Details for: MARK2

Gene ID: 2011

Symbol: MARK2

Ensembl ID: ENSG00000072518

Description: microtubule affinity regulating kinase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 245.7163
    Cell Significance Index: -38.2200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 148.9690
    Cell Significance Index: -37.7900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 84.6390
    Cell Significance Index: -39.9600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 80.6140
    Cell Significance Index: -32.7500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 72.8637
    Cell Significance Index: -37.4800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 34.8157
    Cell Significance Index: -33.2400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.5786
    Cell Significance Index: -38.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.8678
    Cell Significance Index: -37.1500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.4213
    Cell Significance Index: -35.0800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.2532
    Cell Significance Index: -22.4400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.0049
    Cell Significance Index: -39.4800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 4.5665
    Cell Significance Index: 75.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.1648
    Cell Significance Index: 43.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8905
    Cell Significance Index: 379.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4111
    Cell Significance Index: 1274.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.4071
    Cell Significance Index: 36.1700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3166
    Cell Significance Index: 79.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.3089
    Cell Significance Index: 36.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1695
    Cell Significance Index: 89.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0131
    Cell Significance Index: 164.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0129
    Cell Significance Index: 27.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.0113
    Cell Significance Index: 44.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9768
    Cell Significance Index: 350.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.9109
    Cell Significance Index: 34.5000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8749
    Cell Significance Index: 45.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8466
    Cell Significance Index: 43.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8205
    Cell Significance Index: 162.8300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7075
    Cell Significance Index: 6.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6983
    Cell Significance Index: 20.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6869
    Cell Significance Index: 123.8200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6376
    Cell Significance Index: 440.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5909
    Cell Significance Index: 72.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4289
    Cell Significance Index: 28.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4155
    Cell Significance Index: 18.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3595
    Cell Significance Index: 16.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3487
    Cell Significance Index: 190.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3168
    Cell Significance Index: 14.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2830
    Cell Significance Index: 15.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2527
    Cell Significance Index: 111.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1957
    Cell Significance Index: 6.8800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1637
    Cell Significance Index: 3.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1625
    Cell Significance Index: 306.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1188
    Cell Significance Index: 11.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0989
    Cell Significance Index: 6.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0783
    Cell Significance Index: 4.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0527
    Cell Significance Index: 7.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0376
    Cell Significance Index: 57.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0357
    Cell Significance Index: 22.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0315
    Cell Significance Index: 4.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0292
    Cell Significance Index: 5.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0258
    Cell Significance Index: 11.7000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0199
    Cell Significance Index: 27.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0114
    Cell Significance Index: 20.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0083
    Cell Significance Index: -0.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0099
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0136
    Cell Significance Index: -2.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0261
    Cell Significance Index: -19.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0361
    Cell Significance Index: -2.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0377
    Cell Significance Index: -27.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0394
    Cell Significance Index: -29.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0433
    Cell Significance Index: -6.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0600
    Cell Significance Index: -7.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0648
