Gene EIF2S1 - ENSG00000134001 | NCBI Gene ID: 1965

Details for: EIF2S1

Gene ID: 1965

Symbol: EIF2S1

Ensembl ID: ENSG00000134001

Description: eukaryotic translation initiation factor 2 subunit alpha

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-HSA-72662)
Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to mitochondrial stress
(R-HSA-9840373)
Cellular response to starvation
(R-HSA-9711097)
Cytokine signaling in immune system
(R-HSA-1280215)
Eukaryotic translation initiation
(R-HSA-72613)
Formation of the ternary complex, and subsequently, the 43s complex
(R-HSA-72695)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Immune system
(R-HSA-168256)
Interferon signaling
(R-HSA-913531)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Metabolism of proteins
(R-HSA-392499)
Perk regulates gene expression
(R-HSA-381042)
Pkr-mediated signaling
(R-HSA-9833482)
Recycling of eif2:gdp
(R-HSA-72731)
Response of eif2ak1 (hri) to heme deficiency
(R-HSA-9648895)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Ribosomal scanning and start codon recognition
(R-HSA-72702)
Translation
(R-HSA-72766)
Translation initiation complex formation
(R-HSA-72649)
Transport of small molecules
(R-HSA-382551)
Unfolded protein response (upr)
(R-HSA-381119)
Cellular response to amino acid starvation
(GO:0034198)
Cellular response to heat
(GO:0034605)
Cellular response to oxidative stress
(GO:0034599)
Cellular response to uv
(GO:0034644)
Cytoplasmic stress granule
(GO:0010494)
Cytosol
(GO:0005829)
Eukaryotic 48s preinitiation complex
(GO:0033290)
Eukaryotic translation initiation factor 2 complex
(GO:0005850)
Extracellular exosome
(GO:0070062)
Glial limiting end-foot
(GO:0097451)
Membrane
(GO:0016020)
Negative regulation of translational initiation in response to stress
(GO:0032057)
Nucleus
(GO:0005634)
Perk-mediated unfolded protein response
(GO:0036499)
Positive regulation of type b pancreatic cell apoptotic process
(GO:2000676)
Protein binding
(GO:0005515)
Regulation of translational initiation in response to stress
(GO:0043558)
Regulation of translation in response to endoplasmic reticulum stress
(GO:0036490)
Response to endoplasmic reticulum stress
(GO:0034976)
Response to kainic acid
(GO:1904373)
Response to manganese-induced endoplasmic reticulum stress
(GO:1990737)
Ribosome binding
(GO:0043022)
Rna binding
(GO:0003723)
Stress granule assembly
(GO:0034063)
Synapse
(GO:0045202)
Translational initiation
(GO:0006413)
Translation initiation factor activity
(GO:0003743)
Translation initiation ternary complex
(GO:0044207)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.07
Marker Score: 2210
Cell Name: oogonial cell (CL0000024)
Fold Change: 2.02
Marker Score: 2906
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 1.85
Marker Score: 1925
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.72
Marker Score: 58371
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.6
Marker Score: 1083
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.57
Marker Score: 2313
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.55
Marker Score: 3775
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.47
Marker Score: 2609
Cell Name: mural cell (CL0008034)
Fold Change: 1.45
Marker Score: 166579
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.43
Marker Score: 5622
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.42
Marker Score: 1496.5
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.41
Marker Score: 1767
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.4
Marker Score: 12052
Cell Name: plasmablast (CL0000980)
Fold Change: 1.4
Marker Score: 1857
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.37
Marker Score: 463
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.33
Marker Score: 1335
Cell Name: pro-T cell (CL0000827)
Fold Change: 1.33
Marker Score: 5426
Cell Name: decidual cell (CL2000002)
Fold Change: 1.3
Marker Score: 5607
Cell Name: oocyte (CL0000023)
Fold Change: 1.29
Marker Score: 320
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 1.28
Marker Score: 963
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.28
Marker Score: 1353
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.27
Marker Score: 723
Cell Name: osteoclast (CL0000092)
Fold Change: 1.26
Marker Score: 629
Cell Name: stromal cell (CL0000499)
Fold Change: 1.26
Marker Score: 1478
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.26
Marker Score: 6182
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.24
Marker Score: 1341
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.23
Marker Score: 2563
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.22
Marker Score: 959
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.2
Marker Score: 3270
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.2
Marker Score: 755
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.2
Marker Score: 4612
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 1.2
Marker Score: 9340
Cell Name: blood cell (CL0000081)
Fold Change: 1.19
Marker Score: 13874
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.17
Marker Score: 2670
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1.17
Marker Score: 454
Cell Name: basal cell (CL0000646)
Fold Change: 1.16
Marker Score: 1498
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1.16
Marker Score: 1967
Cell Name: Unknown (CL0000548)
Fold Change: 1.15
Marker Score: 841
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 1.15
Marker Score: 1631
Cell Name: stem cell (CL0000034)
Fold Change: 1.14
Marker Score: 2706
Cell Name: male germ cell (CL0000015)
Fold Change: 1.14
Marker Score: 328
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.13
Marker Score: 12773
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.12
Marker Score: 267
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.11
Marker Score: 1879
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.1
Marker Score: 4064
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.09
Marker Score: 1026
Cell Name: kidney cell (CL1000497)
Fold Change: 1.09
Marker Score: 726
Cell Name: neural crest cell (CL0011012)
Fold Change: 1.09
Marker Score: 1162
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 1.08
Marker Score: 299
Cell Name: radial glial cell (CL0000681)
Fold Change: 1.08
Marker Score: 397
Cell Name: erythroblast (CL0000765)
Fold Change: 1.07
Marker Score: 670
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.07
Marker Score: 1760
Cell Name: hepatocyte (CL0000182)
Fold Change: 1.07
Marker Score: 732
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 1.07
Marker Score: 341
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.07
Marker Score: 2900
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.06
Marker Score: 263
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.06
Marker Score: 1643
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.06
Marker Score: 1188
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 1.06
Marker Score: 4405
Cell Name: epithelial cell (CL0000066)
Fold Change: 1.05
Marker Score: 1676
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.05
Marker Score: 26951
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 1.04
Marker Score: 369
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.04
Marker Score: 571
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.03
Marker Score: 63175
Cell Name: Unknown (CL0002371)
Fold Change: 1.03
Marker Score: 1091
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.02
Marker Score: 8774
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.02
Marker Score: 525
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 1.02
Marker Score: 909
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 1.01
Marker Score: 221
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 1.01
Marker Score: 1013
Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.01
Marker Score: 6126
Cell Name: type I NK T cell (CL0000921)
Fold Change: 1.01
Marker Score: 789
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 1
Marker Score: 489
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1
Marker Score: 9470
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 0.99
Marker Score: 71569
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.99
Marker Score: 1731
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47794
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.99
Marker Score: 346
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.99
Marker Score: 1979
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.99
Marker Score: 827
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 0.99
Marker Score: 894
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 0.99
Marker Score: 411
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30365
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.98
Marker Score: 33905
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.98
Marker Score: 235
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.98
Marker Score: 6238
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.97
Marker Score: 1059
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.97
Marker Score: 9862
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.97
Marker Score: 395
Cell Name: supporting cell (CL0000630)
Fold Change: 0.96
Marker Score: 1803
Cell Name: epidermal cell (CL0000362)
Fold Change: 0.96
Marker Score: 269.5
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.96
Marker Score: 902
Cell Name: neuron (CL0000540)
Fold Change: 0.95
Marker Score: 3885
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.95
Marker Score: 6206
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.95
Marker Score: 252.5
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.95
Marker Score: 2236
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.95
Marker Score: 850
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.95
Marker Score: 250.5
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.95
Marker Score: 1455.5
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.94
Marker Score: 626

