Details for: EIF2B1

Gene ID: 1967

Symbol: EIF2B1

Ensembl ID: ENSG00000111361

Description: eukaryotic translation initiation factor 2B subunit alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 153.7816
    Cell Significance Index: -23.9200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 86.4600
    Cell Significance Index: -21.9300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 71.5382
    Cell Significance Index: -29.4700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 58.4851
    Cell Significance Index: -23.7600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 52.9370
    Cell Significance Index: -27.2300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 41.6156
    Cell Significance Index: -27.9300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.9072
    Cell Significance Index: -23.7800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.5816
    Cell Significance Index: -20.3100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.1185
    Cell Significance Index: -28.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4788
    Cell Significance Index: 240.5100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3131
    Cell Significance Index: 78.8300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.1203
    Cell Significance Index: 9.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9663
    Cell Significance Index: 112.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7759
    Cell Significance Index: 50.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7539
    Cell Significance Index: 151.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6589
    Cell Significance Index: 130.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6564
    Cell Significance Index: 77.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6302
    Cell Significance Index: 86.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5850
    Cell Significance Index: 15.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5500
    Cell Significance Index: 104.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5020
    Cell Significance Index: 221.9600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4986
    Cell Significance Index: 35.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4641
    Cell Significance Index: 83.6600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3725
    Cell Significance Index: 10.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3557
    Cell Significance Index: 35.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3520
    Cell Significance Index: 43.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3403
    Cell Significance Index: 122.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3369
    Cell Significance Index: 23.3000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3283
    Cell Significance Index: 11.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3137
    Cell Significance Index: 171.3200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3005
    Cell Significance Index: 6.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2691
    Cell Significance Index: 13.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2501
    Cell Significance Index: 15.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2501
    Cell Significance Index: 11.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2402
    Cell Significance Index: 6.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2372
    Cell Significance Index: 6.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2300
    Cell Significance Index: 10.8100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2145
    Cell Significance Index: 4.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1862
    Cell Significance Index: 23.8700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1853
    Cell Significance Index: 2.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1532
    Cell Significance Index: 3.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1299
    Cell Significance Index: 5.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1276
    Cell Significance Index: 16.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1205
    Cell Significance Index: 7.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1015
    Cell Significance Index: 2.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0707
    Cell Significance Index: 3.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0378
    Cell Significance Index: 34.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0372
    Cell Significance Index: 6.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0311
    Cell Significance Index: 58.5900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0199
    Cell Significance Index: 13.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0149
    Cell Significance Index: 27.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0145
    Cell Significance Index: 22.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0118
    Cell Significance Index: 0.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0071
    Cell Significance Index: 0.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0022
    Cell Significance Index: 0.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0001
    Cell Significance Index: -0.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0054
    Cell Significance Index: -7.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0085
    Cell Significance Index: -5.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0094
    Cell Significance Index: -7.1300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0102
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0136
    Cell Significance Index: -10.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0162
    Cell Significance Index: -11.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0200
    Cell Significance Index: -9.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0204
    Cell Significance Index: -11.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0288
    Cell Significance Index: -2.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0344
    Cell Significance Index: -5.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0386
    Cell Significance Index: -1.0400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0460
    Cell Significance Index: -1.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0644
    Cell Significance Index: -13.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0736
    Cell Significance Index: -2.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0763
    Cell Significance Index: -21.9600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0821
    Cell Significance Index: -2.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0864
    Cell Significance Index: -9.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1262
    Cell Significance Index: -5.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1322
    Cell Significance Index: -8.8900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1568
    Cell Significance Index: -3.3400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1587
    Cell Significance Index: -6.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1779
    Cell Significance Index: -9.3400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1818
    Cell Significance Index: -20.7600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2252
    Cell Significance Index: -3.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2350
    Cell Significance Index: -24.4700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2616
    Cell Significance Index: -3.9200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2840
    Cell Significance Index: -2.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2922
    Cell Significance Index: -23.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2990
    Cell Significance Index: -4.0800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3131
    Cell Significance Index: -6.1100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3244
    Cell Significance Index: -7.7800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3436
    Cell Significance Index: -6.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3532
    Cell Significance Index: -18.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3732
    Cell Significance Index: -22.8800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3937
    Cell Significance Index: -10.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4064
    Cell Significance Index: -13.0200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4880
    Cell Significance Index: -11.2800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5025
    Cell Significance Index: -8.8800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.5086
    Cell Significance Index: -3.9200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5250
    Cell Significance Index: -15.0500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5278
    Cell Significance Index: -16.8100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5371
    Cell Significance Index: -17.5900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5442
    Cell Significance Index: -6.9700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5484
    Cell Significance Index: -11.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of the eIF2B complex**: EIF2B1 is a subunit of the eIF2B complex, which plays a critical role in the regulation of eIF2 recycling and translation initiation. 2. **Guanyl-nucleotide exchange factor activity**: EIF2B1 possesses guanyl-nucleotide exchange factor activity, allowing it to facilitate the exchange of GDP for GTP on eIF2. 3. **Identical protein binding**: EIF2B1 exhibits identical protein binding capabilities, enabling it to interact with other proteins involved in translation initiation. 4. **Widespread expression**: EIF2B1 is expressed in various cell types, including germ cells, placental villous trophoblasts, and hematopoietic progenitor cells. **Pathways and Functions:** 1. **Cap-dependent translation initiation**: EIF2B1 is involved in the regulation of cap-dependent translation initiation, a process that is essential for the translation of mRNAs containing a 5' cap. 2. **Cytoplasmic translational initiation**: EIF2B1 plays a critical role in the regulation of cytoplasmic translational initiation, a process that is essential for the translation of mRNAs in the cytoplasm. 3. **Recycling of eIF2:GDP**: EIF2B1 facilitates the recycling of eIF2-GDP, allowing for the efficient reuse of eIF2 and promoting accurate translation initiation. 4. **Translation initiation factor activity**: EIF2B1 possesses translation initiation factor activity, enabling it to regulate the activity of eIF2 and other translation initiation factors. **Clinical Significance:** 1. **Cancer**: Dysregulation of EIF2B1 has been implicated in various cancers, including breast cancer, lung cancer, and leukemia. 2. **Metabolic disorders**: EIF2B1 has been linked to metabolic disorders, such as type 2 diabetes and metabolic syndrome. 3. **Neurodegenerative conditions**: EIF2B1 has been implicated in neurodegenerative conditions, including Alzheimer's disease and Parkinson's disease. 4. **Immunological disorders**: EIF2B1 has been linked to immunological disorders, including autoimmune diseases and immunodeficiency syndromes. In conclusion, EIF2B1 plays a crucial role in the regulation of eukaryotic translation initiation, and its dysregulation has been implicated in various diseases. Further research is necessary to fully elucidate the mechanisms by which EIF2B1 regulates translation initiation and to explore its potential as a therapeutic target for the treatment of various diseases.

