Details for: ERH

Gene ID: 2079

Symbol: ERH

Ensembl ID: ENSG00000100632

Description: ERH mRNA splicing and mitosis factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 387.2829
    Cell Significance Index: -60.2400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 247.2172
    Cell Significance Index: -62.7100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 226.9706
    Cell Significance Index: -93.5000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 202.0642
    Cell Significance Index: -82.0900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 194.9070
    Cell Significance Index: -92.0200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 177.7850
    Cell Significance Index: -91.4500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 137.5364
    Cell Significance Index: -92.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 87.1125
    Cell Significance Index: -83.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 69.6132
    Cell Significance Index: -85.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 23.3474
    Cell Significance Index: -92.1300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.6552
    Cell Significance Index: -60.6900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 19.6356
    Cell Significance Index: -60.3100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.4777
    Cell Significance Index: -25.1200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 6.1809
    Cell Significance Index: 49.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 5.5653
    Cell Significance Index: 146.3400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.9748
    Cell Significance Index: 104.1300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 4.9405
    Cell Significance Index: 171.6800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 4.8706
    Cell Significance Index: 52.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.4321
    Cell Significance Index: 471.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.1554
    Cell Significance Index: 148.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.0011
    Cell Significance Index: 353.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.9409
    Cell Significance Index: 1606.0900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.9262
    Cell Significance Index: 37.4800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.7536
    Cell Significance Index: 80.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.5285
    Cell Significance Index: 188.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.5002
    Cell Significance Index: 71.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.4772
    Cell Significance Index: 130.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.2915
    Cell Significance Index: 106.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.2824
    Cell Significance Index: 280.6500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.0458
    Cell Significance Index: 12.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.9260
    Cell Significance Index: 347.1900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.9233
    Cell Significance Index: 136.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.9181
    Cell Significance Index: 848.0200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.8343
    Cell Significance Index: 235.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8189
    Cell Significance Index: 49.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.7408
    Cell Significance Index: 224.9100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.6443
    Cell Significance Index: 37.9900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.3353
    Cell Significance Index: 15.1700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.1898
    Cell Significance Index: 6.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0698
    Cell Significance Index: 69.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.0197
    Cell Significance Index: 64.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8033
    Cell Significance Index: 21.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7954
    Cell Significance Index: 41.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7338
    Cell Significance Index: 145.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5967
    Cell Significance Index: 119.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5896
    Cell Significance Index: 30.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5678
    Cell Significance Index: 56.1700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5452
    Cell Significance Index: 88.6800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5310
    Cell Significance Index: 4.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5050
    Cell Significance Index: 10.9400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4139
    Cell Significance Index: 7.3200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.3439
    Cell Significance Index: 4.1000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2412
    Cell Significance Index: 45.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2324
    Cell Significance Index: 175.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2301
    Cell Significance Index: 39.2900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2090
    Cell Significance Index: 12.5500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1766
    Cell Significance Index: 2.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1109
    Cell Significance Index: 39.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0964
    Cell Significance Index: 70.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0164
    Cell Significance Index: 30.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0049
    Cell Significance Index: -3.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0358
    Cell Significance Index: -66.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0405
    Cell Significance Index: -62.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0514
    Cell Significance Index: -32.0800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0519
    Cell Significance Index: -5.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0703
    Cell Significance Index: -95.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0875
    Cell Significance Index: -55.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.1013
    Cell Significance Index: -70.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1105
    Cell Significance Index: -62.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1422
    Cell Significance Index: -64.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1749
    Cell Significance Index: -36.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2080
    Cell Significance Index: -9.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2702
    Cell Significance Index: -77.7400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2924
    Cell Significance Index: -7.4700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3480
    Cell Significance Index: -37.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3561
    Cell Significance Index: -40.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3957
    Cell Significance Index: -46.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3975
    Cell Significance Index: -12.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4497
    Cell Significance Index: -65.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5027
    Cell Significance Index: -14.0500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5070
    Cell Significance Index: -9.3700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5554
    Cell Significance Index: -14.8600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5727
    Cell Significance Index: -65.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5903
    Cell Significance Index: -46.7600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.6354
    Cell Significance Index: -5.4600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6736
    Cell Significance Index: -4.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6847
    Cell Significance Index: -38.4200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.6930
    Cell Significance Index: -9.7200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.7330
    Cell Significance Index: -5.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8635
    Cell Significance Index: -89.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.9005
    Cell Significance Index: -69.1100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.9366
    Cell Significance Index: -16.0500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9602
    Cell Significance Index: -13.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.0300
    Cell Significance Index: -69.2600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.1533
    Cell Significance Index: -33.9700
  • Cell Name: glioblast (CL0000030)
    Fold Change: -1.2652
    Cell Significance Index: -7.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.3194
    Cell Significance Index: -35.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.3834
    Cell Significance Index: -34.5800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.4611
    Cell Significance Index: -15.1300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.5025
    Cell Significance Index: -10.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ERH is a gene that codes for a protein, Enhancer of Rudimentary Homolog (ERH_HUMAN), which is significantly expressed in various cell types, including erythroid progenitor cells, mesodermal cells, radial glial cells, and fibroblasts from the mammary gland. The ERH protein is involved in mRNA splicing and mitosis, highlighting its importance in regulating cellular growth and division. **Pathways and Functions:** ERH is involved in several cellular pathways, including: 1. **Cell Cycle:** ERH plays a crucial role in regulating the cell cycle, particularly during mitosis. By controlling mRNA splicing and mitosis, ERH ensures accurate and efficient cell division. 2. **Methyl-Cpg Binding:** ERH interacts with methyl-Cpg binding proteins, which are essential for DNA methylation and gene regulation. 3. **Methylosome:** ERH is also involved in the methylosome pathway, which is responsible for the synthesis of methionine, an essential amino acid. 4. **Nucleobase-containing Compound Metabolic Process:** ERH is involved in the metabolic process of nucleobase-containing compounds, which are essential for DNA and RNA synthesis. 5. **Protein Binding:** ERH binds to various proteins, including those involved in mRNA splicing and mitosis, highlighting its regulatory role in cellular processes. **Clinical Significance:** The ERH gene has been found to be significantly expressed in various cell types, including: 1. **Erythroid Progenitor Cells:** ERH plays a crucial role in regulating the development of erythroid progenitor cells, which are essential for the production of red blood cells. 2. **Mesodermal Cells:** ERH is involved in the development and maintenance of mesodermal cells, which give rise to various tissues, including muscles, bones, and connective tissue. 3. **Radial Glial Cells:** ERH is essential for the development and maintenance of radial glial cells, which are involved in the formation of the central nervous system. 4. **Fibroblasts from the Mammary Gland:** ERH plays a role in regulating the growth and differentiation of fibroblasts from the mammary gland, which are essential for breast development and function. In conclusion, the ERH gene plays a vital role in regulating various cellular processes, including mRNA splicing and mitosis. Its involvement in different cell types and pathways highlights its importance in maintaining cellular homeostasis and regulating cellular growth and division. Further research is necessary to fully elucidate the clinical significance of ERH in human diseases. **Recommendations:** 1. Further studies are necessary to investigate the role of ERH in human diseases, including cancer and genetic disorders. 2. The development of ERH-specific therapies could provide new avenues for treating diseases related to cellular growth and division. 3. The investigation of ERH's interaction with other genes and proteins could provide insights into its regulatory role in cellular processes. **Limitations:** 1. The current knowledge of ERH is based on a limited number of studies, and further research is necessary to fully elucidate its functions and clinical significance. 2. The expression of ERH in different cell types and tissues highlights its complexity, and further studies are necessary to understand its regulatory role in these contexts. **Future Directions:** 1. The development of ERH-specific therapies could provide new avenues for treating diseases related to cellular growth and division. 2. The investigation of ERH's interaction with other genes and proteins could provide insights into its regulatory role in cellular processes. 3. The study of ERH's expression in different cell types and tissues could provide new insights into its clinical significance and potential therapeutic applications.

