Details for: ECE1
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: endocardial cell (CL0002350)
Fold Change: 4
Marker Score: 2,260 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 3.95
Marker Score: 70,043 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 3.1
Marker Score: 27,180 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2.82
Marker Score: 3,250 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.37
Marker Score: 3,443 - Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 2.33
Marker Score: 17,324 - Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 2.07
Marker Score: 5,258 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 2.05
Marker Score: 1,349 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.04
Marker Score: 43,481 - Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 1.95
Marker Score: 1,677 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.93
Marker Score: 606 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.87
Marker Score: 1,995 - Cell Name: acinar cell (CL0000622)
Fold Change: 1.82
Marker Score: 1,281 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 1.71
Marker Score: 2,129 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.69
Marker Score: 1,006 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.67
Marker Score: 1,594 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.67
Marker Score: 102,598 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.66
Marker Score: 1,110 - Cell Name: contractile cell (CL0000183)
Fold Change: 1.63
Marker Score: 883 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.63
Marker Score: 475 - Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 1.62
Marker Score: 593 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.58
Marker Score: 23,599 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.57
Marker Score: 1,093 - Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 1.56
Marker Score: 772 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.56
Marker Score: 3,683 - Cell Name: keratocyte (CL0002363)
Fold Change: 1.56
Marker Score: 359 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.55
Marker Score: 11,883 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.54
Marker Score: 3,142 - Cell Name: lung goblet cell (CL1000143)
Fold Change: 1.53
Marker Score: 442 - Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1.49
Marker Score: 1,405 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.48
Marker Score: 2,952 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 1.47
Marker Score: 353 - Cell Name: tracheobronchial goblet cell (CL0019003)
Fold Change: 1.46
Marker Score: 400 - Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167,206 - Cell Name: fat cell (CL0000136)
Fold Change: 1.45
Marker Score: 813 - Cell Name: endothelial cell (CL0000115)
Fold Change: 1.42
Marker Score: 1,276 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 1.42
Marker Score: 368 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.39
Marker Score: 401 - Cell Name: hepatoblast (CL0005026)
Fold Change: 1.38
Marker Score: 4,519 - Cell Name: sympathetic neuron (CL0011103)
Fold Change: 1.36
Marker Score: 450 - Cell Name: granulosa cell (CL0000501)
Fold Change: 1.35
Marker Score: 13,634 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 1.35
Marker Score: 1,200 - Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.34
Marker Score: 763 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.33
Marker Score: 50,504 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.32
Marker Score: 642 - Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.32
Marker Score: 1,193 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.32
Marker Score: 2,788 - Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 1.32
Marker Score: 1,420 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.32
Marker Score: 20,597 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.31
Marker Score: 11,268 - Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 1.31
Marker Score: 803 - Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.28
Marker Score: 6,270 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.27
Marker Score: 5,272 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1.27
Marker Score: 493 - Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 1.26
Marker Score: 294 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.26
Marker Score: 4,878 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.23
Marker Score: 742 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 1.23
Marker Score: 391 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.22
Marker Score: 3,308 - Cell Name: secretory cell (CL0000151)
Fold Change: 1.22
Marker Score: 2,218 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 1.2
Marker Score: 787 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.19
Marker Score: 1,320 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.17
Marker Score: 442 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.17
Marker Score: 11,107 - Cell Name: pericyte (CL0000669)
Fold Change: 1.15
Marker Score: 673 - Cell Name: club cell (CL0000158)
Fold Change: 1.15
Marker Score: 1,345 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.15
Marker Score: 4,431 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.14
Marker Score: 535 - Cell Name: cell in vitro (CL0001034)
Fold Change: 1.13
Marker Score: 39,023 - Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 1.11
Marker Score: 270 - Cell Name: astrocyte (CL0000127)
Fold Change: 1.11
Marker Score: 959 - Cell Name: endocrine cell (CL0000163)
Fold Change: 1.11
Marker Score: 572 - Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.09
Marker Score: 3,428 - Cell Name: Leydig cell (CL0000178)
Fold Change: 1.08
Marker Score: 1,166 - Cell Name: basal cell (CL0000646)
Fold Change: 1.08
Marker Score: 1,395 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 1.07
Marker Score: 6,451 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.07
Marker Score: 1,896 - Cell Name: germ cell (CL0000586)
Fold Change: 1.07
Marker Score: 1,863 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.06
Marker Score: 10,954 - Cell Name: adventitial cell (CL0002503)
Fold Change: 1.04
Marker Score: 257 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.03
Marker Score: 599 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.03
Marker Score: 4,428 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.02
Marker Score: 1,725 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.01
Marker Score: 34,209 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 1
Marker Score: 479 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1
Marker Score: 526 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,667 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47,892 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.99
Marker Score: 318 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.98
Marker Score: 999 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,384 - Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.98
Marker Score: 395 - Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.97
Marker Score: 608 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.97
Marker Score: 948 - Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 0.96
Marker Score: 205 - Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.96
Marker Score: 398 - Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.95
Marker Score: 243 - Cell Name: endothelial tip cell (CL0000704)
Fold Change: 0.95
Marker Score: 221 - Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.95
Marker Score: 953 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.95
Marker Score: 1,821
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3239516794
Symbol: ECE1_HUMAN
Name: Endothelin-converting enzyme 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7695628
Title: Cloning and sequencing of a human endothelin converting enzyme in renal adenocarcinoma (ACHN) cells producing endothelin-2.
