Details for: MEGF9

Gene ID: 1955

Symbol: MEGF9

Ensembl ID: ENSG00000106780

Description: multiple EGF like domains 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 253.8169
    Cell Significance Index: -39.4800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 154.9419
    Cell Significance Index: -39.3000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 85.8675
    Cell Significance Index: -40.5400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 77.1406
    Cell Significance Index: -39.6800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.1990
    Cell Significance Index: -39.7000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.4987
    Cell Significance Index: -38.8400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.3385
    Cell Significance Index: -44.0400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.1367
    Cell Significance Index: -40.0000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.2010
    Cell Significance Index: -15.7600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.6067
    Cell Significance Index: 43.9100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.2956
    Cell Significance Index: 27.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1632
    Cell Significance Index: 433.9300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.0447
    Cell Significance Index: 58.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.0005
    Cell Significance Index: 197.8900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.7908
    Cell Significance Index: 29.5100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.7516
    Cell Significance Index: 17.6700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.6726
    Cell Significance Index: 36.6300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.3822
    Cell Significance Index: 77.5600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.3065
    Cell Significance Index: 16.2100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.2816
    Cell Significance Index: 29.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.2646
    Cell Significance Index: 77.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.2273
    Cell Significance Index: 30.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1739
    Cell Significance Index: 421.0700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.1252
    Cell Significance Index: 26.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1174
    Cell Significance Index: 221.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.1158
    Cell Significance Index: 75.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1027
    Cell Significance Index: 69.5000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0758
    Cell Significance Index: 744.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0152
    Cell Significance Index: 165.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9037
    Cell Significance Index: 98.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8277
    Cell Significance Index: 96.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8209
    Cell Significance Index: 147.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.6078
    Cell Significance Index: 386.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5870
    Cell Significance Index: 72.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5750
    Cell Significance Index: 16.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.5200
    Cell Significance Index: 707.0300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.4856
    Cell Significance Index: 6.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4391
    Cell Significance Index: 26.3600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4258
    Cell Significance Index: 7.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3892
    Cell Significance Index: 732.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3466
    Cell Significance Index: 15.3300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3356
    Cell Significance Index: 12.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3087
    Cell Significance Index: 136.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2850
    Cell Significance Index: 438.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2531
    Cell Significance Index: 138.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2169
    Cell Significance Index: 400.0500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1856
    Cell Significance Index: 3.1800
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.1584
    Cell Significance Index: 1.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1115
    Cell Significance Index: 8.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0632
    Cell Significance Index: 1.8200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0630
    Cell Significance Index: 0.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0371
    Cell Significance Index: 16.8200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0220
    Cell Significance Index: 0.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0040
    Cell Significance Index: -0.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0082
    Cell Significance Index: -6.2100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0085
    Cell Significance Index: -1.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0120
    Cell Significance Index: -7.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0153
    Cell Significance Index: -11.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0321
    Cell Significance Index: -23.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0400
    Cell Significance Index: -22.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0459
    Cell Significance Index: -2.0800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0508
    Cell Significance Index: -0.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0713
    Cell Significance Index: -12.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1008
    Cell Significance Index: -21.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1100
    Cell Significance Index: -11.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1170
    Cell Significance Index: -33.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1171
    Cell Significance Index: -17.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1192
    Cell Significance Index: -12.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1492
    Cell Significance Index: -20.4900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1707
    Cell Significance Index: -12.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2069
    Cell Significance Index: -10.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2402
    Cell Significance Index: -30.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2448
    Cell Significance Index: -31.6300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2469
    Cell Significance Index: -28.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2542
    Cell Significance Index: -29.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2739
    Cell Significance Index: -31.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3305
    Cell Significance Index: -17.3500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3315
    Cell Significance Index: -7.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3801
    Cell Significance Index: -24.5200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3822
    Cell Significance Index: -8.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3934
    Cell Significance Index: -18.3400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4001
    Cell Significance Index: -8.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4129
    Cell Significance Index: -29.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4505
    Cell Significance Index: -14.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4641
    Cell Significance Index: -21.8100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4653
    Cell Significance Index: -36.8600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4731
    Cell Significance Index: -8.1800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4735
    Cell Significance Index: -15.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4846
    Cell Significance Index: -15.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5865
    Cell Significance Index: -35.9600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6191
    Cell Significance Index: -32.2500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6273
    Cell Significance Index: -16.1300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6848
    Cell Significance Index: -13.5400
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.6881
    Cell Significance Index: -8.5900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7178
    Cell Significance Index: -14.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7545
    Cell Significance Index: -26.4300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.7571
    Cell Significance Index: -10.1000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.7771
    Cell Significance Index: -11.7100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.7899
    Cell Significance Index: -9.8500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7911
    Cell Significance Index: -15.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MEGF9 is a member of the EGF-like domain family, which consists of proteins that share a common structural motif. The MEGF9 protein contains nine EGF-like domains, which are involved in protein-protein interactions. These domains are highly conserved across species, suggesting their importance in cellular function. MEGF9 is also characterized by its ability to interact with other proteins, such as integrins and other growth factors, to regulate cellular processes. **Pathways and Functions:** MEGF9 is involved in several signaling pathways, including: 1. **Regulation of Actin Filament Polymerization:** MEGF9 interacts with proteins involved in actin filament polymerization, regulating the dynamics of the cytoskeleton and cell migration. 2. **Basement Membrane Formation:** MEGF9 is involved in the formation and maintenance of the basement membrane, a critical structure that separates epithelial and endothelial cells from the surrounding tissue. 3. **Cell Migration and Proliferation:** MEGF9 regulates cell migration and proliferation by interacting with growth factors and other signaling molecules. 4. **Small GTPase Binding:** MEGF9 interacts with small GTPases, which are involved in regulating various cellular processes, including cell migration and differentiation. **Clinical Significance:** MEGF9 has been implicated in various diseases, including: 1. **Neurological Disorders:** MEGF9 has been found to be overexpressed in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, suggesting its potential role in disease pathogenesis. 2. **Cancer:** MEGF9 has been found to be overexpressed in certain types of cancer, including breast cancer and lung cancer, suggesting its potential role in tumor progression. 3. **Immune Disorders:** MEGF9 has been found to be involved in immune responses, including the regulation of monocyte function and the development of autoimmune diseases. In conclusion, MEGF9 is a protein that plays a crucial role in regulating cellular processes, including cell migration, proliferation, and differentiation. Its involvement in various signaling pathways and diseases suggests its potential as a therapeutic target for the treatment of neurological and immune disorders. **Recommendations:** 1. Further studies are needed to elucidate the mechanisms by which MEGF9 regulates cellular processes. 2. The potential of MEGF9 as a therapeutic target for the treatment of neurological and immune disorders should be explored. 3. The role of MEGF9 in cancer development and progression should be further investigated. **Future Directions:** 1. Investigate the mechanisms by which MEGF9 regulates cellular processes, including cell migration and proliferation. 2. Explore the potential of MEGF9 as a therapeutic target for the treatment of neurological and immune disorders. 3. Investigate the role of MEGF9 in cancer development and progression. **References:** [Insert references to relevant studies on MEGF9] Note: The references provided are fictional and for demonstration purposes only.

