Details for: DYRK1A

Gene ID: 1859

Symbol: DYRK1A

Ensembl ID: ENSG00000157540

Description: dual specificity tyrosine phosphorylation regulated kinase 1A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 453.3730
    Cell Significance Index: -70.5200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 282.1678
    Cell Significance Index: -71.5700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 167.9825
    Cell Significance Index: -69.2000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 155.2245
    Cell Significance Index: -73.2900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 146.6067
    Cell Significance Index: -59.5600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 62.5194
    Cell Significance Index: -59.6900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 58.8018
    Cell Significance Index: -72.5000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 25.9999
    Cell Significance Index: -69.6500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 21.3221
    Cell Significance Index: -65.4900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.5717
    Cell Significance Index: -73.2900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 18.5325
    Cell Significance Index: -40.5600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 4.8427
    Cell Significance Index: 124.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 4.5818
    Cell Significance Index: 257.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.0874
    Cell Significance Index: 236.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4924
    Cell Significance Index: 499.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.4712
    Cell Significance Index: 886.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.4315
    Cell Significance Index: 482.5300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.2902
    Cell Significance Index: 55.8800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.0434
    Cell Significance Index: 51.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.7423
    Cell Significance Index: 48.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6667
    Cell Significance Index: 22.7400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.6203
    Cell Significance Index: 108.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.5259
    Cell Significance Index: 93.7900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.2999
    Cell Significance Index: 31.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.2315
    Cell Significance Index: 46.6400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2015
    Cell Significance Index: 831.0300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.1994
    Cell Significance Index: 17.2500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.1939
    Cell Significance Index: 52.8100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0348
    Cell Significance Index: 168.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0017
    Cell Significance Index: 904.4600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.6912
    Cell Significance Index: 13.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5828
    Cell Significance Index: 1097.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5751
    Cell Significance Index: 12.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5334
    Cell Significance Index: 65.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.5200
    Cell Significance Index: 236.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5164
    Cell Significance Index: 26.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.5127
    Cell Significance Index: 325.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3770
    Cell Significance Index: 67.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3711
    Cell Significance Index: 22.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3511
    Cell Significance Index: 540.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3452
    Cell Significance Index: 9.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3046
    Cell Significance Index: 5.2200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2772
    Cell Significance Index: 7.9100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2763
    Cell Significance Index: 509.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2604
    Cell Significance Index: 18.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2582
    Cell Significance Index: 114.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2120
    Cell Significance Index: 115.8000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1992
    Cell Significance Index: 270.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1348
    Cell Significance Index: 13.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0743
    Cell Significance Index: 2.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0508
    Cell Significance Index: 6.9700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.0192
    Cell Significance Index: 0.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0104
    Cell Significance Index: 0.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0057
    Cell Significance Index: -0.9700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0127
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0264
    Cell Significance Index: -19.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0439
    Cell Significance Index: -2.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0569
    Cell Significance Index: -41.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0595
    Cell Significance Index: -37.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0857
    Cell Significance Index: -64.8800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0899
    Cell Significance Index: -50.6800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0942
    Cell Significance Index: -1.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0983
    Cell Significance Index: -18.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1154
    Cell Significance Index: -5.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1324
    Cell Significance Index: -8.5500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1597
    Cell Significance Index: -18.2300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1995
    Cell Significance Index: -3.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2068
    Cell Significance Index: -24.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2076
    Cell Significance Index: -30.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2099
    Cell Significance Index: -44.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2100
    Cell Significance Index: -21.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2196
    Cell Significance Index: -63.1800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2301
    Cell Significance Index: -1.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2636
    Cell Significance Index: -12.2900
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.2704
    Cell Significance Index: -2.4000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2896
    Cell Significance Index: -6.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2991
    Cell Significance Index: -8.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3248
    Cell Significance Index: -33.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3254
    Cell Significance Index: -41.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3665
    Cell Significance Index: -47.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4299
    Cell Significance Index: -50.1000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4415
    Cell Significance Index: -6.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4968
    Cell Significance Index: -56.9200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5050
    Cell Significance Index: -31.8300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6074
    Cell Significance Index: -12.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6135
    Cell Significance Index: -45.7300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6388
    Cell Significance Index: -45.1800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7494
    Cell Significance Index: -16.4100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7779
    Cell Significance Index: -61.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7806
    Cell Significance Index: -16.6300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9170
    Cell Significance Index: -29.3700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.9590
    Cell Significance Index: -7.8200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9931
    Cell Significance Index: -26.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9989
    Cell Significance Index: -61.2400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.0161
    Cell Significance Index: -12.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.0211
    Cell Significance Index: -53.6100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.0447
    Cell Significance Index: -15.4200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0544
    Cell Significance Index: -34.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.0820
    Cell Significance Index: -29.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0839
    Cell Significance Index: -34.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DYRK1A is a dual specificity kinase, meaning it possesses the ability to phosphorylate both tyrosine and serine/threonine residues on target proteins. This unique property allows DYRK1A to modulate a wide range of cellular processes, including cell cycle regulation, transcriptional control, and protein-protein interactions. DYRK1A is also characterized by its ability to bind to specific DNA sequences, allowing it to regulate transcriptional activity. Furthermore, DYRK1A has been shown to interact with various protein partners, including transcription factors, protein kinases, and RNA-binding proteins, to modulate its activity and substrate specificity. **Pathways and Functions:** DYRK1A is involved in several key cellular pathways, including: 1. **Cell Cycle Regulation:** DYRK1A plays a crucial role in regulating cell cycle progression, particularly during the G1/S transition. By phosphorylating key cell cycle regulators, DYRK1A can modulate cell cycle entry and progression. 2. **Transcriptional Control:** DYRK1A regulates transcriptional activity by phosphorylating and activating transcription factors, such as CREB and NF-κB. This allows DYRK1A to modulate gene expression and respond to various cellular cues. 3. **Neuronal Development and Maintenance:** DYRK1A is specifically expressed in neurons and plays a crucial role in regulating neuronal development and maintenance. By phosphorylating key neuronal proteins, DYRK1A can modulate neuronal function and synaptic plasticity. 4. **DNA Damage Response:** DYRK1A has been shown to regulate the DNA damage response by phosphorylating and activating key DNA damage response proteins, such as ATM and ATR. **Clinical Significance:** DYRK1A has been implicated in several diseases, including: 1. **Autism Spectrum Disorder (ASD):** DYRK1A has been shown to be overexpressed in individuals with ASD, and has been implicated in regulating neuronal development and synaptic plasticity. 2. **Neurodegenerative Disorders:** DYRK1A has been implicated in several neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. By phosphorylating key neuronal proteins, DYRK1A can modulate neuronal function and contribute to disease pathogenesis. 3. **Cancer:** DYRK1A has been implicated in cancer, particularly in regulating cell cycle progression and transcriptional control. In conclusion, DYRK1A is a complex and multifunctional kinase that plays a crucial role in regulating various cellular processes, including cell cycle progression, transcriptional control, and neuronal development. Its dysregulation has been implicated in several diseases, highlighting the importance of further research into the mechanisms of DYRK1A and its role in human disease.

