Details for: MARK2
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.76
Marker Score: 1857 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.7
Marker Score: 104447 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.67
Marker Score: 1846 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.65
Marker Score: 15540 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.62
Marker Score: 15353 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.61
Marker Score: 13818 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.56
Marker Score: 6021 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.54
Marker Score: 1332 - Cell Name: neuron (CL0000540)
Fold Change: 1.52
Marker Score: 6195 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.51
Marker Score: 57496 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.49
Marker Score: 6240 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.48
Marker Score: 11353 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.48
Marker Score: 22094 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.47
Marker Score: 54110 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.41
Marker Score: 30135 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.4
Marker Score: 27897 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.38
Marker Score: 2136 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.37
Marker Score: 14148 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.36
Marker Score: 1998 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.33
Marker Score: 429 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.32
Marker Score: 29608 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.29
Marker Score: 5353 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.28
Marker Score: 1453 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.25
Marker Score: 2951 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.21
Marker Score: 18866 - Cell Name: endocrine cell (CL0000163)
Fold Change: 1.2
Marker Score: 619 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 1.19
Marker Score: 590 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.18
Marker Score: 1275 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.18
Marker Score: 1358 - Cell Name: acinar cell (CL0000622)
Fold Change: 1.17
Marker Score: 828 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.17
Marker Score: 578 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.16
Marker Score: 2648 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1.11
Marker Score: 352 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.11
Marker Score: 1157 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.11
Marker Score: 1344 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.11
Marker Score: 347 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.08
Marker Score: 651 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.08
Marker Score: 9489 - Cell Name: keratinocyte (CL0000312)
Fold Change: 1.08
Marker Score: 899 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.07
Marker Score: 2345 - Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.06
Marker Score: 3331 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.06
Marker Score: 2149 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 1.05
Marker Score: 862 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.03
Marker Score: 1825 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.03
Marker Score: 714 - Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 1.02
Marker Score: 440 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.02
Marker Score: 596 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 1
Marker Score: 4157 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71659 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47884 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30385 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.97
Marker Score: 664 - Cell Name: basal cell (CL0000646)
Fold Change: 0.97
Marker Score: 1249 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.97
Marker Score: 2041.5 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.96
Marker Score: 465 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.95
Marker Score: 277 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.95
Marker Score: 4377 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.94
Marker Score: 564 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.94
Marker Score: 631 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2394 - Cell Name: renal principal cell (CL0005009)
Fold Change: 0.94
Marker Score: 725 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.93
Marker Score: 1790 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.93
Marker Score: 479 - Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.93
Marker Score: 267 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.93
Marker Score: 1310 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.92
Marker Score: 435 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.91
Marker Score: 480 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.91
Marker Score: 1479 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.91
Marker Score: 424 - Cell Name: mesangial cell (CL0000650)
Fold Change: 0.9
Marker Score: 1092 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2696 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.9
Marker Score: 895.5 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.89
Marker Score: 5090 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.89
Marker Score: 256 - Cell Name: enterocyte (CL0000584)
Fold Change: 0.88
Marker Score: 4207 - Cell Name: podocyte (CL0000653)
Fold Change: 0.88
Marker Score: 324 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.88
Marker Score: 888 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.87
Marker Score: 1057 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5293 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.87
Marker Score: 2088 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.87
Marker Score: 325 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.86
Marker Score: 312 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.86
Marker Score: 501 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.86
Marker Score: 2440 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.85
Marker Score: 307 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.85
Marker Score: 782 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.85
Marker Score: 495 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.85
Marker Score: 735 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.84
Marker Score: 47194 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.84
Marker Score: 350 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.83
Marker Score: 7191 - Cell Name: ciliated cell (CL0000064)
Fold Change: 0.83
Marker Score: 2868 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.83
Marker Score: 3077 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.83
Marker Score: 5291 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.82
Marker Score: 2063 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.82
Marker Score: 27793 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.81
Marker Score: 2024 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.81
Marker Score: 6322 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.8
Marker Score: 4826 - Cell Name: club cell (CL0000158)
Fold Change: 0.8
Marker Score: 934
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Other Information
Genular Protein ID: 322926651
Symbol: MARK2_HUMAN
Name: Serine/threonine-protein kinase MARK2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9730619
Title: Human serine/threonine protein kinase EMK1: genome structure and cDNA cloning of isoforms produced by alternative splicing.
