell Significance Index: -7.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0656
    Cell Significance Index: -3.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0676
    Cell Significance Index: -8.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0689
    Cell Significance Index: -13.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0699
    Cell Significance Index: -14.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0704
    Cell Significance Index: -0.9600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0831
    Cell Significance Index: -11.4100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1458
    Cell Significance Index: -8.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1499
    Cell Significance Index: -21.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2008
    Cell Significance Index: -5.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2364
    Cell Significance Index: -24.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2390
    Cell Significance Index: -16.0700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2544
    Cell Significance Index: -4.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2673
    Cell Significance Index: -15.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2727
    Cell Significance Index: -16.7200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2811
    Cell Significance Index: -3.6200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3207
    Cell Significance Index: -6.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3260
    Cell Significance Index: -8.3800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3292
    Cell Significance Index: -3.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3466
    Cell Significance Index: -26.6000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3489
    Cell Significance Index: -22.5100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3553
    Cell Significance Index: -7.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3660
    Cell Significance Index: -23.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3933
    Cell Significance Index: -10.9900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.4765
    Cell Significance Index: -4.0500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4979
    Cell Significance Index: -13.3200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5046
    Cell Significance Index: -22.3200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5154
    Cell Significance Index: -18.9200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5272
    Cell Significance Index: -26.6400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5380
    Cell Significance Index: -22.0500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.5783
    Cell Significance Index: -9.5300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5989
    Cell Significance Index: -22.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6060
    Cell Significance Index: -21.2300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6198
    Cell Significance Index: -19.7400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6267
    Cell Significance Index: -13.5400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6775
    Cell Significance Index: -19.4200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6830
    Cell Significance Index: -15.7800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6831
    Cell Significance Index: -20.1200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6991
    Cell Significance Index: -22.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DUSP4 exhibits several key characteristics that distinguish it from other phosphatases: 1. **Dual specificity**: DUSP4 possesses dual specificity phosphatase activity, allowing it to dephosphorylate both serine/threonine and tyrosine residues on target proteins. 2. **Regulation of MAPK pathways**: DUSP4 is involved in the negative regulation of the MAPK (Mitogen-Activated Protein Kinase) signaling pathways, which play a crucial role in immune responses, cell growth, and differentiation. 3. **Innate and adaptive immunity**: DUSP4 is expressed in various immune cells, including T cells, B cells, and innate immune cells, suggesting its involvement in both innate and adaptive immune responses. 4. **Tissue-specific expression**: DUSP4 is expressed in multiple cell types, including epithelial cells, neural cells, and progenitor cells, indicating its role in tissue-specific regulation of immune responses. **Pathways and Functions:** DUSP4 is involved in several key signaling pathways, including: 1. **Cytokine signaling**: DUSP4 regulates cytokine signaling pathways, including those involved in the activation of immune cells and the production of pro-inflammatory cytokines. 2. **MAPK signaling cascades**: DUSP4 negatively regulates MAPK signaling cascades, which are essential for the activation of transcription factors and the regulation of gene expression. 3. **Toll-like receptor (TLR) signaling**: DUSP4 is involved in the regulation of TLR signaling pathways, which are critical for the recognition of pathogens and the activation of innate immune responses. 4. **Nuclear events**: DUSP4 regulates nuclear events, including the activation of transcription factors and the regulation of gene expression. **Clinical Significance:** DUSP4 dysregulation has been implicated in various diseases, including: 1. **Autoimmune disorders**: Altered DUSP4 expression has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: DUSP4 dysregulation has been associated with cancer progression and metastasis. 3. **Neurological disorders**: DUSP4 has been implicated in the regulation of neural signaling pathways, and dysregulation has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Inflammatory disorders**: DUSP4 is involved in the regulation of inflammatory responses, and dysregulation has been linked to inflammatory disorders, such as asthma and inflammatory bowel disease. In conclusion, DUSP4 is a critical regulator of signaling pathways in the immune system, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of DUSP4 in immune function and disease.

Genular Protein ID: 2532129583

Symbol: DUS4_HUMAN

Name: Dual specificity protein phosphatase 4

UniProtKB Accession Codes:

Q13115 B2RBU5 D3DSU4 G5E930 Q13524

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CPTAC 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 11 Ensembl 2 EvolutionaryTrace 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 3 Rhea 9 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7535768

Title: Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase.

PubMed ID: 7535768

DOI: 10.1074/jbc.270.13.7197

PubMed ID: 8626452

Title: The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation.

PubMed ID: 8626452

DOI: 10.1074/jbc.271.11.6497

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21084841

Title: Post-translational regulation of mitogen-activated protein kinase phosphatase-2 (MKP-2) by ERK.

PubMed ID: 21084841

DOI: 10.4161/cc.9.23.13957

PubMed ID: 19843478

Title: Differential regulation of MAP kinase activation by a novel splice variant of human MAP kinase phosphatase-2.

PubMed ID: 19843478

DOI: 10.1016/j.cellsig.2009.10.002

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25489052

Title: Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects.

PubMed ID: 25489052

DOI: 10.1093/hmg/ddu611

PubMed ID: 19415758

Title: Crystal structure of the catalytic domain of human MKP-2 reveals a 24-mer assembly.

PubMed ID: 19415758

DOI: 10.1002/prot.22423

Sequence Information:

  • Length: 394
  • Mass: 42953
  • Checksum: 0603971759B6952E
  • Sequence:
    • MVTMEELREM DCSVLKRLMN RDENGGGAGG SGSHGTLGLP SGGKCLLLDC RPFLAHSAGY 
ILGSVNVRCN TIVRRRAKGS VSLEQILPAE EEVRARLRSG LYSAVIVYDE RSPRAESLRE 
DSTVSLVVQA LRRNAERTDI CLLKGGYERF SSEYPEFCSK TKALAAIPPP VPPSATEPLD 
LGCSSCGTPL HDQGGPVEIL PFLYLGSAYH AARRDMLDAL GITALLNVSS DCPNHFEGHY 
QYKCIPVEDN HKADISSWFM EAIEYIDAVK DCRGRVLVHC QAGISRSATI CLAYLMMKKR 
VRLEEAFEFV KQRRSIISPN FSFMGQLLQF ESQVLATSCA AEAASPSGPL RERGKTPATP 
TSQFVFSFPV SVGVHSAPSS LPYLHSPITT SPSC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.