Details for: GABRR3

Gene ID: 200959

Symbol: GABRR3

Ensembl ID: ENSG00000183185

Description: gamma-aminobutyric acid type A receptor subunit rho3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 12.9050
    Cell Significance Index: 72.3600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 4.2463
    Cell Significance Index: 32.7300
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.8900
    Cell Significance Index: 26.5500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.6621
    Cell Significance Index: 40.2600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.9760
    Cell Significance Index: 14.2300
  • Cell Name: diffuse bipolar 1 cell (CL4033027)
    Fold Change: 0.6756
    Cell Significance Index: 8.2700
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.6357
    Cell Significance Index: 5.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3211
    Cell Significance Index: 20.2400
  • Cell Name: diffuse bipolar 6 cell (CL4033032)
    Fold Change: 0.1589
    Cell Significance Index: 1.8400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0942
    Cell Significance Index: 0.9800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0881
    Cell Significance Index: 1.0500
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.0794
    Cell Significance Index: 0.9100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0506
    Cell Significance Index: 1.2600
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: 0.0233
    Cell Significance Index: 0.2900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0228
    Cell Significance Index: 0.3700
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0217
    Cell Significance Index: 0.2100
  • Cell Name: diffuse bipolar 3b cell (CL4033030)
    Fold Change: 0.0216
    Cell Significance Index: 0.2600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0165
    Cell Significance Index: 0.2000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0163
    Cell Significance Index: 11.2700
  • Cell Name: diffuse bipolar 4 cell (CL4033031)
    Fold Change: 0.0123
    Cell Significance Index: 0.1500
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0115
    Cell Significance Index: 0.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0075
    Cell Significance Index: 1.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0066
    Cell Significance Index: 0.3700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0028
    Cell Significance Index: 0.0400
  • Cell Name: diffuse bipolar 2 cell (CL4033028)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0005
    Cell Significance Index: -0.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0005
    Cell Significance Index: -0.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0005
    Cell Significance Index: -0.7900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0007
    Cell Significance Index: -1.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0012
    Cell Significance Index: -0.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0014
    Cell Significance Index: -0.9200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0020
    Cell Significance Index: -0.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0024
    Cell Significance Index: -1.0700
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0025
    Cell Significance Index: -0.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0026
    Cell Significance Index: -0.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0028
    Cell Significance Index: -1.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0030
    Cell Significance Index: -1.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0042
    Cell Significance Index: -0.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0052
    Cell Significance Index: -1.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0053
    Cell Significance Index: -0.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0075
    Cell Significance Index: -0.3900
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0079
    Cell Significance Index: -0.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0082
    Cell Significance Index: -1.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0092
    Cell Significance Index: -1.2600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0104
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0115
    Cell Significance Index: -1.3200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0130
    Cell Significance Index: -0.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0133
    Cell Significance Index: -1.3900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0138
    Cell Significance Index: -0.5700
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.0143
    Cell Significance Index: -0.1400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0153
    Cell Significance Index: -0.7700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0154
    Cell Significance Index: -0.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0173
    Cell Significance Index: -0.9100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0182
    Cell Significance Index: -0.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0192
    Cell Significance Index: -0.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0215
    Cell Significance Index: -1.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0225
    Cell Significance Index: -1.3900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0238
    Cell Significance Index: -0.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0269
    Cell Significance Index: -0.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0283
    Cell Significance Index: -2.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0288
    Cell Significance Index: -0.7700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0297
    Cell Significance Index: -0.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0313
    Cell Significance Index: -1.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0324
    Cell Significance Index: -1.4400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0331
    Cell Significance Index: -1.1600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0340
    Cell Significance Index: -0.6700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0348
    Cell Significance Index: -0.3300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0351
    Cell Significance Index: -0.2900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0359
    Cell Significance Index: -0.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0377
    Cell Significance Index: -1.4300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0381
    Cell Significance Index: -0.9300
  • Cell Name: diffuse bipolar 3a cell (CL4033029)
    Fold Change: -0.0382
    Cell Significance Index: -0.4600
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0382
    Cell Significance Index: -0.3900
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0385
    Cell Significance Index: -0.2800
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0390
    Cell Significance Index: -0.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0393
    Cell Significance Index: -0.8600
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.0415
    Cell Significance Index: -0.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0435
    Cell Significance Index: -1.3900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0441
    Cell Significance Index: -0.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0448
    Cell Significance Index: -1.3200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0451
    Cell Significance Index: -1.4800
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0456
    Cell Significance Index: -0.5300
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0458
    Cell Significance Index: -0.6000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0484
    Cell Significance Index: -0.8300
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0496
    Cell Significance Index: -0.6700
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -0.0498
    Cell Significance Index: -0.6200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0501
    Cell Significance Index: -1.4300
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0521
    Cell Significance Index: -0.3900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0535
    Cell Significance Index: -0.7300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0556
    Cell Significance Index: -0.5900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0571
    Cell Significance Index: -0.4100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0578
    Cell Significance Index: -0.6300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0583
    Cell Significance Index: -0.8300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0590
    Cell Significance Index: -1.6900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0594
    Cell Significance Index: -1.2700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0597
    Cell Significance Index: -1.4900
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0601
    Cell Significance Index: -0.9700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0608
    Cell Significance Index: -0.8100
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0608
    Cell Significance Index: -0.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit structure:** GABRR3 is a single polypeptide chain, comprising approximately 175 amino acids, which forms a distinct subunit of the GABA_A receptor complex. 2. **Function:** GABRR3 is involved in the assembly and function of GABA_A receptors, which are ligand-gated chloride channels responsible for regulating neuronal excitability and synaptic transmission. 3. **Expression:** GABRR3 is expressed in a wide range of cell types, including progenitor cells, blood vessel endothelial cells, T cells, plasma cells, goblet cells, B cells, kidney proximal convoluted tubule epithelial cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, and absorptive cells. 4. **Pathway involvement:** GABRR3 is implicated in various signaling pathways, including gamma-aminobutyric acid signaling, chloride channel activity, chloride transmembrane transport, and regulation of membrane potential. **Pathways and Functions:** 1. **GABA signaling pathway:** GABRR3 is a critical component of the GABA_A receptor complex, which is the primary target of the inhibitory neurotransmitter GABA. The binding of GABA to GABA_A receptors triggers a conformational change, leading to the opening of chloride channels and a subsequent hyperpolarization of the neuronal membrane. 2. **Chloride channel activity:** GABRR3 contributes to the assembly and function of GABA_A receptors, which are ligand-gated chloride channels responsible for regulating neuronal excitability and synaptic transmission. 3. **Chloride transmembrane transport:** GABRR3 is involved in the regulation of chloride ion transport across the plasma membrane, which is essential for maintaining the resting membrane potential and regulating neuronal excitability. 4. **Regulation of membrane potential:** GABRR3 plays a role in regulating the resting membrane potential and excitability of neurons, which is critical for maintaining proper neuronal function and preventing excessive neuronal activity. **Clinical Significance:** 1. **Neurological disorders:** Alterations in GABRR3 expression or function have been implicated in various neurological disorders, including epilepsy, anxiety disorders, and schizophrenia. 2. **Neuropsychiatric disorders:** The dysregulation of GABAergic signaling, mediated by GABRR3, has been linked to neuropsychiatric disorders, such as depression, anxiety, and bipolar disorder. 3. **Cancer and inflammation:** GABRR3 expression has been found to be altered in various types of cancer and inflammatory disorders, suggesting a potential role in cancer progression and inflammation. 4. **Therapeutic applications:** Targeting GABRR3 and GABA_A receptors has been proposed as a potential therapeutic strategy for various neurological and neuropsychiatric disorders, including epilepsy, anxiety disorders, and schizophrenia. In conclusion, GABRR3 is a critical component of the GABA_A receptor complex, playing a pivotal role in regulating neuronal excitability and synaptic transmission. Its widespread expression across various cell types and involvement in multiple signaling pathways underscore its importance in maintaining proper neuronal function and preventing excessive neuronal activity. Further research is needed to fully elucidate the function and clinical significance of GABRR3, with potential therapeutic applications in various neurological and neuropsychiatric disorders.

