Details for: DYRK1A
Gene ID: 1859
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: DYRK1A
Ensembl ID: ENSG00000157540
Description: dual specificity tyrosine phosphorylation regulated kinase 1A
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 42.2rCSI 70.84%PRS 39.99
-
CSI 42.12rCSI 67.74%PRS 42.25
-
CSI 37.8rCSI 45.15%PRS 39.82
-
CSI 34.44rCSI 60.82%PRS 39.03
-
CSI 34.31rCSI 42.69%PRS 38.12
-
CSI 31.68rCSI 45.46%PRS 47.93
-
CSI 29.64rCSI 72.03%PRS 38.7
-
CSI 29.14rCSI 37.56%PRS 41.17
-
CSI 27.39rCSI 19.66%PRS 72
-
CSI 26.82rCSI 23.81%PRS 55.83
-
CSI 26.26rCSI 18.44%PRS 76.87
-
CSI 26.05rCSI 32.4%PRS 59.72
-
CSI 23.77rCSI 74.29%PRS 41.49
-
CSI 23.45rCSI 51.8%PRS 44.26
-
CSI 21.05rCSI 65.85%PRS 44.1
-
CSI 21.05rCSI 36.4%PRS 47.93
-
CSI 20.28rCSI 72.99%PRS 38.49
-
CSI 19.96rCSI 17.53%PRS 62.94
-
CSI 19.28rCSI 72.88%PRS 40.86
-
CSI 18.33rCSI 25.05%PRS 59.57
-
CSI 17.39rCSI 59.56%PRS 47.17
-
CSI 17.29rCSI 46.2%PRS 49.22
-
CSI 16.82rCSI 44.64%PRS 69.77
-
CSI 16.47rCSI 34.18%PRS 55.08
-
CSI 16.34rCSI 33.16%PRS 37.79
-
CSI 16.18rCSI 22.93%PRS 54.09
-
CSI 15.51rCSI 40.3%PRS 61.81
-
CSI 14.67rCSI 10.2%PRS 68.38
-
CSI 14.47rCSI 18.57%PRS 55.2
-
CSI 14rCSI 22.93%PRS 47.41
-
CSI 13.87rCSI 11.21%PRS 68.3
-
CSI 13.32rCSI 34.44%PRS 52.91
-
CSI 12.53rCSI 73.78%PRS 41.39
-
CSI 12.18rCSI 32.43%PRS 47.72
-
CSI 12.11rCSI 13.98%PRS 51.22
-
CSI 11.77rCSI 17.99%PRS 62.06
-
CSI 11.66rCSI 16.64%PRS 60.24
-
CSI 11.65rCSI 26.65%PRS 57.51
-
CSI 11.64rCSI 65.81%PRS 43.21
-
CSI 11.58rCSI 43.38%PRS 50
-
CSI 11.29rCSI 17.24%PRS 58.39
-
CSI 11.27rCSI 49.52%PRS 54.68
-
CSI 10.92rCSI 8.63%PRS 44.69
-
CSI 10.88rCSI 43.08%PRS 58.06
-
CSI 10.56rCSI 12.76%PRS 66.39
-
CSI 10.42rCSI 10.91%PRS 54.28
-
CSI 10.38rCSI 14.38%PRS 59.61
-
CSI 10.19rCSI 50.67%PRS 56.01
-
CSI 10.05rCSI 19.16%PRS 73.23
-
CSI 9.96rCSI 8.54%PRS 65.84
-
CSI 9.95rCSI 73.14%PRS 44.81
-
CSI 9.87rCSI 31.76%PRS 56.47
-
CSI 9.84rCSI 32.34%PRS 45.19
-
CSI 9.74rCSI 22.48%PRS 47.41
-
CSI 9.73rCSI 15.52%PRS 50.68
-
CSI 9.72rCSI 12.48%PRS 51.1
-
CSI 9.64rCSI 23.54%PRS 51.69
-
CSI 9.54rCSI 20.7%PRS 46.31
-
CSI 9.52rCSI 17.1%PRS 50.81
-
CSI 9.48rCSI 11.11%PRS 74.1
-
CSI 9.26rCSI 22.14%PRS 45.5
-
CSI 9.15rCSI 60.72%PRS 55.28
-
CSI 9.06rCSI 25.4%PRS 70.02
-
CSI 9.06rCSI 18.19%PRS 46.99
-