PubMed ID: 7695628
PubMed ID: 7864876
Title: Cloning and functional expression of human endothelin-converting enzyme cDNA.
PubMed ID: 7864876
PubMed ID: 8530372
Title: Organization of the gene encoding the human endothelin-converting enzyme (ECE-1).
PubMed ID: 8530372
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10491078
Title: A fourth isoform of endothelin-converting enzyme (ECE-1) is generated from an additional promoter.
PubMed ID: 10491078
PubMed ID: 9396733
Title: Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations.
PubMed ID: 9396733
DOI: 10.1042/bj3280871
PubMed ID: 7805846
Title: Molecular characterization of human and bovine endothelin converting enzyme (ECE-1).
PubMed ID: 7805846
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16263699
Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.
PubMed ID: 16263699
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 19349973
Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.
PubMed ID: 19349973
DOI: 10.1038/nbt.1532
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 26931059
Title: N-terminal domain of Bothrops asper Myotoxin II enhances the activity of endothelin converting enzyme-1 and neprilysin.
PubMed ID: 26931059
DOI: 10.1038/srep22413
PubMed ID: 27102936
Title: Corrigendum: N-terminal domain of Bothrops asper Myotoxin II enhances the activity of endothelin converting enzyme-1 and neprilysin.
PubMed ID: 27102936
DOI: 10.1038/srep24333
PubMed ID: 18992253
Title: Structure of human endothelin-converting enzyme I complexed with phosphoramidon.
PubMed ID: 18992253
PubMed ID: 9915973
Title: A loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1) associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction.
PubMed ID: 9915973
DOI: 10.1086/302184
Sequence Information:
- Length: 770
- Mass: 87164
- Checksum: DD88A59748B22F80
- Sequence:
MRGVWPPPVS ALLSALGMST YKRATLDEED LVDSLSEGDA YPNGLQVNFH SPRSGQRCWA ARTQVEKRLV VLVVLLAAGL VACLAALGIQ YQTRSPSVCL SEACVSVTSS ILSSMDPTVD PCHDFFSYAC GGWIKANPVP DGHSRWGTFS NLWEHNQAII KHLLENSTAS VSEAERKAQV YYRACMNETR IEELRAKPLM ELIERLGGWN ITGPWAKDNF QDTLQVVTAH YRTSPFFSVY VSADSKNSNS NVIQVDQSGL GLPSRDYYLN KTENEKVLTG YLNYMVQLGK LLGGGDEEAI RPQMQQILDF ETALANITIP QEKRRDEELI YHKVTAAELQ TLAPAINWLP FLNTIFYPVE INESEPIVVY DKEYLEQIST LINTTDRCLL NNYMIWNLVR KTSSFLDQRF QDADEKFMEV MYGTKKTCLP RWKFCVSDTE NNLGFALGPM FVKATFAEDS KSIATEIILE IKKAFEESLS TLKWMDEETR KSAKEKADAI YNMIGYPNFI MDPKELDKVF NDYTAVPDLY FENAMRFFNF SWRVTADQLR KAPNRDQWSM TPPMVNAYYS PTKNEIVFPA GILQAPFYTR SSPKALNFGG IGVVVGHELT HAFDDQGREY DKDGNLRPWW KNSSVEAFKR QTECMVEQYS NYSVNGEPVN GRHTLGENIA DNGGLKAAYR AYQNWVKKNG AEHSLPTLGL TNNQLFFLGF AQVWCSVRTP ESSHEGLITD PHSPSRFRVI GSLSNSKEFS EHFRCPPGSP MNPPHKCEVW
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.