Gene E2F1 - ENSG00000101412 | NCBI Gene ID: 1869

Details for: E2F1

Gene ID: 1869

Symbol: E2F1

Ensembl ID: ENSG00000101412

Description: E2F transcription factor 1

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic g1/s transition in cancer due to rb1 defects
(R-HSA-9659787)
Activation of bh3-only proteins
(R-HSA-114452)
Activation of noxa and translocation to mitochondria
(R-HSA-111448)
Activation of puma and translocation to mitochondria
(R-HSA-139915)
Apoptosis
(R-HSA-109581)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin d associated events in g1
(R-HSA-69231)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Defective binding of rb1 mutants to e2f1,(e2f2, e2f3)
(R-HSA-9661069)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
E2f mediated regulation of dna replication
(R-HSA-113510)
G0 and early g1
(R-HSA-1538133)
G1 phase
(R-HSA-69236)
G1/s-specific transcription
(R-HSA-69205)
G1/s transition
(R-HSA-69206)
G2 phase
(R-HSA-68911)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Inhibition of replication initiation of damaged dna by rb1/e2f1
(R-HSA-113501)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Oncogene induced senescence
(R-HSA-2559585)
Oxidative stress induced senescence
(R-HSA-2559580)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Programmed cell death
(R-HSA-5357801)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by notch
(R-HSA-157118)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tp53 regulates transcription of cell cycle genes
(R-HSA-6791312)
Tp53 regulates transcription of genes involved in g1 cell cycle arrest
(R-HSA-6804116)
Transcriptional regulation by e2f6
(R-HSA-8953750)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Transcription of e2f targets under negative control by dream complex
(R-HSA-1362277)
Transcription of e2f targets under negative control by p107 (rbl1) and p130 (rbl2) in complex with hdac1
(R-HSA-1362300)
Anoikis
(GO:0043276)
Cellular response to xenobiotic stimulus
(GO:0071466)
Centrosome
(GO:0005813)
Chromatin
(GO:0000785)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Cytoplasm
(GO:0005737)
Dna-binding transcription activator activity
(GO:0001216)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription factor binding
(GO:0140297)
Dna-templated transcription
(GO:0006351)
Dna binding
(GO:0003677)
Dna damage checkpoint signaling
(GO:0000077)
Forebrain development
(GO:0030900)
Intrinsic apoptotic signaling pathway by p53 class mediator
(GO:0072332)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Lens fiber cell apoptotic process
(GO:1990086)
Molecular adaptor activity
(GO:0060090)
Mrna stabilization
(GO:0048255)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of dna binding
(GO:0043392)
Negative regulation of fat cell differentiation
(GO:0045599)
Negative regulation of fat cell proliferation
(GO:0070345)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Rb-e2f complex
(GO:0035189)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of g1/s transition of mitotic cell cycle
(GO:2000045)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: respiratory basal cell (CL0002633)
Fold Change: 1.59
Marker Score: 2285
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 1.54
Marker Score: 3188.5
Cell Name: germ cell (CL0000586)
Fold Change: 1.22
Marker Score: 2131
Cell Name: erythroblast (CL0000765)
Fold Change: 1.04
Marker Score: 649
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71819
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48044
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.99
Marker Score: 15441
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 502
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 455
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5219
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2735
Cell Name: Unknown (CL0000548)
Fold Change: 0.89
Marker Score: 649
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 320
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5283
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.81
Marker Score: 1531
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.81
Marker Score: 1641
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1255
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 389
Cell Name: brush cell (CL0002204)
Fold Change: 0.75
Marker Score: 680
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.74
Marker Score: 564
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.72
Marker Score: 278.5
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.72
Marker Score: 227
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.69
Marker Score: 278
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.68
Marker Score: 410
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 174
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.67
Marker Score: 2812.5
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.61
Marker Score: 415
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.61
Marker Score: 876
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 443
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.53
Marker Score: 1562
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.52
Marker Score: 491
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.51
Marker Score: 636
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.5
Marker Score: 237
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.5
Marker Score: 160
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.49
Marker Score: 1325
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.48
Marker Score: 121
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.47
Marker Score: 298
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.45
Marker Score: 1057
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.44
Marker Score: 4487
Cell Name: neural crest cell (CL0011012)
Fold Change: 0.44
Marker Score: 473
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.44
Marker Score: 195
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.39
Marker Score: 209
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.39
Marker Score: 191.5
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.37
Marker Score: 116
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 371
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.36
Marker Score: 1027.5
Cell Name: male germ cell (CL0000015)
Fold Change: 0.35
Marker Score: 101
Cell Name: promonocyte (CL0000559)
Fold Change: 0.35
Marker Score: 223
Cell Name: neural cell (CL0002319)
Fold Change: 0.34
Marker Score: 164
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.33
Marker Score: 192
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.31
Marker Score: 739
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.31
Marker Score: 303
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.31
Marker Score: 98
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.3
Marker Score: 79
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.3
Marker Score: 474
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.3
Marker Score: 308
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.29
Marker Score: 75
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.29
Marker Score: 215
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.29
Marker Score: 779
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.28
Marker Score: 118
Cell Name: thymocyte (CL0000893)
Fold Change: 0.28
Marker Score: 291
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 0.27
Marker Score: 89
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.27
Marker Score: 151
Cell Name: stem cell (CL0000034)
Fold Change: 0.26
Marker Score: 625
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.26
Marker Score: 241
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.25
Marker Score: 122
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.24
Marker Score: 92
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 0.24
Marker Score: 159
Cell Name: promyelocyte (CL0000836)
Fold Change: 0.23
Marker Score: 116
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.23
Marker Score: 150
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.23
Marker Score: 154
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 63
Cell Name: platelet (CL0000233)
Fold Change: 0.22
Marker Score: 99
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.22
Marker Score: 1289
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.21
Marker Score: 72
Cell Name: mature B cell (CL0000785)
Fold Change: 0.21
Marker Score: 155
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.21
Marker Score: 255
Cell Name: malignant cell (CL0001064)
Fold Change: 0.21
Marker Score: 2810
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.21
Marker Score: 75
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.21
Marker Score: 116
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.2
Marker Score: 129
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.2
Marker Score: 2656
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.2
Marker Score: 119
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.2
Marker Score: 71.5
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2
Marker Score: 126
Cell Name: megakaryocyte progenitor cell (CL0000553)
Fold Change: 0.19
Marker Score: 53
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.19
Marker Score: 65
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.18
Marker Score: 103
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.18
Marker Score: 717
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.18
Marker Score: 284
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.18
Marker Score: 97
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.17
Marker Score: 295
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.17
Marker Score: 52
Cell Name: Schwann cell precursor (CL0002375)
Fold Change: 0.17
Marker Score: 43
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.17
Marker Score: 194
Cell Name: leukocyte (CL0000738)
Fold Change: 0.17
Marker Score: 98
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.17
Marker Score: 71
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 0.17
Marker Score: 80