CSI 9rCSI 12.3%PRS 63.53
-
CSI 8.97rCSI 14.43%PRS 47.47
-
CSI 8.73rCSI 59.41%PRS 54.07
-
CSI 8.72rCSI 29.53%PRS 50.5
-
CSI 8.68rCSI 32.75%PRS 45.02
-
CSI 8.63rCSI 8.88%PRS 74.71
-
CSI 8.54rCSI 13.84%PRS 54.76
-
CSI 8.42rCSI 11.7%PRS 56.71
-
CSI 8.31rCSI 10.45%PRS 70.08
-
CSI 7.97rCSI 9.93%PRS 68.53
-
CSI 7.89rCSI 46.6%PRS 53.19
-
CSI 7.82rCSI 19.83%PRS 47.36
-
CSI 7.81rCSI 25.42%PRS 58.77
-
CSI 7.71rCSI 12.26%PRS 50.16
-
CSI 7.64rCSI 20.17%PRS 66.67
-
CSI 7.64rCSI 8.84%PRS 47.81
-
CSI 7.58rCSI 17.3%PRS 49.84
-
CSI 7.5rCSI 16.74%PRS 65.35
-
CSI 7.2rCSI 7.45%PRS 63.36
-
CSI 7.09rCSI 15.6%PRS 40.34
-
CSI 7.04rCSI 6.49%PRS 58.81
-
CSI 7.01rCSI 9.59%PRS 52.01
-
CSI 6.98rCSI 28.44%PRS 52.91
-
CSI 6.97rCSI 13.85%PRS 55.73
-
CSI 6.94rCSI 15.82%PRS 54.69
-
CSI 6.93rCSI 16.53%PRS 59.07
-
CSI 6.91rCSI 9.41%PRS 49.89
-
CSI 6.88rCSI 35.22%PRS 63.06
-
CSI 6.84rCSI 70.77%PRS 51.4
-
CSI 6.77rCSI 12.68%PRS 46.36
-
CSI 6.76rCSI 10.2%PRS 61.33
-
CSI 6.74rCSI 52.24%PRS 54.81
-
CSI 6.47rCSI 9.89%PRS 67.02
-
CSI 6.47rCSI 16.86%PRS 57.38
-
CSI 6.34rCSI 14.38%PRS 62.23
-
CSI 6.34rCSI 16.52%PRS 55.73
-
CSI 0.2rCSI 1.2%PRS 67.5%
-
CSI 0.2rCSI 2.3%PRS 76.7%
-
CSI 0.3rCSI 1.5%PRS 67.4%
-
CSI 0.3rCSI 2.7%PRS 73.9%
-
CSI 0.3rCSI 2.6%PRS 74.9%
-
CSI 0.4rCSI 1.4%PRS 62.9%
-
CSI 0.5rCSI 2.6%PRS 68.6%
-
CSI 0.5rCSI 3.1%PRS 77.6%
-
CSI 0.5rCSI 2.3%PRS 73.5%
-
CSI 0.6rCSI 0.9%PRS 74.1%
-
CSI 0.6rCSI 2.5%PRS 75.0%
-
CSI 0.8rCSI 3.5%PRS 77.3%
-
CSI 0.8rCSI 5.1%PRS 60.8%
-
CSI 0.8rCSI 1.2%PRS 63.7%
-
CSI 0.8rCSI 1.1%PRS 64.0%
-
CSI 0.9rCSI 6.7%PRS 67.3%
-
CSI 0.9rCSI 0.8%PRS 68.2%
-
CSI 0.9rCSI 1.9%PRS 60.4%
-
CSI 1.0rCSI 2.2%PRS 71.2%
-
CSI 1.0rCSI 2.0%PRS 69.9%
-
CSI 1.0rCSI 1.9%PRS 60.5%
-
CSI 1.0rCSI 2.7%PRS 71.1%
-
CSI 1.0rCSI 4.6%PRS 42.1%
-
CSI 1.1rCSI 1.8%PRS 59.7%
-
CSI 1.1rCSI 4.4%PRS 77.9%
-
CSI 1.2rCSI 2.2%PRS 74.1%
-
CSI 1.2rCSI 3.0%PRS 52.3%
-
CSI 1.2rCSI 3.5%PRS 71.6%
-
CSI 1.3rCSI 9.3%PRS 49.8%
-
CSI 1.3rCSI 8.5%PRS 68.4%
-
CSI 1.4rCSI 3.3%PRS 62.1%
-
CSI 1.4rCSI 3.1%PRS 66.4%
-
CSI 1.4rCSI 2.1%PRS 69.4%
-
CSI 1.5rCSI 6.6%PRS 76.4%
-
CSI 1.5rCSI 2.2%PRS 73.7%
-
CSI 1.5rCSI 2.4%PRS 69.0%
-
CSI 1.5rCSI 4.1%PRS 65.7%
-
CSI 1.5rCSI 1.8%PRS 55.8%
-
CSI 1.5rCSI 8.6%PRS 69.6%
-
CSI 1.6rCSI 1.6%PRS 56.0%
-
CSI 1.6rCSI 4.2%PRS 58.1%
-
CSI 1.7rCSI 2.3%PRS 79.3%
