Details for: DYRK1A

Gene ID: 1859

Symbol: DYRK1A

Ensembl ID: ENSG00000157540

Description: dual specificity tyrosine phosphorylation regulated kinase 1A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.09
    Marker Score: 6789.5
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.87
    Marker Score: 11994
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.76
    Marker Score: 3339
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.74
    Marker Score: 2110
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.71
    Marker Score: 3122
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.64
    Marker Score: 1390
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.62
    Marker Score: 3528.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.57
    Marker Score: 54797
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.54
    Marker Score: 56745
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.5
    Marker Score: 1392
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.5
    Marker Score: 731
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.49
    Marker Score: 4785
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.36
    Marker Score: 18075
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.36
    Marker Score: 89457.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.35
    Marker Score: 35079
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.32
    Marker Score: 46094
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.32
    Marker Score: 1383
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.24
    Marker Score: 1312
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.23
    Marker Score: 1109
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.23
    Marker Score: 2777
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.22
    Marker Score: 9207
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.22
    Marker Score: 1968
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.18
    Marker Score: 690
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.18
    Marker Score: 38615.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.16
    Marker Score: 79587
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.14
    Marker Score: 1611
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.14
    Marker Score: 1246
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.14
    Marker Score: 1483.5
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.12
    Marker Score: 1190
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.12
    Marker Score: 1831
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.11
    Marker Score: 8788
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.1
    Marker Score: 2319
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.09
    Marker Score: 8094
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.09
    Marker Score: 70637
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.05
    Marker Score: 1953
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.04
    Marker Score: 9428
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.03
    Marker Score: 585
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.02
    Marker Score: 2290.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.01
    Marker Score: 18932
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.98
    Marker Score: 629
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.98
    Marker Score: 121851.5
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.98
    Marker Score: 4732
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.97
    Marker Score: 2128
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.94
    Marker Score: 7896
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.89
    Marker Score: 790
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.88
    Marker Score: 5353
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.87
    Marker Score: 678
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.86
    Marker Score: 688
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.83
    Marker Score: 17430
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.83
    Marker Score: 18938
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.8
    Marker Score: 15428
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.77
    Marker Score: 9523.5
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.77
    Marker Score: 4425
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.71
    Marker Score: 27527
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.7
    Marker Score: 8897
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.67
    Marker Score: 2011
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.63
    Marker Score: 5481
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.61
    Marker Score: 1997
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.61
    Marker Score: 773
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.61
    Marker Score: 933
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.59
    Marker Score: 891
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.57
    Marker Score: 5570
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.56
    Marker Score: 494
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.54
    Marker Score: 5477
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.54
    Marker Score: 1332
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.54
    Marker Score: 2370
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.53
    Marker Score: 522
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.53
    Marker Score: 575
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.51
    Marker Score: 1613.5
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.5
    Marker Score: 11336
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.5
    Marker Score: 1599
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.48
    Marker Score: 2100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.48
    Marker Score: 732
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.48
    Marker Score: 404
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.48
    Marker Score: 552
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.47
    Marker Score: 2141
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.45
    Marker Score: 1525
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.44
    Marker Score: 1185
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.42
    Marker Score: 3269
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.42
    Marker Score: 769
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.4
    Marker Score: 2353
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.39
    Marker Score: 353
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.38
    Marker Score: 672
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.36
    Marker Score: 3213
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.36
    Marker Score: 524
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.36
    Marker Score: 928
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.34
    Marker Score: 484
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.33
    Marker Score: 20878
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.32
    Marker Score: 881
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.32
    Marker Score: 791
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.31
    Marker Score: 8411
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.3
    Marker Score: 406
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.29
    Marker Score: 408
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.28
    Marker Score: 412
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.28
    Marker Score: 1796
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.26
    Marker Score: 1283
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.26
    Marker Score: 3097
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.25
    Marker Score: 448
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.25
    Marker Score: 1835
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.23
    Marker Score: 4029.5

