Details for: EPB41L2

Gene ID: 2037

Symbol: EPB41L2

Ensembl ID: ENSG00000079819

Description: erythrocyte membrane protein band 4.1 like 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 579.9599
    Cell Significance Index: -90.2100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 353.6067
    Cell Significance Index: -89.6900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 187.4301
    Cell Significance Index: -88.4900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 179.0155
    Cell Significance Index: -73.7500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 156.5142
    Cell Significance Index: -63.5900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 73.3765
    Cell Significance Index: -90.4700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 66.6986
    Cell Significance Index: -63.6800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 31.6478
    Cell Significance Index: -84.7800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 28.7160
    Cell Significance Index: -88.2000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 23.1130
    Cell Significance Index: -91.2100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.5156
    Cell Significance Index: -29.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 6.8586
    Cell Significance Index: 133.8600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 5.2832
    Cell Significance Index: 122.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 5.0300
    Cell Significance Index: 222.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 4.8732
    Cell Significance Index: 307.1400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 4.7307
    Cell Significance Index: 179.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.3952
    Cell Significance Index: 190.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.6269
    Cell Significance Index: 526.9500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.5114
    Cell Significance Index: 36.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.9548
    Cell Significance Index: 131.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.7680
    Cell Significance Index: 1122.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5449
    Cell Significance Index: 306.6000
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.5020
    Cell Significance Index: 21.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.1680
    Cell Significance Index: 1798.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.0662
    Cell Significance Index: 1449.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0182
    Cell Significance Index: 139.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.8745
    Cell Significance Index: 1612.7300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5728
    Cell Significance Index: 396.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5708
    Cell Significance Index: 62.0900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.5334
    Cell Significance Index: 7.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4683
    Cell Significance Index: 167.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4359
    Cell Significance Index: 238.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3840
    Cell Significance Index: 9.6000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3460
    Cell Significance Index: 20.7700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2579
    Cell Significance Index: 485.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2417
    Cell Significance Index: 30.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2387
    Cell Significance Index: 6.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2078
    Cell Significance Index: 94.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1813
    Cell Significance Index: 32.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1510
    Cell Significance Index: 14.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1035
    Cell Significance Index: 12.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0777
    Cell Significance Index: 70.1300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0612
    Cell Significance Index: 0.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0607
    Cell Significance Index: 26.8300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0513
    Cell Significance Index: 2.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0498
    Cell Significance Index: 8.1000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0133
    Cell Significance Index: 2.5300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0099
    Cell Significance Index: -0.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0941
    Cell Significance Index: -68.9600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1255
    Cell Significance Index: -95.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1302
    Cell Significance Index: -96.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1592
    Cell Significance Index: -99.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1640
    Cell Significance Index: -92.5000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2377
    Cell Significance Index: -12.0100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2408
    Cell Significance Index: -4.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2662
    Cell Significance Index: -76.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2719
    Cell Significance Index: -39.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2786
    Cell Significance Index: -32.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3552
    Cell Significance Index: -16.1000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3890
    Cell Significance Index: -11.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.4595
    Cell Significance Index: -78.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.4604
