Details for: EPHA3

Gene ID: 2042

Symbol: EPHA3

Ensembl ID: ENSG00000044524

Description: EPH receptor A3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 83.2387
    Cell Significance Index: -34.2900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.8178
    Cell Significance Index: -17.1100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 2.9007
    Cell Significance Index: 41.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.6929
    Cell Significance Index: 165.5200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.5848
    Cell Significance Index: 61.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8073
    Cell Significance Index: 362.5500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.5635
    Cell Significance Index: 33.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2775
    Cell Significance Index: 458.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.2162
    Cell Significance Index: 68.2500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.8822
    Cell Significance Index: 7.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8255
    Cell Significance Index: 570.9300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4060
    Cell Significance Index: 8.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3180
    Cell Significance Index: 20.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2971
    Cell Significance Index: 11.2500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1854
    Cell Significance Index: 8.2000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0003
    Cell Significance Index: -0.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0133
    Cell Significance Index: -24.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0150
    Cell Significance Index: -28.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0164
    Cell Significance Index: -25.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0194
    Cell Significance Index: -26.3300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0253
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0259
    Cell Significance Index: -19.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0345
    Cell Significance Index: -15.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0472
    Cell Significance Index: -29.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0528
    Cell Significance Index: -40.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0541
    Cell Significance Index: -30.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0546
    Cell Significance Index: -34.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0594
    Cell Significance Index: -26.9800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0652
    Cell Significance Index: -0.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0652
    Cell Significance Index: -35.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1047
    Cell Significance Index: -30.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1192
    Cell Significance Index: -21.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1207
    Cell Significance Index: -25.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1340
    Cell Significance Index: -26.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1479
    Cell Significance Index: -25.2600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1746
    Cell Significance Index: -4.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1921
    Cell Significance Index: -27.9300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1933
    Cell Significance Index: -2.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2008
    Cell Significance Index: -24.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2461
    Cell Significance Index: -33.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2609
    Cell Significance Index: -33.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2730
    Cell Significance Index: -31.8100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2847
    Cell Significance Index: -9.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3262
    Cell Significance Index: -25.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3378
    Cell Significance Index: -34.5100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3420
    Cell Significance Index: -7.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3461
    Cell Significance Index: -39.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3633
    Cell Significance Index: -37.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4149
    Cell Significance Index: -27.9000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4413
    Cell Significance Index: -5.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4522
    Cell Significance Index: -33.7000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4553
    Cell Significance Index: -6.5200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5032
    Cell Significance Index: -10.6800
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.5243
    Cell Significance Index: -5.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5577
    Cell Significance Index: -29.0500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5997
    Cell Significance Index: -12.0400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.6110
    Cell Significance Index: -3.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6126
    Cell Significance Index: -17.1200
  • Cell Name: medial ganglionic eminence derived GABAergic cortical interneuron (CL4023069)
    Fold Change: -0.6432
    Cell Significance Index: -6.0800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6446
    Cell Significance Index: -12.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6456
    Cell Significance Index: -33.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6482
    Cell Significance Index: -33.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6636
    Cell Significance Index: -30.9400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.6669
    Cell Significance Index: -7.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6907
    Cell Significance Index: -32.4600
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.7015
    Cell Significance Index: -5.1000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.7036
