Details for: EDN2

Gene ID: 1907

Symbol: EDN2

Ensembl ID: ENSG00000127129

Description: endothelin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 16.7497
    Cell Significance Index: -6.9000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.4837
    Cell Significance Index: -7.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.4996
    Cell Significance Index: 285.3900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8818
    Cell Significance Index: 25.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8177
    Cell Significance Index: 80.8900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7449
    Cell Significance Index: 672.6200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.7311
    Cell Significance Index: 6.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7050
    Cell Significance Index: 36.6200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5538
    Cell Significance Index: 33.2500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5218
    Cell Significance Index: 56.7600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4504
    Cell Significance Index: 73.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4405
    Cell Significance Index: 6.0100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3084
    Cell Significance Index: 21.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2797
    Cell Significance Index: 6.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2592
    Cell Significance Index: 11.7500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.2381
    Cell Significance Index: 0.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2197
    Cell Significance Index: 5.9800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1757
    Cell Significance Index: 77.7000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1480
    Cell Significance Index: 3.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1418
    Cell Significance Index: 3.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1198
    Cell Significance Index: 8.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0667
    Cell Significance Index: 7.7700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0549
    Cell Significance Index: 1.9300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0517
    Cell Significance Index: 0.7200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0396
    Cell Significance Index: 0.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0258
    Cell Significance Index: 1.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0210
    Cell Significance Index: 2.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0087
    Cell Significance Index: 16.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0060
    Cell Significance Index: 3.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0039
    Cell Significance Index: 0.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0018
    Cell Significance Index: 2.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0005
    Cell Significance Index: 0.2200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0013
    Cell Significance Index: -0.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0024
    Cell Significance Index: -1.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0042
    Cell Significance Index: -6.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0050
    Cell Significance Index: -9.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0076
    Cell Significance Index: -4.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0076
    Cell Significance Index: -5.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0118
    Cell Significance Index: -8.7300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0133
    Cell Significance Index: -0.5400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0142
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0158
    Cell Significance Index: -1.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0159
    Cell Significance Index: -8.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0166
    Cell Significance Index: -1.7000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0187
    Cell Significance Index: -0.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0189
    Cell Significance Index: -6.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0191
    Cell Significance Index: -1.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0262
    Cell Significance Index: -7.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0296
    Cell Significance Index: -3.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0299
    Cell Significance Index: -0.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0322
    Cell Significance Index: -4.6800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0330
    Cell Significance Index: -6.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0341
    Cell Significance Index: -7.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0370
    Cell Significance Index: -7.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0410
    Cell Significance Index: -7.0000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0527
    Cell Significance Index: -7.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0589
    Cell Significance Index: -2.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0627
    Cell Significance Index: -8.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0676
    Cell Significance Index: -7.0400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0757
    Cell Significance Index: -0.8600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0802
    Cell Significance Index: -6.3500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0823
    Cell Significance Index: -1.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0856
    Cell Significance Index: -6.5700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1011
    Cell Significance Index: -2.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1063
    Cell Significance Index: -7.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1076
    Cell Significance Index: -6.0400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1208
    Cell Significance Index: -6.2900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1383
    Cell Significance Index: -1.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1536
    Cell Significance Index: -9.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1701
    Cell Significance Index: -3.5600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1706
    Cell Significance Index: -1.8000
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.1725
    Cell Significance Index: -0.7500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1730
    Cell Significance Index: -4.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1750
    Cell Significance Index: -8.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1891
    Cell Significance Index: -5.5700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1897
    Cell Significance Index: -9.9600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1937
    Cell Significance Index: -6.7300
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1982
    Cell Significance Index: -2.7400
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1983
    Cell Significance Index: -1.2300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2024
    Cell Significance Index: -7.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2069
    Cell Significance Index: -5.4400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2069
    Cell Significance Index: -4.7800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2072
    Cell Significance Index: -3.0200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2101
    Cell Significance Index: -7.3600
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.2157
    Cell Significance Index: -3.0300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2239
    Cell Significance Index: -9.7400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2273
    Cell Significance Index: -2.6200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2300
    Cell Significance Index: -7.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2310
    Cell Significance Index: -6.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2361
    Cell Significance Index: -7.5200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.2399
    Cell Significance Index: -1.4800
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.2432
    Cell Significance Index: -2.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2438
    Cell Significance Index: -10.7900
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.2515
    Cell Significance Index: -4.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2520
    Cell Significance Index: -7.1900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.2667
    Cell Significance Index: -3.1000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.2693
    Cell Significance Index: -3.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2857
    Cell Significance Index: -10.8200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2901
    Cell Significance Index: -7.4100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2931
    Cell Significance Index: -7.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Peptide structure:** EDN2 is a 16-amino acid peptide, consisting of two disulfide-bonded loops, which are essential for its biological activity. 2. **Receptor specificity:** EDN2 binds to two distinct receptors, ETA and ETB, which are expressed on various cell types, including vascular smooth muscle cells, endothelial cells, and immune cells. 3. **Biological activity:** EDN2 exhibits potent vasoconstrictive, pro-inflammatory, and pro-angiogenic properties, making it a key regulator of vascular tone, immune response, and tissue development. **Pathways and Functions:** 1. **Angiogenesis:** EDN2 promotes angiogenesis by stimulating the proliferation and migration of endothelial cells, leading to the formation of new blood vessels. 2. **Vascular tone regulation:** EDN2 acts as a potent vasoconstrictor, regulating vascular tone by binding to ETA receptors on vascular smooth muscle cells. 3. **Immune response:** EDN2 modulates immune responses by activating macrophages, promoting neutrophil chemotaxis, and regulating the expression of cytokines and chemokines. 4. **Cell migration:** EDN2 facilitates cell migration by interacting with cell surface receptors, such as integrins and chemokine receptors, which are essential for cell movement and tissue development. 5. **Signaling pathways:** EDN2 activates various signaling pathways, including the MAPK/ERK, PI3K/Akt, and NF-κB pathways, which regulate gene expression, cell proliferation, and survival. **Clinical Significance:** 1. **Hypertension:** EDN2 has been implicated in the pathogenesis of hypertension, as it regulates vascular tone and blood pressure. 2. **Cardiovascular disease:** EDN2 plays a critical role in the development and progression of cardiovascular diseases, including atherosclerosis, heart failure, and cardiac arrhythmias. 3. **Cancer:** EDN2 has been shown to promote angiogenesis and tumor growth in various types of cancer, highlighting its potential as a therapeutic target. 4. **Neurological disorders:** EDN2 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis, where it regulates inflammation and neurodegeneration. 5. **Infectious diseases:** EDN2 modulates immune responses to infections, making it a potential target for the treatment of infectious diseases. In conclusion, the EDN2 gene is a critical regulator of vascular tone, cell migration, and immune response, with significant implications for various physiological and pathological processes. Further research is needed to fully elucidate the mechanisms of EDN2 and its role in human diseases, ultimately leading to the development of novel therapeutic strategies.

