Details for: EIF2D

Gene ID: 1939

Symbol: EIF2D

Ensembl ID: ENSG00000143486

Description: eukaryotic translation initiation factor 2D

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 106.9785
    Cell Significance Index: -16.6400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 51.2136
    Cell Significance Index: -12.9900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 48.6526
    Cell Significance Index: -22.9700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 47.7284
    Cell Significance Index: -19.3900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 43.5277
    Cell Significance Index: -22.3900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.5396
    Cell Significance Index: -19.6100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.2617
    Cell Significance Index: -20.0500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.4435
    Cell Significance Index: -19.9400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2990
    Cell Significance Index: -20.9100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.2679
    Cell Significance Index: -16.1800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4913
    Cell Significance Index: 89.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.3744
    Cell Significance Index: 160.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2702
    Cell Significance Index: 1146.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9528
    Cell Significance Index: 25.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9190
    Cell Significance Index: 149.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7446
    Cell Significance Index: 38.6800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.7286
    Cell Significance Index: 6.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6808
    Cell Significance Index: 67.3500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.6639
    Cell Significance Index: 17.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6257
    Cell Significance Index: 43.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5920
    Cell Significance Index: 118.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5915
    Cell Significance Index: 27.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5613
    Cell Significance Index: 36.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5397
    Cell Significance Index: 69.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5174
    Cell Significance Index: 63.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5173
    Cell Significance Index: 102.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4900
    Cell Significance Index: 67.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4837
    Cell Significance Index: 87.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4637
    Cell Significance Index: 253.2300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4608
    Cell Significance Index: 32.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3812
    Cell Significance Index: 44.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3377
    Cell Significance Index: 149.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2786
    Cell Significance Index: 12.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2469
    Cell Significance Index: 5.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2445
    Cell Significance Index: 18.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2416
    Cell Significance Index: 6.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2414
    Cell Significance Index: 86.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2404
    Cell Significance Index: 11.3000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2047
    Cell Significance Index: 4.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1835
    Cell Significance Index: 23.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1783
    Cell Significance Index: 11.2400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1545
    Cell Significance Index: 2.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1304
    Cell Significance Index: 4.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1280
    Cell Significance Index: 9.5400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1216
    Cell Significance Index: 3.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1179
    Cell Significance Index: 3.1000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1032
    Cell Significance Index: 71.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0961
    Cell Significance Index: 18.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0883
    Cell Significance Index: 3.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0614
    Cell Significance Index: 3.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0570
    Cell Significance Index: 2.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0525
    Cell Significance Index: 1.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0392
    Cell Significance Index: 0.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0365
    Cell Significance Index: 4.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0363
    Cell Significance Index: 0.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0333
    Cell Significance Index: 0.7100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0296
    Cell Significance Index: 0.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0286
    Cell Significance Index: 53.8500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0254
    Cell Significance Index: 0.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0233
    Cell Significance Index: 0.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0193
    Cell Significance Index: 3.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0136
    Cell Significance Index: 25.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0115
    Cell Significance Index: 17.6600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0113
    Cell Significance Index: 0.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0035
    Cell Significance Index: 4.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0007
    Cell Significance Index: 0.4200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0033
    Cell Significance Index: -2.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0040
    Cell Significance Index: -2.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0101
    Cell Significance Index: -4.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0135
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0266
    Cell Significance Index: -19.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0298
    Cell Significance Index: -3.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0343
    Cell Significance Index: -19.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0369
    Cell Significance Index: -2.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0372
    Cell Significance Index: -5.4100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0379
    Cell Significance Index: -23.6700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0423
    Cell Significance Index: -1.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0467
    Cell Significance Index: -2.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0768
    Cell Significance Index: -22.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0904
    Cell Significance Index: -6.0800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0916
    Cell Significance Index: -1.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1122
    Cell Significance Index: -23.6300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1288
    Cell Significance Index: -1.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1726
    Cell Significance Index: -9.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1786
    Cell Significance Index: -18.6000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1797
    Cell Significance Index: -9.0800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1976
    Cell Significance Index: -2.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2140
    Cell Significance Index: -16.9500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2433
    Cell Significance Index: -3.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2616
    Cell Significance Index: -7.5000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2940
    Cell Significance Index: -4.3400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2965
    Cell Significance Index: -3.5400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3393
    Cell Significance Index: -6.0000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3658
    Cell Significance Index: -7.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3683
    Cell Significance Index: -22.5800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3738
    Cell Significance Index: -3.8700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3838
    Cell Significance Index: -12.1400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3895
    Cell Significance Index: -14.3000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4156
    Cell Significance Index: -13.2400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.4424
    Cell Significance Index: -7.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EIF2D is a conserved protein that belongs to the eukaryotic translation initiation factor 2 (eIF2) family. It is composed of two domains: the N-terminal domain, which is similar to eIF2, and the C-terminal domain, which is distinct from eIF2. EIF2D is highly expressed in various cell types, including extravillous trophoblasts, cardiac muscle cells, and proerythroblasts. Its expression is also observed in certain types of cancer cells, suggesting a potential role in tumorigenesis. **Pathways and Functions:** EIF2D is involved in various cellular processes, including: 1. **Translation initiation:** EIF2D facilitates the recruitment of ribosomes to mRNA, ensuring the accurate translation of mRNAs into proteins. 2. **Intracellular protein transport:** EIF2D is involved in the transport of proteins within the cell, regulating the localization of proteins to different cellular compartments. 3. **Viral translation initiation:** EIF2D plays a crucial role in the initiation of viral translation, particularly in Ires-dependent viral translational initiation. 4. **Ribosome disassembly:** EIF2D is involved in the disassembly of ribosomes, regulating the release of newly synthesized proteins from the ribosome. **Clinical Significance:** EIF2D has been implicated in various diseases, including: 1. **Cancer:** Overexpression of EIF2D has been observed in certain types of cancer, suggesting a potential role in tumorigenesis. 2. **Neurodegenerative diseases:** EIF2D has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it may contribute to protein misfolding and aggregation. 3. **Infectious diseases:** EIF2D has been shown to play a role in the initiation of viral translation, particularly in Ires-dependent viral translational initiation, which may have implications for the development of antiviral therapies. In conclusion, EIF2D is a multifunctional protein that plays a crucial role in eukaryotic translation initiation, intracellular protein transport, and ribosome disassembly. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of EIF2D and its potential therapeutic applications. **References:** * [Insert references to relevant research articles and studies on EIF2D] Note: As an expert immunologist, it is essential to emphasize that EIF2D is a conserved protein involved in various cellular processes, and its dysregulation may have implications for the development of diseases. Further research is necessary to fully understand the mechanisms of EIF2D and its potential therapeutic applications.

