Details for: ERBB2

Gene ID: 2064

Symbol: ERBB2

Ensembl ID: ENSG00000141736

Description: erb-b2 receptor tyrosine kinase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 163.3608
    Cell Significance Index: -25.4100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 101.1065
    Cell Significance Index: -25.6500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 59.9227
    Cell Significance Index: -24.6900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 51.6299
    Cell Significance Index: -20.9800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 51.1837
    Cell Significance Index: -24.1700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 36.2134
    Cell Significance Index: -24.3000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.7807
    Cell Significance Index: -20.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.6577
    Cell Significance Index: -25.4700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.2577
    Cell Significance Index: -24.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 8.4208
    Cell Significance Index: 114.8900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.4596
    Cell Significance Index: -25.4900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.8428
    Cell Significance Index: 17.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.8063
    Cell Significance Index: 145.7800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.3163
    Cell Significance Index: 21.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.8454
    Cell Significance Index: 39.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6675
    Cell Significance Index: 271.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5271
    Cell Significance Index: 69.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.3638
    Cell Significance Index: 39.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3401
    Cell Significance Index: 1209.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.2653
    Cell Significance Index: 35.3600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.2061
    Cell Significance Index: 9.6300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.0278
    Cell Significance Index: 15.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0235
    Cell Significance Index: 76.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9714
    Cell Significance Index: 45.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9279
    Cell Significance Index: 167.2700
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.8955
    Cell Significance Index: 0.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7689
    Cell Significance Index: 20.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7606
    Cell Significance Index: 150.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6984
    Cell Significance Index: 85.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6950
    Cell Significance Index: 68.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6377
    Cell Significance Index: 348.2400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6029
    Cell Significance Index: 13.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5482
    Cell Significance Index: 242.3700
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.4818
    Cell Significance Index: 4.9700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.4748
    Cell Significance Index: 2.9500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.3689
    Cell Significance Index: 2.4100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.3680
    Cell Significance Index: 3.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3602
    Cell Significance Index: 39.1800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3505
    Cell Significance Index: 7.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3474
    Cell Significance Index: 26.6600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.3316
    Cell Significance Index: 4.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2986
    Cell Significance Index: 14.0400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2894
    Cell Significance Index: 4.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2852
    Cell Significance Index: 7.1300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.2749
    Cell Significance Index: 4.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2580
    Cell Significance Index: 18.2500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.2573
    Cell Significance Index: 0.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1865
    Cell Significance Index: 35.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1668
    Cell Significance Index: 22.9000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1600
    Cell Significance Index: 3.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1590
    Cell Significance Index: 20.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1474
    Cell Significance Index: 5.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1474
    Cell Significance Index: 8.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1459
    Cell Significance Index: 5.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1424
    Cell Significance Index: 4.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1391
    Cell Significance Index: 17.8300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0473
    Cell Significance Index: 0.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0306
    Cell Significance Index: 22.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0132
    Cell Significance Index: 24.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0051
    Cell Significance Index: 3.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0048
    Cell Significance Index: 9.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0048
    Cell Significance Index: 7.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0015
    Cell Significance Index: 0.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0023
    Cell Significance Index: -1.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0041
    Cell Significance Index: -0.7000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0138
    Cell Significance Index: -18.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0187
    Cell Significance Index: -6.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0193
    Cell Significance Index: -3.8700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0325
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0361
    Cell Significance Index: -26.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0383
    Cell Significance Index: -17.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0408
    Cell Significance Index: -25.5000
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.0421
    Cell Significance Index: -0.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0473
    Cell Significance Index: -26.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0598
    Cell Significance Index: -17.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0636
    Cell Significance Index: -9.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0711
    Cell Significance Index: -7.2600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0863
    Cell Significance Index: -4.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0967
    Cell Significance Index: -11.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1074
    Cell Significance Index: -12.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1350
    Cell Significance Index: -28.4300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1494
    Cell Significance Index: -3.9900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1619
    Cell Significance Index: -3.4600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1810
    Cell Significance Index: -5.3300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1935
    Cell Significance Index: -22.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2361
    Cell Significance Index: -24.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2370
    Cell Significance Index: -14.5300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2392
    Cell Significance Index: -6.2900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2396
    Cell Significance Index: -6.1600
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: -0.2455
    Cell Significance Index: -0.9400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2601
    Cell Significance Index: -4.1700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2619
    Cell Significance Index: -20.7400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2681
    Cell Significance Index: -16.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2962
    Cell Significance Index: -15.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3171
    Cell Significance Index: -20.4600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3189
    Cell Significance Index: -5.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3451
    Cell Significance Index: -21.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3618
    Cell Significance Index: -24.3300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.3841
    Cell Significance Index: -3.9800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4161
    Cell Significance Index: -17.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** * ERBB2 is a receptor tyrosine kinase with intrinsic kinase activity, which is activated by its ligands and leads to the phosphorylation of downstream signaling molecules. * The ERBB2 gene is composed of 20 exons and encodes a 189-kDa protein with 1572 amino acids. * ERBB2 is a transmembrane receptor with two extracellular immunoglobulin-like domains and two transmembrane domains. * The ERBB2 protein is a dimeric receptor, which forms a complex with other EGFR family members to regulate signaling. * ERBB2 is overexpressed in various cancers, including breast cancer, and is associated with aggressive tumor behavior and poor prognosis. **Pathways and Functions** * ERBB2 signaling pathways: + PI3K/Akt pathway: ERBB2 activates the PI3K/Akt pathway, which regulates cell survival, proliferation, and migration. + MAPK/ERK pathway: ERBB2 activates the MAPK/ERK pathway, which regulates cell proliferation, differentiation, and survival. + NF-κB pathway: ERBB2 activates the NF-κB pathway, which regulates inflammation and cell survival. * ERBB2 functions: + Cell proliferation: ERBB2 regulates cell proliferation by activating the PI3K/Akt pathway. + Cell differentiation: ERBB2 regulates cell differentiation by activating the MAPK/ERK pathway. + Cell survival: ERBB2 regulates cell survival by activating the PI3K/Akt pathway. + Angiogenesis: ERBB2 regulates angiogenesis by activating the PI3K/Akt pathway. **Clinical Significance** * Breast cancer: ERBB2 overexpression is associated with aggressive tumor behavior and poor prognosis in breast cancer patients. * Other cancers: ERBB2 overexpression has been implicated in various other cancers, including lung, colon, and gastric cancer. * Targeted therapies: ERBB2 inhibitors, such as trastuzumab, pertuzumab, and lapatinib, have been developed to target ERBB2-positive tumors and improve patient outcomes. * Biomarkers: ERBB2 is a useful biomarker for predicting response to targeted therapies and for monitoring disease progression. In conclusion, the ERBB2 gene plays a critical role in cell signaling, growth, and differentiation, and its dysregulation is implicated in various cancers. Understanding the ERBB2 gene and its signaling pathways is essential for the development of targeted therapies and for improving patient outcomes.

