Details for: EIF2S1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 225.5936
Cell Significance Index: -35.0900 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 151.8076
Cell Significance Index: -38.5100 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 108.1934
Cell Significance Index: -44.5700 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 96.0238
Cell Significance Index: -45.3400 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 92.4291
Cell Significance Index: -37.5500 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 84.4698
Cell Significance Index: -43.4500 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 67.6580
Cell Significance Index: -45.4000 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 39.5185
Cell Significance Index: -37.7300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 34.7052
Cell Significance Index: -42.7900 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 12.6360
Cell Significance Index: -33.8500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 11.4773
Cell Significance Index: -45.2900 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 8.4618
Cell Significance Index: -25.9900 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 6.5019
Cell Significance Index: -14.2300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.6555
Cell Significance Index: 183.6400 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.7064
Cell Significance Index: 102.4400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.4930
Cell Significance Index: 162.3900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.4298
Cell Significance Index: 19.5100 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.1929
Cell Significance Index: 32.4700 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 1.1703
Cell Significance Index: 9.8300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.9734
Cell Significance Index: 25.9900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.9494
Cell Significance Index: 44.6200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.9360
Cell Significance Index: 26.8300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.9030
Cell Significance Index: 46.9100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.8125
Cell Significance Index: 162.9900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.7613
Cell Significance Index: 93.6100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.7393
Cell Significance Index: 133.2700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.6927
Cell Significance Index: 95.1300 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.6633
Cell Significance Index: 293.2500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.6267
Cell Significance Index: 124.3700 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.6202
Cell Significance Index: 80.1200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.6062
Cell Significance Index: 42.8700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.5928
Cell Significance Index: 44.1800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.5656
Cell Significance Index: 308.8700 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.5262
Cell Significance Index: 5.7200 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.4467
Cell Significance Index: 9.3500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.4387
Cell Significance Index: 28.3100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.4159
Cell Significance Index: 19.3900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3971
Cell Significance Index: 11.4400 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3739
Cell Significance Index: 36.9900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.3734
Cell Significance Index: 44.0400 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.3723
Cell Significance Index: 9.9800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.3514
Cell Significance Index: 22.1500 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.3285
Cell Significance Index: 5.8000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3273
Cell Significance Index: 117.3800 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.2644
Cell Significance Index: 2.4400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2464
Cell Significance Index: 42.0800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2363
Cell Significance Index: 5.1200 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1761
Cell Significance Index: 22.5700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.1724
Cell Significance Index: 5.9900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1299
Cell Significance Index: 3.6300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1282
Cell Significance Index: 24.4000 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.1212
Cell Significance Index: 3.1900 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1113
Cell Significance Index: 77.0000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0649
Cell Significance Index: 2.9400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0252
Cell Significance Index: 47.5300 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.0014
Cell Significance Index: -0.0400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0024
Cell Significance Index: -1.5500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0071
Cell Significance Index: -13.1100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0080
Cell Significance Index: -6.0500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0085
Cell Significance Index: -6.3300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0107
Cell Significance Index: -16.4900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0148
Cell Significance Index: -9.2700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0201
Cell Significance Index: -27.3500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0207
Cell Significance Index: -15.1800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0321
Cell Significance Index: -18.1000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0350
Cell Significance Index: -15.8700 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0449
Cell Significance Index: -4.5900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0467
Cell Significance Index: -2.6200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0508
Cell Significance Index: -8.2700 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0577
Cell Significance Index: -0.9700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0592
Cell Significance Index: -4.5500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1077
Cell Significance Index: -22.6800 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.1208
Cell Significance Index: -0.7300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1256
Cell Significance Index: -14.6400 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.1263
Cell Significance Index: -1.0300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1335
Cell Significance Index: -38.4000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1370
Cell Significance Index: -15.6900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1501
Cell Significance Index: -21.8200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1625
Cell Significance Index: -8.5300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1866
Cell Significance Index: -11.4700 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2187
Cell Significance Index: -24.9700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2521
Cell Significance Index: -16.9500 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2603
Cell Significance Index: -6.6500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3071
Cell Significance Index: -6.5400 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.3503
Cell Significance Index: -3.9800 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.3716
Cell Significance Index: -4.4300 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.3844
Cell Significance Index: -9.8800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4099
Cell Significance Index: -42.6800 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.4133
Cell Significance Index: -11.0600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4186
Cell Significance Index: -33.1500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4578
Cell Significance Index: -20.2500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.4803
Cell Significance Index: -25.0200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.5117
Cell Significance Index: -16.3900 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.5129
Cell Significance Index: -12.8200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.5518
Cell Significance Index: -20.9000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.6232
Cell Significance Index: -21.9000 - Cell Name: germ cell (CL0000586)
Fold Change: -0.6311
Cell Significance Index: -4.7700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6364
Cell Significance Index: -39.0200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.7986
Cell Significance Index: -13.6900 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.8362
Cell Significance Index: -16.3200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2203592282
Symbol: IF2A_HUMAN
Name: Eukaryotic translation initiation factor 2 subunit 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2948954
Title: Cloning and sequencing of complementary DNAs encoding the alpha-subunit of translational initiation factor eIF-2. Characterization of the protein and its messenger RNA.
