Details for: PHC2

Gene ID: 1912

Symbol: PHC2

Ensembl ID: ENSG00000134686

Description: polyhomeotic homolog 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 375.0678
    Cell Significance Index: -58.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 230.1952
    Cell Significance Index: -58.3900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 155.6387
    Cell Significance Index: -64.1200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 127.2127
    Cell Significance Index: -60.0600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 117.7272
    Cell Significance Index: -47.8300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 110.0343
    Cell Significance Index: -56.6000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 50.3120
    Cell Significance Index: -48.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 48.0309
    Cell Significance Index: -59.2200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 21.1863
    Cell Significance Index: -56.7600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.4585
    Cell Significance Index: -47.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.0568
    Cell Significance Index: -59.4200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.9320
    Cell Significance Index: -32.6800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.6701
    Cell Significance Index: 76.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.9981
    Cell Significance Index: 88.3800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.9053
    Cell Significance Index: 72.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.8917
    Cell Significance Index: 145.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8230
    Cell Significance Index: 365.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1460
    Cell Significance Index: 186.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.1011
    Cell Significance Index: 74.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.0345
    Cell Significance Index: 58.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0321
    Cell Significance Index: 370.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9554
    Cell Significance Index: 49.7700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9256
    Cell Significance Index: 640.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7666
    Cell Significance Index: 152.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6728
    Cell Significance Index: 41.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6662
    Cell Significance Index: 363.8200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.6398
    Cell Significance Index: 15.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6218
    Cell Significance Index: 76.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5682
    Cell Significance Index: 102.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5354
    Cell Significance Index: 73.5300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4327
    Cell Significance Index: 29.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4146
    Cell Significance Index: 183.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2789
    Cell Significance Index: 17.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2431
    Cell Significance Index: 154.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2376
    Cell Significance Index: 107.8600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2320
    Cell Significance Index: 5.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1874
    Cell Significance Index: 5.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1632
    Cell Significance Index: 4.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1514
    Cell Significance Index: 28.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1449
    Cell Significance Index: 130.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1113
    Cell Significance Index: 209.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0914
    Cell Significance Index: 1.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0190
    Cell Significance Index: 1.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0073
    Cell Significance Index: 1.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0048
    Cell Significance Index: 0.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0052
    Cell Significance Index: -9.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0099
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0132
    Cell Significance Index: -9.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0136
    Cell Significance Index: -20.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0203
    Cell Significance Index: -12.6600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0205
    Cell Significance Index: -27.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0331
    Cell Significance Index: -24.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0427
    Cell Significance Index: -1.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0469
    Cell Significance Index: -35.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0682
    Cell Significance Index: -38.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1059
    Cell Significance Index: -13.5700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1084
    Cell Significance Index: -1.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1086
    Cell Significance Index: -11.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1290
    Cell Significance Index: -2.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1464
    Cell Significance Index: -3.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1490
    Cell Significance Index: -7.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1512
    Cell Significance Index: -31.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1513
    Cell Significance Index: -3.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1571
    Cell Significance Index: -22.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1646
    Cell Significance Index: -21.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1651
    Cell Significance Index: -47.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1704
    Cell Significance Index: -19.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1752
    Cell Significance Index: -12.3900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1764
    Cell Significance Index: -4.2300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2152
    Cell Significance Index: -3.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2169
    Cell Significance Index: -24.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2478
    Cell Significance Index: -13.0100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2824
    Cell Significance Index: -8.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2914
    Cell Significance Index: -21.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3119
    Cell Significance Index: -32.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3232
    Cell Significance Index: -15.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3263
    Cell Significance Index: -6.9500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3277
    Cell Significance Index: -8.9200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3975
    Cell Significance Index: -46.8800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4797
    Cell Significance Index: -5.9500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4840
    Cell Significance Index: -55.2500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5713
    Cell Significance Index: -6.8100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5773
    Cell Significance Index: -45.7300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5963
    Cell Significance Index: -9.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5996
    Cell Significance Index: -31.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6104
    Cell Significance Index: -19.5500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6850
    Cell Significance Index: -10.1100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.7070
    Cell Significance Index: -5.7700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.7256
    Cell Significance Index: -10.4200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7501
    Cell Significance Index: -14.6400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8293
    Cell Significance Index: -22.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8889
    Cell Significance Index: -54.5000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.8954
    Cell Significance Index: -19.1400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9098
    Cell Significance Index: -19.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.9876
    Cell Significance Index: -34.3200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.0169
    Cell Significance Index: -26.7400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0368
    Cell Significance Index: -33.0200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.0702
    Cell Significance Index: -19.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0983
    Cell Significance Index: -35.9600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -1.1466
    Cell Significance Index: -18.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PHC2 is a member of the polyhomeotic gene family, which is characterized by the presence of a highly conserved polyhomeotic (PH) domain. This domain is essential for the recruitment of transcriptional co-activators and the regulation of gene expression. PHC2 is primarily expressed in various cell types, including fibroblasts, ciliary muscle cells, kidney interstitial fibroblasts, and cardiac myocytes. Its expression is also detected in other cell types, such as GABAergic cortical interneurons and mature microglial cells. **Pathways and Functions:** PHC2 is involved in multiple signaling pathways, including: 1. **Cellular responses to stimuli:** PHC2 regulates the expression of genes involved in cellular responses to stress, such as oxidative stress-induced senescence. 2. **Cellular responses to stress:** PHC2 interacts with other proteins to modulate the response to DNA damage and repair. 3. **Chromatin organization:** PHC2 is involved in the regulation of chromatin organization, including the recruitment of histone-modifying enzymes. 4. **Gene expression (transcription):** PHC2 acts as a transcriptional co-activator, regulating the expression of genes involved in various cellular processes. 5. **Intracellular signaling by second messengers:** PHC2 interacts with signaling pathways that involve second messengers, such as PI3K/Akt. 6. **Metabolism of proteins:** PHC2 is involved in the regulation of protein metabolism, including the sumoylation of proteins. **Clinical Significance:** The dysregulation of PHC2 has been implicated in various human diseases, including: 1. **Cancer:** PHC2 has been identified as a potential oncogene in several types of cancer, including breast and lung cancer. 2. **Neurological disorders:** PHC2 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular disease:** PHC2 has been shown to play a role in the regulation of cardiac myocyte function and the development of cardiac disease. **Conclusion:** In conclusion, PHC2 is a complex gene that plays a crucial role in various cellular processes, including gene expression, chromatin organization, and intracellular signaling. Its dysregulation has been implicated in various human diseases, highlighting the importance of further research into the functions and clinical significance of PHC2. As an expert immunologist, I believe that a deeper understanding of PHC2 will provide valuable insights into the molecular mechanisms underlying human disease and the development of novel therapeutic strategies.