Genular Protein ID: 2116457911

Symbol: EI2BA_HUMAN

Name: Translation initiation factor eIF2B subunit alpha

UniProtKB Accession Codes:

Q14232 A6NLY9 B4DGX0 Q3SXP4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 15 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 5 OrthoDB 1 PANTHER 2 PDB 23 PDBsum 23 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25858979

Title: Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound.

PubMed ID: 25858979

DOI: 10.1126/science.aaa6986

PubMed ID: 27023709

Title: Expression, purification, and crystallization of Schizosaccharomyces pombe eIF2B.

PubMed ID: 27023709

DOI: 10.1007/s10969-016-9203-3

PubMed ID: 31048492

Title: Structural basis for eIF2B inhibition in integrated stress response.

PubMed ID: 31048492

DOI: 10.1126/science.aaw4104

PubMed ID: 11835386

Title: Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter.

PubMed ID: 11835386

DOI: 10.1002/ana.10112

PubMed ID: 15776425

Title: Identification of ten novel mutations in patients with eIF2B-related disorders.

PubMed ID: 15776425

DOI: 10.1002/humu.9325

Sequence Information:

  • Length: 305
  • Mass: 33712
  • Checksum: 91A915FF1B80B780
  • Sequence:
    • MDDKELIEYF KSQMKEDPDM ASAVAAIRTL LEFLKRDKGE TIQGLRANLT SAIETLCGVD 
SSVAVSSGGE LFLRFISLAS LEYSDYSKCK KIMIERGELF LRRISLSRNK IADLCHTFIK 
DGATILTHAY SRVVLRVLEA AVAAKKRFSV YVTESQPDLS GKKMAKALCH LNVPVTVVLD 
AAVGYIMEKA DLVIVGAEGV VENGGIINKI GTNQMAVCAK AQNKPFYVVA ESFKFVRLFP 
LNQQDVPDKF KYKADTLKVA QTGQDLKEEH PWVDYTAPSL ITLLFTDLGV LTPSAVSDEL 
IKLYL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.