    Cell Significance Index: -6.6700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7294
    Cell Significance Index: -18.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7360
    Cell Significance Index: -23.4400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.7437
    Cell Significance Index: -9.6500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7830
    Cell Significance Index: -27.4300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.7884
    Cell Significance Index: -9.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8099
    Cell Significance Index: -13.8800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.8217
    Cell Significance Index: -17.2000
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.8283
    Cell Significance Index: -7.5300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.8359
    Cell Significance Index: -13.9900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8894
    Cell Significance Index: -32.6500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.8970
    Cell Significance Index: -14.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.9278
    Cell Significance Index: -32.2400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.9367
    Cell Significance Index: -19.5500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.9391
    Cell Significance Index: -26.8000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.9454
    Cell Significance Index: -11.9300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.9746
    Cell Significance Index: -19.2700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.9911
    Cell Significance Index: -12.2900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -1.0238
    Cell Significance Index: -12.4100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -1.0243
    Cell Significance Index: -10.1400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0858
    Cell Significance Index: -31.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.0948
    Cell Significance Index: -38.4700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.1104
    Cell Significance Index: -31.8300
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -1.1157
    Cell Significance Index: -12.6700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.1262
    Cell Significance Index: -35.6200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.1323
    Cell Significance Index: -22.5800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -1.1402
    Cell Significance Index: -23.2000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.1413
    Cell Significance Index: -28.4700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -1.1463
    Cell Significance Index: -15.2800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.1660
    Cell Significance Index: -7.9000
  • Cell Name: mural cell (CL0008034)
    Fold Change: -1.1829
    Cell Significance Index: -14.4000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.2296
    Cell Significance Index: -24.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.2372
    Cell Significance Index: -16.8800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.2424
    Cell Significance Index: -31.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Receptor Tyrosine Kinase**: EPHA3 is a receptor tyrosine kinase, which means it possesses intrinsic tyrosine kinase activity and can phosphorylate tyrosine residues on its own and on downstream substrates. 2. **Ephrin Receptor**: EPHA3 is a member of the Eph family of receptors, which are characterized by their ability to interact with ephrin ligands and mediate complex signaling pathways. 3. **Cellular Localization**: EPHA3 is primarily localized to the plasma membrane, where it can interact with ephrin ligands and initiate downstream signaling cascades. 4. **Signaling Pathways**: EPHA3 is involved in various signaling pathways, including the regulation of the actin cytoskeleton, cell migration, and axon guidance. These pathways involve the activation of downstream kinases and transcription factors, leading to changes in cellular behavior and tissue development. **Pathways and Functions** 1. **Eph-ephrin Signaling**: The EPHA3 gene encodes for a receptor that interacts with ephrin ligands to initiate a signaling cascade. This cascade involves the activation of downstream kinases, including EphB4 and EphB6, which in turn regulate various cellular processes, including cell migration and axon guidance. 2. **Regulation of Actin Cytoskeleton Organization**: EPHA3 has been shown to regulate the organization of the actin cytoskeleton, which is essential for cell migration, adhesion, and shape changes. 3. **Axon Guidance**: EPHA3 plays a crucial role in axon guidance, which is the process by which axons navigate their way to their target destinations during neuronal development. 4. **Cell Migration**: EPHA3 has been implicated in cell migration, which is a critical process in tissue development, wound healing, and immune responses. 5. **Regulation of Neuron Projection Development**: EPHA3 has been shown to regulate the development of neuronal projections, including axons and dendrites. **Clinical Significance** 1. **Neurological Disorders**: Alterations in EPHA3 expression have been implicated in various neurological disorders, including autism, schizophrenia, and Alzheimer's disease. 2. **Cancer**: EPHA3 has been shown to play a role in cancer, including the development and progression of tumors. 3. **Neurodevelopmental Disorders**: EPHA3 has been implicated in neurodevelopmental disorders, including ADHD and intellectual disability. 4. **Regenerative Medicine**: EPHA3 has been identified as a potential target for regenerative medicine, including the development of therapies for tissue repair and regeneration. In conclusion, the EPHA3 gene plays a critical role in regulating various cellular processes, including cell migration, axon guidance, and the organization of the actin cytoskeleton. Its dysregulation has been implicated in various neurological and cancer-related disorders, highlighting its importance as a therapeutic target. Further research is needed to fully elucidate the mechanisms by which EPHA3 regulates cellular behavior and to explore its potential as a therapeutic target.