Genular Protein ID: 2393239600

Symbol: ERBB2_HUMAN

Name: Receptor tyrosine-protein kinase erbB-2

UniProtKB Accession Codes:

P04626 B2RZG3 B4DHN3 Q14256 Q6LDV1 Q9UMK4 X5D2V5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CORUM 1 CPTAC 17 CPTC 1 CTD 1 CarbonylDB 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 14 DrugCentral 1 EC 2 ELM 1 EMBL 15 EMDB 8 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 70 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 15 KEGG 1 MANE-Select 1 MIM 11 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 51 PDBsum 51 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 30 RefSeq 4 Rhea 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3003577

Title: Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor.

PubMed ID: 3003577

DOI: 10.1038/319230a0

PubMed ID: 2999974

Title: Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.

PubMed ID: 2999974

DOI: 10.1126/science.2999974

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3039351

Title: Human HER2 (neu) promoter: evidence for multiple mechanisms for transcriptional initiation.

PubMed ID: 3039351

DOI: 10.1128/mcb.7.7.2597-2601.1987

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

DOI: 10.1038/ncomms4650

PubMed ID: 2995967

Title: A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma.

PubMed ID: 2995967

DOI: 10.1073/pnas.82.19.6497

PubMed ID: 2992089

Title: Amplification of a novel v-erbB-related gene in a human mammary carcinoma.

PubMed ID: 2992089

DOI: 10.1126/science.2992089

PubMed ID: 8104414

Title: Molecular cloning and sequencing of an intron of Her-2/neu (ERBB2) gene.

PubMed ID: 8104414

DOI: 10.1089/dna.1993.12.611

PubMed ID: 10358079

Title: ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases.

PubMed ID: 10358079

DOI: 10.1074/jbc.274.24.17209

PubMed ID: 10805725

Title: Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors.

PubMed ID: 10805725

DOI: 10.1128/mcb.20.11.3817-3830.2000

PubMed ID: 12939402

Title: Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein.