-
CSI 1.8rCSI 15.1%PRS 55.8%
-
CSI 1.8rCSI 1.5%PRS 62.5%
-
CSI 1.8rCSI 1.1%PRS 74.8%
-
CSI 1.8rCSI 1.2%PRS 70.6%
-
CSI 1.8rCSI 11.0%PRS 66.9%
-
CSI 1.9rCSI 2.7%PRS 67.4%
-
CSI 1.9rCSI 1.7%PRS 66.4%
-
CSI 1.9rCSI 7.4%PRS 62.6%
-
CSI 1.9rCSI 1.7%PRS 54.5%
-
CSI 1.9rCSI 20.2%PRS 56.8%
-
CSI 1.9rCSI 2.4%PRS 68.1%
-
CSI 2.0rCSI 5.7%PRS 77.3%
-
CSI 2.0rCSI 7.6%PRS 49.0%
-
CSI 2.0rCSI 2.1%PRS 61.2%
-
CSI 2.0rCSI 2.0%PRS 60.4%
-
CSI 2.1rCSI 8.4%PRS 69.6%
-
CSI 2.1rCSI 32.7%PRS 62.6%
-
CSI 2.1rCSI 5.2%PRS 56.1%
-
CSI 2.2rCSI 3.1%PRS 69.1%
-
CSI 2.2rCSI 1.6%PRS 71.3%
-
CSI 2.2rCSI 14.3%PRS 76.4%
-
CSI 2.2rCSI 2.9%PRS 62.6%
-
CSI 2.3rCSI 26.1%PRS 49.2%
-
CSI 2.3rCSI 2.8%PRS 54.0%
-
CSI 2.3rCSI 14.4%PRS 49.7%
-
CSI 2.4rCSI 2.4%PRS 80.1%
-
CSI 2.5rCSI 5.5%PRS 76.1%
-
CSI 2.5rCSI 4.4%PRS 56.9%
-
CSI 2.6rCSI 3.1%PRS 75.4%
-
CSI 2.6rCSI 3.8%PRS 63.2%
-
CSI 2.6rCSI 13.6%PRS 63.6%
-
CSI 2.6rCSI 3.9%PRS 59.5%
-
CSI 2.6rCSI 4.7%PRS 66.4%
-
CSI 2.7rCSI 3.6%PRS 69.7%
-
CSI 2.7rCSI 6.3%PRS 67.7%
-
CSI 2.7rCSI 6.0%PRS 55.7%
-
CSI 2.7rCSI 6.4%PRS 63.8%
-
CSI 2.8rCSI 23.2%PRS 50.1%
-
CSI 2.8rCSI 7.9%PRS 54.9%
-
CSI 2.8rCSI 11.6%PRS 58.1%
-
CSI 2.8rCSI 13.5%PRS 56.8%
-
CSI 2.9rCSI 13.4%PRS 74.6%
-
CSI 2.9rCSI 4.3%PRS 51.9%
-
CSI 2.9rCSI 11.8%PRS 56.4%
-
CSI 3.0rCSI 2.2%PRS 50.5%
-
CSI 3.0rCSI 6.3%PRS 76.3%
-
CSI 3.0rCSI 2.4%PRS 59.0%
-
CSI 3.0rCSI 7.3%PRS 75.7%
-
CSI 3.0rCSI 11.7%PRS 73.4%
-
CSI 3.0rCSI 2.8%PRS 72.3%
-
CSI 3.1rCSI 4.8%PRS 65.9%
-
CSI 3.1rCSI 3.1%PRS 51.1%
-
CSI 3.1rCSI 14.0%PRS 76.6%
-
CSI 3.2rCSI 4.9%PRS 55.8%
-
CSI 3.2rCSI 16.0%PRS 69.1%
-
CSI 3.3rCSI 66.2%PRS 50.4%
-
CSI 3.3rCSI 4.8%PRS 61.9%
-
CSI 3.3rCSI 79.4%PRS 40.2%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2938402413
Symbol: DYR1A_HUMAN
Name: Dual specificity tyrosine-phosphorylation-regulated kinase 1A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8975710
Title: Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome 'critical region'.
PubMed ID: 8975710
PubMed ID: 8872470
Title: A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region.
PubMed ID: 8872470
DOI: 10.1093/hmg/5.9.1305
PubMed ID: 8769099
Title: Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from 'the Down syndrome critical region' of chromosome 21.
PubMed ID: 8769099