Genular Protein ID: 2844535648

Symbol: EPHA3_HUMAN

Name: Ephrin type-A receptor 3

UniProtKB Accession Codes:

P29320 Q9H2V3 Q9H2V4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CPTAC 3 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 3 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 28 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 20 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 28 PDBsum 28 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 9 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 2 Rhea 3 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1311845

Title: Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines.

PubMed ID: 1311845

DOI: 10.1073/pnas.89.5.1611

PubMed ID: 10987298

Title: Identification of a tumor-specific shared antigen derived from an Eph receptor and presented to CD4 T cells on HLA class II molecules.

PubMed ID: 10987298

PubMed ID: 1737782

Title: Isolation and characterization of a novel receptor-type protein tyrosine kinase (hek) from a human pre-B cell line.

PubMed ID: 1737782

DOI: 10.1016/s0021-9258(19)50725-6

PubMed ID: 9267020

Title: Unified nomenclature for Eph family receptors and their ligands, the ephrins.

PubMed ID: 9267020

DOI: 10.1016/s0092-8674(00)80500-0

PubMed ID: 11870224

Title: Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling.

PubMed ID: 11870224

DOI: 10.1242/jcs.115.5.1059

PubMed ID: 12738854

Title: Mutational analysis of the tyrosine kinome in colorectal cancers.

PubMed ID: 12738854

DOI: 10.1126/science.1082596

PubMed ID: 14660665

Title: Dissecting the EphA3/Ephrin-A5 interactions using a novel functional mutagenesis screen.

PubMed ID: 14660665

DOI: 10.1074/jbc.m309326200

PubMed ID: 16239146

Title: Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans.

PubMed ID: 16239146

DOI: 10.1016/j.cell.2005.08.014

PubMed ID: 15901737

Title: Three distinct molecular surfaces in ephrin-A5 are essential for a functional interaction with EphA3.

PubMed ID: 15901737

DOI: 10.1074/jbc.m504972200

PubMed ID: 21135139

Title: PTP1B regulates Eph receptor function and trafficking.

PubMed ID: 21135139

DOI: 10.1083/jcb.201005035

PubMed ID: 18547520

Title: Autoregulation by the juxtamembrane region of the human ephrin receptor tyrosine kinase A3 (EphA3).

PubMed ID: 18547520

DOI: 10.1016/j.str.2008.03.008

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 16941478

Title: Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers.

PubMed ID: 16941478

DOI: 10.1002/humu.9452

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 20838624

Title: Mutational profiling of kinases in human tumours of pancreatic origin identifies candidate cancer genes in ductal and ampulla of vater carcinomas.

PubMed ID: 20838624

DOI: 10.1371/journal.pone.0012653

Sequence Information:

  • Length: 983
  • Mass: 110131
  • Checksum: BE04DBF958245424
  • Sequence:
    • MDCQLSILLL LSCSVLDSFG ELIPQPSNEV NLLDSKTIQG ELGWISYPSH GWEEISGVDE 
HYTPIRTYQV CNVMDHSQNN WLRTNWVPRN SAQKIYVELK FTLRDCNSIP LVLGTCKETF 
NLYYMESDDD HGVKFREHQF TKIDTIAADE SFTQMDLGDR ILKLNTEIRE VGPVNKKGFY 
LAFQDVGACV ALVSVRVYFK KCPFTVKNLA MFPDTVPMDS QSLVEVRGSC VNNSKEEDPP 
RMYCSTEGEW LVPIGKCSCN AGYEERGFMC QACRPGFYKA LDGNMKCAKC PPHSSTQEDG 
SMNCRCENNY FRADKDPPSM ACTRPPSSPR NVISNINETS VILDWSWPLD TGGRKDVTFN 
IICKKCGWNI KQCEPCSPNV RFLPRQFGLT NTTVTVTDLL AHTNYTFEID AVNGVSELSS 
PPRQFAAVSI TTNQAAPSPV LTIKKDRTSR NSISLSWQEP EHPNGIILDY EVKYYEKQEQ 
ETSYTILRAR GTNVTISSLK PDTIYVFQIR ARTAAGYGTN SRKFEFETSP DSFSISGESS 
QVVMIAISAA VAIILLTVVI YVLIGRFCGY KSKHGADEKR LHFGNGHLKL PGLRTYVDPH 
TYEDPTQAVH EFAKELDATN ISIDKVVGAG EFGEVCSGRL KLPSKKEISV AIKTLKVGYT 
EKQRRDFLGE ASIMGQFDHP NIIRLEGVVT KSKPVMIVTE YMENGSLDSF LRKHDAQFTV 
IQLVGMLRGI ASGMKYLSDM GYVHRDLAAR NILINSNLVC KVSDFGLSRV LEDDPEAAYT 
TRGGKIPIRW TSPEAIAYRK FTSASDVWSY GIVLWEVMSY GERPYWEMSN QDVIKAVDEG 
YRLPPPMDCP AALYQLMLDC WQKDRNNRPK FEQIVSILDK LIRNPGSLKI ITSAAARPSN 
LLLDQSNVDI TTFRTTGDWL NGVWTAHCKE IFTGVEYSSC DTIAKISTDD MKKVGVTVVG 
PQKKIISSIK ALETQSKNGP VPV

