Gene EDN2 - ENSG00000127129 | NCBI Gene ID: 1907

Details for: EDN2

Gene ID: 1907

Symbol: EDN2

Ensembl ID: ENSG00000127129

Description: endothelin 2

Associated with

Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (q) signalling events
(R-HSA-416476)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Peptide ligand-binding receptors
(R-HSA-375276)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Angiogenesis
(GO:0001525)
Artery smooth muscle contraction
(GO:0014824)
Axon extension
(GO:0048675)
Cell surface receptor signaling pathway
(GO:0007166)
Cell tip growth
(GO:0009932)
Cytokine-mediated signaling pathway
(GO:0019221)
Endothelial cell migration
(GO:0043542)
Endothelin b receptor binding
(GO:0031708)
Energy homeostasis
(GO:0097009)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Hormonal regulation of the force of heart contraction
(GO:0003058)
Hormone activity
(GO:0005179)
Intracellular calcium ion homeostasis
(GO:0006874)
Lung alveolus development
(GO:0048286)
Macrophage activation
(GO:0042116)
Macrophage chemotaxis
(GO:0048246)
Neutrophil chemotaxis
(GO:0030593)
Positive regulation of calcium-mediated signaling
(GO:0050850)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of heart rate
(GO:0010460)
Positive regulation of leukocyte chemotaxis
(GO:0002690)
Positive regulation of prostaglandin-endoperoxide synthase activity
(GO:0060585)
Positive regulation of smooth muscle contraction
(GO:0045987)
Positive regulation of the force of heart contraction by chemical signal
(GO:0003099)
Prostaglandin biosynthetic process
(GO:0001516)
Regulation of systemic arterial blood pressure by endothelin
(GO:0003100)
Regulation of vasoconstriction
(GO:0019229)
Temperature homeostasis
(GO:0001659)
Vasoconstriction
(GO:0042310)
Vein smooth muscle contraction
(GO:0014826)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.77
Marker Score: 3359
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 1.49
Marker Score: 1027
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 869
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.31
Marker Score: 20555
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.03
Marker Score: 2094
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71824.5
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48050
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 508
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 462
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.97
Marker Score: 2014
Cell Name: lung secretory cell (CL1000272)
Fold Change: 0.96
Marker Score: 854
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.96
Marker Score: 648
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5331
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2737
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 326
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5290
Cell Name: mast cell (CL0000097)
Fold Change: 0.83
Marker Score: 484
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.82
Marker Score: 328.5
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.79
Marker Score: 379
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1266
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 590.5
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 703
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 397
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.74
Marker Score: 1141
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.69
Marker Score: 2899
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.68
Marker Score: 1197
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.61
Marker Score: 390
Cell Name: secretory cell (CL0000151)
Fold Change: 0.59
Marker Score: 1074
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.57
Marker Score: 454
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 148
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.55
Marker Score: 244
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.51
Marker Score: 304
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.51
Marker Score: 448
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.5
Marker Score: 208
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.49
Marker Score: 475
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.47
Marker Score: 278
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.45
Marker Score: 1110
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.45
Marker Score: 142
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 0.42
Marker Score: 614
Cell Name: basal cell (CL0000646)
Fold Change: 0.4
Marker Score: 511
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.39
Marker Score: 220
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 372
Cell Name: enterocyte (CL0000584)
Fold Change: 0.37
Marker Score: 1757
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.35
Marker Score: 827
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.33
Marker Score: 192
Cell Name: plasma cell (CL0000786)
Fold Change: 0.33
Marker Score: 363
Cell Name: club cell (CL0000158)
Fold Change: 0.32
Marker Score: 373
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.31
Marker Score: 987
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 0.3
Marker Score: 189
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.3
Marker Score: 654
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.3
Marker Score: 112
Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
Fold Change: 0.29
Marker Score: 83
Cell Name: erythroblast (CL0000765)
Fold Change: 0.28
Marker Score: 175
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.28
Marker Score: 191
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.27
Marker Score: 387
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.26
Marker Score: 172
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.25
Marker Score: 266
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.25
Marker Score: 250
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.24
Marker Score: 358
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.24
Marker Score: 128
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.24
Marker Score: 77
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.24
Marker Score: 200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.23
Marker Score: 242
Cell Name: B cell (CL0000236)
Fold Change: 0.23
Marker Score: 219
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64
Cell Name: malignant cell (CL0001064)
Fold Change: 0.22
Marker Score: 3001
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 74
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.21
Marker Score: 214
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.21
Marker Score: 99
Cell Name: pericyte (CL0000669)
Fold Change: 0.21
Marker Score: 124
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.21
Marker Score: 96
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.21
Marker Score: 108
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.2
Marker Score: 160
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.2
Marker Score: 554
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.2
Marker Score: 105
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.19
Marker Score: 38
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.19
Marker Score: 171
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.19
Marker Score: 87
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.19
Marker Score: 85
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.18
Marker Score: 260
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.18
Marker Score: 57
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.18
Marker Score: 73
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.17
Marker Score: 282
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.17
Marker Score: 468
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.17
Marker Score: 38
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.16
Marker Score: 96
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.16
Marker Score: 534
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.15
Marker Score: 549
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.15
Marker Score: 241
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.15
Marker Score: 368
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.15
Marker Score: 573
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.15
Marker Score: 59
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.14
Marker Score: 37
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.14
Marker Score: 35
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.14
Marker Score: 151
Cell Name: acinar cell (CL0000622)
Fold Change: 0.14
Marker Score: 97
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 0.14
Marker Score: 147

