Details for: ECE1

Gene ID: 1889

Symbol: ECE1

Ensembl ID: ENSG00000117298

Description: endothelin converting enzyme 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 4
    Marker Score: 2,260
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.95
    Marker Score: 70,043
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.1
    Marker Score: 27,180
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.82
    Marker Score: 3,250
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.37
    Marker Score: 3,443
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.33
    Marker Score: 17,324
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.07
    Marker Score: 5,258
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.05
    Marker Score: 1,349
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.04
    Marker Score: 43,481
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.95
    Marker Score: 1,677
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.93
    Marker Score: 606
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.87
    Marker Score: 1,995
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.82
    Marker Score: 1,281
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.71
    Marker Score: 2,129
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.69
    Marker Score: 1,006
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.67
    Marker Score: 1,594
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.67
    Marker Score: 102,598
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.66
    Marker Score: 1,110
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.63
    Marker Score: 883
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.63
    Marker Score: 475
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.62
    Marker Score: 593
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.58
    Marker Score: 23,599
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.57
    Marker Score: 1,093
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.56
    Marker Score: 772
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.56
    Marker Score: 3,683
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.56
    Marker Score: 359
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.55
    Marker Score: 11,883
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.54
    Marker Score: 3,142
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.53
    Marker Score: 442
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.49
    Marker Score: 1,405
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.48
    Marker Score: 2,952
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.47
    Marker Score: 353
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.46
    Marker Score: 400
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,206
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.45
    Marker Score: 813
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.42
    Marker Score: 1,276
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.42
    Marker Score: 368
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.39
    Marker Score: 401
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.38
    Marker Score: 4,519
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.36
    Marker Score: 450
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.35
    Marker Score: 13,634
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.35
    Marker Score: 1,200
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.34
    Marker Score: 763
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.33
    Marker Score: 50,504
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.32
    Marker Score: 642
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.32
    Marker Score: 1,193
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.32
    Marker Score: 2,788
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.32
    Marker Score: 1,420
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.32
    Marker Score: 20,597
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.31
    Marker Score: 11,268
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.31
    Marker Score: 803
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.28
    Marker Score: 6,270
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.27
    Marker Score: 5,272
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.27
    Marker Score: 493
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.26
    Marker Score: 294
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.26
    Marker Score: 4,878
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.23
    Marker Score: 742
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.23
    Marker Score: 391
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.22
    Marker Score: 3,308
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.22
    Marker Score: 2,218
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.2
    Marker Score: 787
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.19
    Marker Score: 1,320
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.17
    Marker Score: 442
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.17
    Marker Score: 11,107
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.15
    Marker Score: 673
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.15
    Marker Score: 1,345
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.15
    Marker Score: 4,431
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.14
    Marker Score: 535
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.13
    Marker Score: 39,023
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.11
    Marker Score: 270
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.11
    Marker Score: 959
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.11
    Marker Score: 572
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.09
    Marker Score: 3,428
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.08
    Marker Score: 1,166
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.08
    Marker Score: 1,395
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.07
    Marker Score: 6,451
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.07
    Marker Score: 1,896
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.07
    Marker Score: 1,863
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.06
    Marker Score: 10,954
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.04
    Marker Score: 257
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.03
    Marker Score: 599
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.03
    Marker Score: 4,428
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.02
    Marker Score: 1,725
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.01
    Marker Score: 34,209
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 1
    Marker Score: 479
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1
    Marker Score: 526
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,667
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,892
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.99
    Marker Score: 318
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.98
    Marker Score: 999
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,384
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.98
    Marker Score: 395
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.97
    Marker Score: 608
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.97
    Marker Score: 948
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.96
    Marker Score: 205
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.96
    Marker Score: 398
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.95
    Marker Score: 243
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.95
    Marker Score: 221
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.95
    Marker Score: 953
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.95
    Marker Score: 1,821

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Expression Pattern**: ECE1 is predominantly expressed in endothelial cells, but also found in cortical cells of the adrenal gland, lung endothelial cells, vascular leptomeningeal cells, and other cell types. 2. **Function**: ECE1 converts big endothelin-1 to endothelin-1, the biologically active form of endothelin, which plays a crucial role in regulating vascular tone and blood pressure. 3. **Metalloendopeptidase Activity**: ECE1 exhibits metalloendopeptidase activity, allowing it to cleave and activate peptides, including endothelins. 4. **Signaling Pathways**: ECE1 is involved in multiple signaling pathways, including those regulating vascular development, axon guidance, hormone regulation, and blood pressure. **Pathways and Functions** ECE1's involvement in various signaling pathways highlights its multifaceted role in maintaining physiological balance: 1. **Regulation of Vascular Tone**: ECE1 converts big endothelin-1 to endothelin-1, the biologically active form of endothelin, which regulates vascular tone and blood pressure. 2. **Axon Guidance**: ECE1 is involved in semaphorin-plexin signaling pathway, which regulates axon guidance and neuronal development. 3. **Hormone Regulation**: ECE1 processes peptide hormones, such as substance P, which plays a role in regulating various physiological processes. 4. **Developmental Processes**: ECE1 is involved in embryonic heart tube development, ear development, and pharyngeal system development, highlighting its importance in embryonic development. 5. **Blood Pressure Regulation**: ECE1's expression in endothelial cells and its role in regulating endothelin-1 levels make it a key player in maintaining systemic arterial blood pressure. **Clinical Significance** Dysregulation of ECE1 has been implicated in various diseases, including: 1. **Hypertension**: ECE1's role in regulating endothelin-1 levels makes it a potential target for the treatment of hypertension. 2. **Cardiovascular Diseases**: ECE1's involvement in vascular development and maintenance highlights its potential role in cardiovascular diseases, such as atherosclerosis and heart failure. 3. **Neurological Disorders**: ECE1's role in axon guidance and neuronal development suggests its potential involvement in neurological disorders, such as stroke and neurodegenerative diseases. 4. **Cancer**: ECE1's expression in various cell types and its role in processing peptide hormones make it a potential target for cancer therapy. In conclusion, ECE1 is a critical gene involved in multiple physiological and pathological processes. Its role in regulating endothelin-1 levels, processing peptide hormones, and participating in signaling pathways underscores its importance in maintaining vascular homeostasis and overall physiological balance. Further research is necessary to fully elucidate the functions and clinical significance of ECE1.

