Details for: ELK4

Gene ID: 2005

Symbol: ELK4

Ensembl ID: ENSG00000158711

Description: ETS transcription factor ELK4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 155.9996
    Cell Significance Index: -24.2700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 94.8970
    Cell Significance Index: -24.0700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 56.8728
    Cell Significance Index: -23.1100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 54.4350
    Cell Significance Index: -25.7000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 49.9431
    Cell Significance Index: -25.6900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.2736
    Cell Significance Index: -23.1800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.0956
    Cell Significance Index: -26.0100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.0785
    Cell Significance Index: -24.3200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.3613
    Cell Significance Index: -22.6100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.8035
    Cell Significance Index: -14.8900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.6801
    Cell Significance Index: -26.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.9286
    Cell Significance Index: 313.6800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6762
    Cell Significance Index: 22.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5899
    Cell Significance Index: 43.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.3977
    Cell Significance Index: 162.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1996
    Cell Significance Index: 147.5000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1633
    Cell Significance Index: 126.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0925
    Cell Significance Index: 56.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0717
    Cell Significance Index: 212.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0623
    Cell Significance Index: 191.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0504
    Cell Significance Index: 63.0600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.8767
    Cell Significance Index: 9.9600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8719
    Cell Significance Index: 23.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8413
    Cell Significance Index: 168.7700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.7437
    Cell Significance Index: 5.7300
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.6153
    Cell Significance Index: 5.4200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.4890
    Cell Significance Index: 5.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4734
    Cell Significance Index: 46.8300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4197
    Cell Significance Index: 12.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3783
    Cell Significance Index: 24.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3753
    Cell Significance Index: 51.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3728
    Cell Significance Index: 10.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3582
    Cell Significance Index: 7.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3407
    Cell Significance Index: 186.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3398
    Cell Significance Index: 150.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3396
    Cell Significance Index: 9.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2496
    Cell Significance Index: 225.4100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2393
    Cell Significance Index: 45.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2390
    Cell Significance Index: 28.1800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2051
    Cell Significance Index: 10.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1998
    Cell Significance Index: 9.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1936
    Cell Significance Index: 69.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1880
    Cell Significance Index: 4.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1742
    Cell Significance Index: 8.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1716
    Cell Significance Index: 7.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1666
    Cell Significance Index: 11.7900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1604
    Cell Significance Index: 3.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1175
    Cell Significance Index: 9.0200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1167
    Cell Significance Index: 6.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1123
    Cell Significance Index: 7.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1109
    Cell Significance Index: 14.2200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0778
    Cell Significance Index: 0.4700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0750
    Cell Significance Index: 1.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0709
    Cell Significance Index: 2.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0705
    Cell Significance Index: 3.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0567
    Cell Significance Index: 3.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0497
    Cell Significance Index: 8.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0131
    Cell Significance Index: 24.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0057
    Cell Significance Index: 8.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0022
    Cell Significance Index: 3.9800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0007
    Cell Significance Index: 0.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0018
    Cell Significance Index: -0.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0025
    Cell Significance Index: -1.5800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0055
    Cell Significance Index: -7.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0106
    Cell Significance Index: -6.6300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0119
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0144
    Cell Significance Index: -10.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0200
    Cell Significance Index: -15.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0207
    Cell Significance Index: -9.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0286
    Cell Significance Index: -16.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0374
    Cell Significance Index: -5.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0381
    Cell Significance Index: -2.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0437
    Cell Significance Index: -0.9300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0591
    Cell Significance Index: -1.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0641
    Cell Significance Index: -13.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0687
    Cell Significance Index: -19.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0707
    Cell Significance Index: -7.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0761
    Cell Significance Index: -5.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0819
    Cell Significance Index: -9.3800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1211
    Cell Significance Index: -13.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1541
    Cell Significance Index: -4.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1890
    Cell Significance Index: -8.3600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2056
    Cell Significance Index: -5.5000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2113
    Cell Significance Index: -8.0000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2143
    Cell Significance Index: -4.4500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2148
    Cell Significance Index: -3.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2305
    Cell Significance Index: -24.0000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2847
    Cell Significance Index: -22.5500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3046
    Cell Significance Index: -7.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3062
    Cell Significance Index: -10.6400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3070
    Cell Significance Index: -3.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3210
    Cell Significance Index: -19.6800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3307
    Cell Significance Index: -5.5700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3906
    Cell Significance Index: -7.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3909
    Cell Significance Index: -12.5200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4146
    Cell Significance Index: -11.8300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4309
    Cell Significance Index: -8.4100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4463
    Cell Significance Index: -9.5400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4725
    Cell Significance Index: -7.1200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4981
    Cell Significance Index: -7.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation**: ELK4 acts as a transcriptional activator, binding to specific DNA sequences and recruiting RNA polymerase II to initiate transcription. 2. **ETS Family Member**: As a member of the ETS family, ELK4 shares structural and functional similarities with other ETS transcription factors, such as ETS1 and ETS2. 3. **Cell Type-Specific Expression**: ELK4 is significantly expressed in glandular epithelial cells, bladder urothelial cells, and other epithelial cell types, highlighting its involvement in tissue-specific processes. 4. **Regulation of Transcription by RNA Polymerase II**: ELK4 interacts with RNA polymerase II to modulate transcription, influencing the expression of target genes involved in cellular differentiation and proliferation. **Pathways and Functions:** 1. **Cell Differentiation**: ELK4 regulates the expression of genes involved in cellular differentiation, influencing the development and maturation of epithelial cells. 2. **Transcriptional Regulation**: ELK4 interacts with RNA polymerase II to modulate transcription, influencing the expression of target genes involved in cellular proliferation, differentiation, and survival. 3. **DNA Binding**: ELK4 binds to specific DNA sequences, recruiting RNA polymerase II to initiate transcription and regulating gene expression. 4. **Regulation of Transcription by RNA Polymerase II**: ELK4 modulates transcription by interacting with RNA polymerase II, influencing the expression of target genes involved in cellular differentiation and proliferation. **Clinical Significance:** 1. **Cancer Development**: Dysregulation of ELK4 expression has been implicated in various types of cancer, including bladder, prostate, and pancreatic cancer, highlighting its potential as a therapeutic target. 2. **Immune Cell Function**: ELK4 plays a critical role in regulating immune cell function, influencing the expression of genes involved in inflammation and immune response. 3. **Neurological Disorders**: ELK4 has been implicated in the regulation of gene expression in neural cells, influencing the development and function of the nervous system. 4. **Tissue Homeostasis**: ELK4 expression is essential for maintaining tissue homeostasis, influencing the expression of genes involved in cellular differentiation and proliferation. In conclusion, ELK4 is a critical regulator of cellular differentiation and transcription, influencing various cellular processes and tissue homeostasis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying ELK4 function and its role in human disease.