Hover over a box to see details here...

**Key characteristics:** * E2F1 is a transcription factor belonging to the E2F family. * It is a key regulator of cell cycle progression and apoptosis. * E2F1 is involved in the regulation of proliferation, differentiation, and survival of various cell types. * It is a key regulator of cell growth, differentiation, and apoptosis. **Pathways and functions:** * E2F1 is involved in the regulation of the cell cycle. It is a key regulator of the G1/S transition, where cells make the decision to divide or enter apoptosis. * It also plays a role in the regulation of apoptosis. * It is involved in the regulation of cell growth, differentiation, and survival. * It is involved in the development and maintenance of the brain and spinal cord. **Clinical significance:** * Mutations in the E2F1 gene have been linked to several human cancers, including glioblastoma, colon cancer, and acute myeloid leukemia. * E2F1 inhibitors are being investigated as potential cancer therapies. * Dysregulation of E2F1 has been implicated in a variety of developmental disorders and diseases. **Additional notes:** * E2F1 is a highly conserved gene across different species. * It is a key regulator of stem cells. * It is a target for cancer therapy.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

PBR3
Q9BSD8_HUMAN

Genular Protein ID: 2520966589

Symbol: E2F1_HUMAN

Name: PBR3

UniProtKB Accession Codes:

Q01094 Q13143 Q92768

Database IDs:

Citations:

PubMed ID: 1638634

Title: A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F.

PubMed ID: 1638634

DOI: 10.1016/0092-8674(92)90107-n

PubMed ID: 1638635

Title: Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties.

PubMed ID: 1638635

DOI: 10.1016/0092-8674(92)90108-o

PubMed ID: 1448092

Title: Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F.

PubMed ID: 1448092

DOI: 10.1128/mcb.12.12.5620-5631.1992

PubMed ID: 8964493

Title: Structure and partial genomic sequence of the human E2F1 gene.

PubMed ID: 8964493

DOI: 10.1016/0378-1119(96)00184-9

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7958836

Title: Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression.

PubMed ID: 7958836

DOI: 10.1101/gad.8.13.1514

PubMed ID: 8336704

Title: A bipartite nuclear localization signal in the retinoblastoma gene product and its importance for biological activity.