Genular Protein ID: 3239516794

Symbol: ECE1_HUMAN

Name: Endothelin-converting enzyme 1

UniProtKB Accession Codes:

P42892 A8K3P1 B4E291 Q14217 Q17RN5 Q2Z2K8 Q58GE7 Q5THM5 Q5THM7 Q5THM8 Q9UJQ6 Q9UPF4 Q9UPM4 Q9Y501

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 51 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 35 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 7 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7695628

Title: Cloning and sequencing of a human endothelin converting enzyme in renal adenocarcinoma (ACHN) cells producing endothelin-2.

PubMed ID: 7695628

DOI: 10.1006/bbrc.1995.1397

PubMed ID: 7864876

Title: Cloning and functional expression of human endothelin-converting enzyme cDNA.

PubMed ID: 7864876

DOI: 10.1006/bbrc.1995.1258

PubMed ID: 8530372

Title: Organization of the gene encoding the human endothelin-converting enzyme (ECE-1).

PubMed ID: 8530372

DOI: 10.1074/jbc.270.50.29794

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10491078

Title: A fourth isoform of endothelin-converting enzyme (ECE-1) is generated from an additional promoter.

PubMed ID: 10491078

DOI: 10.1046/j.1432-1327.1999.00602.x

PubMed ID: 9396733

Title: Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations.

PubMed ID: 9396733

DOI: 10.1042/bj3280871

PubMed ID: 7805846

Title: Molecular characterization of human and bovine endothelin converting enzyme (ECE-1).

PubMed ID: 7805846

DOI: 10.1016/0014-5793(94)01277-6

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16263699

Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.

PubMed ID: 16263699

DOI: 10.1074/mcp.m500324-mcp200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26931059

Title: N-terminal domain of Bothrops asper Myotoxin II enhances the activity of endothelin converting enzyme-1 and neprilysin.

PubMed ID: 26931059

DOI: 10.1038/srep22413

PubMed ID: 27102936

Title: Corrigendum: N-terminal domain of Bothrops asper Myotoxin II enhances the activity of endothelin converting enzyme-1 and neprilysin.

PubMed ID: 27102936

DOI: 10.1038/srep24333

PubMed ID: 18992253

Title: Structure of human endothelin-converting enzyme I complexed with phosphoramidon.

PubMed ID: 18992253

DOI: 10.1016/j.jmb.2008.10.052

PubMed ID: 9915973

Title: A loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1) associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction.

PubMed ID: 9915973

DOI: 10.1086/302184

Sequence Information:

  • Length: 770
  • Mass: 87164
  • Checksum: DD88A59748B22F80
  • Sequence:
    • MRGVWPPPVS ALLSALGMST YKRATLDEED LVDSLSEGDA YPNGLQVNFH SPRSGQRCWA 
ARTQVEKRLV VLVVLLAAGL VACLAALGIQ YQTRSPSVCL SEACVSVTSS ILSSMDPTVD 
PCHDFFSYAC GGWIKANPVP DGHSRWGTFS NLWEHNQAII KHLLENSTAS VSEAERKAQV 
YYRACMNETR IEELRAKPLM ELIERLGGWN ITGPWAKDNF QDTLQVVTAH YRTSPFFSVY 
VSADSKNSNS NVIQVDQSGL GLPSRDYYLN KTENEKVLTG YLNYMVQLGK LLGGGDEEAI 
RPQMQQILDF ETALANITIP QEKRRDEELI YHKVTAAELQ TLAPAINWLP FLNTIFYPVE 
INESEPIVVY DKEYLEQIST LINTTDRCLL NNYMIWNLVR KTSSFLDQRF QDADEKFMEV 
MYGTKKTCLP RWKFCVSDTE NNLGFALGPM FVKATFAEDS KSIATEIILE IKKAFEESLS 
TLKWMDEETR KSAKEKADAI YNMIGYPNFI MDPKELDKVF NDYTAVPDLY FENAMRFFNF 
SWRVTADQLR KAPNRDQWSM TPPMVNAYYS PTKNEIVFPA GILQAPFYTR SSPKALNFGG 
IGVVVGHELT HAFDDQGREY DKDGNLRPWW KNSSVEAFKR QTECMVEQYS NYSVNGEPVN 
GRHTLGENIA DNGGLKAAYR AYQNWVKKNG AEHSLPTLGL TNNQLFFLGF AQVWCSVRTP 
ESSHEGLITD PHSPSRFRVI GSLSNSKEFS EHFRCPPGSP MNPPHKCEVW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.