Details for: EIF2B1
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: germ cell (CL0000586)
Fold Change: 2.5
Marker Score: 4361 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.41
Marker Score: 5538 - Cell Name: oogonial cell (CL0000024)
Fold Change: 1.13
Marker Score: 1631 - Cell Name: proerythroblast (CL0000547)
Fold Change: 1.12
Marker Score: 758 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 1.12
Marker Score: 1165 - Cell Name: pro-T cell (CL0000827)
Fold Change: 1.11
Marker Score: 4541 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.09
Marker Score: 1096 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.06
Marker Score: 1633 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.06
Marker Score: 3138 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.06
Marker Score: 10707 - Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.05
Marker Score: 1318 - Cell Name: blood cell (CL0000081)
Fold Change: 1.04
Marker Score: 12037 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.02
Marker Score: 426 - Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1
Marker Score: 2731.5 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71658 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47882.5 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30384 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.98
Marker Score: 2037 - Cell Name: plasmablast (CL0000980)
Fold Change: 0.96
Marker Score: 1280 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.96
Marker Score: 8245 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.96
Marker Score: 1012 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.95
Marker Score: 9046 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2387 - Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.93
Marker Score: 701 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.93
Marker Score: 1585 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.92
Marker Score: 476 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.92
Marker Score: 432.5 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.91
Marker Score: 55978 - Cell Name: Unknown (CL0002371)
Fold Change: 0.91
Marker Score: 963 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.9
Marker Score: 5733.5 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2683 - Cell Name: Unknown (CL0000548)
Fold Change: 0.89
Marker Score: 648 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.89
Marker Score: 9175.5 - Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.89
Marker Score: 362 - Cell Name: ependymal cell (CL0000065)
Fold Change: 0.88
Marker Score: 307 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.88
Marker Score: 463 - Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.87
Marker Score: 980 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5291 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.87
Marker Score: 3221 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.86
Marker Score: 2344.5 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 308 - Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.84
Marker Score: 1193 - Cell Name: decidual cell (CL2000002)
Fold Change: 0.84
Marker Score: 3634 - Cell Name: kidney cell (CL1000497)
Fold Change: 0.84
Marker Score: 561 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.84
Marker Score: 7873 - Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.83
Marker Score: 1629 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.83
Marker Score: 402 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.83
Marker Score: 30485 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.82
Marker Score: 4700 - Cell Name: oocyte (CL0000023)
Fold Change: 0.82
Marker Score: 202 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.82
Marker Score: 7031 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.81
Marker Score: 1197 - Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.81
Marker Score: 446 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.81
Marker Score: 324 - Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.8
Marker Score: 756 - Cell Name: Leydig cell (CL0000178)
Fold Change: 0.8
Marker Score: 866 - Cell Name: centrocyte (CL0009111)
Fold Change: 0.8
Marker Score: 191 - Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.8
Marker Score: 277 - Cell Name: neural crest cell (CL0011012)
Fold Change: 0.8
Marker Score: 852 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.8
Marker Score: 710 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.79
Marker Score: 1297 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.79
Marker Score: 8893.5 - Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 0.78
Marker Score: 251 - Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.78
Marker Score: 792 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.78
Marker Score: 714 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1261 - Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 0.77
Marker Score: 559 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 589 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.77
Marker Score: 5007 - Cell Name: adventitial cell (CL0002503)
Fold Change: 0.77
Marker Score: 190 - Cell Name: preosteoblast (CL0007010)
Fold Change: 0.77
Marker Score: 217 - Cell Name: malignant cell (CL0001064)
Fold Change: 0.76
Marker Score: 10238 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.76
Marker Score: 208 - Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.76
Marker Score: 540 - Cell Name: hepatocyte (CL0000182)
Fold Change: 0.75
Marker Score: 513 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.75
Marker Score: 776 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.75
Marker Score: 411 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.75
Marker Score: 178 - Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.74
Marker Score: 260 - Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.73
Marker Score: 461 - Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.73
Marker Score: 1278 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.73
Marker Score: 2820 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.73
Marker Score: 462 - Cell Name: osteoclast (CL0000092)
Fold Change: 0.73
Marker Score: 362 - Cell Name: centroblast (CL0009112)
Fold Change: 0.72
Marker Score: 357 - Cell Name: male germ cell (CL0000015)
Fold Change: 0.72
Marker Score: 208 - Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.72
Marker Score: 9514 - Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.72
Marker Score: 169 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.72
Marker Score: 7227 - Cell Name: basal cell (CL0000646)
Fold Change: 0.72
Marker Score: 927 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.72
Marker Score: 371 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.71
Marker Score: 156.5 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.71
Marker Score: 2996 - Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.71
Marker Score: 450.5 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.71
Marker Score: 1097 - Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.71
Marker Score: 348 - Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 0.71
Marker Score: 335 - Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.71
Marker Score: 345 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.7
Marker Score: 466 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.7
Marker Score: 186
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Other Information
Genular Protein ID: 2116457911
Symbol: EI2BA_HUMAN
Name: Translation initiation factor eIF2B subunit alpha
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25858979
Title: Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound.
PubMed ID: 25858979
PubMed ID: 27023709
Title: Expression, purification, and crystallization of Schizosaccharomyces pombe eIF2B.
PubMed ID: 27023709
PubMed ID: 31048492
Title: Structural basis for eIF2B inhibition in integrated stress response.
PubMed ID: 31048492
PubMed ID: 11835386
Title: Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter.
PubMed ID: 11835386
DOI: 10.1002/ana.10112
PubMed ID: 15776425
Title: Identification of ten novel mutations in patients with eIF2B-related disorders.
PubMed ID: 15776425
DOI: 10.1002/humu.9325
Sequence Information:
- Length: 305
- Mass: 33712
- Checksum: 91A915FF1B80B780
- Sequence:
MDDKELIEYF KSQMKEDPDM ASAVAAIRTL LEFLKRDKGE TIQGLRANLT SAIETLCGVD SSVAVSSGGE LFLRFISLAS LEYSDYSKCK KIMIERGELF LRRISLSRNK IADLCHTFIK DGATILTHAY SRVVLRVLEA AVAAKKRFSV YVTESQPDLS GKKMAKALCH LNVPVTVVLD AAVGYIMEKA DLVIVGAEGV VENGGIINKI GTNQMAVCAK AQNKPFYVVA ESFKFVRLFP LNQQDVPDKF KYKADTLKVA QTGQDLKEEH PWVDYTAPSL ITLLFTDLGV LTPSAVSDEL IKLYL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.