PubMed ID: 12939402

PubMed ID: 15380516

Title: Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2.

PubMed ID: 15380516

DOI: 10.1016/j.ccr.2004.07.012

PubMed ID: 15210733

Title: Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2.

PubMed ID: 15210733

DOI: 10.1083/jcb.200312094

PubMed ID: 15156151

Title: Memo mediates ErbB2-driven cell motility.

PubMed ID: 15156151

DOI: 10.1038/ncb1134

PubMed ID: 16314522

Title: Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor.

PubMed ID: 16314522

DOI: 10.1128/mcb.25.24.11005-11018.2005

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16794579

Title: Biosynthesis of tumorigenic HER2 C-terminal fragments by alternative initiation of translation.

PubMed ID: 16794579

DOI: 10.1038/sj.emboj.7601191

PubMed ID: 16978839

Title: Neuregulin-1 only induces trans-phosphorylation between ErbB receptor heterodimer partners.

PubMed ID: 16978839

DOI: 10.1016/j.cellsig.2006.07.020

PubMed ID: 17554007

Title: Plexin-B2, but not Plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system in vivo.

PubMed ID: 17554007

DOI: 10.1523/jneurosci.5381-06.2007

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18719096

Title: Brk is coamplified with ErbB2 to promote proliferation in breast cancer.

PubMed ID: 18719096

DOI: 10.1073/pnas.0805009105

PubMed ID: 19372587

Title: ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells.

PubMed ID: 19372587

DOI: 10.1158/1541-7786.mcr-08-0316

PubMed ID: 20010870

Title: Copine-III interacts with ErbB2 and promotes tumor cell migration.

PubMed ID: 20010870

DOI: 10.1038/onc.2009.456

PubMed ID: 20937854

Title: ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.

PubMed ID: 20937854

DOI: 10.1073/pnas.1000975107

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21097718

Title: Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing.

PubMed ID: 21097718

DOI: 10.1158/0008-5472.can-10-1749

PubMed ID: 21555369

Title: Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes.

PubMed ID: 21555369

DOI: 10.1158/0008-5472.can-10-3504

PubMed ID: 21190959

Title: Dissociation of epidermal growth factor receptor and ErbB2 heterodimers in the presence of somatostatin receptor 5 modulate signaling pathways.

PubMed ID: 21190959

DOI: 10.1210/en.2010-0940

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26517842

Title: Client proteins and small molecule inhibitors display distinct binding preferences for constitutive and stress-induced HSP90 isoforms and their conformationally restricted mutants.

PubMed ID: 26517842

DOI: 10.1371/journal.pone.0141786

PubMed ID: 27134172

Title: Crystal structure and substrate specificity of PTPN12.

PubMed ID: 27134172

DOI: 10.1016/j.celrep.2016.04.016

PubMed ID: 31138794

Title: SORLA regulates endosomal trafficking and oncogenic fitness of HER2.

PubMed ID: 31138794

DOI: 10.1038/s41467-019-10275-0

PubMed ID: 32381043

Title: SH3BGRL confers innate drug resistance in breast cancer by stabilizing HER2 activation on cell membrane.

PubMed ID: 32381043

DOI: 10.1186/s13046-020-01577-z

PubMed ID: 34380438

Title: SH3BGRL3 binds to myosin 1c in a calcium dependent manner and modulates migration in the MDA-MB-231 cell line.

PubMed ID: 34380438

DOI: 10.1186/s12860-021-00379-1

PubMed ID: 36949068

Title: IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis.

PubMed ID: 36949068

DOI: 10.1038/s41467-023-37306-1

PubMed ID: 10593938

Title: Poor binding of a HER-2/neu epitope (GP2) to HLA-A2.1 is due to a lack of interactions with the center of the peptide.

PubMed ID: 10593938

DOI: 10.1074/jbc.274.51.36422

PubMed ID: 12444095

Title: Novel mode of ligand recognition by the Erbin PDZ domain.

PubMed ID: 12444095

DOI: 10.1074/jbc.c200571200

PubMed ID: 12975581

Title: Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2.

PubMed ID: 12975581

DOI: 10.1023/a:1025498409113

PubMed ID: 12610629

Title: Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab.

PubMed ID: 12610629

DOI: 10.1038/nature01392

PubMed ID: 15093539

Title: Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex.

PubMed ID: 15093539

DOI: 10.1016/s1535-6108(04)00083-2

PubMed ID: 19299620

Title: Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site.