PubMed ID: 2948954
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15207627
Title: Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L.
PubMed ID: 15207627
PubMed ID: 16289705
Title: An efficient mammalian cell-free translation system supplemented with translation factors.
PubMed ID: 16289705
PubMed ID: 17894550
Title: The N-terminal region of ABC50 interacts with eukaryotic initiation factor eIF2 and is a target for regulatory phosphorylation by CK2.
PubMed ID: 17894550
DOI: 10.1042/bj20070811
PubMed ID: 18032499
Title: Rotavirus infection induces the phosphorylation of eIF2alpha but prevents the formation of stress granules.
PubMed ID: 18032499
DOI: 10.1128/jvi.01779-07
PubMed ID: 18596238
Title: The DEAD-box RNA helicase DDX3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational control.
PubMed ID: 18596238
PubMed ID: 19131336
Title: An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation.
PubMed ID: 19131336
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23063529
Title: eIF2gamma mutation that disrupts eIF2 complex integrity links intellectual disability to impaired translation initiation.
PubMed ID: 23063529
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 30258011
Title: Rotavirus Induces Formation of Remodeled Stress Granules and P Bodies and Their Sequestration in Viroplasms To Promote Progeny Virus Production.
PubMed ID: 30258011
DOI: 10.1128/jvi.01363-18
PubMed ID: 31836389
Title: Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB.
PubMed ID: 31836389
PubMed ID: 33384352
Title: QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis.
PubMed ID: 33384352
PubMed ID: 35031321
Title: Stepwise assembly of the eukaryotic translation initiation factor 2 complex.
PubMed ID: 35031321
PubMed ID: 38340717
Title: The HRI branch of the integrated stress response selectively triggers mitophagy.
PubMed ID: 38340717
PubMed ID: 11859078
Title: Crystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2alpha.
PubMed ID: 11859078
PubMed ID: 15341733
Title: Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B.
PubMed ID: 15341733
PubMed ID: 31048492
Title: Structural basis for eIF2B inhibition in integrated stress response.
PubMed ID: 31048492
Sequence Information:
- Length: 315
- Mass: 36112
- Checksum: FF3E75E3816E6B1E
- Sequence:
MPGLSCRFYQ HKFPEVEDVV MVNVRSIAEM GAYVSLLEYN NIEGMILLSE LSRRRIRSIN KLIRIGRNEC VVVIRVDKEK GYIDLSKRRV SPEEAIKCED KFTKSKTVYS ILRHVAEVLE YTKDEQLESL FQRTAWVFDD KYKRPGYGAY DAFKHAVSDP SILDSLDLNE DEREVLINNI NRRLTPQAVK IRADIEVACY GYEGIDAVKE ALRAGLNCST ENMPIKINLI APPRYVMTTT TLERTEGLSV LSQAMAVIKE KIEEKRGVFN VQMEPKVVTD TDETELARQM ERLERENAEV DGDDDAEEME AKAED
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.