Details for: ERCC6

Gene ID: 2074

Symbol: ERCC6

Ensembl ID: ENSG00000225830

Description: ERCC excision repair 6, chromatin remodeling factor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.98
    Marker Score: 2192
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.98
    Marker Score: 1152
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.51
    Marker Score: 5857
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.42
    Marker Score: 12180
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.39
    Marker Score: 85401
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.37
    Marker Score: 13018
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.33
    Marker Score: 49178
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.32
    Marker Score: 2043
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.28
    Marker Score: 48673
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.27
    Marker Score: 11900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.23
    Marker Score: 9417.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.14
    Marker Score: 4650
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.14
    Marker Score: 17063
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.11
    Marker Score: 17357
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.05
    Marker Score: 4353
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71770
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47995
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.99
    Marker Score: 19772
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 488
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 442
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.93
    Marker Score: 1888
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.91
    Marker Score: 19497
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2723
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5025
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.83
    Marker Score: 8529
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.82
    Marker Score: 1573
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8
    Marker Score: 843
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1254
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.76
    Marker Score: 1794
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 579
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 378.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 292
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.72
    Marker Score: 380
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.72
    Marker Score: 969
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.71
    Marker Score: 1026
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2921.5
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.69
    Marker Score: 203
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.68
    Marker Score: 527
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 623
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.67
    Marker Score: 401
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.64
    Marker Score: 431
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.64
    Marker Score: 207
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.62
    Marker Score: 195
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.62
    Marker Score: 1412
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.62
    Marker Score: 663.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.61
    Marker Score: 3679
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.61
    Marker Score: 20520
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.61
    Marker Score: 526
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.6
    Marker Score: 2775
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.59
    Marker Score: 343
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.59
    Marker Score: 217
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.59
    Marker Score: 169
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.58
    Marker Score: 729.5
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.56
    Marker Score: 234
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.55
    Marker Score: 275
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.55
    Marker Score: 629.5
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.54
    Marker Score: 234
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 431
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.52
    Marker Score: 877
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.51
    Marker Score: 245
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.5
    Marker Score: 11223
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.5
    Marker Score: 710
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.49
    Marker Score: 728.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.49
    Marker Score: 294
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.49
    Marker Score: 1397
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.48
    Marker Score: 281
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.47
    Marker Score: 449
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.47
    Marker Score: 3016
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.47
    Marker Score: 128
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.47
    Marker Score: 1662
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.47
    Marker Score: 163
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.47
    Marker Score: 483
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.46
    Marker Score: 1235
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.45
    Marker Score: 212
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.45
    Marker Score: 307
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.45
    Marker Score: 416
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.45
    Marker Score: 236
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.45
    Marker Score: 447
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.45
    Marker Score: 129
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.44
    Marker Score: 132
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.44
    Marker Score: 535
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.44
    Marker Score: 150
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.43
    Marker Score: 1814
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.43
    Marker Score: 162
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.43
    Marker Score: 137
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.43
    Marker Score: 1856
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.42
    Marker Score: 503
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.41
    Marker Score: 141
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.41
    Marker Score: 416
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.41
    Marker Score: 432
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.41
    Marker Score: 201
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.4
    Marker Score: 3011
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.4
    Marker Score: 100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.4
    Marker Score: 499

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Other Information

**Key characteristics** * ERCC6 is a protein that is expressed in a variety of cell types, including neurons, glial cells, and epithelial cells. * ERCC6 is a chromatin remodeling factor that is involved in the regulation of gene expression. * ERCC6 is a key regulator of the transcription-coupled nucleotide excision repair (tc-ner) pathway, which is responsible for repairing DNA damage that occurs during cell division. * ERCC6 is also involved in the regulation of other DNA repair pathways, including the base excision repair pathway and the homologous recombination pathway. **Pathways and functions** * ERCC6 is involved in the regulation of cell cycle regulation. It is a key regulator of the G1/S transition, and it is necessary for the normal proliferation of cells. * ERCC6 is also involved in the regulation of DNA repair. It is a key regulator of the tc-ner pathway, which is responsible for repairing DNA damage that occurs during cell division. * ERCC6 is also involved in the regulation of neuronal differentiation and function. It is a key regulator of the development of the central nervous system, and it is necessary for the proper function of neurons. **Clinical significance** ERCC6 is a promising target for cancer therapy. Inhibition of ERCC6 has been shown to be effective in inhibiting the growth of cancer cells, and it is currently being investigated as a treatment for a variety of cancers.