Genular Protein ID: 4042344319

Symbol: GBRR3_HUMAN

Name: Gamma-aminobutyric acid receptor subunit rho-3

UniProtKB Accession Codes:

A8MPY1 Q9UIV9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 2 Ensembl 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMR 1 STRING 1 SUPFAM 2 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 10542332

Title: Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3.

PubMed ID: 10542332

DOI: 10.1016/s0167-4781(99)00167-0

Sequence Information:

  • Length: 467
  • Mass: 54272
  • Checksum: A374DCA1CF6079C6
  • Sequence:
    • MVLAFQLVSF TYIWIILKPN VCAASNIKMT HQRCSSSMKQ TCKQETRMKK DDSTKARPQK 
YEQLLHIEDN DFAMRPGFGG SPVPVGIDVH VESIDSISET NMDFTMTFYL RHYWKDERLS 
FPSTANKSMT FDHRLTRKIW VPDIFFVHSK RSFIHDTTME NIMLRVHPDG NVLLSLRITV 
SAMCFMDFSR FPLDTQNCSL ELESYAYNED DLMLYWKHGN KSLNTEEHMS LSQFFIEDFS 
ASSGLAFYSS TGWYNRLFIN FVLRRHVFFF VLQTYFPAIL MVMLSWVSFW IDRRAVPARV 
SLGITTVLTM STIITAVSAS MPQVSYLKAV DVYLWVSSLF VFLSVIEYAA VNYLTTVEER 
KQFKKTGKIS RMYNIDAVQA MAFDGCYHDS EIDMDQTSLS LNSEDFMRRK SICSPSTDSS 
RIKRRKSLGG HVGRIILENN HVIDTYSRIL FPIVYILFNL FYWGVYV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.