    Cell Significance Index: -47.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4675
    Cell Significance Index: -98.4700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4900
    Cell Significance Index: -57.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.5005
    Cell Significance Index: -64.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5629
    Cell Significance Index: -34.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.5790
    Cell Significance Index: -40.0400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.6148
    Cell Significance Index: -4.7300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6190
    Cell Significance Index: -16.5900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6318
    Cell Significance Index: -18.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6548
    Cell Significance Index: -75.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6722
    Cell Significance Index: -43.3700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.6748
    Cell Significance Index: -23.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7232
    Cell Significance Index: -37.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7633
    Cell Significance Index: -79.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7679
    Cell Significance Index: -47.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.8061
    Cell Significance Index: -37.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8257
    Cell Significance Index: -63.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9141
    Cell Significance Index: -72.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.9971
    Cell Significance Index: -74.3200
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -1.0609
    Cell Significance Index: -16.1400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -1.1246
    Cell Significance Index: -15.9800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.1246
    Cell Significance Index: -23.9500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.1370
    Cell Significance Index: -80.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2286
    Cell Significance Index: -39.3500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.3874
    Cell Significance Index: -8.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.3970
    Cell Significance Index: -72.5700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.4019
    Cell Significance Index: -27.7200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.4600
    Cell Significance Index: -46.5000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.4941
    Cell Significance Index: -51.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.5453
    Cell Significance Index: -72.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.7410
    Cell Significance Index: -45.7800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.7638
    Cell Significance Index: -61.7900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -1.8606
    Cell Significance Index: -29.8500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.8815
    Cell Significance Index: -59.5100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.9387
    Cell Significance Index: -40.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.9428
    Cell Significance Index: -42.0900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.9523
    Cell Significance Index: -63.9200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -2.0141
    Cell Significance Index: -41.7800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -2.0286
    Cell Significance Index: -48.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EPB41L2 is a band 4.1-like protein, a subfamily of proteins known for their involvement in cytoskeletal organization, cell junction formation, and signal transduction. This protein is predominantly expressed in cells of the nervous system, including photoreceptor cells, cardiac neurons, and oligodendrocytes. Its unique structure, comprising multiple domains and interactions with other proteins, enables it to participate in various cellular processes. **Pathways and Functions:** EPB41L2 is implicated in several signaling pathways, including: 1. **Actin binding and cytoskeleton organization**: EPB41L2 interacts with actin-binding proteins, such as spectrin, to regulate cytoskeletal dynamics, cell shape, and motility. 2. **Cell cycle and cell division**: This protein is involved in the regulation of cell cycle progression, particularly during mitosis, by interacting with cytoskeletal components and signaling molecules. 3. **Neural system and synaptic function**: EPB41L2 is expressed in photoreceptor cells and neurons, where it contributes to the organization of the cytoskeleton and the regulation of synaptic transmission. 4. **Immune response and phagocytosis**: EPB41L2 is also expressed in microglial cells, where it may play a role in the regulation of immune responses and phagocytic activity. **Clinical Significance:** Dysregulation of EPB41L2 has been implicated in various diseases, including: 1. **Retinal degeneration**: Mutations in EPB41L2 have been associated with retinal degeneration, highlighting the protein's importance in photoreceptor cell function and survival. 2. **Neurodegenerative disorders**: EPB41L2 has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's, where it may contribute to the disruption of cytoskeletal organization and synaptic function. 3. **Immune system disorders**: Abnormal expression of EPB41L2 in microglial cells may contribute to the pathogenesis of autoimmune diseases, such as multiple sclerosis. In conclusion, EPB41L2 is a complex protein with far-reaching implications in various cellular processes, including cytoskeleton organization, cell cycle regulation, and immune response. Further research is necessary to fully elucidate the mechanisms underlying its function and the clinical significance of its dysregulation in human diseases.