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Other Information

**Key characteristics:** - It is a serine/threonine/tyrosine kinase. - It is expressed in a wide range of cell types, including ciliary muscle cells, pigmented epithelial cells, lens epithelial cells, renal cells, vascular cells, and many others. - It is a key regulator of cell cycle progression and growth. **Pathways and functions:** - **Cell cycle regulation:** DYRK1A is essential for the regulation of cell cycle progression. It is involved in the G0/G1 transition, where it promotes cell cycle entry. It also plays a role in the regulation of cell cycle checkpoints and apoptosis. - **Proliferation:** DYRK1A is also involved in cell proliferation. It is a key regulator of epithelial cell growth and differentiation. - **Differentiation:** DYRK1A is essential for the differentiation of neural stem cells into various cell types. - **Apoptosis:** DYRK1A is involved in apoptosis, where it promotes the activation of caspases and ultimately leads to cell death. **Clinical significance:** - Dysregulation of DYRK1A has been linked to various human diseases, including cancer, cardiovascular disease, and diabetes. - Inhibition of DYRK1A has been shown to suppress cancer growth and metastasis. - Therefore, DYRK1A is a potential target for the treatment of cancer. **Additional information:** - The human DYRK1A gene is located on chromosome 15q21.1. - It is a highly conserved protein, with a similar gene found in other vertebrates. - It is a member of the DYRK family of tyrosine kinases, which are involved in a variety of cellular processes.

Genular Protein ID: 2938402413

Symbol: DYR1A_HUMAN

Name: Dual specificity tyrosine-phosphorylation-regulated kinase 1A

UniProtKB Accession Codes:

Q13627 O60769 Q92582 Q92810 Q9UNM5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CPTAC 1 CTD 1 ChEBI 23 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 4 ELM 1 EMBL 6 EPD 1 Ensembl 9 EvolutionaryTrace 1 ExpressionAtlas 1 GO 42 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 87 PDBsum 78 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 1 RefSeq 11 Rhea 13 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8975710

Title: Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome 'critical region'.

PubMed ID: 8975710

DOI: 10.1006/geno.1996.0636

PubMed ID: 8872470

Title: A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region.

PubMed ID: 8872470

DOI: 10.1093/hmg/5.9.1305

PubMed ID: 8769099

Title: Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from 'the Down syndrome critical region' of chromosome 21.

PubMed ID: 8769099

DOI: 10.1006/bbrc.1996.1135

PubMed ID: 9037601

Title: Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21.

PubMed ID: 9037601

DOI: 10.1101/gr.7.1.47

PubMed ID: 10329007

Title: Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome.

PubMed ID: 10329007

DOI: 10.1006/geno.1999.5775

PubMed ID: 9503011

Title: Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome.

PubMed ID: 9503011

DOI: 10.1006/geno.1997.5146

PubMed ID: 14500717

Title: Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M.

PubMed ID: 14500717

DOI: 10.1074/jbc.m307556200

PubMed ID: 14593110

Title: Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases.

PubMed ID: 14593110

DOI: 10.1074/jbc.m301769200

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19266028

Title: Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment.

PubMed ID: 19266028

DOI: 10.1371/journal.pgen.1000397

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20167603

Title: DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.

PubMed ID: 20167603

DOI: 10.1074/jbc.m110.102574

PubMed ID: 21294719

Title: Intragenic deletion in DYRK1A leads to mental retardation and primary microcephaly.

PubMed ID: 21294719

DOI: 10.1111/j.1399-0004.2010.01544.x

PubMed ID: 21127067

Title: Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity.

PubMed ID: 21127067

DOI: 10.1074/jbc.m110.157909

PubMed ID: 23160955

Title: Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders.

PubMed ID: 23160955

DOI: 10.1126/science.1227764

PubMed ID: 23415227

Title: Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signaling.

PubMed ID: 23415227

DOI: 10.1016/j.cell.2013.01.033

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23864635

Title: Dissection of the C-terminal region of E1A redefines the roles of CtBP and other cellular targets in oncogenic transformation.

PubMed ID: 23864635

DOI: 10.1128/jvi.00786-13

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31024071

Title: The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.

PubMed ID: 31024071

DOI: 10.1038/s41598-019-42990-5

PubMed ID: 30773093

Title: DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169.

PubMed ID: 30773093

DOI: 10.1080/15384101.2019.1577525

PubMed ID: 20981014

Title: Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A.

PubMed ID: 20981014

DOI: 10.1038/ncomms1090

PubMed ID: 22998443

Title: Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.

PubMed ID: 22998443

DOI: 10.1021/jm301034u

PubMed ID: 24239188

Title: Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors.

PubMed ID: 24239188

DOI: 10.1016/j.bmcl.2013.10.055

PubMed ID: 25620562

Title: Chromatin-wide profiling of DYRK1A reveals a role as a gene-specific RNA polymerase II CTD kinase.

