Details for: ERBB2

Gene ID: 2064

Symbol: ERBB2

Ensembl ID: ENSG00000141736

Description: erb-b2 receptor tyrosine kinase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.67
    Marker Score: 6733
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.37
    Marker Score: 1895
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.1
    Marker Score: 1406
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.02
    Marker Score: 3348
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.99
    Marker Score: 2114
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.92
    Marker Score: 5137
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.85
    Marker Score: 1602
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.78
    Marker Score: 2523
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.62
    Marker Score: 2393
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.59
    Marker Score: 459
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.53
    Marker Score: 11359
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5
    Marker Score: 1577
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.5
    Marker Score: 1802
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.49
    Marker Score: 5115
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.49
    Marker Score: 1508
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.43
    Marker Score: 335
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.41
    Marker Score: 4428
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.4
    Marker Score: 773
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.38
    Marker Score: 1431
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.37
    Marker Score: 1514
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.36
    Marker Score: 3215
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.36
    Marker Score: 6529
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.34
    Marker Score: 5172
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.32
    Marker Score: 618
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.31
    Marker Score: 493
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.3
    Marker Score: 3088
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.3
    Marker Score: 1000
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.29
    Marker Score: 11126
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.27
    Marker Score: 8129
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.27
    Marker Score: 11063
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.26
    Marker Score: 873
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.25
    Marker Score: 953
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.24
    Marker Score: 6525
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.22
    Marker Score: 4319
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.2
    Marker Score: 802
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.19
    Marker Score: 240
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.17
    Marker Score: 577
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.17
    Marker Score: 796
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.15
    Marker Score: 2041
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.15
    Marker Score: 363
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.14
    Marker Score: 2081
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.11
    Marker Score: 4622
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.08
    Marker Score: 211
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.07
    Marker Score: 1252
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.07
    Marker Score: 37079
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.05
    Marker Score: 1352
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.05
    Marker Score: 16364
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.04
    Marker Score: 1032
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.03
    Marker Score: 1964
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.03
    Marker Score: 2354
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.03
    Marker Score: 2329
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1
    Marker Score: 1544
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1
    Marker Score: 583
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71778
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48003
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1
    Marker Score: 7781
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.99
    Marker Score: 286
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.99
    Marker Score: 1122.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.99
    Marker Score: 519
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.98
    Marker Score: 1056.5
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.98
    Marker Score: 242
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.94
    Marker Score: 1526
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5313
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2728
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.89
    Marker Score: 1858
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.89
    Marker Score: 243
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.88
    Marker Score: 538
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.87
    Marker Score: 211
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.86
    Marker Score: 406
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 640
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.83
    Marker Score: 1325
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.83
    Marker Score: 794
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.81
    Marker Score: 721
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.81
    Marker Score: 2882
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.81
    Marker Score: 723
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.81
    Marker Score: 676
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.8
    Marker Score: 360
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 320
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.76
    Marker Score: 12143
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.75
    Marker Score: 691.5
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.75
    Marker Score: 716
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.75
    Marker Score: 1436
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3083
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.73
    Marker Score: 260
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 467
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 655
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7
    Marker Score: 1487
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.7
    Marker Score: 842.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.7
    Marker Score: 224
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7
    Marker Score: 1700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.69
    Marker Score: 4458.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.67
    Marker Score: 1075.5

