Details for: DUSP8

Gene ID: 1850

Symbol: DUSP8

Ensembl ID: ENSG00000184545

Description: dual specificity phosphatase 8

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.22
    Marker Score: 5446
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.29
    Marker Score: 43922
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.26
    Marker Score: 478.5
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.14
    Marker Score: 284
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.1
    Marker Score: 9441
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.06
    Marker Score: 4391.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.03
    Marker Score: 4211
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.03
    Marker Score: 2417
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.01
    Marker Score: 406
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71777
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1
    Marker Score: 1540
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48001
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.99
    Marker Score: 3820
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.97
    Marker Score: 9216
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.96
    Marker Score: 58771
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.95
    Marker Score: 944
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 488
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 442
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5241
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2727
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.88
    Marker Score: 8298
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5268
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.87
    Marker Score: 902
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.83
    Marker Score: 6373
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.82
    Marker Score: 290
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.81
    Marker Score: 182
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.81
    Marker Score: 30621
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.8
    Marker Score: 16005.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.8
    Marker Score: 12020.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.79
    Marker Score: 29290
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.78
    Marker Score: 8102
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.75
    Marker Score: 1718
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 563.5
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.73
    Marker Score: 343
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 380
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.73
    Marker Score: 1030
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 461
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.71
    Marker Score: 308
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.7
    Marker Score: 2591
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2856
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 619
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.67
    Marker Score: 755
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.67
    Marker Score: 628.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.67
    Marker Score: 269
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.65
    Marker Score: 1158
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.65
    Marker Score: 203
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.65
    Marker Score: 428
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.65
    Marker Score: 241
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.64
    Marker Score: 190
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.64
    Marker Score: 197
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.63
    Marker Score: 328
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.63
    Marker Score: 213
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.6
    Marker Score: 359
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.58
    Marker Score: 2687
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.56
    Marker Score: 160
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.55
    Marker Score: 6212
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.54
    Marker Score: 271
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 430
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.53
    Marker Score: 162
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.53
    Marker Score: 2050
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.53
    Marker Score: 523.5
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.53
    Marker Score: 365.5
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.53
    Marker Score: 442
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.52
    Marker Score: 1461
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.52
    Marker Score: 134
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.5
    Marker Score: 239.5
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.49
    Marker Score: 130
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.49
    Marker Score: 284
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.48
    Marker Score: 239
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.48
    Marker Score: 470
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.48
    Marker Score: 249
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.47
    Marker Score: 697
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.46
    Marker Score: 966
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.45
    Marker Score: 187
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.45
    Marker Score: 2141
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.44
    Marker Score: 229
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.44
    Marker Score: 117
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.44
    Marker Score: 421
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.44
    Marker Score: 1375.5
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.43
    Marker Score: 952
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.43
    Marker Score: 521
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.43
    Marker Score: 149
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.42
    Marker Score: 857
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.42
    Marker Score: 2178
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.41
    Marker Score: 440
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.41
    Marker Score: 1728
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.41
    Marker Score: 119
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.4
    Marker Score: 256
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.39
    Marker Score: 174
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.39
    Marker Score: 137
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.39
    Marker Score: 261
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.38
    Marker Score: 12931
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.38
    Marker Score: 297
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.37
    Marker Score: 1796
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.36
    Marker Score: 861

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - DUSP8 is a serine/threonine phosphatase. - It has two specific substrates: MAPK1 and MAPK3. - It is a key regulator of the MAPK pathway, which is involved in cell growth, differentiation, and survival. - It is also involved in the regulation of cell migration, proliferation, and differentiation. **Pathways and functions:** - DUSP8 is a key regulator of the MAPK pathway. - It is activated by the MAPK pathway, which is activated by growth factors and other extracellular signals. - Once activated, DUSP8 phosphorylates and inhibits MAPK1 and MAPK3, which leads to the inhibition of cell growth and proliferation. - DUSP8 also regulates the activity of other MAPK pathway-dependent proteins, such as p38 MAPK and ERK. **Clinical significance:** - Mutations in DUSP8 have been linked to several human cancers, including breast cancer, lung cancer, and colorectal cancer. - Overexpression of DUSP8 has been associated with poor prognosis in cancer patients. - Inhibition of DUSP8 has been shown to inhibit tumor growth in preclinical models. **Additional notes:** - DUSP8 is a highly conserved protein with homologs in other species. - It is a novel therapeutic target for cancer and other diseases that are characterized by abnormal MAPK signaling.

Genular Protein ID: 745478861

Symbol: DUS8_HUMAN

Name: Dual specificity protein phosphatase 8

UniProtKB Accession Codes:

Q13202 Q86SS8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 12 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 5 EMBL 4 Ensembl 8 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PRINTS 1 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 Rhea 9 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7561881

Title: hVH-5: a protein tyrosine phosphatase abundant in brain that inactivates mitogen-activated protein kinase.

PubMed ID: 7561881

DOI: 10.1046/j.1471-4159.1995.65041823.x

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24531476

Title: The family-wide structure and function of human dual-specificity protein phosphatases.

PubMed ID: 24531476

DOI: 10.1107/s1399004713029866

Sequence Information:

  • Length: 625
  • Mass: 65827
  • Checksum: C7C808407B724FFC
  • Sequence:
    • MAGDRLPRKV MDAKKLASLL RGGPGGPLVI DSRSFVEYNS WHVLSSVNIC CSKLVKRRLQ 
QGKVTIAELI QPAARSQVEA TEPQDVVVYD QSTRDASVLA ADSFLSILLS KLDGCFDSVA 
ILTGGFATFS SCFPGLCEGK PAALLPMSLS QPCLPVPSVG LTRILPHLYL GSQKDVLNKD 
LMTQNGISYV LNASNSCPKP DFICESRFMR VPINDNYCEK LLPWLDKSIE FIDKAKLSSC 
QVIVHCLAGI SRSATIAIAY IMKTMGMSSD DAYRFVKDRR PSISPNFNFL GQLLEYERSL 
KLLAALQGDP GTPSGTPEPP PSPAAGAPLP RLPPPTSESA ATGNAAAREG GLSAGGEPPA 
PPTPPATSAL QQGLRGLHLS SDRLQDTNRL KRSFSLDIKS AYAPSRRPDG PGPPDPGEAP 
KLCKLDSPSG AALGLSSPSP DSPDAAPEAR PRPRRRPRPP AGSPARSPAH SLGLNFGDAA 
RQTPRHGLSA LSAPGLPGPG QPAGPGAWAP PLDSPGTPSP DGPWCFSPEG AQGAGGVLFA 
PFGRAGAPGP GGGSDLRRRE AARAEPRDAR TGWPEEPAPE TQFKRRSCQM EFEEGMVEGR 
ARGEELAALG KQASFSGSVE VIEVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.