Genular Protein ID: 3060618583

Symbol: EIF2D_HUMAN

Name: Eukaryotic translation initiation factor 2D

UniProtKB Accession Codes:

P41214 Q5SY40 Q8IXV3 Q96DG3 Q96TG7 Q9NR27 Q9NSN0 Q9NV18 Q9NZ21

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 11 EMDB 1 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 20566627

Title: GTP-independent tRNA delivery to the ribosomal P-site by a novel eukaryotic translation factor.

PubMed ID: 20566627

DOI: 10.1074/jbc.m110.119693

PubMed ID: 12097419

Title: Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies.

PubMed ID: 12097419

DOI: 10.4049/jimmunol.169.2.1102

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 2482295

Title: Molecular cloning of the cDNA for ligatin.

PubMed ID: 2482295

DOI: 10.1242/jcs.93.2.227

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20713520

Title: Activities of ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling.

PubMed ID: 20713520

DOI: 10.1101/gad.1957510

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 584
  • Mass: 64706
  • Checksum: C302B63268231154
  • Sequence:
    • MFAKAFRVKS NTAIKGSDRR KLRADVTTAF PTLGTDQVSE LVPGKEELNI VKLYAHKGDA 
VTVYVSGGNP ILFELEKNLY PTVYTLWSYP DLLPTFTTWP LVLEKLVGGA DLMLPGLVMP 
PAGLPQVQKG DLCAISLVGN RAPVAIGVAA MSTAEMLTSG LKGRGFSVLH TYQDHLWRSG 
NKSSPPSIAP LALDSADLSE EKGSVQMDST LQGDMRHMTL EGEEENGEVH QAREDKSLSE 
APEDTSTRGL NQDSTDSKTL QEQMDELLQQ CFLHALKCRV KKADLPLLTS TFLGSHMFSC 
CPEGRQLDIK KSSYKKLSKF LQQMQQEQII QVKELSKGVE SIVAVDWKHP RITSFVIPEP 
SPTSQTIQEG SREQPYHPPD IKPLYCVPAS MTLLFQESGH KKGSFLEGSE VRTIVINYAK 
KNDLVDADNK NLVRLDPILC DCILEKNEQH TVMKLPWDSL LTRCLEKLQP AYQVTLPGQE 
PIVKKGRICP IDITLAQRAS NKKVTVVRNL EAYGLDPYSV AAILQQRCQA STTVNPAPGA 
KDSLQVQIQG NQVHHLGWLL LEEYQLPRKH IQGLEKALKP GKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.