Genular Protein ID: 4198437798

Symbol: EDN2_HUMAN

Name: Endothelin-2

UniProtKB Accession Codes:

P20800 Q5T1R3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 31 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 2 SMART 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1701397

Title: Specific expression of human endothelin-2 (ET-2) gene in a renal adenocarcinoma cell line. Molecular cloning of cDNA encoding the precursor of ET-2 and its characterization.

PubMed ID: 1701397

DOI: 10.1016/0014-5793(90)81348-r

PubMed ID: 1840558

Title: cDNA cloning and chromosomal assignment of the endothelin 2 gene: vasoactive intestinal contractor peptide is rat endothelin 2.

PubMed ID: 1840558

DOI: 10.1016/0888-7543(91)90505-9

PubMed ID: 1725387

Title: Expression of endothelin-2 (ET-2) gene in a human renal adenocarcinoma cell line: purification and cDNA cloning of ET-2.

PubMed ID: 1725387

DOI: 10.1097/00005344-199100177-00011

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2649896

Title: The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

PubMed ID: 2649896

DOI: 10.1073/pnas.86.8.2863

PubMed ID: 10438732

Title: Proteolytic processing of big endothelin-3 by the kell blood group protein.

PubMed ID: 10438732

PubMed ID: 9284755

Title: Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3.

PubMed ID: 9284755

DOI: 10.1210/jcem.82.9.4209

Sequence Information:

  • Length: 178
  • Mass: 19960
  • Checksum: 7711B2B6F075CFB4
  • Sequence:
    • MVSVPTTWCS VALALLVALH EGKGQAAATL EQPASSSHAQ GTHLRLRRCS CSSWLDKECV 
YFCHLDIIWV NTPEQTAPYG LGNPPRRRRR SLPRRCQCSS ARDPACATFC LRRPWTEAGA 
VPSRKSPADV FQTGKTGATT GELLQRLRDI STVKSLFAKR QQEAMREPRS THSRWRKR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.