Gene ELK4 - ENSG00000158711 | NCBI Gene ID: 2005

Details for: ELK4

Gene ID: 2005

Symbol: ELK4

Ensembl ID: ENSG00000158711

Description: ETS transcription factor ELK4

Associated with

Cell differentiation
(GO:0030154)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Cytosol
(GO:0005829)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific double-stranded dna binding
(GO:1990837)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 2
Marker Score: 4904
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.39
Marker Score: 2050
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.37
Marker Score: 799
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.32
Marker Score: 1370
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.31
Marker Score: 1203
Cell Name: endocardial cell (CL0002350)
Fold Change: 1.26
Marker Score: 713
Cell Name: follicular B cell (CL0000843)
Fold Change: 1.23
Marker Score: 1335.5
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.23
Marker Score: 1291
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.16
Marker Score: 917
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.11
Marker Score: 1222
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 1.1
Marker Score: 267
Cell Name: basal cell (CL0000646)
Fold Change: 1.09
Marker Score: 1409
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.04
Marker Score: 622
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 1.03
Marker Score: 247
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.02
Marker Score: 1085
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.01
Marker Score: 2382
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1
Marker Score: 61776
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71655
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47878
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.99
Marker Score: 977
Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.98
Marker Score: 368
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30387
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.96
Marker Score: 32505
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.95
Marker Score: 410
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2388
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.93
Marker Score: 560
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.93
Marker Score: 268
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.92
Marker Score: 7878
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.92
Marker Score: 472
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.92
Marker Score: 324
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.91
Marker Score: 456
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.91
Marker Score: 898
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.91
Marker Score: 429
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.9
Marker Score: 8532
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 0.9
Marker Score: 468
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2682
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.89
Marker Score: 1784
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.87
Marker Score: 1349
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5292
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.86
Marker Score: 454
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.85
Marker Score: 296
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.85
Marker Score: 305
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.84
Marker Score: 967
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 0.84
Marker Score: 755
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.83
Marker Score: 476
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.83
Marker Score: 897
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.82
Marker Score: 551
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.81
Marker Score: 4648
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.8
Marker Score: 249
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.8
Marker Score: 309
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 0.79
Marker Score: 1155
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.78
Marker Score: 313
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 0.78
Marker Score: 237
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.77
Marker Score: 12110
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 591
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1256
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.77
Marker Score: 1886
Cell Name: Schwann cell precursor (CL0002375)
Fold Change: 0.77
Marker Score: 191
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.77
Marker Score: 3765
Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
Fold Change: 0.76
Marker Score: 173
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.76
Marker Score: 182
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.75
Marker Score: 670
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.75
Marker Score: 509
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.75
Marker Score: 371
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.74
Marker Score: 1231
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 0.73
Marker Score: 171
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.73
Marker Score: 510
Cell Name: keratocyte (CL0002363)
Fold Change: 0.73
Marker Score: 169
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.73
Marker Score: 159
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.73
Marker Score: 1125.5
Cell Name: memory B cell (CL0000787)
Fold Change: 0.73
Marker Score: 553
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.73
Marker Score: 688
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.73
Marker Score: 2507
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 0.73
Marker Score: 160
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.73
Marker Score: 2693
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.73
Marker Score: 162
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.72
Marker Score: 452
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 0.72
Marker Score: 778
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.72
Marker Score: 1468
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.72
Marker Score: 488
Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 0.72
Marker Score: 179
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.72
Marker Score: 456
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 0.72
Marker Score: 672
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.71
Marker Score: 370
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.71
Marker Score: 1912.5
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 0.71
Marker Score: 182
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.71
Marker Score: 351
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 0.71
Marker Score: 1797
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.71
Marker Score: 357
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.71
Marker Score: 7955
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.7
Marker Score: 533
Cell Name: cardiac mesenchymal cell (CL0000569)
Fold Change: 0.7
Marker Score: 173
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.7
Marker Score: 285
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.7
Marker Score: 1237
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.7
Marker Score: 1760
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.7
Marker Score: 461
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 0.7
Marker Score: 183
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.7
Marker Score: 224
Cell Name: microglial cell (CL0000129)
Fold Change: 0.69
Marker Score: 1264
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.69
Marker Score: 140

Hover over a box to see details here...

