Details for: DYRK1A
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 453.3730
Cell Significance Index: -70.5200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 282.1678
Cell Significance Index: -71.5700 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 167.9825
Cell Significance Index: -69.2000 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 155.2245
Cell Significance Index: -73.2900 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 146.6067
Cell Significance Index: -59.5600 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 62.5194
Cell Significance Index: -59.6900 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 58.8018
Cell Significance Index: -72.5000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 25.9999
Cell Significance Index: -69.6500 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 21.3221
Cell Significance Index: -65.4900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 18.5717
Cell Significance Index: -73.2900 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 18.5325
Cell Significance Index: -40.5600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 4.8427
Cell Significance Index: 124.4800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 4.5818
Cell Significance Index: 257.1100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 3.0874
Cell Significance Index: 236.9300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.4924
Cell Significance Index: 499.9800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.4712
Cell Significance Index: 886.3900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.4315
Cell Significance Index: 482.5300 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 2.2902
Cell Significance Index: 55.8800 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 2.0434
Cell Significance Index: 51.0800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.7423
Cell Significance Index: 48.6900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.6667
Cell Significance Index: 22.7400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.6203
Cell Significance Index: 108.9500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.5259
Cell Significance Index: 93.7900 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 1.2999
Cell Significance Index: 31.1800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.2315
Cell Significance Index: 46.6400 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.2015
Cell Significance Index: 831.0300 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.1994
Cell Significance Index: 17.2500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.1939
Cell Significance Index: 52.8100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.0348
Cell Significance Index: 168.3000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.0017
Cell Significance Index: 904.4600 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.6912
Cell Significance Index: 13.4900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.5828
Cell Significance Index: 1097.2500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5751
Cell Significance Index: 12.4600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.5334
Cell Significance Index: 65.5900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.5200
Cell Significance Index: 236.0000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.5164
Cell Significance Index: 26.9000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.5127
Cell Significance Index: 325.6400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3770
Cell Significance Index: 67.9600 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3711
Cell Significance Index: 22.2800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.3511
Cell Significance Index: 540.4400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3452
Cell Significance Index: 9.9500 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.3046
Cell Significance Index: 5.2200 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.2772
Cell Significance Index: 7.9100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.2763
Cell Significance Index: 509.5700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2604
Cell Significance Index: 18.0100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2582
Cell Significance Index: 114.1600 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2120
Cell Significance Index: 115.8000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1992
Cell Significance Index: 270.9000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1348
Cell Significance Index: 13.3400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0743
Cell Significance Index: 2.6100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0508
Cell Significance Index: 6.9700 - Cell Name: type II muscle cell (CL0002212)
Fold Change: 0.0192
Cell Significance Index: 0.3100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0104
Cell Significance Index: 0.4700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0057
Cell Significance Index: -0.9700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0127
Cell Significance Index: -0.3400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0264
Cell Significance Index: -19.5900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0439
Cell Significance Index: -2.2800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0569
Cell Significance Index: -41.7500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0595
Cell Significance Index: -37.1800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0857
Cell Significance Index: -64.8800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0899
Cell Significance Index: -50.6800 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.0942
Cell Significance Index: -1.3900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.0983
Cell Significance Index: -18.7100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1154
Cell Significance Index: -5.4300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1324
Cell Significance Index: -8.5500 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1597
Cell Significance Index: -18.2300 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.1995
Cell Significance Index: -3.3600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2068
Cell Significance Index: -24.3900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2076
Cell Significance Index: -30.1700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2099
Cell Significance Index: -44.2000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2100
Cell Significance Index: -21.8700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2196
Cell Significance Index: -63.1800 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2301
Cell Significance Index: -1.3900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2636
Cell Significance Index: -12.2900 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: -0.2704
Cell Significance Index: -2.4000 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.2896
Cell Significance Index: -6.1900 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2991
Cell Significance Index: -8.0100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.3248
Cell Significance Index: -33.1800 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.3254
Cell Significance Index: -41.7200 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.3665
Cell Significance Index: -47.3600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.4299
Cell Significance Index: -50.1000 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.4415
Cell Significance Index: -6.3400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4968
Cell Significance Index: -56.9200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.5050
Cell Significance Index: -31.8300 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.6074
Cell Significance Index: -12.6000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.6135
Cell Significance Index: -45.7300 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.6388
Cell Significance Index: -45.1800 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.7494
Cell Significance Index: -16.4100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.7779
Cell Significance Index: -61.6100 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.7806
Cell Significance Index: -16.6300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.9170
Cell Significance Index: -29.3700 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.9590
Cell Significance Index: -7.8200 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.9931
Cell Significance Index: -26.5700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.9989
Cell Significance Index: -61.2400 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -1.0161
Cell Significance Index: -12.6700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.0211
Cell Significance Index: -53.6100 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -1.0447
Cell Significance Index: -15.4200 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.0544
Cell Significance Index: -34.5200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -1.0820
Cell Significance Index: -29.4500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.0839
Cell Significance Index: -34.5200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2938402413
Symbol: DYR1A_HUMAN
Name: Dual specificity tyrosine-phosphorylation-regulated kinase 1A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8975710
Title: Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome 'critical region'.
PubMed ID: 8975710
PubMed ID: 8872470
Title: A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region.
PubMed ID: 8872470
DOI: 10.1093/hmg/5.9.1305
PubMed ID: 8769099
Title: Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from 'the Down syndrome critical region' of chromosome 21.
PubMed ID: 8769099
PubMed ID: 9037601
Title: Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21.
PubMed ID: 9037601
DOI: 10.1101/gr.7.1.47
PubMed ID: 10329007
Title: Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome.