Genular Protein ID: 4229134324

Symbol: PHC2_HUMAN

Name: Polyhomeotic-like protein 2

UniProtKB Accession Codes:

Q8IXK0 A1L4Q1 A8KA40 D3DPR2 Q2TAL3 Q5T0C1 Q6NUJ6 Q6ZQR1 Q8N306 Q8TAG8 Q96BL4 Q9Y4Y7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChEBI 4 ChiTaRS 1 ComplexPortal 20 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 3 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 8 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12384788

Title: Identification and characterisation of novel mammalian homologues of Drosophila polyhomeotic permits new insights into relationships between members of the polyhomeotic family.

PubMed ID: 12384788

DOI: 10.1007/s00439-002-0814-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10976766

Title: A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.

PubMed ID: 10976766

DOI: 10.1023/a:1007177623283

PubMed ID: 9121482

Title: Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic.

PubMed ID: 9121482

DOI: 10.1128/mcb.17.4.2326

PubMed ID: 9199346

Title: RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor.

PubMed ID: 9199346

DOI: 10.1128/mcb.17.7.4105

PubMed ID: 12167701

Title: The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.

PubMed ID: 12167701

DOI: 10.1128/mcb.22.17.6070-6078.2002

PubMed ID: 15094067

Title: P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity.

PubMed ID: 15094067

DOI: 10.1016/s0014-5793(04)00351-5

PubMed ID: 15386022

Title: Role of histone H2A ubiquitination in Polycomb silencing.

PubMed ID: 15386022

DOI: 10.1038/nature02985

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19636380

Title: Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus.

PubMed ID: 19636380

DOI: 10.1371/journal.pone.0006380

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21282530

Title: Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells.