Genular Protein ID: 4134233255

Symbol: ERH_HUMAN

Name: Enhancer of rudimentary homolog

UniProtKB Accession Codes:

P84090 B2R5H2 P70659 Q14259

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8786099

Title: Cloning and mapping of a novel human cDNA homologous to DROER, the enhancer of the Drosophila melanogaster rudimentary gene.

PubMed ID: 8786099

DOI: 10.1006/geno.1996.0086

PubMed ID: 9074495

Title: The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals.

PubMed ID: 9074495

DOI: 10.1016/s0378-1119(96)00701-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16984396

Title: Human enhancer of rudimentary is a molecular partner of PDIP46/SKAR, a protein interacting with DNA polymerase delta and S6K1 and regulating cell growth.

PubMed ID: 16984396

DOI: 10.1111/j.1742-4658.2006.05477.x

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23145069

Title: Identification and Functional Analysis of the erh1(+) Gene Encoding Enhancer of Rudimentary Homolog from the Fission Yeast Schizosaccharomyces pombe.

PubMed ID: 23145069

DOI: 10.1371/journal.pone.0049059

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25284789

Title: 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex.

PubMed ID: 25284789

DOI: 10.1016/j.celrep.2014.08.071

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 15794639

Title: Structure of the conserved transcriptional repressor enhancer of rudimentary homolog.

PubMed ID: 15794639

DOI: 10.1021/bi047785w

Sequence Information:

  • Length: 104
  • Mass: 12259
  • Checksum: C609AFF7F63E5279
  • Sequence:
    • MSHTILLVQP TKRPEGRTYA DYESVNECME GVCKMYEEHL KRMNPNSPSI TYDISQLFDF 
IDDLADLSCL VYRADTQTYQ PYNKDWIKEK IYVLLRRQAQ QAGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.