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Other Information

**Key characteristics** * ERBB2 is a transmembrane protein with a single extracellular domain and a cytoplasmic domain that contains an intrinsic tyrosine kinase domain. * It is a member of the ERBB family of tyrosine kinases, which are a large family of cell surface receptors that are involved in various cellular signaling pathways. * ERBB2 is a key regulator of cell growth and survival and plays a significant role in tumor development and progression. **Pathways and functions** * ERBB2 is involved in several cellular pathways, including the MAPK/MAPK signaling pathway, the PI3K/AKT signaling pathway, and the Notch signaling pathway. * In the MAPK/MAPK signaling pathway, ERBB2 is a downstream target of the EGFR signaling pathway. * In the PI3K/AKT signaling pathway, ERBB2 is a downstream target of PI3K, which is involved in cell growth, proliferation, and survival. * In the Notch signaling pathway, ERBB2 is a key regulator of Notch signaling. **Clinical significance** * Mutations in ERBB2 have been linked to various human cancers, including lung cancer, breast cancer, and colon cancer. * Inhibition of ERBB2 signaling has been shown to inhibit cancer growth and metastasis. * Therefore, ERBB2 is a promising target for cancer therapy. **Additional information** * ERBB2 is a highly conserved protein, with similar sequences found in mammals, birds, and fish. * It is a well-documented target for cancer therapy. * The development of targeted therapies against ERBB2 has shown promising results in clinical trials.

Genular Protein ID: 2393239600

Symbol: ERBB2_HUMAN

Name: Receptor tyrosine-protein kinase erbB-2

UniProtKB Accession Codes:

P04626 B2RZG3 B4DHN3 Q14256 Q6LDV1 Q9UMK4 X5D2V5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CORUM 1 CPTAC 17 CPTC 1 CTD 1 CarbonylDB 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 14 DrugCentral 1 EC 2 ELM 1 EMBL 15 EMDB 6 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 70 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MANE-Select 1 MIM 11 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 73 PDBsum 45 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 30 RefSeq 4 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3003577

Title: Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor.

PubMed ID: 3003577

DOI: 10.1038/319230a0

PubMed ID: 2999974

Title: Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.

PubMed ID: 2999974

DOI: 10.1126/science.2999974

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3039351

Title: Human HER2 (neu) promoter: evidence for multiple mechanisms for transcriptional initiation.

PubMed ID: 3039351

DOI: 10.1128/mcb.7.7.2597-2601.1987

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

DOI: 10.1038/ncomms4650

PubMed ID: 2995967

Title: A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma.

PubMed ID: 2995967

DOI: 10.1073/pnas.82.19.6497

PubMed ID: 2992089

Title: Amplification of a novel v-erbB-related gene in a human mammary carcinoma.

PubMed ID: 2992089

DOI: 10.1126/science.2992089

PubMed ID: 8104414

Title: Molecular cloning and sequencing of an intron of Her-2/neu (ERBB2) gene.

PubMed ID: 8104414

DOI: 10.1089/dna.1993.12.611

PubMed ID: 10358079

Title: ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases.

PubMed ID: 10358079

DOI: 10.1074/jbc.274.24.17209

PubMed ID: 10805725

Title: Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors.

PubMed ID: 10805725

DOI: 10.1128/mcb.20.11.3817-3830.2000

PubMed ID: 12939402

Title: Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein.

PubMed ID: 12939402

PubMed ID: 15380516

Title: Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2.

PubMed ID: 15380516

DOI: 10.1016/j.ccr.2004.07.012

PubMed ID: 15210733

Title: Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2.

PubMed ID: 15210733

DOI: 10.1083/jcb.200312094

PubMed ID: 15156151

Title: Memo mediates ErbB2-driven cell motility.

PubMed ID: 15156151

DOI: 10.1038/ncb1134

PubMed ID: 16314522

Title: Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor.

PubMed ID: 16314522

DOI: 10.1128/mcb.25.24.11005-11018.2005

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16794579

Title: Biosynthesis of tumorigenic HER2 C-terminal fragments by alternative initiation of translation.

PubMed ID: 16794579

DOI: 10.1038/sj.emboj.7601191

PubMed ID: 16978839

Title: Neuregulin-1 only induces trans-phosphorylation between ErbB receptor heterodimer partners.

PubMed ID: 16978839

DOI: 10.1016/j.cellsig.2006.07.020

PubMed ID: 17554007

Title: Plexin-B2, but not Plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system in vivo.

PubMed ID: 17554007

DOI: 10.1523/jneurosci.5381-06.2007

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18719096

Title: Brk is coamplified with ErbB2 to promote proliferation in breast cancer.