Genular Protein ID: 1209773227

Symbol: E41L2_HUMAN

Name: Band 4.1-like protein 2

UniProtKB Accession Codes:

O43491 B4DHI8 E9PPD9 Q5T4F0 Q68DV2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 3 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 7 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 11 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9598318

Title: Cloning and characterization of 4.1G (EPB41L2), a new member of the skeletal protein 4.1 (EPB41) gene family.

PubMed ID: 9598318

DOI: 10.1006/geno.1998.5265

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 16254212

Title: Activation of the endothelial store-operated ISOC Ca2+ channel requires interaction of protein 4.1 with TRPC4.

PubMed ID: 16254212

DOI: 10.1161/01.res.0000193597.65217.00

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18023480

Title: Protein 4.1G binds to a unique motif within the FcgammaRI cytoplasmic tail.

PubMed ID: 18023480

DOI: 10.1016/j.molimm.2007.10.024

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22361696

Title: Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy.

PubMed ID: 22361696

DOI: 10.1016/j.jprot.2012.01.030

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23870127

Title: Cortical dynein and asymmetric membrane elongation coordinately position the spindle in anaphase.

PubMed ID: 23870127

DOI: 10.1016/j.cell.2013.06.010

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 1005
  • Mass: 112588
  • Checksum: E86CB17488F6045F
  • Sequence:
    • MTTEVGSVSE VKKDSSQLGT DATKEKPKEV AENQQNQSSD PEEEKGSQPP PAAESQSSLR 
RQKREKETSE SRGISRFIPP WLKKQKSYTL VVAKDGGDKK EPTQAVVEEQ VLDKEEPLPE 
EQRQAKGDAE EMAQKKQEIK VEVKEEKPSV SKEEKPSVSK VEMQPTELVS KEREEKVKET 
QEDKLEGGAA KRETKEVQTN ELKAEKASQK VTKKTKTVQC KVTLLDGTEY SCDLEKHAKG 
QVLFDKVCEH LNLLEKDYFG LLFQESPEQK NWLDPAKEIK RQLRNLPWLF TFNVKFYPPD 
PSQLTEDITR YFLCLQLRQD IASGRLPCSF VTHALLGSYT LQAELGDYDP EEHGSIDLSE 
FQFAPTQTKE LEEKVAELHK THRGLSPAQA DSQFLENAKR LSMYGVDLHH AKDSEGVDIK 
LGVCANGLLI YKDRLRINRF AWPKILKISY KRSNFYIKVR PAELEQFEST IGFKLPNHRA 
AKRLWKVCVE HHTFYRLVSP EQPPKAKFLT LGSKFRYSGR TQAQTRQAST LIDRPAPHFE 
RTSSKRVSRS LDGAPIGVMD QSLMKDFPGA AGEISAYGPG LVSIAVVQDG DGRREVRSPT 
KAPHLQLIEG KKNSLRVEGD NIYVRHSNLM LEELDKAQED ILKHQASISE LKRNFMESTP 
EPRPNEWEKR RITPLSLQTQ GSSHETLNIV EEKKRAEVGK DERVITEEMN GKEISPGSGP 
GEIRKVEPVT QKDSTSLSSE SSSSSSESEE EDVGEYRPHH RVTEGTIREE QEYEEEVEEE 
PRPAAKVVER EEAVPEASPV TQAGASVITV ETVIQENVGA QKIPGEKSVH EGALKQDMGE 
EAEEEPQKVN GEVSHVDIDV LPQIICCSEP PVVKTEMVTI SDASQRTEIS TKEVPIVQTE 
TKTITYESPQ IDGGAGGDSG TLLTAQTITS ESVSTTTTTH ITKTVKGGIS ETRIEKRIVI 
TGDGDIDHDQ ALAQAIREAR EQHPDMSVTR VVVHKETELA EEGED

Genular Protein ID: 2642233263

Symbol: B4DJ76_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DJ76

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1

Sequence Information:

  • Length: 294
  • Mass: 31946
  • Checksum: 7B4281F66827CEFC
  • Sequence:
    • MDQSLMKDFP GAAGEISAYG PGLVSIAVVQ DGDGRREVRS PTKAPHLQLI EGKSSHETLN 
IVEEKKRAEV GKDERVITEE MNGKEISPGS GPGEIRKVEP VTQKDSTSLS SESSSSSSES 
EEEDVGEYRP HHRVTEGTIR EEQEYEEEVE EEPRPAAKPP VVKTEMVTIS DASQRTEIST 
KEVPIVQTET KTITYESPQI DGGAGGDSGT LLTAQTITSE SVSTTTTTHI TKTVKGGISE 
TRIEKRIVIT GDGDIDHDQA LAQAIREARE QHPDMSVTRV VVHKETELAE EGED

Genular Protein ID: 1859775122

Symbol: I6L9B1_HUMAN

Name: N/A

UniProtKB Accession Codes:

