E2F1 | ENSG00000101412 | NCBI 1869

Details for: E2F1

Gene ID: 1869

Symbol: E2F1

Ensembl ID: ENSG00000101412

Description: E2F transcription factor 1

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic g1/s transition in cancer due to rb1 defects
(R-HSA-9659787)
Activation of bh3-only proteins
(R-HSA-114452)
Activation of noxa and translocation to mitochondria
(R-HSA-111448)
Activation of puma and translocation to mitochondria
(R-HSA-139915)
Apoptosis
(R-HSA-109581)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin d associated events in g1
(R-HSA-69231)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Defective binding of rb1 mutants to e2f1,(e2f2, e2f3)
(R-HSA-9661069)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
E2f mediated regulation of dna replication
(R-HSA-113510)
G0 and early g1
(R-HSA-1538133)
G1 phase
(R-HSA-69236)
G1/s-specific transcription
(R-HSA-69205)
G1/s transition
(R-HSA-69206)
G2 phase
(R-HSA-68911)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Inhibition of replication initiation of damaged dna by rb1/e2f1
(R-HSA-113501)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Oncogene induced senescence
(R-HSA-2559585)
Oxidative stress induced senescence
(R-HSA-2559580)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Programmed cell death
(R-HSA-5357801)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by notch
(R-HSA-157118)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tp53 regulates transcription of cell cycle genes
(R-HSA-6791312)
Tp53 regulates transcription of genes involved in g1 cell cycle arrest
(R-HSA-6804116)
Transcriptional regulation by e2f6
(R-HSA-8953750)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Transcription of e2f targets under negative control by dream complex
(R-HSA-1362277)
Transcription of e2f targets under negative control by p107 (rbl1) and p130 (rbl2) in complex with hdac1
(R-HSA-1362300)
Anoikis
(GO:0043276)
Cellular response to xenobiotic stimulus
(GO:0071466)
Centrosome
(GO:0005813)
Chromatin
(GO:0000785)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Cytoplasm
(GO:0005737)
Dna-binding transcription activator activity
(GO:0001216)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription factor binding
(GO:0140297)
Dna-templated transcription
(GO:0006351)
Dna binding
(GO:0003677)
Dna damage checkpoint signaling
(GO:0000077)
Forebrain development
(GO:0030900)
Intrinsic apoptotic signaling pathway by p53 class mediator
(GO:0072332)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Lens fiber cell apoptotic process
(GO:1990086)
Molecular adaptor activity
(GO:0060090)
Mrna stabilization
(GO:0048255)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of dna binding
(GO:0043392)
Negative regulation of fat cell differentiation
(GO:0045599)
Negative regulation of fat cell proliferation
(GO:0070345)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Rb-e2f complex
(GO:0035189)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of g1/s transition of mitotic cell cycle
(GO:2000045)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to lipopolysaccharide
(GO:0032496)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 28.2233
Cell Significance Index: -4.3900
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 26.9670
Cell Significance Index: -6.8400
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 14.6213
Cell Significance Index: -5.9400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 5.6531
Cell Significance Index: -6.9700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 2.7549
Cell Significance Index: -7.3800
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 1.8753
Cell Significance Index: -7.4000
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.9535
Cell Significance Index: 25.5100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.9511
Cell Significance Index: 94.0800
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.8185
Cell Significance Index: 49.1400
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6129
Cell Significance Index: 66.6600
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.5821
Cell Significance Index: 8.1700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5640
Cell Significance Index: 91.7400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.5100
Cell Significance Index: 28.6200
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.4763
Cell Significance Index: 3.1600
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.4382
Cell Significance Index: 9.0900
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.4361
Cell Significance Index: 28.1400
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.3808
Cell Significance Index: 4.1400
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3328
Cell Significance Index: 9.5900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.3197
Cell Significance Index: 37.7000
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3174
Cell Significance Index: 62.9900
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.2782
Cell Significance Index: 3.8600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2333
Cell Significance Index: 6.5200
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.2275
Cell Significance Index: 26.5100
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.1883
Cell Significance Index: 5.0500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1679
Cell Significance Index: 31.9500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.1635
Cell Significance Index: 5.6800
Cell Name: sensory neuron (CL0000101)
Fold Change: 0.1249
Cell Significance Index: 0.7100
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0824
Cell Significance Index: 2.6400
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.0817
Cell Significance Index: 1.7100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0794
Cell Significance Index: 3.6000
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0739
Cell Significance Index: 40.3600
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0725
Cell Significance Index: 1.5700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0632
Cell Significance Index: 27.9500
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0556
Cell Significance Index: 50.2300
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0546
Cell Significance Index: 3.7800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0497
Cell Significance Index: 9.9600
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0391
Cell Significance Index: 1.3800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.0294
Cell Significance Index: 8.4500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0289
Cell Significance Index: 3.5600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0289
Cell Significance Index: 1.5000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0286
Cell Significance Index: 0.6100
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0263
Cell Significance Index: 0.4400
Cell Name: germ cell (CL0000586)
Fold Change: 0.0212
Cell Significance Index: 0.1600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0138
Cell Significance Index: 1.8900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0108
Cell Significance Index: 1.9400
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0108
Cell Significance Index: 0.2700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0015
Cell Significance Index: 0.5600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0013
Cell Significance Index: -0.9700
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0025