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**Key characteristics:** * The EIF2S1 gene is located on chromosome 15q26.1. * It is a member of the EIF2A family of proteins, which are essential for translation initiation in eukaryotes. * It is highly expressed in skeletal muscle, oogonial cells, and hematopoietic cells. **Pathways and functions:** * EIF2S1 is involved in the initiation of translation of cap-dependent mRNAs, including those that encode proteins involved in inflammation, metabolism, and cell growth. * It is also involved in the initiation of translation of viral mRNAs. * It is a key regulator of protein synthesis in many cell types. **Clinical significance:** * Mutations in the EIF2S1 gene have been linked to several human diseases, including cancer and neurodegenerative disorders. * Inhibition of EIF2S1 has been shown to suppress protein synthesis and inhibit cell growth. * Therefore, EIF2S1 is a potential target for cancer therapy. **Additional notes:** * The EIF2S1 gene is also involved in the regulation of protein translation in plants. * It is a highly conserved gene, with a similar gene found in all eukaryotes. * The protein encoded by EIF2S1 is a multi-subunit protein that is composed of a catalytic domain and a regulatory domain.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Eukaryotic translation initiation factor 2 subunit 1

Genular Protein ID: 2203592282

Symbol: IF2A_HUMAN

Name: Eukaryotic translation initiation factor 2 subunit 1

UniProtKB Accession Codes:

P05198

Database IDs:

Citations:

PubMed ID: 2948954

Title: Cloning and sequencing of complementary DNAs encoding the alpha-subunit of translational initiation factor eIF-2. Characterization of the protein and its messenger RNA.

PubMed ID: 2948954

DOI: 10.1016/s0021-9258(19)75772-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15207627

Title: Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L.