Genular Protein ID: 3697929176

Symbol: Q6P4R6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6P4R6

Database IDs:

ARBA 14 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 7 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 5 Gene3D 6 InterPro 20 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 3 PRINTS 2 PROSITE 12 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 RefSeq 1 Rhea 3 SAM 2 SMART 5 SMR 1 SUPFAM 5

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 983
  • Mass: 110161
  • Checksum: 1EBDABFC59282527
  • Sequence:
    • MDCQLSILLL LSCSVLDSFG ELIPQPSNEV NLLDSKTIQG ELGWISYPSH GWEEISGVDE 
HYTPIRTYQV CNVMDHSQNN WLRTNWVPRN SAQKIYVELK FTLRDCNSIP LVLGTCKETF 
NLYYMESDDD HGVKFREHQF TKIDTIAADE SFTQMDLGDR ILKLNTEIRE VGPVNKKGFY 
LAFQDVGACV ALVSVRVYFK KCPFTVKNLA MFPDTVPMDS QSLVEVRGSC VNNSKEEDPP 
RMYCSTEGEW LVPIGKCSCN AGYEERGFMC QACRPGFYKA LDGNMKCAKC PPHSSTQEDG 
SMNCRCENNY FRADKDPPSM ACTRPPSSPR NVISNINETS VILDWSWPLD TGGRKDVTFN 
IICKKCGWNI KQCEPCSPNV RFLPRQFGLT NTTVTVTDLL AHTNYTFEID AVNGVSELSS 
PPRQFAAVSI TTNQAAPSPV LTIKKDRTSR NSISLSWQEP EHPNGIILDY EVKYYEKQEQ 
ETSYTILRAR GTNVTISSLK PDTIYVFQIR ARTAAGYGTN SRKFEFETSP DSFSISGESS 
QVVMIAISAA VAIILLTVVI YVLIGRFCGY KSKHGADEKR LHFGNGHLKL PGLRTYVDPH 
TYEDPTQTVH EFAKELDATN ISIDKVVGAG EFGEVCSGRL KLPSKKEISV AIKTLKVGYT 
EKQRRDFLGE ASIMGQFDHP NIIRLEGVVT KSKPVMIVTE YMENGSLDSF LRKHDAQFTV 
IQLVGMLRGI ASGMKYLSDM GYVHRDLAAR NILINSNLVC KVSDFGLSRV LEDDPEAAYT 
TRGGKIPIRW TSPEAIAYRK FTSASDVWSY GIVLWEVMSY GERPYWEMSN QDVIKAVDEG 
YRLPPPMDCP AALYQLMLDC WQKDRNNRPK FEQIVSILDK LIRNPGSLKI ITSAAARPSN 
LLLDQSNVDI TTFRTTGDWL NGVWTAHCKE IFTGVEYSSC DTIAKISTDD MKKVGVTVVG 
PQKKIISSIK ALETQSKNGP VPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.