Cell Significance Index: -4.7200
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0048
Cell Significance Index: -8.8200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0052
Cell Significance Index: -0.1400
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0057
Cell Significance Index: -8.7400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0059
Cell Significance Index: -8.0200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0088
Cell Significance Index: -5.6000
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0090
Cell Significance Index: -6.6300
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0116
Cell Significance Index: -8.5700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0150
Cell Significance Index: -6.8100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0150
Cell Significance Index: -8.4500
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0210
Cell Significance Index: -2.6900
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0227
Cell Significance Index: -2.9300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0288
Cell Significance Index: -2.9500
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0309
Cell Significance Index: -0.7900
Cell Name: hepatoblast (CL0005026)
Fold Change: -0.0392
Cell Significance Index: -0.6600
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0394
Cell Significance Index: -4.5200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0395
Cell Significance Index: -5.7400
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0411
Cell Significance Index: -2.9100
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0417
Cell Significance Index: -8.7800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0420
Cell Significance Index: -2.6500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0426
Cell Significance Index: -7.2800
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.0461
Cell Significance Index: -0.6600
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0469
Cell Significance Index: -0.4900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0474
Cell Significance Index: -2.2100
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0535
Cell Significance Index: -0.7300
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: -0.0660
Cell Significance Index: -0.6000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0679
Cell Significance Index: -7.0700
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0766
Cell Significance Index: -2.2600
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0820
Cell Significance Index: -6.1100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0838
Cell Significance Index: -6.6400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0915
Cell Significance Index: -7.0300
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0946
Cell Significance Index: -4.9300
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0958
Cell Significance Index: -6.4400
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0975
Cell Significance Index: -5.9900
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: -0.0977
Cell Significance Index: -0.7100
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0982
Cell Significance Index: -1.4800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1000
Cell Significance Index: -4.7000
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1006
Cell Significance Index: -1.4400
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.1030
Cell Significance Index: -1.4500
Cell Name: radial glial cell (CL0000681)
Fold Change: -0.1078
Cell Significance Index: -0.6400
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.1099
Cell Significance Index: -1.7000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1108
Cell Significance Index: -5.8200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1245
Cell Significance Index: -7.6300
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1323
Cell Significance Index: -5.8500
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1435
Cell Significance Index: -1.6300
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1517
Cell Significance Index: -3.9000
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1567
Cell Significance Index: -5.4900
Cell Name: salivary gland cell (CL0009005)
Fold Change: -0.1586
Cell Significance Index: -1.9700
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.1609
Cell Significance Index: -1.0900
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.1634
Cell Significance Index: -2.0700
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1637
Cell Significance Index: -6.2000
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.1681
Cell Significance Index: -2.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Cell cycle regulation**: E2F1 is a transcription factor that regulates the expression of genes involved in the G1/S transition and mitotic cell cycle progression. 2. **Transcriptional activation**: E2F1 activates the transcription of target genes involved in cell proliferation, differentiation, and survival. 3. **DNA-binding activity**: E2F1 binds to specific DNA sequences, which are recognized by the retinoblastoma protein (Rb) and other E2F family members. 4. **Interaction with Rb**: E2F1 interacts with Rb to regulate the G1/S transition and mitotic cell cycle progression. 5. **Apoptosis regulation**: E2F1 can regulate apoptosis, either by promoting or inhibiting the expression of pro-apoptotic or anti-apoptotic genes. **Pathways and Functions** 1. **Mitotic cell cycle regulation**: E2F1 regulates the expression of genes involved in the G1/S transition and mitotic cell cycle progression. 2. **Apoptosis regulation**: E2F1 can regulate apoptosis, either by promoting or inhibiting the expression of pro-apoptotic or anti-apoptotic genes. 3. **DNA damage response**: E2F1 can regulate the expression of genes involved in the DNA damage response, including those involved in DNA repair and apoptosis. 4. **Cancer development**: E2F1 has been implicated in various cancers, where it can contribute to tumorigenesis, genomic instability, and resistance to chemotherapy. 5. **Senescence regulation**: E2F1 can regulate senescence, either by promoting or inhibiting the expression of pro-senescence or anti-senescence genes. **Clinical Significance** 1. **Cancer diagnosis and prognosis**: E2F1 expression levels can be used as a diagnostic biomarker for various cancers, including cervical, breast, and lung cancer. 2. **Therapeutic targets**: E2F1 inhibitors have been developed as potential therapeutic agents for treating cancer, including those with E2F1 overexpression. 3. **Genomic instability**: E2F1 can contribute to genomic instability, which can lead to cancer development and progression. 4. **Apoptosis resistance**: E2F1 can contribute to apoptosis resistance, which can lead to cancer progression and chemotherapy resistance. 5. **Senescence and aging**: E2F1 can regulate senescence, which can impact aging and age-related diseases. In conclusion, E2F1 is a critical regulator of the cell cycle and plays a pivotal role in maintaining genomic stability. Its dysregulation has been implicated in various cancers and can contribute to genomic instability, apoptosis resistance, and senescence. Understanding the mechanisms of E2F1 regulation and its clinical significance can lead to the development of novel therapeutic strategies for cancer treatment and prevention.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

