Gene STX2 - ENSG00000111450 | NCBI Gene ID: 2054

Details for: STX2

Gene ID: 2054

Symbol: STX2

Ensembl ID: ENSG00000111450

Description: syntaxin 2

Associated with

Acrosome reaction
(GO:0007340)
Animal organ morphogenesis
(GO:0009887)
Basolateral plasma membrane
(GO:0016323)
Calcium-dependent protein binding
(GO:0048306)
Cellular response to oxidative stress
(GO:0034599)
Cornified envelope assembly
(GO:1903575)
Ectoderm development
(GO:0007398)
Endomembrane system
(GO:0012505)
Exocytosis
(GO:0006887)
Extracellular space
(GO:0005615)
Intracellular membrane-bounded organelle
(GO:0043231)
Intracellular protein transport
(GO:0006886)
Lamellipodium
(GO:0030027)
Plasma membrane
(GO:0005886)
Presynaptic active zone membrane
(GO:0048787)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Signal transduction
(GO:0007165)
Snap receptor activity
(GO:0005484)
Snare binding
(GO:0000149)
Snare complex
(GO:0031201)
Structural molecule activity
(GO:0005198)
Synaptic vesicle
(GO:0008021)
Synaptic vesicle fusion to presynaptic active zone membrane
(GO:0031629)
Vesicle docking
(GO:0048278)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.85
Marker Score: 1081
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 1.62
Marker Score: 6765
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.46
Marker Score: 13830
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.44
Marker Score: 88730
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.32
Marker Score: 11347
Cell Name: germ cell (CL0000586)
Fold Change: 1.31
Marker Score: 2281
Cell Name: neuron (CL0000540)
Fold Change: 1.2
Marker Score: 4905
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 1.18
Marker Score: 10216.5
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.17
Marker Score: 1812
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.14
Marker Score: 10736
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.1
Marker Score: 1262
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.04
Marker Score: 1254
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.02
Marker Score: 1144
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.01
Marker Score: 2051
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1
Marker Score: 15683
Cell Name: proerythroblast (CL0000547)
Fold Change: 1
Marker Score: 679
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71751
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47975
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.99
Marker Score: 10253
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30400
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.98
Marker Score: 409
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2405
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.94
Marker Score: 483
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.93
Marker Score: 439
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.92
Marker Score: 3178
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2719
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.89
Marker Score: 356
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.88
Marker Score: 4997
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.87
Marker Score: 942
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5255
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 310
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.82
Marker Score: 6278
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.81
Marker Score: 844
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.81
Marker Score: 1540
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.81
Marker Score: 17261
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.8
Marker Score: 3102
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.79
Marker Score: 217
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.78
Marker Score: 3245
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.77
Marker Score: 1697
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 589
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.77
Marker Score: 15253
Cell Name: keratocyte (CL0002363)
Fold Change: 0.76
Marker Score: 176
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.76
Marker Score: 520
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.75
Marker Score: 8498
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.75
Marker Score: 1222
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.75
Marker Score: 3147
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.75
Marker Score: 28466
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.75
Marker Score: 27594
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.74
Marker Score: 444
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.73
Marker Score: 377
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 0.73
Marker Score: 275
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.73
Marker Score: 976
Cell Name: male germ cell (CL0000015)
Fold Change: 0.73
Marker Score: 209
Cell Name: interneuron (CL0000099)
Fold Change: 0.72
Marker Score: 330
Cell Name: podocyte (CL0000653)
Fold Change: 0.72
Marker Score: 267
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.71
Marker Score: 336
Cell Name: brush cell (CL0002204)
Fold Change: 0.71
Marker Score: 645
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.7
Marker Score: 254
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.7
Marker Score: 744
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.7
Marker Score: 1986
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.7
Marker Score: 522
Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.7
Marker Score: 220
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.69
Marker Score: 2682
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.69
Marker Score: 455.5
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.68
Marker Score: 4085
Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.67
Marker Score: 831
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.66
Marker Score: 170
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.66
Marker Score: 197
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.65
Marker Score: 391
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.65
Marker Score: 499
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.65
Marker Score: 811
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.64
Marker Score: 1502
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.62
Marker Score: 21113
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.61
Marker Score: 255
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.61
Marker Score: 876
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.61
Marker Score: 1023
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.6
Marker Score: 1421
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.6
Marker Score: 8955
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.6
Marker Score: 377
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 0.6
Marker Score: 200
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.59
Marker Score: 184
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.59
Marker Score: 294
Cell Name: astrocyte (CL0000127)
Fold Change: 0.58
Marker Score: 505
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.58
Marker Score: 139
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.57
Marker Score: 19369
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.57
Marker Score: 2467
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 0.56
Marker Score: 769.5
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.56
Marker Score: 138
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.56
Marker Score: 255
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.55
Marker Score: 355
Cell Name: fibroblast (CL0000057)
Fold Change: 0.55
Marker Score: 534
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.55
Marker Score: 210
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.54
Marker Score: 429
Cell Name: supporting cell (CL0000630)
Fold Change: 0.54
Marker Score: 1008
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.53
Marker Score: 18332
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.53
Marker Score: 504
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 0.53
Marker Score: 249
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.53
Marker Score: 196
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 0.53
Marker Score: 633
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.52
Marker Score: 169