PubMed ID: 8336704

DOI: 10.1128/mcb.13.8.4588-4599.1993

PubMed ID: 8413249

Title: Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein.

PubMed ID: 8413249

DOI: 10.1128/mcb.13.10.6501-6508.1993

PubMed ID: 8033208

Title: Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase.

PubMed ID: 8033208

DOI: 10.1016/0092-8674(94)90582-7

PubMed ID: 7958856

Title: Differential regulation of E2F transactivation by cyclin/cdk2 complexes.

PubMed ID: 7958856

DOI: 10.1101/gad.8.15.1772

PubMed ID: 7969176

Title: Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation.

PubMed ID: 7969176

DOI: 10.1128/mcb.14.12.8420-8431.1994

PubMed ID: 8170954

Title: P53 and E2F-1 cooperate to mediate apoptosis.

PubMed ID: 8170954

DOI: 10.1073/pnas.91.9.3602

PubMed ID: 7494286

Title: Interaction of the 72-kilodalton human cytomegalovirus IE1 gene product with E2F1 coincides with E2F-dependent activation of dihydrofolate reductase transcription.

PubMed ID: 7494286

DOI: 10.1128/jvi.69.12.7759-7767.1995

PubMed ID: 7838523

Title: Phosphorylation of E2F-1 by cyclin A-cdk2.

PubMed ID: 7838523

PubMed ID: 9199321

Title: Specific regulation of E2F family members by cyclin-dependent kinases.

PubMed ID: 9199321

DOI: 10.1128/mcb.17.7.3867

PubMed ID: 9780002

Title: A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer.

PubMed ID: 9780002

DOI: 10.1038/sj.onc.1202163

PubMed ID: 10675335

Title: Regulation of E2F1 activity by acetylation.

PubMed ID: 10675335

DOI: 10.1093/emboj/19.4.662

PubMed ID: 11418595

Title: E2F transcriptional activation requires TRRAP and GCN5 cofactors.

PubMed ID: 11418595

DOI: 10.1074/jbc.m102067200

PubMed ID: 12697828

Title: Regulation of E2F1 by BRCT domain-containing protein TopBP1.

PubMed ID: 12697828

DOI: 10.1128/mcb.23.9.3287-3304.2003

PubMed ID: 12717439

Title: Chk2 activates E2F-1 in response to DNA damage.

PubMed ID: 12717439

DOI: 10.1038/ncb974

PubMed ID: 16360038

Title: Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release.

PubMed ID: 16360038

DOI: 10.1016/j.cell.2005.09.044

PubMed ID: 15716352

Title: EAPP, a novel E2F binding protein that modulates E2F-dependent transcription.

PubMed ID: 15716352

DOI: 10.1091/mbc.e04-11-0975

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17050006

Title: Glycogen synthase kinase-3beta binds to E2F1 and regulates its transcriptional activity.

PubMed ID: 17050006

DOI: 10.1016/j.bbamcr.2006.09.015

PubMed ID: 17704056

Title: Regulation of E2F1 function by the nuclear corepressor KAP1.

PubMed ID: 17704056

DOI: 10.1074/jbc.m704757200

PubMed ID: 18625225

Title: PEG10 directly regulated by E2Fs might have a role in the development of hepatocellular carcinoma.

PubMed ID: 18625225

DOI: 10.1016/j.febslet.2008.07.009

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20040599

Title: Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B.

PubMed ID: 20040599

DOI: 10.1074/jbc.m109.072074

PubMed ID: 20176812

Title: Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes.

PubMed ID: 20176812

DOI: 10.1128/mcb.01619-09

PubMed ID: 20603083

Title: Lysine methylation regulates E2F1-induced cell death.

PubMed ID: 20603083

DOI: 10.1016/j.molcel.2010.06.006

PubMed ID: 21653699

Title: Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription.

PubMed ID: 21653699

DOI: 10.1074/jbc.m110.191239

PubMed ID: 23629655

Title: Mixed lineage leukemia 5 (MLL5) protein regulates cell cycle progression and E2F1-responsive gene expression via association with host cell factor-1 (HCF-1).

PubMed ID: 23629655

DOI: 10.1074/jbc.m112.439729

PubMed ID: 28992046

Title: Phosphorylated E2F1 is stabilized by nuclear USP11 to drive Peg10 gene expression and activate lung epithelial cells.

PubMed ID: 28992046

DOI: 10.1093/jmcb/mjx034

PubMed ID: 29691401

Title: Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4-DCAF5 ubiquitin ligase.

PubMed ID: 29691401

DOI: 10.1038/s41467-018-04019-9

PubMed ID: 12501191

Title: Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A.