PubMed ID: 19299620

DOI: 10.1126/science.1165480

PubMed ID: 20696930

Title: Structural basis for high-affinity HER2 receptor binding by an engineered protein.

PubMed ID: 20696930

DOI: 10.1073/pnas.1005025107

PubMed ID: 21454582

Title: Structural analysis of the mechanism of inhibition and allosteric activation of the kinase domain of HER2 protein.

PubMed ID: 21454582

DOI: 10.1074/jbc.m110.206193

PubMed ID: 8095488

Title: Characterization of a new allele of the human ERBB2 gene by allele-specific competition hybridization.

PubMed ID: 8095488

DOI: 10.1006/geno.1993.1081

PubMed ID: 15457249

Title: Lung cancer: intragenic ERBB2 kinase mutations in tumours.

PubMed ID: 15457249

DOI: 10.1038/431525b

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 33497358

Title: Dysregulation of the NRG1/ERBB pathway causes a developmental disorder with gastrointestinal dysmotility in humans.

PubMed ID: 33497358

DOI: 10.1172/jci145837

Sequence Information:

  • Length: 1255
  • Mass: 137910
  • Checksum: 39E9DFDA04DCF962
  • Sequence:
    • MELAALCRWG LLLALLPPGA ASTQVCTGTD MKLRLPASPE THLDMLRHLY QGCQVVQGNL 
ELTYLPTNAS LSFLQDIQEV QGYVLIAHNQ VRQVPLQRLR IVRGTQLFED NYALAVLDNG 
DPLNNTTPVT GASPGGLREL QLRSLTEILK GGVLIQRNPQ LCYQDTILWK DIFHKNNQLA 
LTLIDTNRSR ACHPCSPMCK GSRCWGESSE DCQSLTRTVC AGGCARCKGP LPTDCCHEQC 
AAGCTGPKHS DCLACLHFNH SGICELHCPA LVTYNTDTFE SMPNPEGRYT FGASCVTACP 
YNYLSTDVGS CTLVCPLHNQ EVTAEDGTQR CEKCSKPCAR VCYGLGMEHL REVRAVTSAN 
IQEFAGCKKI FGSLAFLPES FDGDPASNTA PLQPEQLQVF ETLEEITGYL YISAWPDSLP 
DLSVFQNLQV IRGRILHNGA YSLTLQGLGI SWLGLRSLRE LGSGLALIHH NTHLCFVHTV 
PWDQLFRNPH QALLHTANRP EDECVGEGLA CHQLCARGHC WGPGPTQCVN CSQFLRGQEC 
VEECRVLQGL PREYVNARHC LPCHPECQPQ NGSVTCFGPE ADQCVACAHY KDPPFCVARC 
PSGVKPDLSY MPIWKFPDEE GACQPCPINC THSCVDLDDK GCPAEQRASP LTSIISAVVG 
ILLVVVLGVV FGILIKRRQQ KIRKYTMRRL LQETELVEPL TPSGAMPNQA QMRILKETEL 
RKVKVLGSGA FGTVYKGIWI PDGENVKIPV AIKVLRENTS PKANKEILDE AYVMAGVGSP 
YVSRLLGICL TSTVQLVTQL MPYGCLLDHV RENRGRLGSQ DLLNWCMQIA KGMSYLEDVR 
LVHRDLAARN VLVKSPNHVK ITDFGLARLL DIDETEYHAD GGKVPIKWMA LESILRRRFT 
HQSDVWSYGV TVWELMTFGA KPYDGIPARE IPDLLEKGER LPQPPICTID VYMIMVKCWM 
IDSECRPRFR ELVSEFSRMA RDPQRFVVIQ NEDLGPASPL DSTFYRSLLE DDDMGDLVDA 
EEYLVPQQGF FCPDPAPGAG GMVHHRHRSS STRSGGGDLT LGLEPSEEEA PRSPLAPSEG 
AGSDVFDGDL GMGAAKGLQS LPTHDPSPLQ RYSEDPTVPL PSETDGYVAP LTCSPQPEYV 
NQPDVRPQPP SPREGPLPAA RPAGATLERP KTLSPGKNGV VKDVFAFGGA VENPEYLTPQ 
GGAAPQPHPP PAFSPAFDNL YYWDQDPPER GAPPSTFKGT PTAENPEYLG LDVPV

Genular Protein ID: 487593169

Symbol: J3QLU9_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3QLU9

Database IDs:

ARBA 12 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 7 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 4 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 15 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 5 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 3 SAM 3 SMART 2 SMR 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 1055
  • Mass: 117103
  • Checksum: 68423CCAE006E009
  • Sequence:
    • MELAALCRWG LLLALLPPGA ASTQVCTGTD MKLRLPASPE THLDMLRHLY QGCQVVQGNL 
ELTYLPTNAS LSFLQDIQEV QGYVLIAHNQ VRQVPLQRLR IVRGTQLFED NYALAVLDNG 
DPLNNTTPVT GASPGGLREL QLRSLTEILK GGVLIQRNPQ LCYQDTILWK DIFHKNNQLA 
LTLIDTNRSR ACHPCSPMCK GSRCWGESSE DCQSLTRTVC AGGCARCKGP LPTDCCHEQC 
AAGCTGPKHS DCLACLHFNH SGICELHCPA LVTYNTDTFE SMPNPEGRYT FGASCVTACP 
YNYLSTDVGS CTLVCPLHNQ EVTAEDGTQR CEKCSKPCAR VCYGLGMEHL REVRAVTSAN 
IQEFAGCKKI FGSLAFLPES FDGDPASNTA PLQPEQLQVF ETLEEITGYL YISAWPDSLP 
DLSVFQNLQV IRGRILHNGA YSLTLQGLGI SWLGLRSLRE LGSGLALIHH NTHLCFVHTV 
PWDQLFRNPH QALLHTANRP EDECVGEGLA CHQLCARGHC WGPGPTQCVN CSQFLRGQEC 
VEECRVLQGL PREYVNARHC LPCHPECQPQ NGSVTCFGPE ADQCVACAHY KDPPFCVARC 
PSGVKPDLSY MPIWKFPDEE GACQPCPINC THSCVDLDDK GCPAEQRASP LTSIISAVVG 
ILLVVVLGVV FGILIKRRQQ KIRKYTMRRL LQETELVEPL TPSGAMPNQA QMRILKETEL 
RKVKVLGSGA FGTVYKGIWI PDGENVKIPV AIKVLRENTS PKANKEILDE AYVMAGVGSP 
YVSRLLGICL TSTVQLVTQL MPYGCLLDHV RENRGRLGSQ DLLNWCMQIA KGMSYLEDVR 
LVHRDLAARN VLVKSPNHVK ITDFGLARLL DIDETEYHAD GGKVPIKWMA LESILRRRFT 
HQSDVWSYGV TVWELMTFGA KPYDGIPARE IPDLLEKGER LPQPPICTID VYMIMVKCWM 
IDSECRPRFR ELVSEFSRMA RDPQRFVVIQ NEDLGPASPL DSTFYRSLLE DDDMGDLVDA 
EEYLVPQQGF FCPDPAPGAG GMVHHRHRSS STRNM

Genular Protein ID: 1053799140

Symbol: F5H1T4_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5H1T4

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PeptideAtlas 2 Pfam 6 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 3 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 603
  • Mass: 66543
  • Checksum: E9E69D9E0052A525
  • Sequence:
    • MKLRLPASPE THLDMLRHLY QGCQVVQGNL ELTYLPTNAS LSFLQDIQEV QGYVLIAHNQ 
VRQVPLQRLR IVRGTQLFED NYALAVLDNG DPLNNTTPVT GASPGGLREL QLRSLTEILK 
GGVLIQRNPQ LCYQDTILWK DIFHKNNQLA LTLIDTNRSR ACHPCSPMCK GSRCWGESSE 
DCQSLTRTVC AGGCARCKGP LPTDCCHEQC AAGCTGPKHS DCLACLHFNH SGICELHCPA 
LVTYNTDTFE SMPNPEGRYT FGASCVTACP YNYLSTDVGS CTLVCPLHNQ EVTAEDGTQR 
CEKCSKPCAR VCYGLGMEHL REVRAVTSAN IQEFAGCKKI FGSLAFLPES FDGDPASNTA 
PLQPEQLQVF ETLEEITGYL YISAWPDSLP DLSVFQNLQV IRGRILHNGA YSLTLQGLGI 
SWLGLRSLRE LGSGLALIHH NTHLCFVHTV PWDQLFRNPH QALLHTANRP EDECVGEGLA 
CHQLCARGHC WGPGPTQCVN CSQFLRGQEC VEECRVLQGL PREYVNARHC LPCHPECQPQ 
NGSVTCFGPE ADQCVACAHY KDPPFCVARC PSGVKPDLSY MPIWKFPDEE GACQPCPINC 
THS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.