Genular Protein ID: 1564159015

Symbol: MEGF9_HUMAN

Name: Multiple epidermal growth factor-like domains protein 9

UniProtKB Accession Codes:

Q9H1U4 B7Z315 O75098

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 9693030

Title: Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.

PubMed ID: 9693030

DOI: 10.1006/geno.1998.5341

Sequence Information:

  • Length: 602
  • Mass: 62984
  • Checksum: C2EF73E588C8E375
  • Sequence:
    • MNGGAERAMR SLPSLGGLAL LCCAAAAAAA AVASAASAGN VTGGGGAAGQ VDASPGPGLR 
GEPSHPFPRA TAPTAQAPRT GPPRATVHRP LAATSPAQSP ETTPLWATAG PSSTTFQAPL 
GPSPTTPPAA ERTSTTSQAP TRPAPTTLST TTGPAPTTPV ATTVPAPTTP RTPTPDLPSS 
SNSSVLPTPP ATEAPSSPPP EYVCNCSVVG SLNVNRCNQT TGQCECRPGY QGLHCETCKE 
GFYLNYTSGL CQPCDCSPHG ALSIPCNSSG KCQCKVGVIG SICDRCQDGY YGFSKNGCLP 
CQCNNRSASC DALTGACLNC QENSKGNHCE ECKEGFYQSP DATKECLRCP CSAVTSTGSC 
SIKSSELEPE CDQCKDGYIG PNCNKCENGY YNFDSICRKC QCHGHVDPVK TPKICKPESG 
ECINCLHNTT GFWCENCLEG YVHDLEGNCI KKEVILPTPE GSTILVSNAS LTTSVPTPVI 
NSTFTPTTLQ TIFSVSTSEN STSALADVSW TQFNIIILTV IIIVVVLLMG FVGAVYMYRE 
YQNRKLNAPF WTIELKEDNI SFSSYHDSIP NADVSGLLED DGNEVAPNGQ LTLTTPIHNY 
KA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.