PubMed ID: 12501191

DOI: 10.1021/bi0268910

PubMed ID: 12598654

Title: Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation.

PubMed ID: 12598654

DOI: 10.1073/pnas.0436813100

Sequence Information:

Length: 437
Mass: 46920
Checksum: 003B3F654F0C60DF
Sequence:

MALAGAPAGG PCAPALEALL GAGALRLLDS SQIVIISAAQ DASAPPAPTG PAAPAAGPCD 
PDLLLFATPQ APRPTPSAPR PALGRPPVKR RLDLETDHQY LAESSGPARG RGRHPGKGVK 
SPGEKSRYET SLNLTTKRFL ELLSHSADGV VDLNWAAEVL KVQKRRIYDI TNVLEGIQLI 
AKKSKNHIQW LGSHTTVGVG GRLEGLTQDL RQLQESEQQL DHLMNICTTQ LRLLSEDTDS 
QRLAYVTCQD LRSIADPAEQ MVMVIKAPPE TQLQAVDSSE NFQISLKSKQ GPIDVFLCPE 
ETVGGISPGK TPSQEVTSEE ENRATDSATI VSPPPSSPPS SLTTDPSQSL LSLEQEPLLS 
RMGSLRAPVD EDRLSPLVAA DSLLEHVRED FSGLLPEEFI SLSPPHEALD YHFGLEEGEG 
IRDLFDCDFG DLTPLDF

Genular Protein ID: 3761017447

Symbol: Q9BSD8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BSD8

Database IDs:

Sequence Information:

Length: 96
Mass: 10666
Checksum: 1C99163A4620FFC4
Sequence:

LLGHPRPVML PVSPEPLLSR MGSLRAPVDE DRLSPLVAAD SLLEHVREDF SGLLPEEFIS 
LSPPHEALDY HFGLEEGEGI RDLFDCDFGD LTPLDF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: E2F1

Associated with

Cells (max top 100)

Other Information

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. PubMed ID: 1638634

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. PubMed ID: 1638635

Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F. PubMed ID: 1448092

Structure and partial genomic sequence of the human E2F1 gene. PubMed ID: 8964493

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. PubMed ID: 7958836

A bipartite nuclear localization signal in the retinoblastoma gene product and its importance for biological activity. PubMed ID: 8336704

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein. PubMed ID: 8413249

Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase. PubMed ID: 8033208

Differential regulation of E2F transactivation by cyclin/cdk2 complexes. PubMed ID: 7958856

Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. PubMed ID: 7969176

P53 and E2F-1 cooperate to mediate apoptosis. PubMed ID: 8170954

Interaction of the 72-kilodalton human cytomegalovirus IE1 gene product with E2F1 coincides with E2F-dependent activation of dihydrofolate reductase transcription. PubMed ID: 7494286

Phosphorylation of E2F-1 by cyclin A-cdk2. PubMed ID: 7838523

Specific regulation of E2F family members by cyclin-dependent kinases. PubMed ID: 9199321

A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer. PubMed ID: 9780002

Regulation of E2F1 activity by acetylation. PubMed ID: 10675335

E2F transcriptional activation requires TRRAP and GCN5 cofactors. PubMed ID: 11418595

Regulation of E2F1 by BRCT domain-containing protein TopBP1. PubMed ID: 12697828

Chk2 activates E2F-1 in response to DNA damage. PubMed ID: 12717439

Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. PubMed ID: 16360038

EAPP, a novel E2F binding protein that modulates E2F-dependent transcription. PubMed ID: 15716352

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Glycogen synthase kinase-3beta binds to E2F1 and regulates its transcriptional activity. PubMed ID: 17050006

Regulation of E2F1 function by the nuclear corepressor KAP1. PubMed ID: 17704056

PEG10 directly regulated by E2Fs might have a role in the development of hepatocellular carcinoma. PubMed ID: 18625225

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B. PubMed ID: 20040599

Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes. PubMed ID: 20176812

Lysine methylation regulates E2F1-induced cell death. PubMed ID: 20603083

Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription. PubMed ID: 21653699

Mixed lineage leukemia 5 (MLL5) protein regulates cell cycle progression and E2F1-responsive gene expression via association with host cell factor-1 (HCF-1). PubMed ID: 23629655

Phosphorylated E2F1 is stabilized by nuclear USP11 to drive Peg10 gene expression and activate lung epithelial cells. PubMed ID: 28992046

Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4-DCAF5 ubiquitin ligase. PubMed ID: 29691401

Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A. PubMed ID: 12501191

Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation. PubMed ID: 12598654