    Cell Significance Index: -36.5600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0732
    Cell Significance Index: -45.7200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0803
    Cell Significance Index: -1.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0962
    Cell Significance Index: -9.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1182
    Cell Significance Index: -34.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1454
    Cell Significance Index: -10.2800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1559
    Cell Significance Index: -4.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1723
    Cell Significance Index: -22.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1989
    Cell Significance Index: -23.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2064
    Cell Significance Index: -43.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2417
    Cell Significance Index: -27.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2507
    Cell Significance Index: -26.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2788
    Cell Significance Index: -6.0400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3000
    Cell Significance Index: -6.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3150
    Cell Significance Index: -19.8600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3346
    Cell Significance Index: -4.9400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3794
    Cell Significance Index: -7.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4061
    Cell Significance Index: -32.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4064
    Cell Significance Index: -10.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4228
    Cell Significance Index: -22.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4551
    Cell Significance Index: -27.9000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5027
    Cell Significance Index: -14.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5176
    Cell Significance Index: -16.5800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5220
    Cell Significance Index: -12.5200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5516
    Cell Significance Index: -5.7100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5551
    Cell Significance Index: -10.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5919
    Cell Significance Index: -20.5700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6260
    Cell Significance Index: -15.2800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6454
    Cell Significance Index: -20.5600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.6454
    Cell Significance Index: -9.1900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6767
    Cell Significance Index: -22.1600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6837
    Cell Significance Index: -14.5100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.7444
    Cell Significance Index: -10.6600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7761
    Cell Significance Index: -17.9300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7967
    Cell Significance Index: -15.5500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8173
    Cell Significance Index: -28.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8337
    Cell Significance Index: -24.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8504
    Cell Significance Index: -21.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MARK2 is a serine/threonine kinase that belongs to the MARK (Microtubule Affinity Regulating Kinase) family of kinases. The gene is characterized by its ability to regulate microtubule binding and organization, which is essential for maintaining cellular structure and function. MARK2 also exhibits autophosphorylation activity, which is a key mechanism for activating protein kinase activity. Additionally, MARK2 interacts with various proteins, including tau protein, and regulates their activity. **Pathways and Functions** MARK2 is involved in multiple cellular pathways, including: 1. **Cytoskeleton organization**: MARK2 regulates microtubule binding and organization, which is essential for maintaining cellular structure and function. 2. **Cell polarity**: MARK2 regulates the establishment and maintenance of cell polarity, which is critical for cellular differentiation and migration. 3. **Axon development**: MARK2 plays a crucial role in regulating axonogenesis, the process by which axons develop and extend from neurons. 4. **Wnt signaling pathway**: MARK2 is involved in the Wnt signaling pathway, which is a key regulator of cellular development and differentiation. 5. **Autophagy of mitochondrion**: MARK2 regulates autophagy of mitochondrion, a process by which cells recycle damaged or dysfunctional mitochondria. **Clinical Significance** MARK2's involvement in various cellular processes makes it a potential target for therapeutic intervention in several diseases, including: 1. **Neurodegenerative diseases**: MARK2's role in regulating axon development and maintaining cellular structure suggests its potential involvement in neurodegenerative diseases, such as Alzheimer's and Parkinson's. 2. **Cancer**: MARK2's involvement in cell polarity and autophagy of mitochondrion suggests its potential role in cancer development and progression. 3. **Neuropathic pain**: MARK2's role in regulating axon development and maintaining cellular structure suggests its potential involvement in neuropathic pain. In conclusion, MARK2 is a serine/threonine kinase gene that plays a crucial role in regulating various cellular processes, including cytoskeleton organization, cell polarity, and axon development. Its involvement in multiple biological pathways and its potential role in several diseases make it an important target for further research and therapeutic intervention.