PubMed ID: 9037601
Title: Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21.
PubMed ID: 9037601
DOI: 10.1101/gr.7.1.47
PubMed ID: 10329007
Title: Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome.
PubMed ID: 10329007
PubMed ID: 9503011
Title: Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome.
PubMed ID: 9503011
PubMed ID: 14500717
Title: Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M.
PubMed ID: 14500717
PubMed ID: 14593110
Title: Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases.
PubMed ID: 14593110
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 19266028
Title: Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment.
PubMed ID: 19266028
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20167603
Title: DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.
PubMed ID: 20167603
PubMed ID: 21294719
Title: Intragenic deletion in DYRK1A leads to mental retardation and primary microcephaly.
PubMed ID: 21294719
PubMed ID: 21127067
Title: Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity.
PubMed ID: 21127067
PubMed ID: 23160955
Title: Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders.
PubMed ID: 23160955
PubMed ID: 23415227
Title: Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signaling.
PubMed ID: 23415227
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23864635
Title: Dissection of the C-terminal region of E1A redefines the roles of CtBP and other cellular targets in oncogenic transformation.
PubMed ID: 23864635
DOI: 10.1128/jvi.00786-13
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 31024071
Title: The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.
PubMed ID: 31024071
PubMed ID: 30773093
Title: DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169.
PubMed ID: 30773093
PubMed ID: 20981014
Title: Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A.
PubMed ID: 20981014
DOI: 10.1038/ncomms1090
PubMed ID: 22998443
Title: Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.
PubMed ID: 22998443
DOI: 10.1021/jm301034u
PubMed ID: 24239188
Title: Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors.
PubMed ID: 24239188
PubMed ID: 25620562
Title: Chromatin-wide profiling of DYRK1A reveals a role as a gene-specific RNA polymerase II CTD kinase.