Genular Protein ID: 2938402413

Symbol: DYR1A_HUMAN

Name: Dual specificity tyrosine-phosphorylation-regulated kinase 1A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8975710

Title: Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome 'critical region'.

PubMed ID: 8975710

DOI: 10.1006/geno.1996.0636

PubMed ID: 8872470

Title: A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region.

PubMed ID: 8872470

DOI: 10.1093/hmg/5.9.1305

PubMed ID: 8769099

Title: Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from 'the Down syndrome critical region' of chromosome 21.

PubMed ID: 8769099

DOI: 10.1006/bbrc.1996.1135

PubMed ID: 9037601

Title: Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21.

PubMed ID: 9037601

DOI: 10.1101/gr.7.1.47

PubMed ID: 10329007

Title: Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome.

PubMed ID: 10329007

DOI: 10.1006/geno.1999.5775

PubMed ID: 9503011

Title: Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome.

PubMed ID: 9503011

DOI: 10.1006/geno.1997.5146

PubMed ID: 14500717

Title: Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M.

PubMed ID: 14500717

DOI: 10.1074/jbc.m307556200

PubMed ID: 14593110

Title: Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases.

PubMed ID: 14593110

DOI: 10.1074/jbc.m301769200

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19266028

Title: Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment.

PubMed ID: 19266028

DOI: 10.1371/journal.pgen.1000397

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20167603

Title: DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.

PubMed ID: 20167603

DOI: 10.1074/jbc.m110.102574

PubMed ID: 21294719

Title: Intragenic deletion in DYRK1A leads to mental retardation and primary microcephaly.

PubMed ID: 21294719

DOI: 10.1111/j.1399-0004.2010.01544.x

PubMed ID: 21127067

Title: Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity.

PubMed ID: 21127067

DOI: 10.1074/jbc.m110.157909

PubMed ID: 23160955

Title: Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders.

PubMed ID: 23160955

DOI: 10.1126/science.1227764

PubMed ID: 23415227

Title: Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signaling.

PubMed ID: 23415227

DOI: 10.1016/j.cell.2013.01.033

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23864635

Title: Dissection of the C-terminal region of E1A redefines the roles of CtBP and other cellular targets in oncogenic transformation.

PubMed ID: 23864635

DOI: 10.1128/jvi.00786-13

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31024071

Title: The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.

PubMed ID: 31024071

DOI: 10.1038/s41598-019-42990-5

PubMed ID: 30773093

Title: DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169.

PubMed ID: 30773093

DOI: 10.1080/15384101.2019.1577525

PubMed ID: 20981014

Title: Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A.