PBR3
Q9BSD8_HUMAN

Genular Protein ID: 2520966589

Symbol: E2F1_HUMAN

Name: PBR3

UniProtKB Accession Codes:

Q01094 Q13143 Q92768

Database IDs:

Citations:

PubMed ID: 1638634

Title: A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F.

PubMed ID: 1638634

DOI: 10.1016/0092-8674(92)90107-n

PubMed ID: 1638635

Title: Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties.

PubMed ID: 1638635

DOI: 10.1016/0092-8674(92)90108-o

PubMed ID: 1448092

Title: Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F.

PubMed ID: 1448092

DOI: 10.1128/mcb.12.12.5620-5631.1992

PubMed ID: 8964493

Title: Structure and partial genomic sequence of the human E2F1 gene.

PubMed ID: 8964493

DOI: 10.1016/0378-1119(96)00184-9

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7958836

Title: Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression.

PubMed ID: 7958836

DOI: 10.1101/gad.8.13.1514

PubMed ID: 8336704

Title: A bipartite nuclear localization signal in the retinoblastoma gene product and its importance for biological activity.

PubMed ID: 8336704

DOI: 10.1128/mcb.13.8.4588-4599.1993

PubMed ID: 8413249

Title: Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein.

PubMed ID: 8413249

DOI: 10.1128/mcb.13.10.6501-6508.1993

PubMed ID: 8033208

Title: Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase.

PubMed ID: 8033208

DOI: 10.1016/0092-8674(94)90582-7

PubMed ID: 7958856

Title: Differential regulation of E2F transactivation by cyclin/cdk2 complexes.

PubMed ID: 7958856

DOI: 10.1101/gad.8.15.1772

PubMed ID: 7969176

Title: Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation.

PubMed ID: 7969176

DOI: 10.1128/mcb.14.12.8420-8431.1994

PubMed ID: 8170954

Title: P53 and E2F-1 cooperate to mediate apoptosis.