PubMed ID: 15207627

DOI: 10.1016/j.virol.2004.03.012

PubMed ID: 16289705

Title: An efficient mammalian cell-free translation system supplemented with translation factors.

PubMed ID: 16289705

DOI: 10.1016/j.pep.2005.09.021

PubMed ID: 17894550

Title: The N-terminal region of ABC50 interacts with eukaryotic initiation factor eIF2 and is a target for regulatory phosphorylation by CK2.

PubMed ID: 17894550

DOI: 10.1042/bj20070811

PubMed ID: 18032499

Title: Rotavirus infection induces the phosphorylation of eIF2alpha but prevents the formation of stress granules.

PubMed ID: 18032499

DOI: 10.1128/jvi.01779-07

PubMed ID: 18596238

Title: The DEAD-box RNA helicase DDX3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational control.

PubMed ID: 18596238

DOI: 10.1091/mbc.e07-12-1264

PubMed ID: 19131336

Title: An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation.

PubMed ID: 19131336

DOI: 10.1074/jbc.m806735200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23063529

Title: eIF2gamma mutation that disrupts eIF2 complex integrity links intellectual disability to impaired translation initiation.

PubMed ID: 23063529

DOI: 10.1016/j.molcel.2012.09.005

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30258011

Title: Rotavirus Induces Formation of Remodeled Stress Granules and P Bodies and Their Sequestration in Viroplasms To Promote Progeny Virus Production.

PubMed ID: 30258011

DOI: 10.1128/jvi.01363-18

PubMed ID: 31836389

Title: Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB.

PubMed ID: 31836389

DOI: 10.1016/j.molcel.2019.11.008

PubMed ID: 33384352

Title: QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis.

PubMed ID: 33384352

DOI: 10.1126/science.abb6896

PubMed ID: 35031321

Title: Stepwise assembly of the eukaryotic translation initiation factor 2 complex.

PubMed ID: 35031321

DOI: 10.1016/j.jbc.2022.101583

PubMed ID: 11859078

Title: Crystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2alpha.

PubMed ID: 11859078

DOI: 10.1074/jbc.m111804200

PubMed ID: 15341733

Title: Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B.

PubMed ID: 15341733

DOI: 10.1016/j.str.2004.07.010

PubMed ID: 31048492

Title: Structural basis for eIF2B inhibition in integrated stress response.

PubMed ID: 31048492

DOI: 10.1126/science.aaw4104

Sequence Information:

Length: 315
Mass: 36112
Checksum: FF3E75E3816E6B1E
Sequence:

MPGLSCRFYQ HKFPEVEDVV MVNVRSIAEM GAYVSLLEYN NIEGMILLSE LSRRRIRSIN 
KLIRIGRNEC VVVIRVDKEK GYIDLSKRRV SPEEAIKCED KFTKSKTVYS ILRHVAEVLE 
YTKDEQLESL FQRTAWVFDD KYKRPGYGAY DAFKHAVSDP SILDSLDLNE DEREVLINNI 
NRRLTPQAVK IRADIEVACY GYEGIDAVKE ALRAGLNCST ENMPIKINLI APPRYVMTTT 
TLERTEGLSV LSQAMAVIKE KIEEKRGVFN VQMEPKVVTD TDETELARQM ERLERENAEV 
DGDDDAEEME AKAED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: EIF2S1

Associated with

Cells (max top 100)

Other Information

Cloning and sequencing of complementary DNAs encoding the alpha-subunit of translational initiation factor eIF-2. Characterization of the protein and its messenger RNA. PubMed ID: 2948954

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L. PubMed ID: 15207627

An efficient mammalian cell-free translation system supplemented with translation factors. PubMed ID: 16289705

The N-terminal region of ABC50 interacts with eukaryotic initiation factor eIF2 and is a target for regulatory phosphorylation by CK2. PubMed ID: 17894550

Rotavirus infection induces the phosphorylation of eIF2alpha but prevents the formation of stress granules. PubMed ID: 18032499

The DEAD-box RNA helicase DDX3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational control. PubMed ID: 18596238

An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation. PubMed ID: 19131336

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

eIF2gamma mutation that disrupts eIF2 complex integrity links intellectual disability to impaired translation initiation. PubMed ID: 23063529

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Rotavirus Induces Formation of Remodeled Stress Granules and P Bodies and Their Sequestration in Viroplasms To Promote Progeny Virus Production. PubMed ID: 30258011

Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB. PubMed ID: 31836389

QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis. PubMed ID: 33384352

Stepwise assembly of the eukaryotic translation initiation factor 2 complex. PubMed ID: 35031321

Crystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2alpha. PubMed ID: 11859078

Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B. PubMed ID: 15341733

Structural basis for eIF2B inhibition in integrated stress response. PubMed ID: 31048492