Genular Protein ID: 322926651

Symbol: MARK2_HUMAN

Name: Serine/threonine-protein kinase MARK2

UniProtKB Accession Codes:

Q7KZI7 Q15449 Q15524 Q5XGA3 Q68A18 Q96HB3 Q96RG0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 3 CORUM 1 CPTAC 2 CTD 1 ChEBI 23 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 6 EMBL 8 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 39 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 2 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 16 Pumba 1 RNAct 1 RefSeq 5 Rhea 12 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9730619

Title: Human serine/threonine protein kinase EMK1: genome structure and cDNA cloning of isoforms produced by alternative splicing.

PubMed ID: 9730619

DOI: 10.1159/000015046

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11433294

Title: PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.

PubMed ID: 11433294

DOI: 10.1038/35083016

PubMed ID: 8274451

Title: Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.

PubMed ID: 8274451

PubMed ID: 12429843

Title: Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity.

PubMed ID: 12429843

DOI: 10.1091/mbc.02-03-0046

PubMed ID: 15158914

Title: Splicing alterations in human renal allografts: detection of a new splice variant of protein kinase Par1/Emk1 whose expression is associated with an increase of inflammation in protocol biopsies of transplanted patients.

PubMed ID: 15158914

DOI: 10.1016/j.bbadis.2004.01.008

PubMed ID: 14976552

Title: LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.

PubMed ID: 14976552

DOI: 10.1038/sj.emboj.7600110

PubMed ID: 15365179

Title: Par-1 promotes a hepatic mode of apical protein trafficking in MDCK cells.

PubMed ID: 15365179

DOI: 10.1073/pnas.0403684101

PubMed ID: 15084291

Title: Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity.

PubMed ID: 15084291

DOI: 10.1016/j.cub.2004.04.007

PubMed ID: 15324659

Title: aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity.

PubMed ID: 15324659

DOI: 10.1016/j.cub.2004.08.021

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16775013

Title: MARK2/EMK1/Par-1Balpha phosphorylation of Rab11-family interacting protein 2 is necessary for the timely establishment of polarity in Madin-Darby canine kidney cells.

PubMed ID: 16775013

DOI: 10.1091/mbc.e05-08-0736

PubMed ID: 16980613

Title: New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases.

PubMed ID: 16980613

DOI: 10.1128/mcb.00231-06

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17507984

Title: Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity.

PubMed ID: 17507984

DOI: 10.1038/nature05765

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18626018

Title: Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2.

PubMed ID: 18626018

DOI: 10.1073/pnas.0800796105

PubMed ID: 16396636

Title: The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation.

PubMed ID: 16396636

DOI: 10.1042/bj20051844

PubMed ID: 16959763

Title: Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.

PubMed ID: 16959763

DOI: 10.1074/mcp.m600147-mcp200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20194617

Title: Par1b/MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation.

PubMed ID: 20194617

DOI: 10.1128/mcb.01181-09

PubMed ID: 19559622

Title: The tau of MARK: a polarized view of the cytoskeleton.

PubMed ID: 19559622

DOI: 10.1016/j.tibs.2009.03.008

PubMed ID: 20071654

Title: Structure and function of polarity-inducing kinase family MARK/Par-1 within the branch of AMPK/Snf1-related kinases.

PubMed ID: 20071654

DOI: 10.1096/fj.09-148064

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23902687

Title: The novel PAR-1-binding protein MTCL1 has crucial roles in organizing microtubules in polarizing epithelial cells.

PubMed ID: 23902687

DOI: 10.1242/jcs.127845

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23666762

Title: Role of individual MARK isoforms in phosphorylation of tau at Ser262 in Alzheimer's disease.

PubMed ID: 23666762

DOI: 10.1007/s12017-013-8232-3

PubMed ID: 19966800

Title: Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates.

PubMed ID: 19966800

DOI: 10.1038/nsmb.1705

Sequence Information:

  • Length: 788
  • Mass: 87911
  • Checksum: F307BF4DDB543A70
  • Sequence:
    • MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI GNYRLLKTIG 
KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE VRIMKVLNHP NIVKLFEVIE 
TEKTLYLVME YASGGEVFDY LVAHGRMKEK EARAKFRQIV SAVQYCHQKF IVHRDLKAEN 
LLLDADMNIK IADFGFSNEF TFGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL 
YTLVSGSLPF DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK 
DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR YNEVMATYLL 
LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS ANPKQRRFSD QAAGPAIPTS 
NSYSKKTQSN NAENKRPEED RESGRKASST AKVPASPLPG LERKKTTPTP STNSVLSTST 
NRSRNSPLLE RASLGQASIQ NGKDSLTMPG SRASTASASA AVSAARPRQH QKSMSASVHP 
NKASGLPPTE SNCEVPRPST APQRVPVASP SAHNISSSGG APDRTNFPRG VSSRSTFHAG 
QLRQVRDQQN LPYGVTPASP SGHSQGRRGA SGSIFSKFTS KFVRRNLSFR FARRNLNEPE 
SKDRVETLRP HVVGSGGNDK EKEEFREAKP RSLRFTWSMK TTSSMEPNEM MREIRKVLDA 
NSCQSELHEK YMLLCMHGTP GHEDFVQWEM EVCKLPRLSL NGVRFKRISG TSMAFKNIAS 
KIANELKL

