Details for: DUSP4

Gene ID: 1846

Symbol: DUSP4

Ensembl ID: ENSG00000120875

Description: dual specificity phosphatase 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.03
    Marker Score: 2990
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.9
    Marker Score: 18769.5
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.84
    Marker Score: 618
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.58
    Marker Score: 1775
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.53
    Marker Score: 5908.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.53
    Marker Score: 3160.5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.45
    Marker Score: 836
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.44
    Marker Score: 979
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.43
    Marker Score: 675
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.25
    Marker Score: 2549
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.24
    Marker Score: 7936
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.21
    Marker Score: 2469
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.19
    Marker Score: 7630
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.19
    Marker Score: 1254.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.18
    Marker Score: 1262
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.18
    Marker Score: 701
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.13
    Marker Score: 412
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.12
    Marker Score: 1193
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1
    Marker Score: 17259
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.06
    Marker Score: 1177
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.05
    Marker Score: 827.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.03
    Marker Score: 8928
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.01
    Marker Score: 486
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1
    Marker Score: 355
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71739
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1
    Marker Score: 34522
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47963.5
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.99
    Marker Score: 427
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.99
    Marker Score: 314
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30401
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.97
    Marker Score: 2693
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.95
    Marker Score: 446
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.95
    Marker Score: 302
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.95
    Marker Score: 387
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 485
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.94
    Marker Score: 455
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.94
    Marker Score: 2123
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.93
    Marker Score: 561
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.92
    Marker Score: 865
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2718
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5162
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.9
    Marker Score: 1601
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.89
    Marker Score: 644
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.88
    Marker Score: 555
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5257
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.85
    Marker Score: 217
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.82
    Marker Score: 4012.5
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.82
    Marker Score: 419
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.81
    Marker Score: 432.5
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.8
    Marker Score: 1518
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.79
    Marker Score: 443
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.79
    Marker Score: 412
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.79
    Marker Score: 1920
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.78
    Marker Score: 699
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.78
    Marker Score: 225
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1245
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 305
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.75
    Marker Score: 779
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 572
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.75
    Marker Score: 227
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.74
    Marker Score: 297
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.74
    Marker Score: 2084
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.74
    Marker Score: 434
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.73
    Marker Score: 1902
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 377
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3053.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.72
    Marker Score: 1645
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.72
    Marker Score: 2475
  • Cell Name: T follicular regulatory cell (CL0009113)
    Fold Change: 0.71
    Marker Score: 193
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.7
    Marker Score: 284
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.7
    Marker Score: 593
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.7
    Marker Score: 1277
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 638
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.69
    Marker Score: 331
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.69
    Marker Score: 1435
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.69
    Marker Score: 1448
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.69
    Marker Score: 1197
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.68
    Marker Score: 420
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.68
    Marker Score: 674
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.68
    Marker Score: 253
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.66
    Marker Score: 766
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.64
    Marker Score: 318
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.64
    Marker Score: 330
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.64
    Marker Score: 331
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.64
    Marker Score: 199
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.62
    Marker Score: 1406
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.62
    Marker Score: 342
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.62
    Marker Score: 3239
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.61
    Marker Score: 348
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.6
    Marker Score: 413
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6
    Marker Score: 724
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.59
    Marker Score: 552
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.57
    Marker Score: 413
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.57
    Marker Score: 159
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.57
    Marker Score: 195
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.56
    Marker Score: 175

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Other Information

**Key characteristics:** - DUSP4 is a serine/threonine phosphatase. - It is expressed in high levels in immune cells. - It is involved in the regulation of innate immune responses. - It acts as a negative regulator of the MAPK1/MAPK3 signaling pathway. **Pathways and functions:** - DUSP4 negatively regulates the MAPK1/MAPK3 signaling pathway. - This pathway is involved in the regulation of inflammation and immune responses. - DUSP4 dephosphorylates and inhibits the MAPK1 and MAPK3 kinases, which are key regulators of this pathway. - By inhibiting the MAPK1/MAPK3 pathway, DUSP4 helps to dampen inflammation and immune responses. **Clinical significance:** - DUSP4 has been implicated in the pathogenesis of several inflammatory diseases, including rheumatoid arthritis, asthma, and inflammatory bowel disease. - Dysregulation of DUSP4 has been shown to contribute to the inflammatory response in these diseases. - Targeting DUSP4 has been explored as a therapeutic strategy for these diseases. **Additional information:** - DUSP4 is a member of the Dual specificity protein phosphatase family. - It is expressed in high levels in various immune cell types, including macrophages, dendritic cells, and neutrophils. - It is also expressed in stromal cells in the skin and mucosa. - It is a highly conserved protein with a similar sequence in mammals and humans.

Genular Protein ID: 2532129583

Symbol: DUS4_HUMAN

Name: Dual specificity protein phosphatase 4

UniProtKB Accession Codes:

Q13115 B2RBU5 D3DSU4 G5E930 Q13524

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CPTAC 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 11 EPD 1 Ensembl 2 EvolutionaryTrace 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 3 Rhea 9 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7535768

Title: Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase.

PubMed ID: 7535768

DOI: 10.1074/jbc.270.13.7197

PubMed ID: 8626452

Title: The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation.

PubMed ID: 8626452

DOI: 10.1074/jbc.271.11.6497

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21084841

Title: Post-translational regulation of mitogen-activated protein kinase phosphatase-2 (MKP-2) by ERK.

PubMed ID: 21084841

DOI: 10.4161/cc.9.23.13957

PubMed ID: 19843478

Title: Differential regulation of MAP kinase activation by a novel splice variant of human MAP kinase phosphatase-2.

PubMed ID: 19843478

DOI: 10.1016/j.cellsig.2009.10.002

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25489052

Title: Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects.

PubMed ID: 25489052

DOI: 10.1093/hmg/ddu611

PubMed ID: 19415758

Title: Crystal structure of the catalytic domain of human MKP-2 reveals a 24-mer assembly.

PubMed ID: 19415758

DOI: 10.1002/prot.22423

Sequence Information:

  • Length: 394
  • Mass: 42953
  • Checksum: 0603971759B6952E
  • Sequence:
    • MVTMEELREM DCSVLKRLMN RDENGGGAGG SGSHGTLGLP SGGKCLLLDC RPFLAHSAGY 
ILGSVNVRCN TIVRRRAKGS VSLEQILPAE EEVRARLRSG LYSAVIVYDE RSPRAESLRE 
DSTVSLVVQA LRRNAERTDI CLLKGGYERF SSEYPEFCSK TKALAAIPPP VPPSATEPLD 
LGCSSCGTPL HDQGGPVEIL PFLYLGSAYH AARRDMLDAL GITALLNVSS DCPNHFEGHY 
QYKCIPVEDN HKADISSWFM EAIEYIDAVK DCRGRVLVHC QAGISRSATI CLAYLMMKKR 
VRLEEAFEFV KQRRSIISPN FSFMGQLLQF ESQVLATSCA AEAASPSGPL RERGKTPATP 
TSQFVFSFPV SVGVHSAPSS LPYLHSPITT SPSC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.