PubMed ID: 10329007
PubMed ID: 9503011
Title: Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome.
PubMed ID: 9503011
PubMed ID: 14500717
Title: Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M.
PubMed ID: 14500717
PubMed ID: 14593110
Title: Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases.
PubMed ID: 14593110
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 19266028
Title: Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment.
PubMed ID: 19266028
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20167603
Title: DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.
PubMed ID: 20167603
PubMed ID: 21294719
Title: Intragenic deletion in DYRK1A leads to mental retardation and primary microcephaly.
PubMed ID: 21294719
PubMed ID: 21127067
Title: Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity.
PubMed ID: 21127067
PubMed ID: 23160955
Title: Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders.
PubMed ID: 23160955
PubMed ID: 23415227
Title: Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signaling.
PubMed ID: 23415227
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23864635
Title: Dissection of the C-terminal region of E1A redefines the roles of CtBP and other cellular targets in oncogenic transformation.
PubMed ID: 23864635
DOI: 10.1128/jvi.00786-13
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 31024071
Title: The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.
PubMed ID: 31024071
PubMed ID: 30773093
Title: DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169.
PubMed ID: 30773093
PubMed ID: 20981014
Title: Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A.
PubMed ID: 20981014
DOI: 10.1038/ncomms1090
PubMed ID: 22998443
Title: Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.
PubMed ID: 22998443
DOI: 10.1021/jm301034u
PubMed ID: 24239188
Title: Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors.
PubMed ID: 24239188
PubMed ID: 25620562
Title: Chromatin-wide profiling of DYRK1A reveals a role as a gene-specific RNA polymerase II CTD kinase.
PubMed ID: 25620562
PubMed ID: 29849146
Title: Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II.
PubMed ID: 29849146
PubMed ID: 23665168
Title: Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition.
PubMed ID: 23665168
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 763
- Mass: 85584
- Checksum: 7C3A52A3CBB04FB5
- Sequence:
MHTGGETSAC KPSSVRLAPS FSFHAAGLQM AGQMPHSHQY SDRRQPNISD QQVSALSYSD QIQQPLTNQV MPDIVMLQRR MPQTFRDPAT APLRKLSVDL IKTYKHINEV YYAKKKRRHQ QGQGDDSSHK KERKVYNDGY DDDNYDYIVK NGEKWMDRYE IDSLIGKGSF GQVVKAYDRV EQEWVAIKII KNKKAFLNQA QIEVRLLELM NKHDTEMKYY IVHLKRHFMF RNHLCLVFEM LSYNLYDLLR NTNFRGVSLN LTRKFAQQMC TALLFLATPE LSIIHCDLKP ENILLCNPKR SAIKIVDFGS SCQLGQRIYQ YIQSRFYRSP EVLLGMPYDL AIDMWSLGCI LVEMHTGEPL FSGANEVDQM NKIVEVLGIP PAHILDQAPK ARKFFEKLPD GTWNLKKTKD GKREYKPPGT RKLHNILGVE TGGPGGRRAG ESGHTVADYL KFKDLILRML DYDPKTRIQP YYALQHSFFK KTADEGTNTS NSVSTSPAME QSQSSGTTSS TSSSSGGSSG TSNSGRARSD PTHQHRHSGG HFTAAVQAMD CETHSPQVRQ QFPAPLGWSG TEAPTQVTVE THPVQETTFH VAPQQNALHH HHGNSSHHHH HHHHHHHHHG QQALGNRTRP RVYNSPTNSS STQDSMEVGH SHHSMTSLSS STTSSSTSSS STGNQGNQAY QNRPVAANTL DFGQNGAMDV NLTVYSNPRQ ETGIAGHPTY QFSANTGPAH YMTEGHLTMR QGADREESPM TGVCVQQSPV ASS
Genular Protein ID: 2191849470
Symbol: A0A2R8Y6I6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10830953
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 725
- Mass: 81599
- Checksum: B293E0326947C872
- Sequence:
MAGQMPHSHQ YSDRRQPNIS DQQVSALSYS DQIQQPLTNQ RRMPQTFRDP ATAPLRKLSV DLIKTYKHIN EVYYAKKKRR HQQGQGDDSS HKKERKVYND GYDDDNYDYI VKNGEKWMDR YEIDSLIGKG SFGQVVKAYD RVEQEWVAIK IIKNKKAFLN QAQIEVRLLE LMNKHDTEMK YYIVHLKRHF MFRNHLCLVF EMLSYNLYDL LRNTNFRGVS LNLTRKFAQQ MCTALLFLAT PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGMPY DLAIDMWSLG CILVEMHTGE PLFSGANEVD QMNKIVEVLG IPPAHILDQA PKARKFFEKL PDGTWNLKKT KDGKREYKPP GTRKLHNILG VETGGPGGRR AGESGHTVAD YLKFKDLILR MLDYDPKTRI QPYYALQHSF FKKTADEGTN TSNSVSTSPA MEQSQSSGTT SSTSSSSGGS SGTSNSGRAR SDPTHQHRHS GGHFTAAVQA MDCETHSPQV RQQFPAPLGW SGTEAPTQVT VETHPVQETT FHVAPQQNAL HHHHGNSSHH HHHHHHHHHH HGQQALGNRT RPRVYNSPTN SSSTQDSMEV GHSHHSMTSL SSSTTSSSTS SSSTGNQGNQ AYQNRPVAAN TLDFGQNGAM DVNLTVYSNP RQETGIAGHP TYQFSANTGP AHYMTEGHLT MRQGADREES PMTGVCVQQS PVASS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.