PubMed ID: 9730619
DOI: 10.1159/000015046
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11433294
Title: PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
PubMed ID: 11433294
DOI: 10.1038/35083016
PubMed ID: 8274451
Title: Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.
PubMed ID: 8274451
PubMed ID: 12429843
Title: Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity.
PubMed ID: 12429843
PubMed ID: 15158914
Title: Splicing alterations in human renal allografts: detection of a new splice variant of protein kinase Par1/Emk1 whose expression is associated with an increase of inflammation in protocol biopsies of transplanted patients.
PubMed ID: 15158914
PubMed ID: 14976552
Title: LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.
PubMed ID: 14976552
PubMed ID: 15365179
Title: Par-1 promotes a hepatic mode of apical protein trafficking in MDCK cells.
PubMed ID: 15365179
PubMed ID: 15084291
Title: Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity.
PubMed ID: 15084291
PubMed ID: 15324659
Title: aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity.
PubMed ID: 15324659
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16775013
Title: MARK2/EMK1/Par-1Balpha phosphorylation of Rab11-family interacting protein 2 is necessary for the timely establishment of polarity in Madin-Darby canine kidney cells.
PubMed ID: 16775013
PubMed ID: 16980613
Title: New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases.
PubMed ID: 16980613
DOI: 10.1128/mcb.00231-06
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 17507984
Title: Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity.
PubMed ID: 17507984
DOI: 10.1038/nature05765
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18088087
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18626018
Title: Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2.
PubMed ID: 18626018
PubMed ID: 16396636
Title: The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation.
PubMed ID: 16396636
DOI: 10.1042/bj20051844
PubMed ID: 16959763
Title: Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.
PubMed ID: 16959763
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 20194617
Title: Par1b/MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation.
PubMed ID: 20194617
DOI: 10.1128/mcb.01181-09
PubMed ID: 19559622
Title: The tau of MARK: a polarized view of the cytoskeleton.
PubMed ID: 19559622
PubMed ID: 20071654
Title: Structure and function of polarity-inducing kinase family MARK/Par-1 within the branch of AMPK/Snf1-related kinases.
PubMed ID: 20071654
DOI: 10.1096/fj.09-148064
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23902687
Title: The novel PAR-1-binding protein MTCL1 has crucial roles in organizing microtubules in polarizing epithelial cells.
PubMed ID: 23902687
DOI: 10.1242/jcs.127845
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23666762
Title: Role of individual MARK isoforms in phosphorylation of tau at Ser262 in Alzheimer's disease.
PubMed ID: 23666762
PubMed ID: 19966800
Title: Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates.
