Details for: ERH

Gene ID: 2079

Symbol: ERH

Ensembl ID: ENSG00000100632

Description: ERH mRNA splicing and mitosis factor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.65
    Marker Score: 3809
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.57
    Marker Score: 47146
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 3.55
    Marker Score: 1307
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.1
    Marker Score: 105467
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.93
    Marker Score: 19058
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.86
    Marker Score: 5367
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.85
    Marker Score: 98659
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.8
    Marker Score: 4306
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.77
    Marker Score: 2469
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.76
    Marker Score: 1734
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.73
    Marker Score: 5699
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.73
    Marker Score: 4980
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.69
    Marker Score: 31294
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.63
    Marker Score: 2477
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.63
    Marker Score: 35360
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.63
    Marker Score: 4184
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.62
    Marker Score: 10090
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.62
    Marker Score: 11285
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.61
    Marker Score: 2928
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.61
    Marker Score: 2786
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.6
    Marker Score: 3680
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.6
    Marker Score: 3386
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.59
    Marker Score: 4397
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.58
    Marker Score: 4233
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.57
    Marker Score: 22327
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.56
    Marker Score: 10470
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.56
    Marker Score: 4110
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.54
    Marker Score: 4215
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.53
    Marker Score: 25030
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.53
    Marker Score: 1008
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.5
    Marker Score: 14824
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.5
    Marker Score: 1790
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.49
    Marker Score: 5864.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.49
    Marker Score: 6279
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.48
    Marker Score: 6646
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.48
    Marker Score: 27922
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.47
    Marker Score: 7343
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.46
    Marker Score: 6011
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.45
    Marker Score: 6678
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.45
    Marker Score: 1162
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.45
    Marker Score: 2953
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.44
    Marker Score: 1734
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.43
    Marker Score: 15509
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.41
    Marker Score: 3471
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.41
    Marker Score: 2447
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.4
    Marker Score: 791
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.4
    Marker Score: 24151.5
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.4
    Marker Score: 908
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.4
    Marker Score: 4786
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.39
    Marker Score: 1456
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.39
    Marker Score: 768
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.39
    Marker Score: 2255.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.39
    Marker Score: 2404
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.38
    Marker Score: 2876.5
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.38
    Marker Score: 1071
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.37
    Marker Score: 4808.5
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.37
    Marker Score: 2762
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.36
    Marker Score: 1215
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.36
    Marker Score: 1574
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.35
    Marker Score: 2770
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.34
    Marker Score: 12309
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.34
    Marker Score: 6467
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.34
    Marker Score: 17422
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.34
    Marker Score: 1231
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.34
    Marker Score: 4072
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.33
    Marker Score: 1384
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.33
    Marker Score: 15190
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.32
    Marker Score: 2456
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 2.32
    Marker Score: 741
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.31
    Marker Score: 1089
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.3
    Marker Score: 58938
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.29
    Marker Score: 2444
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.29
    Marker Score: 1505
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.29
    Marker Score: 19707
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.28
    Marker Score: 2425
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.28
    Marker Score: 1658
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.27
    Marker Score: 543
  • Cell Name: basophil (CL0000767)
    Fold Change: 2.26
    Marker Score: 1073
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 2.24
    Marker Score: 6095.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.22
    Marker Score: 8214
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.22
    Marker Score: 8713
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.22
    Marker Score: 1735
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.21
    Marker Score: 5795
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.21
    Marker Score: 762
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.21
    Marker Score: 2380
  • Cell Name: oocyte (CL0000023)
    Fold Change: 2.21
    Marker Score: 546
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.21
    Marker Score: 5010
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.21
    Marker Score: 1393
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.2
    Marker Score: 655
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.19
    Marker Score: 6260
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.19
    Marker Score: 2570
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 2.18
    Marker Score: 2104
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.18
    Marker Score: 2051
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.18
    Marker Score: 1241
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.16
    Marker Score: 16843.5
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.16
    Marker Score: 1299
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 2.15
    Marker Score: 746
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.15
    Marker Score: 1060
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.15
    Marker Score: 2280
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.15
    Marker Score: 2076

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Other Information

**Key characteristics:** * ERH is a protein with a molecular weight of approximately 100 kDa. * It is a member of the ERH family of proteins. * ERH is involved in the regulation of cell cycle progression and mitosis. **Pathways and functions:** * ERH is involved in cell cycle regulation by binding to the E2F1 transcription factor and promoting its binding to the promoters of cell cycle genes. * ERH is also involved in the regulation of apoptosis by binding to the BH3-only protein and promoting its interaction with the BH3 domain of Bcl-2. * ERH is involved in the maintenance of genomic integrity by binding to DNA methyltransferase and promoting its activity. * ERH is also involved in the regulation of cell migration by binding to the extracellular matrix protein fibronectin and promoting its interaction with the integrins. **Clinical significance:** * Mutations in the ERH gene have been linked to several human cancers, including leukemia and breast cancer. * ERH inhibitors are being investigated as a potential treatment for cancer. **Additional notes:** * ERH is a highly conserved gene, with a similar gene found in humans, mice, and flies. * ERH is a multi-functional protein that can interact with a variety of proteins involved in cell cycle regulation and apoptosis.

Genular Protein ID: 4134233255

Symbol: ERH_HUMAN

Name: Enhancer of rudimentary homolog

UniProtKB Accession Codes:

P84090 B2R5H2 P70659 Q14259

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8786099

Title: Cloning and mapping of a novel human cDNA homologous to DROER, the enhancer of the Drosophila melanogaster rudimentary gene.

PubMed ID: 8786099

DOI: 10.1006/geno.1996.0086

PubMed ID: 9074495

Title: The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals.

PubMed ID: 9074495

DOI: 10.1016/s0378-1119(96)00701-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16984396

Title: Human enhancer of rudimentary is a molecular partner of PDIP46/SKAR, a protein interacting with DNA polymerase delta and S6K1 and regulating cell growth.

PubMed ID: 16984396

DOI: 10.1111/j.1742-4658.2006.05477.x

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23145069

Title: Identification and Functional Analysis of the erh1(+) Gene Encoding Enhancer of Rudimentary Homolog from the Fission Yeast Schizosaccharomyces pombe.

PubMed ID: 23145069

DOI: 10.1371/journal.pone.0049059

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25284789

Title: 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex.

PubMed ID: 25284789

DOI: 10.1016/j.celrep.2014.08.071

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 15794639

Title: Structure of the conserved transcriptional repressor enhancer of rudimentary homolog.

PubMed ID: 15794639

DOI: 10.1021/bi047785w

Sequence Information:

  • Length: 104
  • Mass: 12259
  • Checksum: C609AFF7F63E5279
  • Sequence:
    • MSHTILLVQP TKRPEGRTYA DYESVNECME GVCKMYEEHL KRMNPNSPSI TYDISQLFDF 
IDDLADLSCL VYRADTQTYQ PYNKDWIKEK IYVLLRRQAQ QAGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.