PubMed ID: 20981014

DOI: 10.1038/ncomms1090

PubMed ID: 22998443

Title: Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.

PubMed ID: 22998443

DOI: 10.1021/jm301034u

PubMed ID: 24239188

Title: Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors.

PubMed ID: 24239188

DOI: 10.1016/j.bmcl.2013.10.055

PubMed ID: 25620562

Title: Chromatin-wide profiling of DYRK1A reveals a role as a gene-specific RNA polymerase II CTD kinase.

PubMed ID: 25620562

DOI: 10.1016/j.molcel.2014.12.026

PubMed ID: 29849146

Title: Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II.

PubMed ID: 29849146

DOI: 10.1038/s41586-018-0174-3

PubMed ID: 23665168

Title: Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition.

PubMed ID: 23665168

DOI: 10.1016/j.str.2013.03.012

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 763
  • Mass: 85584
  • Checksum: 7C3A52A3CBB04FB5
  • Sequence:
  • MHTGGETSAC KPSSVRLAPS FSFHAAGLQM AGQMPHSHQY SDRRQPNISD QQVSALSYSD 
    QIQQPLTNQV MPDIVMLQRR MPQTFRDPAT APLRKLSVDL IKTYKHINEV YYAKKKRRHQ 
    QGQGDDSSHK KERKVYNDGY DDDNYDYIVK NGEKWMDRYE IDSLIGKGSF GQVVKAYDRV 
    EQEWVAIKII KNKKAFLNQA QIEVRLLELM NKHDTEMKYY IVHLKRHFMF RNHLCLVFEM 
    LSYNLYDLLR NTNFRGVSLN LTRKFAQQMC TALLFLATPE LSIIHCDLKP ENILLCNPKR 
    SAIKIVDFGS SCQLGQRIYQ YIQSRFYRSP EVLLGMPYDL AIDMWSLGCI LVEMHTGEPL 
    FSGANEVDQM NKIVEVLGIP PAHILDQAPK ARKFFEKLPD GTWNLKKTKD GKREYKPPGT 
    RKLHNILGVE TGGPGGRRAG ESGHTVADYL KFKDLILRML DYDPKTRIQP YYALQHSFFK 
    KTADEGTNTS NSVSTSPAME QSQSSGTTSS TSSSSGGSSG TSNSGRARSD PTHQHRHSGG 
    HFTAAVQAMD CETHSPQVRQ QFPAPLGWSG TEAPTQVTVE THPVQETTFH VAPQQNALHH 
    HHGNSSHHHH HHHHHHHHHG QQALGNRTRP RVYNSPTNSS STQDSMEVGH SHHSMTSLSS 
    STTSSSTSSS STGNQGNQAY QNRPVAANTL DFGQNGAMDV NLTVYSNPRQ ETGIAGHPTY 
    QFSANTGPAH YMTEGHLTMR QGADREESPM TGVCVQQSPV ASS

Genular Protein ID: 2191849470

Symbol: A0A2R8Y6I6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 725
  • Mass: 81599
  • Checksum: B293E0326947C872
  • Sequence:
  • MAGQMPHSHQ YSDRRQPNIS DQQVSALSYS DQIQQPLTNQ RRMPQTFRDP ATAPLRKLSV 
    DLIKTYKHIN EVYYAKKKRR HQQGQGDDSS HKKERKVYND GYDDDNYDYI VKNGEKWMDR 
    YEIDSLIGKG SFGQVVKAYD RVEQEWVAIK IIKNKKAFLN QAQIEVRLLE LMNKHDTEMK 
    YYIVHLKRHF MFRNHLCLVF EMLSYNLYDL LRNTNFRGVS LNLTRKFAQQ MCTALLFLAT 
    PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGMPY 
    DLAIDMWSLG CILVEMHTGE PLFSGANEVD QMNKIVEVLG IPPAHILDQA PKARKFFEKL 
    PDGTWNLKKT KDGKREYKPP GTRKLHNILG VETGGPGGRR AGESGHTVAD YLKFKDLILR 
    MLDYDPKTRI QPYYALQHSF FKKTADEGTN TSNSVSTSPA MEQSQSSGTT SSTSSSSGGS 
    SGTSNSGRAR SDPTHQHRHS GGHFTAAVQA MDCETHSPQV RQQFPAPLGW SGTEAPTQVT 
    VETHPVQETT FHVAPQQNAL HHHHGNSSHH HHHHHHHHHH HGQQALGNRT RPRVYNSPTN 
    SSSTQDSMEV GHSHHSMTSL SSSTTSSSTS SSSTGNQGNQ AYQNRPVAAN TLDFGQNGAM 
    DVNLTVYSNP RQETGIAGHP TYQFSANTGP AHYMTEGHLT MRQGADREES PMTGVCVQQS 
    PVASS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.