Genular Protein ID: 75698908

Symbol: ERCC6_HUMAN

Name: DNA excision repair protein ERCC-6

UniProtKB Accession Codes:

Q03468 D3DX94 E7EV46 Q5W0L9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CORUM 1 CTD 1 ChEBI 6 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 5 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 50 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 11 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 6 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 8 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 7 RefSeq 2 Rhea 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 2 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1339317

Title: ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne's syndrome and preferential repair of active genes.

PubMed ID: 1339317

DOI: 10.1016/0092-8674(92)90390-x

PubMed ID: 8382798

Title: Structure and expression of the excision repair gene ERCC6, involved in the human disorder Cockayne's syndrome group B.

PubMed ID: 8382798

DOI: 10.1093/nar/21.3.419

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 10447254

Title: A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy.

PubMed ID: 10447254

DOI: 10.1002/(sici)1098-1004(1999)14:1<9::aid-humu2>3.0.co;2-6

PubMed ID: 10739753

Title: Manitoba aboriginal kindred with original cerebro-oculo-facio-skeletal syndrome has a mutation in the Cockayne syndrome group B (CSB) gene.

PubMed ID: 10739753

DOI: 10.1086/302867

PubMed ID: 10767341

Title: Identical mutations in the CSB gene associated with either Cockayne syndrome or the DeSanctis-Cacchione variant of xeroderma pigmentosum.

PubMed ID: 10767341

DOI: 10.1093/hmg/9.8.1171

PubMed ID: 15486090

Title: Complete absence of Cockayne syndrome group B gene product gives rise to UV-sensitive syndrome but not Cockayne syndrome.

PubMed ID: 15486090

DOI: 10.1073/pnas.0404587101

PubMed ID: 16128801

Title: The Cockayne syndrome group B protein is a functional dimer.

PubMed ID: 16128801

DOI: 10.1111/j.1742-4658.2005.04844.x

PubMed ID: 15548521

Title: The CSB protein actively wraps DNA.

PubMed ID: 15548521

DOI: 10.1074/jbc.m409147200

PubMed ID: 16246722

Title: Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome.

PubMed ID: 16246722

DOI: 10.1016/j.molcel.2005.09.022

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16751180

Title: CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome.

PubMed ID: 16751180

DOI: 10.1101/gad.378206

PubMed ID: 16603771

Title: The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription.

PubMed ID: 16603771

DOI: 10.1074/jbc.m600233200

PubMed ID: 16916636

Title: Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo.

PubMed ID: 16916636

DOI: 10.1016/j.molcel.2006.06.029

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16754848

Title: Synergic effect of polymorphisms in ERCC6 5' flanking region and complement factor H on age-related macular degeneration predisposition.

PubMed ID: 16754848

DOI: 10.1073/pnas.0603485103

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18438403

Title: Protein lysine methyltransferase G9a acts on non-histone targets.

PubMed ID: 18438403

DOI: 10.1038/nchembio.88

PubMed ID: 18369450

Title: An abundant evolutionarily conserved CSB-PiggyBac fusion protein expressed in Cockayne syndrome.

PubMed ID: 18369450

DOI: 10.1371/journal.pgen.1000031

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20541997

Title: A ubiquitin-binding domain in cockayne syndrome B required for transcription-coupled nucleotide excision repair.