PubMed ID: 18719096

DOI: 10.1073/pnas.0805009105

PubMed ID: 19372587

Title: ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells.

PubMed ID: 19372587

DOI: 10.1158/1541-7786.mcr-08-0316

PubMed ID: 20010870

Title: Copine-III interacts with ErbB2 and promotes tumor cell migration.

PubMed ID: 20010870

DOI: 10.1038/onc.2009.456

PubMed ID: 20937854

Title: ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.

PubMed ID: 20937854

DOI: 10.1073/pnas.1000975107

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21097718

Title: Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing.

PubMed ID: 21097718

DOI: 10.1158/0008-5472.can-10-1749

PubMed ID: 21555369

Title: Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes.

PubMed ID: 21555369

DOI: 10.1158/0008-5472.can-10-3504

PubMed ID: 21190959

Title: Dissociation of epidermal growth factor receptor and ErbB2 heterodimers in the presence of somatostatin receptor 5 modulate signaling pathways.

PubMed ID: 21190959

DOI: 10.1210/en.2010-0940

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26517842

Title: Client proteins and small molecule inhibitors display distinct binding preferences for constitutive and stress-induced HSP90 isoforms and their conformationally restricted mutants.

PubMed ID: 26517842

DOI: 10.1371/journal.pone.0141786

PubMed ID: 27134172

Title: Crystal structure and substrate specificity of PTPN12.

PubMed ID: 27134172

DOI: 10.1016/j.celrep.2016.04.016

PubMed ID: 31138794

Title: SORLA regulates endosomal trafficking and oncogenic fitness of HER2.

PubMed ID: 31138794

DOI: 10.1038/s41467-019-10275-0

PubMed ID: 32381043

Title: SH3BGRL confers innate drug resistance in breast cancer by stabilizing HER2 activation on cell membrane.

PubMed ID: 32381043

DOI: 10.1186/s13046-020-01577-z

PubMed ID: 34380438

Title: SH3BGRL3 binds to myosin 1c in a calcium dependent manner and modulates migration in the MDA-MB-231 cell line.

PubMed ID: 34380438

DOI: 10.1186/s12860-021-00379-1

PubMed ID: 10593938

Title: Poor binding of a HER-2/neu epitope (GP2) to HLA-A2.1 is due to a lack of interactions with the center of the peptide.

PubMed ID: 10593938

DOI: 10.1074/jbc.274.51.36422

PubMed ID: 12444095

Title: Novel mode of ligand recognition by the Erbin PDZ domain.

PubMed ID: 12444095

DOI: 10.1074/jbc.c200571200

PubMed ID: 12975581

Title: Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2.

PubMed ID: 12975581

DOI: 10.1023/a:1025498409113

PubMed ID: 12610629

Title: Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab.

PubMed ID: 12610629

DOI: 10.1038/nature01392

PubMed ID: 15093539

Title: Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex.

PubMed ID: 15093539

DOI: 10.1016/s1535-6108(04)00083-2

PubMed ID: 19299620

Title: Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site.

PubMed ID: 19299620

DOI: 10.1126/science.1165480

PubMed ID: 20696930

Title: Structural basis for high-affinity HER2 receptor binding by an engineered protein.

PubMed ID: 20696930

DOI: 10.1073/pnas.1005025107

PubMed ID: 21454582

Title: Structural analysis of the mechanism of inhibition and allosteric activation of the kinase domain of HER2 protein.

PubMed ID: 21454582

DOI: 10.1074/jbc.m110.206193

PubMed ID: 8095488

Title: Characterization of a new allele of the human ERBB2 gene by allele-specific competition hybridization.

PubMed ID: 8095488

DOI: 10.1006/geno.1993.1081

PubMed ID: 15457249

Title: Lung cancer: intragenic ERBB2 kinase mutations in tumours.

PubMed ID: 15457249

DOI: 10.1038/431525b

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 33497358

Title: Dysregulation of the NRG1/ERBB pathway causes a developmental disorder with gastrointestinal dysmotility in humans.

