Details for: STX2

Gene ID: 2054

Symbol: STX2

Ensembl ID: ENSG00000111450

Description: syntaxin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 155.4532
    Cell Significance Index: -24.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 107.0400
    Cell Significance Index: -27.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 59.6349
    Cell Significance Index: -28.1600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 54.2637
    Cell Significance Index: -22.0500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 50.8957
    Cell Significance Index: -26.1800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.1685
    Cell Significance Index: -22.1200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.9878
    Cell Significance Index: -27.1100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.1536
    Cell Significance Index: -27.2000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.9791
    Cell Significance Index: -27.5400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.9158
    Cell Significance Index: -18.1700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 4.7504
    Cell Significance Index: 78.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5164
    Cell Significance Index: 68.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3611
    Cell Significance Index: 273.0300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7769
    Cell Significance Index: 537.3500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.7645
    Cell Significance Index: 12.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7297
    Cell Significance Index: 72.1800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.7220
    Cell Significance Index: 6.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6597
    Cell Significance Index: 595.6300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5908
    Cell Significance Index: 11.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4751
    Cell Significance Index: 29.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4446
    Cell Significance Index: 61.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4366
    Cell Significance Index: 29.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3826
    Cell Significance Index: 21.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3748
    Cell Significance Index: 60.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3511
    Cell Significance Index: 125.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2915
    Cell Significance Index: 159.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2688
    Cell Significance Index: 29.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2659
    Cell Significance Index: 16.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2387
    Cell Significance Index: 47.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1722
    Cell Significance Index: 32.7700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1589
    Cell Significance Index: 3.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1289
    Cell Significance Index: 16.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1212
    Cell Significance Index: 164.7600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0851
    Cell Significance Index: 1.0200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0746
    Cell Significance Index: 1.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0686
    Cell Significance Index: 4.4300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0665
    Cell Significance Index: 4.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0638
    Cell Significance Index: 98.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0460
    Cell Significance Index: 2.8200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0363
    Cell Significance Index: 2.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0334
    Cell Significance Index: 61.6000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0324
    Cell Significance Index: 14.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0192
    Cell Significance Index: 0.8500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0162
    Cell Significance Index: 30.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0058
    Cell Significance Index: 2.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0031
    Cell Significance Index: 0.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0031
    Cell Significance Index: -1.9600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0058
    Cell Significance Index: -0.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0232
    Cell Significance Index: -17.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0233
    Cell Significance Index: -2.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0240
    Cell Significance Index: -17.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0250
    Cell Significance Index: -1.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0263
    Cell Significance Index: -19.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0267
    Cell Significance Index: -4.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0329
    Cell Significance Index: -1.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0404
    Cell Significance Index: -1.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0420
    Cell Significance Index: -0.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0476
    Cell Significance Index: -26.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0520
    Cell Significance Index: -32.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0609
    Cell Significance Index: -4.6700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0730
    Cell Significance Index: -1.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0771
    Cell Significance Index: -22.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1053
    Cell Significance Index: -10.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1152
    Cell Significance Index: -14.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1155
    Cell Significance Index: -19.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1178
    Cell Significance Index: -17.1300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1368
    Cell Significance Index: -2.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1487
    Cell Significance Index: -31.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1570
    Cell Significance Index: -4.5000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1720