PubMed ID: 8170954

DOI: 10.1073/pnas.91.9.3602

PubMed ID: 7494286

Title: Interaction of the 72-kilodalton human cytomegalovirus IE1 gene product with E2F1 coincides with E2F-dependent activation of dihydrofolate reductase transcription.

PubMed ID: 7494286

DOI: 10.1128/jvi.69.12.7759-7767.1995

PubMed ID: 7838523

Title: Phosphorylation of E2F-1 by cyclin A-cdk2.

PubMed ID: 7838523

PubMed ID: 9199321

Title: Specific regulation of E2F family members by cyclin-dependent kinases.

PubMed ID: 9199321

DOI: 10.1128/mcb.17.7.3867

PubMed ID: 9780002

Title: A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer.

PubMed ID: 9780002

DOI: 10.1038/sj.onc.1202163

PubMed ID: 10675335

Title: Regulation of E2F1 activity by acetylation.

PubMed ID: 10675335

DOI: 10.1093/emboj/19.4.662

PubMed ID: 11418595

Title: E2F transcriptional activation requires TRRAP and GCN5 cofactors.

PubMed ID: 11418595

DOI: 10.1074/jbc.m102067200

PubMed ID: 12697828

Title: Regulation of E2F1 by BRCT domain-containing protein TopBP1.

PubMed ID: 12697828

DOI: 10.1128/mcb.23.9.3287-3304.2003

PubMed ID: 12717439

Title: Chk2 activates E2F-1 in response to DNA damage.

PubMed ID: 12717439

DOI: 10.1038/ncb974

PubMed ID: 16360038

Title: Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release.

PubMed ID: 16360038

DOI: 10.1016/j.cell.2005.09.044

PubMed ID: 15716352

Title: EAPP, a novel E2F binding protein that modulates E2F-dependent transcription.

PubMed ID: 15716352

DOI: 10.1091/mbc.e04-11-0975

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17050006

Title: Glycogen synthase kinase-3beta binds to E2F1 and regulates its transcriptional activity.

PubMed ID: 17050006

DOI: 10.1016/j.bbamcr.2006.09.015

PubMed ID: 17704056

Title: Regulation of E2F1 function by the nuclear corepressor KAP1.

PubMed ID: 17704056

DOI: 10.1074/jbc.m704757200

PubMed ID: 18625225

Title: PEG10 directly regulated by E2Fs might have a role in the development of hepatocellular carcinoma.

PubMed ID: 18625225

DOI: 10.1016/j.febslet.2008.07.009

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20040599

Title: Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B.

PubMed ID: 20040599

DOI: 10.1074/jbc.m109.072074

PubMed ID: 20176812

Title: Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes.

PubMed ID: 20176812

DOI: 10.1128/mcb.01619-09

PubMed ID: 20603083

Title: Lysine methylation regulates E2F1-induced cell death.

PubMed ID: 20603083

DOI: 10.1016/j.molcel.2010.06.006

PubMed ID: 21653699

Title: Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription.

PubMed ID: 21653699

DOI: 10.1074/jbc.m110.191239

PubMed ID: 23629655

Title: Mixed lineage leukemia 5 (MLL5) protein regulates cell cycle progression and E2F1-responsive gene expression via association with host cell factor-1 (HCF-1).

PubMed ID: 23629655

DOI: 10.1074/jbc.m112.439729

PubMed ID: 28992046

Title: Phosphorylated E2F1 is stabilized by nuclear USP11 to drive Peg10 gene expression and activate lung epithelial cells.

PubMed ID: 28992046

DOI: 10.1093/jmcb/mjx034

PubMed ID: 29691401

Title: Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4-DCAF5 ubiquitin ligase.

PubMed ID: 29691401

DOI: 10.1038/s41467-018-04019-9

PubMed ID: 12501191

Title: Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A.

PubMed ID: 12501191

DOI: 10.1021/bi0268910

PubMed ID: 12598654

Title: Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation.