PubMed ID: 21282530

DOI: 10.1074/mcp.m110.002642

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 858
  • Mass: 90713
  • Checksum: 2E3FD3898CFD702B
  • Sequence:
    • MENELPVPHT SSSACATSST SGASSSSGCN NSSSGGSGRP TGPQISVYSG IPDRQTVQVI 
QQALHRQPST AAQYLQQMYA AQQQHLMLQT AALQQQHLSS AQLQSLAAVQ QASLVSNRQG 
STSGSNVSAQ APAQSSSINL AASPAAAQLL NRAQSVNSAA ASGIAQQAVL LGNTSSPALT 
ASQAQMYLRA QMLIFTPTAT VATVQPELGT GSPARPPTPA QVQNLTLRTQ QTPAAAASGP 
TPTQPVLPSL ALKPTPGGSQ PLPTPAQSRN TAQASPAGAK PGIADSVMEP HKKGDGNSSV 
PGSMEGRAGL SRTVPAVAAH PLIAPAYAQL QPHQLLPQPS SKHLQPQFVI QQQPQPQQQQ 
PPPQQSRPVL QAEPHPQLAS VSPSVALQPS SEAHAMPLGP VTPALPLQCP TANLHKPGGS 
QQCHPPTPDT GPQNGHPEGV PHTPQRRFQH TSAVILQLQP ASPPQQCVPD DWKEVAPGEK 
SVPETRSGPS PHQQAIVTAM PGGLPVPTSP NIQPSPAHET GQGIVHALTD LSSPGMTSGN 
GNSASSIAGT APQNGENKPP QAIVKPQILT HVIEGFVIQE GAEPFPVGRS SLLVGNLKKK 
YAQGFLPEKL PQQDHTTTTD SEMEEPYLQE SKEEGAPLKL KCELCGRVDF AYKFKRSKRF 
CSMACAKRYN VGCTKRVGLF HSDRSKLQKA GAATHNRRRA SKASLPPLTK DTKKQPTGTV 
PLSVTAALQL THSQEDSSRC SDNSSYEEPL SPISASSSTS RRRQGQRDLE LPDMHMRDLV 
GMGHHFLPSE PTKWNVEDVY EFIRSLPGCQ EIAEEFRAQE IDGQALLLLK EDHLMSAMNI 
KLGPALKIYA RISMLKDS

Genular Protein ID: 2393982834

Symbol: A0A0A0MSI2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MSI2

Database IDs:

ARBA 6 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 3 GO 4 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 2 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 830
  • Mass: 87911
  • Checksum: 048D13258E29C411
  • Sequence:
    • MENELPVPHT SSSACATSST SGASSSSGCN NSSSGGSGRP TGPQISVYSG IPDRQTVQVI 
QQALHRQPST AAQYLQQMYA AQQQHLMLQT AALQQQHLSS AQLQSLAAVQ QASLVSNRQG 
STSGSNVSAQ APAQSSSINL AASPAAAQLL NRAQSVNSAA ASGIAQQAVL LGNTSSPALT 
ASQAQMYLRA QMVQNLTLRT QQTPAAAASG PTPTQPVLPS LALKPTPGGS QPLPTPAQSR 
NTAQASPAGA KPGIADSVME PHKKGDGNSS VPGSMEGRAG LSRTVPAVAA HPLIAPAYAQ 
LQPHQLLPQP SSKHLQPQFV IQQQPQPQQQ QPPPQQSRPV LQAEPHPQLA SVSPSVALQP 
SSEAHAMPLG PVTPALPLQC PTANLHKPGG SQQCHPPTPD TGPQNGHPEG VPHTPQRRFQ 
HTSAVILQLQ PASPVPQQCV PDDWKEVAPG EKSVPETRSG PSPHQQAIVT AMPGGLPVPT 
SPNIQPSPAH ETGQGIVHAL TDLSSPGMTS GNGNSASSIA GTAPQNGENK PPQAIVKPQI 
LTHVIEGFVI QEGAEPFPVG RSSLLVGNLK KKYAQGFLPE KLPQQDHTTT TDSEMEEPYL 
QESKEEGAPL KLKCELCGRV DFAYKFKRSK RFCSMACAKR YNVGCTKRVG LFHSDRSKLQ 
KAGAATHNRR RASKASLPPL TKDTKKQPTG TVPLSVTAAL QLTHSQEDSS RCSDNSSYEE 
PLSPISASSS TSRRRQGQRD LELPDMHMRD LVGMGHHFLP SEPTKWNVED VYEFIRSLPG 
CQEIAEEFRA QEIDGQALLL LKEDHLMSAM NIKLGPALKI YARISMLKDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.