PubMed ID: 33497358

DOI: 10.1172/jci145837

Sequence Information:

  • Length: 1255
  • Mass: 137910
  • Checksum: 39E9DFDA04DCF962
  • Sequence:
    • MELAALCRWG LLLALLPPGA ASTQVCTGTD MKLRLPASPE THLDMLRHLY QGCQVVQGNL 
ELTYLPTNAS LSFLQDIQEV QGYVLIAHNQ VRQVPLQRLR IVRGTQLFED NYALAVLDNG 
DPLNNTTPVT GASPGGLREL QLRSLTEILK GGVLIQRNPQ LCYQDTILWK DIFHKNNQLA 
LTLIDTNRSR ACHPCSPMCK GSRCWGESSE DCQSLTRTVC AGGCARCKGP LPTDCCHEQC 
AAGCTGPKHS DCLACLHFNH SGICELHCPA LVTYNTDTFE SMPNPEGRYT FGASCVTACP 
YNYLSTDVGS CTLVCPLHNQ EVTAEDGTQR CEKCSKPCAR VCYGLGMEHL REVRAVTSAN 
IQEFAGCKKI FGSLAFLPES FDGDPASNTA PLQPEQLQVF ETLEEITGYL YISAWPDSLP 
DLSVFQNLQV IRGRILHNGA YSLTLQGLGI SWLGLRSLRE LGSGLALIHH NTHLCFVHTV 
PWDQLFRNPH QALLHTANRP EDECVGEGLA CHQLCARGHC WGPGPTQCVN CSQFLRGQEC 
VEECRVLQGL PREYVNARHC LPCHPECQPQ NGSVTCFGPE ADQCVACAHY KDPPFCVARC 
PSGVKPDLSY MPIWKFPDEE GACQPCPINC THSCVDLDDK GCPAEQRASP LTSIISAVVG 
ILLVVVLGVV FGILIKRRQQ KIRKYTMRRL LQETELVEPL TPSGAMPNQA QMRILKETEL 
RKVKVLGSGA FGTVYKGIWI PDGENVKIPV AIKVLRENTS PKANKEILDE AYVMAGVGSP 
YVSRLLGICL TSTVQLVTQL MPYGCLLDHV RENRGRLGSQ DLLNWCMQIA KGMSYLEDVR 
LVHRDLAARN VLVKSPNHVK ITDFGLARLL DIDETEYHAD GGKVPIKWMA LESILRRRFT 
HQSDVWSYGV TVWELMTFGA KPYDGIPARE IPDLLEKGER LPQPPICTID VYMIMVKCWM 
IDSECRPRFR ELVSEFSRMA RDPQRFVVIQ NEDLGPASPL DSTFYRSLLE DDDMGDLVDA 
EEYLVPQQGF FCPDPAPGAG GMVHHRHRSS STRSGGGDLT LGLEPSEEEA PRSPLAPSEG 
AGSDVFDGDL GMGAAKGLQS LPTHDPSPLQ RYSEDPTVPL PSETDGYVAP LTCSPQPEYV 
NQPDVRPQPP SPREGPLPAA RPAGATLERP KTLSPGKNGV VKDVFAFGGA VENPEYLTPQ 
GGAAPQPHPP PAFSPAFDNL YYWDQDPPER GAPPSTFKGT PTAENPEYLG LDVPV

Genular Protein ID: 487593169

Symbol: J3QLU9_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3QLU9

Database IDs:

