Details for: DUSP8

Gene ID: 1850

Symbol: DUSP8

Ensembl ID: ENSG00000184545

Description: dual specificity phosphatase 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 111.2860
    Cell Significance Index: -17.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 68.2848
    Cell Significance Index: -17.3200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 38.5224
    Cell Significance Index: -15.6500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 16.4128
    Cell Significance Index: -15.6700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.0394
    Cell Significance Index: -17.3100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.8947
    Cell Significance Index: -18.4700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 5.8680
    Cell Significance Index: 45.2300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.9037
    Cell Significance Index: -11.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.6159
    Cell Significance Index: 118.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.4667
    Cell Significance Index: 53.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.2051
    Cell Significance Index: 419.6400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.0088
    Cell Significance Index: 30.1000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.8961
    Cell Significance Index: 54.6300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.5305
    Cell Significance Index: 25.2200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.3092
    Cell Significance Index: 37.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2432
    Cell Significance Index: 1122.5500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8034
    Cell Significance Index: 87.3900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7965
    Cell Significance Index: 129.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7433
    Cell Significance Index: 46.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6902
    Cell Significance Index: 138.4500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6653
    Cell Significance Index: 39.9400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4944
    Cell Significance Index: 10.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4748
    Cell Significance Index: 170.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4734
    Cell Significance Index: 16.6400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4392
    Cell Significance Index: 30.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4240
    Cell Significance Index: 9.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3694
    Cell Significance Index: 5.0400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3659
    Cell Significance Index: 7.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3139
    Cell Significance Index: 31.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2957
    Cell Significance Index: 15.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2382
    Cell Significance Index: 40.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2232
    Cell Significance Index: 10.4900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2186
    Cell Significance Index: 5.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2163
    Cell Significance Index: 16.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1950
    Cell Significance Index: 22.3400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1900
    Cell Significance Index: 4.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1894
    Cell Significance Index: 8.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1620
    Cell Significance Index: 20.9400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1568
    Cell Significance Index: 17.9000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1476
    Cell Significance Index: 3.6800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.1121
    Cell Significance Index: 0.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0908
    Cell Significance Index: 49.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0685
    Cell Significance Index: 3.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0670
    Cell Significance Index: 29.6400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0536
    Cell Significance Index: 0.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0291
    Cell Significance Index: 2.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0220
    Cell Significance Index: 41.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0160
    Cell Significance Index: 0.8400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0068
    Cell Significance Index: 9.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0051
    Cell Significance Index: 0.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0011
    Cell Significance Index: 0.4800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0002
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0034
    Cell Significance Index: -2.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0045
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0052
    Cell Significance Index: -3.2400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0064
    Cell Significance Index: -0.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0090
    Cell Significance Index: -16.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0091
    Cell Significance Index: -13.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0096
    Cell Significance Index: -1.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0152
    Cell Significance Index: -8.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0163
    Cell Significance Index: -11.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0180
    Cell Significance Index: -2.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0185
    Cell Significance Index: -14.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0239
    Cell Significance Index: -15.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0284
    Cell Significance Index: -5.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0286
    Cell Significance Index: -6.0200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0442
    Cell Significance Index: -2.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0488
    Cell Significance Index: -14.0500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0521
    Cell Significance Index: -2.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0531
    Cell Significance Index: -6.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0661
    Cell Significance Index: -8.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0697
    Cell Significance Index: -4.9300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0730
    Cell Significance Index: -1.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0814
    Cell Significance Index: -8.3200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0978
    Cell Significance Index: -1.4000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0993
    Cell Significance Index: -3.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1006
    Cell Significance Index: -14.6300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1109
    Cell Significance Index: -1.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1109
    Cell Significance Index: -3.1000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1196
    Cell Significance Index: -1.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1258
    Cell Significance Index: -7.0600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1383
    Cell Significance Index: -1.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1390
    Cell Significance Index: -14.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1476
    Cell Significance Index: -17.4100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1572
    Cell Significance Index: -3.9300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1854
    Cell Significance Index: -1.1200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1861
    Cell Significance Index: -3.9500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1933
    Cell Significance Index: -10.0700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2011
    Cell Significance Index: -15.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2052
    Cell Significance Index: -5.4800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2106
    Cell Significance Index: -2.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2265
    Cell Significance Index: -14.6200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2386
    Cell Significance Index: -2.4700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2462
    Cell Significance Index: -5.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2568
    Cell Significance Index: -8.1800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2587
    Cell Significance Index: -8.4700
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.2621
    Cell Significance Index: -1.2100
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.2740
    Cell Significance Index: -2.9700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2854
    Cell Significance Index: -3.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2856
    Cell Significance Index: -17.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DUSP8 is a dual specificity phosphatase, meaning it has the ability to dephosphorylate both tyrosine and threonine residues on protein substrates. This unique property allows DUSP8 to regulate multiple signaling pathways, including the MAPK pathway. DUSP8 is also known to be involved in the negative regulation of the MAPK pathway, which prevents excessive activation of this pathway and subsequent cellular damage. **Pathways and Functions:** DUSP8 is involved in the following signaling pathways: 1. **MAPK signaling pathway:** DUSP8 dephosphorylates and thereby inactivates MAPK kinases, such as JNK and p38, which are key regulators of the MAPK pathway. This negative regulation prevents the activation of downstream targets, including transcription factors and other signaling molecules. 2. **Raf-independent MAPK1/3 activation:** DUSP8 is also involved in the regulation of Raf-independent MAPK1/3 activation, which is a key event in the MAPK signaling pathway. 3. **Negative regulation of MAPK cascade:** DUSP8 acts as a negative regulator of the MAPK cascade, preventing the activation of downstream targets and subsequent cellular damage. **Clinical Significance:** DUSP8 has been implicated in various diseases and disorders, including: 1. **Cancer:** DUSP8 has been shown to be overexpressed in certain types of cancer, including breast and lung cancer. This overexpression is associated with increased tumor growth and metastasis. 2. **Inflammatory disorders:** DUSP8 has been shown to be involved in the regulation of inflammatory responses, and its dysregulation has been implicated in various inflammatory disorders, including arthritis and asthma. 3. **Neurological disorders:** DUSP8 has been implicated in the regulation of neuronal function and has been shown to be involved in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, DUSP8 is a critical regulator of signal transduction pathways in the immune system, and its dysregulation has been implicated in various diseases and disorders. Further research is needed to fully understand the role of DUSP8 in human disease and to develop therapeutic strategies to target this gene in the treatment of these disorders.