PubMed ID: 20541997

DOI: 10.1016/j.molcel.2010.04.017

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22483866

Title: The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells.

PubMed ID: 22483866

DOI: 10.1016/j.dnarep.2012.02.004

PubMed ID: 22466610

Title: Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair.

PubMed ID: 22466610

DOI: 10.1038/ng.2229

PubMed ID: 22466611

Title: UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair.

PubMed ID: 22466611

DOI: 10.1038/ng.2230

PubMed ID: 22466612

Title: Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair.

PubMed ID: 22466612

DOI: 10.1038/ng.2228

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24874740

Title: The cockayne syndrome B protein is essential for neuronal differentiation and neuritogenesis.

PubMed ID: 24874740

DOI: 10.1038/cddis.2014.228

PubMed ID: 25820262

Title: Cockayne syndrome group B protein regulates DNA double-strand break repair and checkpoint activation.

PubMed ID: 25820262

DOI: 10.15252/embj.201490041

PubMed ID: 26030138

Title: Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

PubMed ID: 26030138

DOI: 10.1371/journal.pone.0128558

PubMed ID: 26620705

Title: The C-terminal Region and SUMOylation of Cockayne Syndrome Group B Protein Play Critical Roles in Transcription-coupled Nucleotide Excision Repair.

PubMed ID: 26620705

DOI: 10.1074/jbc.m115.683235

PubMed ID: 28292928

Title: Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage.

PubMed ID: 28292928

DOI: 10.1074/jbc.c117.777946

PubMed ID: 29203878

Title: ATM and CDK2 control chromatin remodeler CSB to inhibit RIF1 in DSB repair pathway choice.

PubMed ID: 29203878

DOI: 10.1038/s41467-017-02114-x

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29545921

Title: CSA and CSB play a role in the response to DNA breaks.

PubMed ID: 29545921

DOI: 10.18632/oncotarget.24342

PubMed ID: 32142649

Title: Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair.

PubMed ID: 32142649

DOI: 10.1016/j.cell.2020.02.010

PubMed ID: 9443879

Title: Molecular analysis of mutations in the CSB (ERCC6) gene in patients with Cockayne syndrome.

PubMed ID: 9443879

DOI: 10.1086/301686

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 18987736

Title: DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.

PubMed ID: 18987736

DOI: 10.1038/nature07485

PubMed ID: 19894250

Title: Mutation update for the CSB/ERCC6 and CSA/ERCC8 genes involved in Cockayne syndrome.

PubMed ID: 19894250

DOI: 10.1002/humu.21154

Sequence Information:

  • Length: 1493
  • Mass: 168416
  • Checksum: 285257E2AEC071AC
  • Sequence:
    • MPNEGIPHSS QTQEQDCLQS QPVSNNEEMA IKQESGGDGE VEEYLSFRSV GDGLSTSAVG 
CASAAPRRGP ALLHIDRHQI QAVEPSAQAL ELQGLGVDVY DQDVLEQGVL QQVDNAIHEA 
SRASQLVDVE KEYRSVLDDL TSCTTSLRQI NKIIEQLSPQ AATSRDINRK LDSVKRQKYN 
KEQQLKKITA KQKHLQAILG GAEVKIELDH ASLEEDAEPG PSSLGSMLMP VQETAWEELI 
RTGQMTPFGT QIPQKQEKKP RKIMLNEASG FEKYLADQAK LSFERKKQGC NKRAARKAPA 
PVTPPAPVQN KNKPNKKARV LSKKEERLKK HIKKLQKRAL QFQGKVGLPK ARRPWESDMR 
PEAEGDSEGE ESEYFPTEEE EEEEDDEVEG AEADLSGDGT DYELKPLPKG GKRQKKVPVQ 
EIDDDFFPSS GEEAEAASVG EGGGGGRKVG RYRDDGDEDY YKQRLRRWNK LRLQDKEKRL 
KLEDDSEESD AEFDEGFKVP GFLFKKLFKY QQTGVRWLWE LHCQQAGGIL GDEMGLGKTI 
QIIAFLAGLS YSKIRTRGSN YRFEGLGPTV IVCPTTVMHQ WVKEFHTWWP PFRVAILHET 
GSYTHKKEKL IRDVAHCHGI LITSYSYIRL MQDDISRYDW HYVILDEGHK IRNPNAAVTL 
ACKQFRTPHR IILSGSPMQN NLRELWSLFD FIFPGKLGTL PVFMEQFSVP ITMGGYSNAS 
PVQVKTAYKC ACVLRDTINP YLLRRMKSDV KMSLSLPDKN EQVLFCRLTD EQHKVYQNFV 
DSKEVYRILN GEMQIFSGLI ALRKICNHPD LFSGGPKNLK GLPDDELEED QFGYWKRSGK 
MIVVESLLKI WHKQGQRVLL FSQSRQMLDI LEVFLRAQKY TYLKMDGTTT IASRQPLITR 
YNEDTSIFVF LLTTRVGGLG VNLTGANRVV IYDPDWNPST DTQARERAWR IGQKKQVTVY 
RLLTAGTIEE KIYHRQIFKQ FLTNRVLKDP KQRRFFKSND LYELFTLTSP DASQSTETSA 
IFAGTGSDVQ TPKCHLKRRI QPAFGADHDV PKRKKFPASN ISVNDATSSE EKSEAKGAEV 
NAVTSNRSDP LKDDPHMSSN VTSNDRLGEE TNAVSGPEEL SVISGNGECS NSSGTGKTSM 
PSGDESIDEK LGLSYKRERP SQAQTEAFWE NKQMENNFYK HKSKTKHHSV AEEETLEKHL 
RPKQKPKNSK HCRDAKFEGT RIPHLVKKRR YQKQDSENKS EAKEQSNDDY VLEKLFKKSV 
GVHSVMKHDA IMDGASPDYV LVEAEANRVA QDALKALRLS RQRCLGAVSG VPTWTGHRGI 
SGAPAGKKSR FGKKRNSNFS VQHPSSTSPT EKCQDGIMKK EGKDNVPEHF SGRAEDADSS 
SGPLASSSLL AKMRARNHLI LPERLESESG HLQEASALLP TTEHDDLLVE MRNFIAFQAH 
TDGQASTREI LQEFESKLSA SQSCVFRELL RNLCTFHRTS GGEGIWKLKP EYC

Genular Protein ID: 1938475289

Symbol: ERPG3_HUMAN

Name: Chimeric ERCC6-PGBD3 protein

UniProtKB Accession Codes:

P0DP91

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 7 GeneCards 1 GeneReviews 1 GeneTree 1 HGNC 2 HPA 1 IntAct 1 InterPro 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SMR 1 SignaLink 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18369450

Title: An abundant evolutionarily conserved CSB-PiggyBac fusion protein expressed in Cockayne syndrome.

PubMed ID: 18369450

DOI: 10.1371/journal.pgen.1000031

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22483866

Title: The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells.

PubMed ID: 22483866

DOI: 10.1016/j.dnarep.2012.02.004

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26218421

Title: CSB-PGBD3 mutations cause premature ovarian failure.