    Cell Significance Index: -20.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1771
    Cell Significance Index: -20.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1896
    Cell Significance Index: -24.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2036
    Cell Significance Index: -14.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2486
    Cell Significance Index: -25.8900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2568
    Cell Significance Index: -4.4000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2882
    Cell Significance Index: -4.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2924
    Cell Significance Index: -21.7900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2955
    Cell Significance Index: -2.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2955
    Cell Significance Index: -6.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2985
    Cell Significance Index: -23.6500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3280
    Cell Significance Index: -4.7100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3393
    Cell Significance Index: -4.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3432
    Cell Significance Index: -16.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3618
    Cell Significance Index: -10.1100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3634
    Cell Significance Index: -9.3400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3793
    Cell Significance Index: -12.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3990
    Cell Significance Index: -12.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3996
    Cell Significance Index: -18.6300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4071
    Cell Significance Index: -13.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4090
    Cell Significance Index: -6.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4098
    Cell Significance Index: -21.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4131
    Cell Significance Index: -21.6900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4698
    Cell Significance Index: -16.3300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5081
    Cell Significance Index: -3.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5256
    Cell Significance Index: -26.5600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5464
    Cell Significance Index: -19.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5669
    Cell Significance Index: -14.1700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5774
    Cell Significance Index: -7.2000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.6013
    Cell Significance Index: -9.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6082
    Cell Significance Index: -16.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** STX2 is a small, membrane-bound protein with a molecular weight of approximately 22 kDa. It belongs to the syntaxin family, which is characterized by their role in regulating vesicle fusion and neurotransmitter release. STX2 is specifically involved in the formation of the presynaptic active zone membrane, where it interacts with other proteins to facilitate the docking and fusion of synaptic vesicles with the plasma membrane. This process is critical for the release of neurotransmitters, such as glutamate and GABA, which are essential for neuronal communication. **Pathways and Functions** STX2 is involved in several key pathways, including: 1. **Exocytosis**: STX2 plays a crucial role in the formation of the presynaptic active zone membrane, where it regulates the docking and fusion of synaptic vesicles with the plasma membrane. 2. **Synaptic transmission**: STX2 is essential for the release of neurotransmitters, such as glutamate and GABA, which are critical for neuronal communication. 3. **Cellular signaling**: STX2 interacts with other proteins to regulate various cellular signaling pathways, including those involved in cell growth, differentiation, and survival. 4. **Membrane trafficking**: STX2 is involved in the regulation of membrane trafficking, including the transport of vesicles and proteins between the endoplasmic reticulum and the Golgi apparatus. **Clinical Significance** Dysregulation of STX2 has been implicated in various neurological and psychiatric disorders, including: 1. **Autism spectrum disorder**: Studies have shown that individuals with autism spectrum disorder exhibit altered expression of STX2, which may contribute to the development of cognitive and behavioral deficits. 2. **Schizophrenia**: STX2 has been identified as a risk factor for schizophrenia, with altered expression and function of the protein contributing to the development of cognitive and psychotic symptoms. 3. **Epilepsy**: STX2 has been implicated in the regulation of synaptic transmission and may contribute to the development of epilepsy. 4. **Neurodegenerative diseases**: STX2 has been shown to be involved in the regulation of synaptic transmission and may contribute to the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's. In conclusion, STX2 is a critical protein involved in various cellular processes, including neurotransmitter release, cellular signaling, and membrane trafficking. Its dysregulation has been implicated in various neurological and psychiatric disorders, highlighting the importance of further research into the molecular mechanisms underlying these conditions.

Genular Protein ID: 351583781

Symbol: STX2_HUMAN

Name: Syntaxin-2

UniProtKB Accession Codes:

P32856 Q86VW8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 25 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 MoonProt 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8466509

Title: Molecular cloning of human epimorphin: identification of isoforms and their unique properties.

PubMed ID: 8466509

DOI: 10.1006/bbrc.1993.1363

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 288
  • Mass: 33341
  • Checksum: 5668E6BF891360B4
  • Sequence:
    • MRDRLPDLTA CRKNDDGDTV VVVEKDHFMD DFFHQVEEIR NSIDKITQYV EEVKKNHSII 
LSAPNPEGKI KEELEDLNKE IKKTANKIRA KLKAIEQSFD QDESGNRTSV DLRIRRTQHS 
VLSRKFVEAM AEYNEAQTLF RERSKGRIQR QLEITGRTTT DDELEEMLES GKPSIFTSDI 
ISDSQITRQA LNEIESRHKD IMKLETSIRE LHEMFMDMAM FVETQGEMIN NIERNVMNAT 
DYVEHAKEET KKAIKYQSKA RRKKWIIIAV SVVLVAIIAL IIGLSVGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.