PubMed ID: 25620562
PubMed ID: 29849146
Title: Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II.
PubMed ID: 29849146
PubMed ID: 23665168
Title: Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition.
PubMed ID: 23665168
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 763
- Mass: 85584
- Checksum: 7C3A52A3CBB04FB5
- Sequence:
MHTGGETSAC KPSSVRLAPS FSFHAAGLQM AGQMPHSHQY SDRRQPNISD QQVSALSYSD QIQQPLTNQV MPDIVMLQRR MPQTFRDPAT APLRKLSVDL IKTYKHINEV YYAKKKRRHQ QGQGDDSSHK KERKVYNDGY DDDNYDYIVK NGEKWMDRYE IDSLIGKGSF GQVVKAYDRV EQEWVAIKII KNKKAFLNQA QIEVRLLELM NKHDTEMKYY IVHLKRHFMF RNHLCLVFEM LSYNLYDLLR NTNFRGVSLN LTRKFAQQMC TALLFLATPE LSIIHCDLKP ENILLCNPKR SAIKIVDFGS SCQLGQRIYQ YIQSRFYRSP EVLLGMPYDL AIDMWSLGCI LVEMHTGEPL FSGANEVDQM NKIVEVLGIP PAHILDQAPK ARKFFEKLPD GTWNLKKTKD GKREYKPPGT RKLHNILGVE TGGPGGRRAG ESGHTVADYL KFKDLILRML DYDPKTRIQP YYALQHSFFK KTADEGTNTS NSVSTSPAME QSQSSGTTSS TSSSSGGSSG TSNSGRARSD PTHQHRHSGG HFTAAVQAMD CETHSPQVRQ QFPAPLGWSG TEAPTQVTVE THPVQETTFH VAPQQNALHH HHGNSSHHHH HHHHHHHHHG QQALGNRTRP RVYNSPTNSS STQDSMEVGH SHHSMTSLSS STTSSSTSSS STGNQGNQAY QNRPVAANTL DFGQNGAMDV NLTVYSNPRQ ETGIAGHPTY QFSANTGPAH YMTEGHLTMR QGADREESPM TGVCVQQSPV ASS
Genular Protein ID: 2191849470
Symbol: A0A2R8Y6I6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10830953
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 725
- Mass: 81599
- Checksum: B293E0326947C872
- Sequence:
MAGQMPHSHQ YSDRRQPNIS DQQVSALSYS DQIQQPLTNQ RRMPQTFRDP ATAPLRKLSV DLIKTYKHIN EVYYAKKKRR HQQGQGDDSS HKKERKVYND GYDDDNYDYI VKNGEKWMDR YEIDSLIGKG SFGQVVKAYD RVEQEWVAIK IIKNKKAFLN QAQIEVRLLE LMNKHDTEMK YYIVHLKRHF MFRNHLCLVF EMLSYNLYDL LRNTNFRGVS LNLTRKFAQQ MCTALLFLAT PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGMPY DLAIDMWSLG CILVEMHTGE PLFSGANEVD QMNKIVEVLG IPPAHILDQA PKARKFFEKL PDGTWNLKKT KDGKREYKPP GTRKLHNILG VETGGPGGRR AGESGHTVAD YLKFKDLILR MLDYDPKTRI QPYYALQHSF FKKTADEGTN TSNSVSTSPA MEQSQSSGTT SSTSSSSGGS SGTSNSGRAR SDPTHQHRHS GGHFTAAVQA MDCETHSPQV RQQFPAPLGW SGTEAPTQVT VETHPVQETT FHVAPQQNAL HHHHGNSSHH HHHHHHHHHH HGQQALGNRT RPRVYNSPTN SSSTQDSMEV GHSHHSMTSL SSSTTSSSTS SSSTGNQGNQ AYQNRPVAAN TLDFGQNGAM DVNLTVYSNP RQETGIAGHP TYQFSANTGP AHYMTEGHLT MRQGADREES PMTGVCVQQS PVASS