PubMed ID: 26218421

DOI: 10.1371/journal.pgen.1005419

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 1061
  • Mass: 119487
  • Checksum: 542A37356E38C376
  • Sequence:
    • MPNEGIPHSS QTQEQDCLQS QPVSNNEEMA IKQESGGDGE VEEYLSFRSV GDGLSTSAVG 
CASAAPRRGP ALLHIDRHQI QAVEPSAQAL ELQGLGVDVY DQDVLEQGVL QQVDNAIHEA 
SRASQLVDVE KEYRSVLDDL TSCTTSLRQI NKIIEQLSPQ AATSRDINRK LDSVKRQKYN 
KEQQLKKITA KQKHLQAILG GAEVKIELDH ASLEEDAEPG PSSLGSMLMP VQETAWEELI 
RTGQMTPFGT QIPQKQEKKP RKIMLNEASG FEKYLADQAK LSFERKKQGC NKRAARKAPA 
PVTPPAPVQN KNKPNKKARV LSKKEERLKK HIKKLQKRAL QFQGKVGLPK ARRPWESDMR 
PEAEGDSEGE ESEYFPTEEE EEEEDDEVEG AEADLSGDGT DYELKPLPKG GKRQKKVPVQ 
EIDDDFFPSS GEEAEAASVG EGGGGGRKVG RYRDDGDEDY YKQRLSPKMP RTLSLHEITD 
LLETDDSIEA SAIVIQPPEN ATAPVSDEES GDEEGGTINN LPGSLLHTAA YLIQDGSDAE 
SDSDDPSYAP KDDSPDEVPS TFTVQQPPPS RRRKMTKILC KWKKADLTVQ PVAGRVTAPP 
NDFFTVMRTP TEILELFLDD EVIELIVKYS NLYACSKGVH LGLTSSEFKC FLGIIFLSGY 
VSVPRRRMFW EQRTDVHNVL VSAAMRRDRF ETIFSNLHVA DNANLDPVDK FSKLRPLISK 
LNERCMKFVP NETYFSFDEF MVPYFGRHGC KQFIRGKPIR FGYKFWCGAT CLGYICWFQP 
YQGKNPNTKH EEYGVGASLV LQFSEALTEA HPGQYHFVFN NFFTSIALLD KLSSMGHQAT 
GTVRKDHIDR VPLESDVALK KKERGTFDYR IDGKGNIVCR WNDNSVVTVA SSGAGIHPLC 
LVSRYSQKLK KKIQVQQPNM IKVYNQFMGG VDRADENIDK YRASIRGKKW YSSPLLFCFE 
LVLQNAWQLH KTYDEKPVDF LEFRRRVVCH YLETHGHPPE PGQKGRPQKR NIDSRYDGIN 
HVIVKQGKQT RCAECHKNTT FRCEKCDVAL HVKCSVEYHT E

Genular Protein ID: 1905480800

Symbol: A8K4Q3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K4Q3

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 4 GenomeRNAi 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 2 RefSeq 2 SAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 1061
  • Mass: 119459
  • Checksum: AB6696AED3FC0D94
  • Sequence:
    • MPNEGIPHSS QTQEQDCLQS QPVSNNEEMA IKQESGGDGE VEEYLSFRSV GDGLSTSAVG 
CASAAPRRGP ALLHIDRHQI QAVEPSAQAL ELQGLGVDVY DQDVLEQGVL QQVDNAIHEA 
SRASQLVDVE KEYRSVLDDL TSCTTSLRQI NKIIEQLSPQ AATSRDINRK LDSVKRQKYN 
KEQQLKKITA KQKHLQAILG GAEVKIELDH ASLEEDAEPG PSSLGSMLMP VQETAWEELI 
RTGQMTPFGT QIPQKQEKKP RKIMLNEASG FEKYLADQAK LSFERKKQGC NKRAARKAPA 
PVTPPAPVQN KNKPNKKARV LSKKEERLKK HIKKLQKRAL QFQGKVGLPK ARRPWESDMR 
PEAEGDSEGE ESEYFPTEEE EEEEDDEVEG AEADLSGDGT DYELKPLPKG GKRQKKVPVQ 
EIDDDFFPSS GEEAEAASVG EGGGGGRKVG RYRDDGDEDY YKQRLSPKMP RTLSLHEITD 
LLETDDSIEA SAIVIQPPEN ATAPVSDEES GDEEGGTINN LPGSLLHTAA YLIQDGSDAE 
SDSDDPSYAP KDDSPDEVPS TFTVQQPPPS RRRKMTKILC KWKKADLTVQ PVAGRVTAPP 
NDFFTVMRTP TEILELFLDD EVIELIVKYS NLYACSKGVH LGLTSSEFKC FLGIIFLSGY 
VSVPRRRMFW EQRTDVHNVL VSAAMRRDRF ETIFSNLHVA DNANLDPVDK FSKLRPLISK 
LNERCMKFVP NETYFSFDEF MVPYFGRHGC KQFIRGKPIR FGYKFWCGAT CLGYICWFQP 
YQGKNPNTKH EEYGVGASLV LQFSEALTEA HPGQYHFVFN NFFTSIALLD KLSSMGHQAT 
GTVRKDHIDK VPLESDVALK KKERGTFDYR IDGKGNIVCR WNDNSVVTVA SSGAGIHPLC 
LVSRYSQKLK KKIQVQQPNM IKVYNQFMGG VDRADENIDK YRASIRGKKW YSSPLLFCFE 
LVLQNAWQLH KTYDEKPVDF LEFRRRVVCH YLETHGHPPE PGQKGRPQKR NIDSRYDGIN 
HVIVKQGKQT RCAECHKNTT FRCEKCDVAL HVKCSVEYHT E