Genular Protein ID: 3583630776

Symbol: A8K2S4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K2S4

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 11 DNASU 1 DisGeNET 1 EC 2 EMBL 2 GO 8 Gene3D 3 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 8 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 Rhea 6 SAM 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 745
  • Mass: 83067
  • Checksum: 6442011D46D4469E
  • Sequence:
    • MIRGRNSATS ADEQPHIGNY RLLKTIGKGN FAKVKLARHI LTGKEVAVKI IDKTQLNSSS 
LQKLFREVRM MKVLNHPNIV KLFEVIETEK TLYLVMEYAS GGEVFDYLVA HGRMKEKEAR 
AKFRQIVSAV QYCHQKFIVH RDLKAENLLL DADMNIKIAD FGLSNEFTFG NKLDTFCGSP 
PYAAPELFQG KKYDGPEVDV WSLGVILYTL VSGSLPFDGQ NLKELRERVL RGKYRIPFYM 
STDCENLLKK FLILNPSKRG TLEQIMKDRW MNVGHEDDEL KPYVEPLPDY KDPRRTELMV 
SMGYTREEIQ DSLVGQRYNE VMATYLLLGY KSSELEGDTI TLKPRPSADL TNSSAPSPSH 
KVQRSVSANP KQRRFSDQAG PAIPTSNSYS KKTQSNNAEN KRPEEDRESG RKASSTAKVP 
ASPLPGLERK KTTPTPSTNS VLSTSTNRSR NSPLLERASL GQASIQNGKD SLTMPGSRAS 
TASASAAVSA ARPRQHQKSM SASVHPNKAS GLPPTESNCE VPRPSTAPQR VPVASPSAHN 
ISSSGGAPDR TNFPRGVSGR STFHAGQLRQ VRDQQNLPYG VTPASPSGHS QGRRGASGSI 
FSKFTSKFVR RNLNEPESKD RVETLRPHVV GSGGNDKEKE EFREAKPRSL RFTWSMKTTS 
SMEPNEMMRE IRKVLDANSC QSELHEKYML LCMHGTPGHE DFVQWEMEVC KLPRLSLNGV 
RFKRISGTSM AFKNIASKIA NELKL

Genular Protein ID: 624916554

Symbol: A0A140VJP1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A140VJP1

Database IDs:

ARBA 8 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 11 DNASU 1 DisGeNET 1 EC 2 EMBL 2 ExpressionAtlas 1 GO 8 Gene3D 3 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 8 PROSITE-ProRule 1 Pfam 3 RefSeq 1 Rhea 6 SAM 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Sequence Information:

  • Length: 719
  • Mass: 80647
  • Checksum: EC39154CF73E9858
  • Sequence:
    • MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI GNYRLLKTIG 
KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE VRIMKVLNHP NIVKLFEVIE 
TEKTLYLVME YASGGEVFDY LVAHGRMKEK EARAKFRQIV SAVQYCHQKF IVHRDLKAEN 
LLLDADMNIK IADFGFSNEF TFGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL 
YTLVSGSLPF DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK 
DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR YNEVMATYLL 
LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS ANPKQRRFSD QAAGPAIPTS 
NSYSKKTQSN NAENKRPEED RESGRKASST AKVPASPLPG LERKKTTPTP STNSVLSTST 
NRSRNSPLLE RASLGQASIQ NGKDSTAPQR VPVASPSAHN ISSSGGAPDR TNFPRGVSSR 
STFHAGQLRQ VRDQQNLPYG VTPASPSGHS QGRRGASGSI FSKFTSKFVR RNLSFRFARR 
PHVVGSGGND KEKEEFREAK PRSLRFTWSM KTTSSMEPNE MMREIRKVLD ANSCQSELHE 
KYMLLCMHGT PGHEDFVQWE MEVCKLPRLS LNGVRFKRIS GTSMAFKNIA SKIANELKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.