ARBA 12 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 7 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 4 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 14 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 5 Proteomes 2 RefSeq 1 Rhea 3 SAM 3 SMART 2 SMR 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 1055
  • Mass: 117103
  • Checksum: 68423CCAE006E009
  • Sequence:
    • MELAALCRWG LLLALLPPGA ASTQVCTGTD MKLRLPASPE THLDMLRHLY QGCQVVQGNL 
ELTYLPTNAS LSFLQDIQEV QGYVLIAHNQ VRQVPLQRLR IVRGTQLFED NYALAVLDNG 
DPLNNTTPVT GASPGGLREL QLRSLTEILK GGVLIQRNPQ LCYQDTILWK DIFHKNNQLA 
LTLIDTNRSR ACHPCSPMCK GSRCWGESSE DCQSLTRTVC AGGCARCKGP LPTDCCHEQC 
AAGCTGPKHS DCLACLHFNH SGICELHCPA LVTYNTDTFE SMPNPEGRYT FGASCVTACP 
YNYLSTDVGS CTLVCPLHNQ EVTAEDGTQR CEKCSKPCAR VCYGLGMEHL REVRAVTSAN 
IQEFAGCKKI FGSLAFLPES FDGDPASNTA PLQPEQLQVF ETLEEITGYL YISAWPDSLP 
DLSVFQNLQV IRGRILHNGA YSLTLQGLGI SWLGLRSLRE LGSGLALIHH NTHLCFVHTV 
PWDQLFRNPH QALLHTANRP EDECVGEGLA CHQLCARGHC WGPGPTQCVN CSQFLRGQEC 
VEECRVLQGL PREYVNARHC LPCHPECQPQ NGSVTCFGPE ADQCVACAHY KDPPFCVARC 
PSGVKPDLSY MPIWKFPDEE GACQPCPINC THSCVDLDDK GCPAEQRASP LTSIISAVVG 
ILLVVVLGVV FGILIKRRQQ KIRKYTMRRL LQETELVEPL TPSGAMPNQA QMRILKETEL 
RKVKVLGSGA FGTVYKGIWI PDGENVKIPV AIKVLRENTS PKANKEILDE AYVMAGVGSP 
YVSRLLGICL TSTVQLVTQL MPYGCLLDHV RENRGRLGSQ DLLNWCMQIA KGMSYLEDVR 
LVHRDLAARN VLVKSPNHVK ITDFGLARLL DIDETEYHAD GGKVPIKWMA LESILRRRFT 
HQSDVWSYGV TVWELMTFGA KPYDGIPARE IPDLLEKGER LPQPPICTID VYMIMVKCWM 
IDSECRPRFR ELVSEFSRMA RDPQRFVVIQ NEDLGPASPL DSTFYRSLLE DDDMGDLVDA 
EEYLVPQQGF FCPDPAPGAG GMVHHRHRSS STRNM

Genular Protein ID: 1053799140

Symbol: F5H1T4_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5H1T4

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 6 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PeptideAtlas 1 Pfam 6 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 3 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 603
  • Mass: 66543
  • Checksum: E9E69D9E0052A525
  • Sequence:
    • MKLRLPASPE THLDMLRHLY QGCQVVQGNL ELTYLPTNAS LSFLQDIQEV QGYVLIAHNQ 
VRQVPLQRLR IVRGTQLFED NYALAVLDNG DPLNNTTPVT GASPGGLREL QLRSLTEILK 
GGVLIQRNPQ LCYQDTILWK DIFHKNNQLA LTLIDTNRSR ACHPCSPMCK GSRCWGESSE 
DCQSLTRTVC AGGCARCKGP LPTDCCHEQC AAGCTGPKHS DCLACLHFNH SGICELHCPA 
LVTYNTDTFE SMPNPEGRYT FGASCVTACP YNYLSTDVGS CTLVCPLHNQ EVTAEDGTQR 
CEKCSKPCAR VCYGLGMEHL REVRAVTSAN IQEFAGCKKI FGSLAFLPES FDGDPASNTA 
PLQPEQLQVF ETLEEITGYL YISAWPDSLP DLSVFQNLQV IRGRILHNGA YSLTLQGLGI 
SWLGLRSLRE LGSGLALIHH NTHLCFVHTV PWDQLFRNPH QALLHTANRP EDECVGEGLA 
CHQLCARGHC WGPGPTQCVN CSQFLRGQEC VEECRVLQGL PREYVNARHC LPCHPECQPQ 
NGSVTCFGPE ADQCVACAHY KDPPFCVARC PSGVKPDLSY MPIWKFPDEE GACQPCPINC 
THS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.