Genular Protein ID: 2740753513

Symbol: Q59FF6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59FF6

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 2 GenomeRNAi 1 InterPro 5 KEGG 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PROSITE 4 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 30753618

Title: Structural basis of ubiquitin recognition by the winged-helix domain of Cockayne syndrome group B protein.

PubMed ID: 30753618

DOI: 10.1093/nar/gkz081

Sequence Information:

  • Length: 870
  • Mass: 98105
  • Checksum: 83542715C9C37ABA
  • Sequence:
    • QQPFHRHLLM TTALHSEKLI RDVAHCHGIL ITSYSYIRLM QDDISRYDWH YVILDEGHKI 
RNPNAAVTLA CKQFRTPHRI ILSGSPMQNN LRELWSLFDF IFPGKLGTLP VFMEQFSVPI 
TMGGYSNASP VQVKTAYKCA CVLRDTINPY LLRRMKSDVK MSLSLPDKNE QIFSGLIALR 
KICNHPDLFS GGPKNLKGLP DDELEEDQFG YWKRSGKMIV VESLLKIWHK QGQRVLLFSQ 
SRQMLDILEV FLRAQKYTYL KMDGTTTIAS RQPLITRYNE DTSIFVFLLT TRVGGLGVNL 
TGANRVVIYD PDWNPSTDTQ ARERAWRIGQ KKQVTVYRLL TAGTIEEKIY HRQIFKQFLT 
NRVLKDPKQR RFFKSNDLYE LFTLTSPDAS QSTETSAIFA GTGSDVQTPK CHLKRRIQPA 
FGADHDVPKR KKFPASNISV NDATSSEEKS EAKGAEVNAV TSNRSDPLKD DPHVSSNVTS 
NDRLGEETNA VSGPEELSVI SGNGECSNSS GTGKTSMPSG DESIDEKLGL SYKRERPSQA 
QTEAFWENKQ MENNFYKHKS KTKHHSVAEE ETLEKHLRPK QKPKNSKHCG DAKFEGTRIP 
HLVKKRRYQK QDSENKSEAK EQSNDDYVLE KLFKKSVGVH SVMKHDAIMD GASPDYVLVE 
AEANRVAQDA LKALRLSRQR CLGAVSGVPT WTGHRGISGA PAGKKSRFGK KRNSNFSVQH 
PSSTSPTEKC QDGIMKKEGK DNVPEHFSGR AEDADSSSGP LASSSLLAKM RARNHLILPE 
RLESESGHLR EASALLPTTE HDDLLVEMRN FIAFQAHTDG QASTREILQE FESKLSASQS 
CVFRELLRNL CTFHRTSGGE GIWKLKPEYC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.