I6L9B1

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 2 InterPro 12 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 2 PROSITE 4 PeptideAtlas 1 Pfam 4 RefSeq 5 SAM 1 SMART 3 SUPFAM 3 UCSC 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.M111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.O114.044792

Sequence Information:

  • Length: 633
  • Mass: 71643
  • Checksum: 9E0DDA950B5B0E95
  • Sequence:
    • MTTEVGSVSE VKKDSSQLGT DATKEKPKEV AENQQNQSSD PEEEKGSQPP PAAESQSSLR 
RQKREKETSE SRGISRFIPP WLKKQKSYTL VVAKDGGDKK EPTQAVVEEQ VLDKEEPLPE 
EQRQAKGDAE EMAQKKQEIK VEVKEEKPSV SKEEKPSVSK VEMQPTELVS KEREEKVKET 
QEDKLEGGAA KRETKEVQTN ELKAEKASQK VTKKTKTVQC KVTLLDGTEY SCDLEKHAKG 
QVLFDKVCEH LNLLEKDYFG LLFQESPEQK NWLDPAKEIK RQLRNLPWLF TFNVKFYPPD 
PSQLTEDITR YFLCLQLRQD IASGRLPCSF VTHALLGSYT LQAELGDYDP EEHGSIDLSE 
FQFAPTQTKE LEEKVAELHK THRGLSPAQA DSQFLENAKR LSMYGVDLHH AKDSEGVDIK 
LGVCANGLLI YKDRLRINRF AWPKILKISY KRSNFYIKVR PAELEQFEST IGFKLPNHRA 
AKRLWKVCVE HHTFYRLVSP EQPPKAKFLT LGSKFRYSGR TQAQTRQAST LIDRPAPHFE 
RTSSKRVSRS LDGAPIGVMD QSLMKDFPGA AGEISAYGPG LVSIAVVQDG DGRREVRSPT 
KAPHLQLIEG KSSHETLNIV EEKSGQRLGK TKE

Genular Protein ID: 2501236292

Symbol: Q59FD8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59FD8

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 13 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 2 PROSITE 4 PeptideAtlas 1 Pfam 5 PharmGKB 1 RefSeq 1 SAM 1 SMART 3 SUPFAM 3

Sequence Information:

  • Length: 676
  • Mass: 76294
  • Checksum: ED787FDB87791B83
  • Sequence:
    • AVAMTTEVGS VSEVKKDSSQ LGTDATKEKP KEVAENQQNQ SSDPEEEKGS QPPPAAESQS 
SLRRQKREKE TSESRGISRF IPPWLKKQKS YTLVVAKDGG DKKEPTQAVV EEQVLDKEEP 
LPEEQRQAKG DAEEMAQKKQ EIKVEVKEEK PSVSKEEKPS VSKVEMQPTE LVSKEREEKV 
KETQEDKLEG GAAKRETKEV QTNELKAEKA SQKVTKKTKT VQCKVTLLDG TEYSCDLEKH 
AKGQVLFDKV CEHLNLLEKD YFGLLFQESP EQKNWLDPAK EIKRQLRNLP WLFTFNVKFY 
PPDPSQLTED ITRYFLCLQL RQDIASGRLP CSFVTHALLG SYTLQAELGD YDPEEHGSID 
LSEFQFAPTQ TKELEEKVAE LHKTHRGLSP AQADSQFLEN AKRLSMYGVD LHHAKDSEGV 
DIKLGVCANG LLIYKDRLRI NRFAWPKILK ISYKRSNFYI KVRPAELEQF ESTIGFKLPN 
HRAAKRLWKV CVEHHTFYRL VSPEQPPKAK FLTLGSKFRY SGRTQAQTRQ ASTLIDRPAP 
HFERTSSKRV SRSLDGAPIG VMDQSLMKDF PGAAGEISAY GPGLVSIAVV QDGDGRREVR 
SPTKAPHLQL IEGKTVKGGI SETRIEKRIV ITGDGDIDHD QALAQAIREA REQHPDMSVT 
RVVVHKETEL AEEGED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.