PubMed ID: 25620562

DOI: 10.1016/j.molcel.2014.12.026

PubMed ID: 29849146

Title: Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II.

PubMed ID: 29849146

DOI: 10.1038/s41586-018-0174-3

PubMed ID: 23665168

Title: Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition.

PubMed ID: 23665168

DOI: 10.1016/j.str.2013.03.012

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 763
  • Mass: 85584
  • Checksum: 7C3A52A3CBB04FB5
  • Sequence:
    • MHTGGETSAC KPSSVRLAPS FSFHAAGLQM AGQMPHSHQY SDRRQPNISD QQVSALSYSD 
QIQQPLTNQV MPDIVMLQRR MPQTFRDPAT APLRKLSVDL IKTYKHINEV YYAKKKRRHQ 
QGQGDDSSHK KERKVYNDGY DDDNYDYIVK NGEKWMDRYE IDSLIGKGSF GQVVKAYDRV 
EQEWVAIKII KNKKAFLNQA QIEVRLLELM NKHDTEMKYY IVHLKRHFMF RNHLCLVFEM 
LSYNLYDLLR NTNFRGVSLN LTRKFAQQMC TALLFLATPE LSIIHCDLKP ENILLCNPKR 
SAIKIVDFGS SCQLGQRIYQ YIQSRFYRSP EVLLGMPYDL AIDMWSLGCI LVEMHTGEPL 
FSGANEVDQM NKIVEVLGIP PAHILDQAPK ARKFFEKLPD GTWNLKKTKD GKREYKPPGT 
RKLHNILGVE TGGPGGRRAG ESGHTVADYL KFKDLILRML DYDPKTRIQP YYALQHSFFK 
KTADEGTNTS NSVSTSPAME QSQSSGTTSS TSSSSGGSSG TSNSGRARSD PTHQHRHSGG 
HFTAAVQAMD CETHSPQVRQ QFPAPLGWSG TEAPTQVTVE THPVQETTFH VAPQQNALHH 
HHGNSSHHHH HHHHHHHHHG QQALGNRTRP RVYNSPTNSS STQDSMEVGH SHHSMTSLSS 
STTSSSTSSS STGNQGNQAY QNRPVAANTL DFGQNGAMDV NLTVYSNPRQ ETGIAGHPTY 
QFSANTGPAH YMTEGHLTMR QGADREESPM TGVCVQQSPV ASS

Genular Protein ID: 2191849470

Symbol: A0A2R8Y6I6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A2R8Y6I6

Database IDs:

ARBA 15 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChEBI 21 ChiTaRS 1 DNASU 1 EC 4 EMBL 7 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 5 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 Rhea 13 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 725
  • Mass: 81599
  • Checksum: B293E0326947C872
  • Sequence:
    • MAGQMPHSHQ YSDRRQPNIS DQQVSALSYS DQIQQPLTNQ RRMPQTFRDP ATAPLRKLSV 
DLIKTYKHIN EVYYAKKKRR HQQGQGDDSS HKKERKVYND GYDDDNYDYI VKNGEKWMDR 
YEIDSLIGKG SFGQVVKAYD RVEQEWVAIK IIKNKKAFLN QAQIEVRLLE LMNKHDTEMK 
YYIVHLKRHF MFRNHLCLVF EMLSYNLYDL LRNTNFRGVS LNLTRKFAQQ MCTALLFLAT 
PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGMPY 
DLAIDMWSLG CILVEMHTGE PLFSGANEVD QMNKIVEVLG IPPAHILDQA PKARKFFEKL 
PDGTWNLKKT KDGKREYKPP GTRKLHNILG VETGGPGGRR AGESGHTVAD YLKFKDLILR 
MLDYDPKTRI QPYYALQHSF FKKTADEGTN TSNSVSTSPA MEQSQSSGTT SSTSSSSGGS 
SGTSNSGRAR SDPTHQHRHS GGHFTAAVQA MDCETHSPQV RQQFPAPLGW SGTEAPTQVT 
VETHPVQETT FHVAPQQNAL HHHHGNSSHH HHHHHHHHHH HGQQALGNRT RPRVYNSPTN 
SSSTQDSMEV GHSHHSMTSL SSSTTSSSTS SSSTGNQGNQ AYQNRPVAAN TLDFGQNGAM 
DVNLTVYSNP RQETGIAGHP TYQFSANTGP AHYMTEGHLT MRQGADREES PMTGVCVQQS 
PVASS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.