Hover over a box to see details here...

**Key characteristics:** - STX2 is a large protein (800 amino acids) that is expressed in high levels in the central nervous system. - It is a member of the syntaxin family of cell adhesion molecules. - It is a transmembrane protein that is expressed on neurons, glial cells, and endothelial cells. - It is a key component of the plasma membrane, where it is involved in the formation of synaptic vesicles and the docking of vesicles to the presynaptic active zone membrane. **Pathways and functions:** - STX2 is involved in the formation of synapses between neurons. - It is a key component of the axonal transport of neurotransmitters. - It is involved in the cellular response to oxidative stress. - It is involved in the assembly of the cornified envelope, a protective layer that surrounds the soma of neurons. - It is involved in the development of the endomembrane system, a network of specialized cells that helps to maintain the integrity of the cell. - It is involved in exocytosis, the process by which vesicles are released from cells. - It is involved in the transport of proteins within the cell. - It is involved in signal transduction, a process by which chemical signals are transmitted from the outside of the cell to the inside. **Clinical significance:** - Mutations in STX2 have been linked to a number of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. - STX2 is a promising target for therapy in these diseases, as it is involved in the early stages of the disease. - Small molecule inhibitors of STX2 have been shown to be effective in protecting neurons from death and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Syntaxin-2

Genular Protein ID: 351583781

Symbol: STX2_HUMAN

Name: Syntaxin-2

UniProtKB Accession Codes:

P32856 Q86VW8

Database IDs:

Citations:

PubMed ID: 8466509

Title: Molecular cloning of human epimorphin: identification of isoforms and their unique properties.

PubMed ID: 8466509

DOI: 10.1006/bbrc.1993.1363

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 288
Mass: 33341
Checksum: 5668E6BF891360B4
Sequence:

MRDRLPDLTA CRKNDDGDTV VVVEKDHFMD DFFHQVEEIR NSIDKITQYV EEVKKNHSII 
LSAPNPEGKI KEELEDLNKE IKKTANKIRA KLKAIEQSFD QDESGNRTSV DLRIRRTQHS 
VLSRKFVEAM AEYNEAQTLF RERSKGRIQR QLEITGRTTT DDELEEMLES GKPSIFTSDI 
ISDSQITRQA LNEIESRHKD IMKLETSIRE LHEMFMDMAM FVETQGEMIN NIERNVMNAT 
DYVEHAKEET KKAIKYQSKA RRKKWIIIAV SVVLVAIIAL IIGLSVGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.