**Key characteristics:** * ELK4 is a member of the ETS family of transcription factors, which are involved in regulating gene expression in a tissue- and cell-specific manner. * It is a highly conserved protein with significant sequence similarities in mammals. * ELK4 is known to be a key regulator of epithelial cell differentiation and function. * It is expressed in various cell types, including epithelial cells, stromal cells, and immune cells. **Pathways and functions:** * ELK4 is a key regulator of epithelial cell differentiation and survival. * It is essential for the development of the gastrointestinal tract, including the formation of the stomach and intestines. * It is also involved in the development and maintenance of the female reproductive tract. * ELK4 is a key regulator of prostate gland development and function. * It is involved in the regulation of cell growth, proliferation, and differentiation in various tissues. **Clinical significance:** * Mutations in the ELK4 gene have been linked to several human cancers, including lung cancer, breast cancer, and prostate cancer. * Targeting ELK4 has emerged as a promising therapeutic strategy for cancer treatment. * Inhibition of ELK4 has been shown to inhibit cancer cell growth and metastasis. **Other notable facts:** * ELK4 is a transcription factor that is highly responsive to various growth factors and cytokines. * It is a key regulator of cell cycle regulation and apoptosis. * It is a target for therapy in cancer.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

ETS domain-containing protein Elk-4
Q8IXL1_HUMAN

Genular Protein ID: 939015747

Symbol: ELK4_HUMAN

Name: ETS domain-containing protein Elk-4

UniProtKB Accession Codes:

P28324 P28323 Q6GSJ2

Database IDs:

Citations:

PubMed ID: 1339307

Title: Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element.

PubMed ID: 1339307

DOI: 10.1016/0092-8674(92)90194-h

PubMed ID: 8293474

Title: Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element.

PubMed ID: 8293474

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 9734357

Title: Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins.

PubMed ID: 9734357

DOI: 10.1016/s1097-2765(00)80130-6

PubMed ID: 22722849

Title: SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation.

PubMed ID: 22722849

DOI: 10.1038/nature11043

Sequence Information:

Length: 431
Mass: 46900
Checksum: 80EE3E69995C7A7D
Sequence:

MDSAITLWQF LLQLLQKPQN KHMICWTSND GQFKLLQAEE VARLWGIRKN KPNMNYDKLS 
RALRYYYVKN IIKKVNGQKF VYKFVSYPEI LNMDPMTVGR IEGDCESLNF SEVSSSSKDV 
ENGGKDKPPQ PGAKTSSRND YIHSGLYSSF TLNSLNSSNV KLFKLIKTEN PAEKLAEKKS 
PQEPTPSVIK FVTTPSKKPP VEPVAATISI GPSISPSSEE TIQALETLVS PKLPSLEAPT 
SASNVMTAFA TTPPISSIPP LQEPPRTPSP PLSSHPDIDT DIDSVASQPM ELPENLSLEP 
KDQDSVLLEK DKVNNSSRSK KPKGLELAPT LVITSSDPSP LGILSPSLPT ASLTPAFFSQ 
TPIILTPSPL LSSIHFWSTL SPVAPLSPAR LQGANTLFQF PSVLNSHGPF TLSGLDGPST 
PGPFSPDLQK T

Genular Protein ID: 1730616436

Symbol: Q8IXL1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IXL1

Database IDs:

Sequence Information:

Length: 521
Mass: 55950
Checksum: A048481E4C8E2FCF
Sequence:

RPQDPRRRCR VRGRGGRGAR SRGGGRCGRL RAPGGLGLAA AAFYGSAAGV AAAAAPSSSF 
QREEEAEGGE AHRVRGGDRG GAPRAASLIA MDSAITLWQF LLQLLQKPQN KHMICWTSND 
GQFKLLQAEE VARLWGIRKN KPNMNYDKLS RALRYYYVKN IIKKVNGQKF VYKFVSYPEI 
LNMDPMTVGR IEGDCESLNF SEVSSSSKDV ENGGKDKPPQ PGAKTSSRND YIHSGLYSSF 
TLNSLNSSNV KLFKLIKTEN PAEKLAEKKS PQEPTPSVIK FVTTPSKKPP VEPVAATISI 
GPSISPSSEE TIQALETLVS PKLPSLEAPT SASNVMTAFA TTPPISSIPP LQEPPRTPSP 
PLSSHPDIDT DIDSVASQPM ELPENLSLEP KDQDSVLLEK DKVNNSSRSK KPKGLELAPT 
LVITSSDPSP LGILSPSLPT ASLTPAFFSQ TPIILTPSPL LSSIHFWSTL SPVAPLSPAR 
LQGANTLFQF PSVLNSHGPF TLSGLDGPST PGPFSPDLQK T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ELK4

Associated with

Cells (max top 100)

Other Information

Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. PubMed ID: 1339307

Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. PubMed ID: 8293474

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins. PubMed ID: 9734357

SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. PubMed ID: 22722849