Hover over a box to see details here...

**Key characteristics:** - It is a cell surface receptor that is expressed in high levels in the heart and blood vessels. - It is a member of the endothelin family of cell surface receptors, which are involved in the regulation of vascular tone and blood flow. - It is a key regulator of systemic arterial blood pressure. - It is involved in the regulation of cardiac contractility and heart rate. - It is also involved in the regulation of inflammation and blood vessel remodeling. **Pathways and functions:** - EDN2 is a ligand for the G alpha (q) signaling pathway. - It is also a ligand for the GPCR (G protein-coupled receptor) pathway. - It is involved in the regulation of blood pressure by binding to the GPCRs on blood vessel smooth muscle cells. - It also plays a role in the regulation of inflammation by binding to the GPCRs on immune cells. **Clinical significance:** Mutations in the EDN2 gene have been linked to a number of cardiovascular diseases, including hypertension, heart failure, and stroke. These mutations can lead to the development of these diseases by disrupting the normal function of EDN2.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Endothelin-2

Genular Protein ID: 4198437798

Symbol: EDN2_HUMAN

Name: Endothelin-2

UniProtKB Accession Codes:

P20800 Q5T1R3

Database IDs:

Citations:

PubMed ID: 1701397

Title: Specific expression of human endothelin-2 (ET-2) gene in a renal adenocarcinoma cell line. Molecular cloning of cDNA encoding the precursor of ET-2 and its characterization.

PubMed ID: 1701397

DOI: 10.1016/0014-5793(90)81348-r

PubMed ID: 1840558

Title: cDNA cloning and chromosomal assignment of the endothelin 2 gene: vasoactive intestinal contractor peptide is rat endothelin 2.

PubMed ID: 1840558

DOI: 10.1016/0888-7543(91)90505-9

PubMed ID: 1725387

Title: Expression of endothelin-2 (ET-2) gene in a human renal adenocarcinoma cell line: purification and cDNA cloning of ET-2.

PubMed ID: 1725387

DOI: 10.1097/00005344-199100177-00011

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2649896

Title: The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

PubMed ID: 2649896

DOI: 10.1073/pnas.86.8.2863

PubMed ID: 10438732

Title: Proteolytic processing of big endothelin-3 by the kell blood group protein.

PubMed ID: 10438732

PubMed ID: 9284755

Title: Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3.

PubMed ID: 9284755

DOI: 10.1210/jcem.82.9.4209

Sequence Information:

Length: 178
Mass: 19960
Checksum: 7711B2B6F075CFB4
Sequence:

MVSVPTTWCS VALALLVALH EGKGQAAATL EQPASSSHAQ GTHLRLRRCS CSSWLDKECV 
YFCHLDIIWV NTPEQTAPYG LGNPPRRRRR SLPRRCQCSS ARDPACATFC LRRPWTEAGA 
VPSRKSPADV FQTGKTGATT GELLQRLRDI STVKSLFAKR QQEAMREPRS THSRWRKR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: EDN2

Associated with

Cells (max top 100)

Other Information

Specific expression of human endothelin-2 (ET-2) gene in a renal adenocarcinoma cell line. Molecular cloning of cDNA encoding the precursor of ET-2 and its characterization. PubMed ID: 1701397

cDNA cloning and chromosomal assignment of the endothelin 2 gene: vasoactive intestinal contractor peptide is rat endothelin 2. PubMed ID: 1840558

Expression of endothelin-2 (ET-2) gene in a human renal adenocarcinoma cell line: purification and cDNA cloning of ET-2. PubMed ID: 1725387

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. PubMed ID: 2649896

Proteolytic processing of big endothelin-3 by the kell blood group protein. PubMed ID: 10438732

Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3. PubMed ID: 9284755