Genular Protein ID: 939015747

Symbol: ELK4_HUMAN

Name: ETS domain-containing protein Elk-4

UniProtKB Accession Codes:

P28324 P28323 Q6GSJ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 4 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 3 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1339307

Title: Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element.

PubMed ID: 1339307

DOI: 10.1016/0092-8674(92)90194-h

PubMed ID: 8293474

Title: Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element.

PubMed ID: 8293474

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 9734357

Title: Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins.

PubMed ID: 9734357

DOI: 10.1016/s1097-2765(00)80130-6

PubMed ID: 22722849

Title: SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation.

PubMed ID: 22722849

DOI: 10.1038/nature11043

Sequence Information:

  • Length: 431
  • Mass: 46900
  • Checksum: 80EE3E69995C7A7D
  • Sequence:
    • MDSAITLWQF LLQLLQKPQN KHMICWTSND GQFKLLQAEE VARLWGIRKN KPNMNYDKLS 
RALRYYYVKN IIKKVNGQKF VYKFVSYPEI LNMDPMTVGR IEGDCESLNF SEVSSSSKDV 
ENGGKDKPPQ PGAKTSSRND YIHSGLYSSF TLNSLNSSNV KLFKLIKTEN PAEKLAEKKS 
PQEPTPSVIK FVTTPSKKPP VEPVAATISI GPSISPSSEE TIQALETLVS PKLPSLEAPT 
SASNVMTAFA TTPPISSIPP LQEPPRTPSP PLSSHPDIDT DIDSVASQPM ELPENLSLEP 
KDQDSVLLEK DKVNNSSRSK KPKGLELAPT LVITSSDPSP LGILSPSLPT ASLTPAFFSQ 
TPIILTPSPL LSSIHFWSTL SPVAPLSPAR LQGANTLFQF PSVLNSHGPF TLSGLDGPST 
PGPFSPDLQK T

Genular Protein ID: 1730616436

Symbol: Q8IXL1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IXL1

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PeptideAtlas 1 Pfam 1 PharmGKB 1 PhylomeDB 1 ProteomicsDB 1 RefSeq 2 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 521
  • Mass: 55950
  • Checksum: A048481E4C8E2FCF
  • Sequence:
    • RPQDPRRRCR VRGRGGRGAR SRGGGRCGRL RAPGGLGLAA AAFYGSAAGV AAAAAPSSSF 
QREEEAEGGE AHRVRGGDRG GAPRAASLIA MDSAITLWQF LLQLLQKPQN KHMICWTSND 
GQFKLLQAEE VARLWGIRKN KPNMNYDKLS RALRYYYVKN IIKKVNGQKF VYKFVSYPEI 
LNMDPMTVGR IEGDCESLNF SEVSSSSKDV ENGGKDKPPQ PGAKTSSRND YIHSGLYSSF 
TLNSLNSSNV KLFKLIKTEN PAEKLAEKKS PQEPTPSVIK FVTTPSKKPP VEPVAATISI 
GPSISPSSEE TIQALETLVS PKLPSLEAPT SASNVMTAFA TTPPISSIPP LQEPPRTPSP 
PLSSHPDIDT DIDSVASQPM ELPENLSLEP KDQDSVLLEK DKVNNSSRSK KPKGLELAPT 
LVITSSDPSP LGILSPSLPT ASLTPAFFSQ TPIILTPSPL LSSIHFWSTL SPVAPLSPAR 
LQGANTLFQF PSVLNSHGPF TLSGLDGPST PGPFSPDLQK T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.