PubMed ID: 19966800
DOI: 10.1038/nsmb.1705
Sequence Information:
- Length: 788
- Mass: 87911
- Checksum: F307BF4DDB543A70
- Sequence:
MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI GNYRLLKTIG KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE VRIMKVLNHP NIVKLFEVIE TEKTLYLVME YASGGEVFDY LVAHGRMKEK EARAKFRQIV SAVQYCHQKF IVHRDLKAEN LLLDADMNIK IADFGFSNEF TFGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL YTLVSGSLPF DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR YNEVMATYLL LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS ANPKQRRFSD QAAGPAIPTS NSYSKKTQSN NAENKRPEED RESGRKASST AKVPASPLPG LERKKTTPTP STNSVLSTST NRSRNSPLLE RASLGQASIQ NGKDSLTMPG SRASTASASA AVSAARPRQH QKSMSASVHP NKASGLPPTE SNCEVPRPST APQRVPVASP SAHNISSSGG APDRTNFPRG VSSRSTFHAG QLRQVRDQQN LPYGVTPASP SGHSQGRRGA SGSIFSKFTS KFVRRNLSFR FARRNLNEPE SKDRVETLRP HVVGSGGNDK EKEEFREAKP RSLRFTWSMK TTSSMEPNEM MREIRKVLDA NSCQSELHEK YMLLCMHGTP GHEDFVQWEM EVCKLPRLSL NGVRFKRISG TSMAFKNIAS KIANELKL
Genular Protein ID: 3583630776
Symbol: A8K2S4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 745
- Mass: 83067
- Checksum: 6442011D46D4469E
- Sequence:
MIRGRNSATS ADEQPHIGNY RLLKTIGKGN FAKVKLARHI LTGKEVAVKI IDKTQLNSSS LQKLFREVRM MKVLNHPNIV KLFEVIETEK TLYLVMEYAS GGEVFDYLVA HGRMKEKEAR AKFRQIVSAV QYCHQKFIVH RDLKAENLLL DADMNIKIAD FGLSNEFTFG NKLDTFCGSP PYAAPELFQG KKYDGPEVDV WSLGVILYTL VSGSLPFDGQ NLKELRERVL RGKYRIPFYM STDCENLLKK FLILNPSKRG TLEQIMKDRW MNVGHEDDEL KPYVEPLPDY KDPRRTELMV SMGYTREEIQ DSLVGQRYNE VMATYLLLGY KSSELEGDTI TLKPRPSADL TNSSAPSPSH KVQRSVSANP KQRRFSDQAG PAIPTSNSYS KKTQSNNAEN KRPEEDRESG RKASSTAKVP ASPLPGLERK KTTPTPSTNS VLSTSTNRSR NSPLLERASL GQASIQNGKD SLTMPGSRAS TASASAAVSA ARPRQHQKSM SASVHPNKAS GLPPTESNCE VPRPSTAPQR VPVASPSAHN ISSSGGAPDR TNFPRGVSGR STFHAGQLRQ VRDQQNLPYG VTPASPSGHS QGRRGASGSI FSKFTSKFVR RNLNEPESKD RVETLRPHVV GSGGNDKEKE EFREAKPRSL RFTWSMKTTS SMEPNEMMRE IRKVLDANSC QSELHEKYML LCMHGTPGHE DFVQWEMEVC KLPRLSLNGV RFKRISGTSM AFKNIASKIA NELKL
Genular Protein ID: 624916554
Symbol: A0A140VJP1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 719
- Mass: 80647
- Checksum: EC39154CF73E9858
- Sequence:
MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI GNYRLLKTIG KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE VRIMKVLNHP NIVKLFEVIE TEKTLYLVME YASGGEVFDY LVAHGRMKEK EARAKFRQIV SAVQYCHQKF IVHRDLKAEN LLLDADMNIK IADFGFSNEF TFGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL YTLVSGSLPF DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR YNEVMATYLL LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS ANPKQRRFSD QAAGPAIPTS NSYSKKTQSN NAENKRPEED RESGRKASST AKVPASPLPG LERKKTTPTP STNSVLSTST NRSRNSPLLE RASLGQASIQ NGKDSTAPQR VPVASPSAHN ISSSGGAPDR TNFPRGVSSR STFHAGQLRQ VRDQQNLPYG VTPASPSGHS QGRRGASGSI FSKFTSKFVR RNLSFRFARR PHVVGSGGND KEKEEFREAK PRSLRFTWSM KTTSSMEPNE MMREIRKVLD ANSCQSELHE KYMLLCMHGT PGHEDFVQWE MEVCKLPRLS LNGVRFKRIS GTSMAFKNIA SKIANELKL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.