PubMed ID: 12598654

DOI: 10.1073/pnas.0436813100

Sequence Information:

Length: 437
Mass: 46920
Checksum: 003B3F654F0C60DF
Sequence:

MALAGAPAGG PCAPALEALL GAGALRLLDS SQIVIISAAQ DASAPPAPTG PAAPAAGPCD 
PDLLLFATPQ APRPTPSAPR PALGRPPVKR RLDLETDHQY LAESSGPARG RGRHPGKGVK 
SPGEKSRYET SLNLTTKRFL ELLSHSADGV VDLNWAAEVL KVQKRRIYDI TNVLEGIQLI 
AKKSKNHIQW LGSHTTVGVG GRLEGLTQDL RQLQESEQQL DHLMNICTTQ LRLLSEDTDS 
QRLAYVTCQD LRSIADPAEQ MVMVIKAPPE TQLQAVDSSE NFQISLKSKQ GPIDVFLCPE 
ETVGGISPGK TPSQEVTSEE ENRATDSATI VSPPPSSPPS SLTTDPSQSL LSLEQEPLLS 
RMGSLRAPVD EDRLSPLVAA DSLLEHVRED FSGLLPEEFI SLSPPHEALD YHFGLEEGEG 
IRDLFDCDFG DLTPLDF

Genular Protein ID: 3761017447

Symbol: Q9BSD8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BSD8

Database IDs:

Sequence Information:

Length: 96
Mass: 10666
Checksum: 1C99163A4620FFC4
Sequence:

LLGHPRPVML PVSPEPLLSR MGSLRAPVDE DRLSPLVAAD SLLEHVREDF SGLLPEEFIS 
LSPPHEALDY HFGLEEGEGI RDLFDCDFGD LTPLDF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: E2F1

Associated with

Cells (max top 100)

Other Information

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. PubMed ID: 1638634

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. PubMed ID: 1638635

Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F. PubMed ID: 1448092

Structure and partial genomic sequence of the human E2F1 gene. PubMed ID: 8964493

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. PubMed ID: 7958836

A bipartite nuclear localization signal in the retinoblastoma gene product and its importance for biological activity. PubMed ID: 8336704

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein. PubMed ID: 8413249

Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase. PubMed ID: 8033208

Differential regulation of E2F transactivation by cyclin/cdk2 complexes. PubMed ID: 7958856

Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. PubMed ID: 7969176

P53 and E2F-1 cooperate to mediate apoptosis. PubMed ID: 8170954

Interaction of the 72-kilodalton human cytomegalovirus IE1 gene product with E2F1 coincides with E2F-dependent activation of dihydrofolate reductase transcription. PubMed ID: 7494286

Phosphorylation of E2F-1 by cyclin A-cdk2. PubMed ID: 7838523

Specific regulation of E2F family members by cyclin-dependent kinases. PubMed ID: 9199321

A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer. PubMed ID: 9780002

Regulation of E2F1 activity by acetylation. PubMed ID: 10675335

E2F transcriptional activation requires TRRAP and GCN5 cofactors. PubMed ID: 11418595

Regulation of E2F1 by BRCT domain-containing protein TopBP1. PubMed ID: 12697828

Chk2 activates E2F-1 in response to DNA damage. PubMed ID: 12717439

Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. PubMed ID: 16360038

EAPP, a novel E2F binding protein that modulates E2F-dependent transcription. PubMed ID: 15716352

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Glycogen synthase kinase-3beta binds to E2F1 and regulates its transcriptional activity. PubMed ID: 17050006

Regulation of E2F1 function by the nuclear corepressor KAP1. PubMed ID: 17704056

PEG10 directly regulated by E2Fs might have a role in the development of hepatocellular carcinoma. PubMed ID: 18625225

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B. PubMed ID: 20040599

Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes. PubMed ID: 20176812

Lysine methylation regulates E2F1-induced cell death. PubMed ID: 20603083

Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription. PubMed ID: 21653699

Mixed lineage leukemia 5 (MLL5) protein regulates cell cycle progression and E2F1-responsive gene expression via association with host cell factor-1 (HCF-1). PubMed ID: 23629655

Phosphorylated E2F1 is stabilized by nuclear USP11 to drive Peg10 gene expression and activate lung epithelial cells. PubMed ID: 28992046

Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4-DCAF5 ubiquitin ligase. PubMed ID: 29691401

Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A. PubMed ID: 12501191

Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation. PubMed ID: 12598654