Genular Protein ID: 745478861

Symbol: DUS8_HUMAN

Name: Dual specificity protein phosphatase 8

UniProtKB Accession Codes:

Q13202 Q86SS8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 12 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 5 EMBL 4 Ensembl 8 EvolutionaryTrace 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 Rhea 9 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7561881

Title: hVH-5: a protein tyrosine phosphatase abundant in brain that inactivates mitogen-activated protein kinase.

PubMed ID: 7561881

DOI: 10.1046/j.1471-4159.1995.65041823.x

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24531476

Title: The family-wide structure and function of human dual-specificity protein phosphatases.

PubMed ID: 24531476

DOI: 10.1107/s1399004713029866

Sequence Information:

  • Length: 625
  • Mass: 65827
  • Checksum: C7C808407B724FFC
  • Sequence:
    • MAGDRLPRKV MDAKKLASLL RGGPGGPLVI DSRSFVEYNS WHVLSSVNIC CSKLVKRRLQ 
QGKVTIAELI QPAARSQVEA TEPQDVVVYD QSTRDASVLA ADSFLSILLS KLDGCFDSVA 
ILTGGFATFS SCFPGLCEGK PAALLPMSLS QPCLPVPSVG LTRILPHLYL GSQKDVLNKD 
LMTQNGISYV LNASNSCPKP DFICESRFMR VPINDNYCEK LLPWLDKSIE FIDKAKLSSC 
QVIVHCLAGI SRSATIAIAY IMKTMGMSSD DAYRFVKDRR PSISPNFNFL GQLLEYERSL 
KLLAALQGDP GTPSGTPEPP PSPAAGAPLP RLPPPTSESA ATGNAAAREG GLSAGGEPPA 
PPTPPATSAL QQGLRGLHLS SDRLQDTNRL KRSFSLDIKS AYAPSRRPDG PGPPDPGEAP 
KLCKLDSPSG AALGLSSPSP DSPDAAPEAR PRPRRRPRPP AGSPARSPAH SLGLNFGDAA 
RQTPRHGLSA LSAPGLPGPG QPAGPGAWAP PLDSPGTPSP DGPWCFSPEG AQGAGGVLFA 
PFGRAGAPGP GGGSDLRRRE AARAEPRDAR TGWPEEPAPE TQFKRRSCQM EFEEGMVEGR 
ARGEELAALG KQASFSGSVE VIEVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.