Details for: ETF1

Gene ID: 2107

Symbol: ETF1

Ensembl ID: ENSG00000120705

Description: eukaryotic translation termination factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 228.1009
    Cell Significance Index: -35.4800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 149.1464
    Cell Significance Index: -37.8300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 109.1886
    Cell Significance Index: -44.9800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 91.8829
    Cell Significance Index: -43.3800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 90.7061
    Cell Significance Index: -36.8500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 80.6205
    Cell Significance Index: -41.4700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 38.7225
    Cell Significance Index: -36.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.6955
    Cell Significance Index: -41.5500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.1553
    Cell Significance Index: -37.9200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.9730
    Cell Significance Index: -43.3000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.4641
    Cell Significance Index: -32.1400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.8224
    Cell Significance Index: -17.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 5.2226
    Cell Significance Index: 139.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.0750
    Cell Significance Index: 358.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.9211
    Cell Significance Index: 79.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.9293
    Cell Significance Index: 1741.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.8806
    Cell Significance Index: 53.9100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.6546
    Cell Significance Index: 17.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.6365
    Cell Significance Index: 76.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.2238
    Cell Significance Index: 91.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1254
    Cell Significance Index: 58.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0934
    Cell Significance Index: 134.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.0070
    Cell Significance Index: 445.2100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.9825
    Cell Significance Index: 24.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9141
    Cell Significance Index: 64.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9099
    Cell Significance Index: 117.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8837
    Cell Significance Index: 175.3800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.8750
    Cell Significance Index: 5.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8487
    Cell Significance Index: 152.9900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7433
    Cell Significance Index: 51.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7328
    Cell Significance Index: 47.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7191
    Cell Significance Index: 144.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6921
    Cell Significance Index: 32.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6795
    Cell Significance Index: 30.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6721
    Cell Significance Index: 19.3700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6330
    Cell Significance Index: 11.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5962
    Cell Significance Index: 325.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5232
    Cell Significance Index: 51.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5070
    Cell Significance Index: 13.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5067
    Cell Significance Index: 69.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5060
    Cell Significance Index: 14.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4948
    Cell Significance Index: 10.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4454
    Cell Significance Index: 52.5300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.4157
    Cell Significance Index: 3.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2997
    Cell Significance Index: 107.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2719
    Cell Significance Index: 34.8500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2571
    Cell Significance Index: 6.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1670
    Cell Significance Index: 28.5100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1511
    Cell Significance Index: 2.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1059
    Cell Significance Index: 8.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0594
    Cell Significance Index: 91.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0569
    Cell Significance Index: 10.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0469
    Cell Significance Index: 88.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0422
    Cell Significance Index: 77.7900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0375
    Cell Significance Index: 0.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0279
    Cell Significance Index: 17.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0106
    Cell Significance Index: 7.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0041
    Cell Significance Index: 5.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0050
    Cell Significance Index: -3.7100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0072
    Cell Significance Index: -3.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0109
    Cell Significance Index: -8.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0149
    Cell Significance Index: -9.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0266
    Cell Significance Index: -3.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0351
    Cell Significance Index: -3.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0443
    Cell Significance Index: -24.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0712
    Cell Significance Index: -4.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0790
    Cell Significance Index: -12.8600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0812
    Cell Significance Index: -9.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0892
    Cell Significance Index: -3.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0953
    Cell Significance Index: -20.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0958
    Cell Significance Index: -2.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1214
    Cell Significance Index: -34.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1512
    Cell Significance Index: -4.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1582
    Cell Significance Index: -10.6400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1682
    Cell Significance Index: -4.9400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1688
    Cell Significance Index: -1.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1810
    Cell Significance Index: -2.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1949
    Cell Significance Index: -22.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1979
    Cell Significance Index: -12.4700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2556
    Cell Significance Index: -6.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2621
    Cell Significance Index: -8.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3101
    Cell Significance Index: -19.0600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3129
    Cell Significance Index: -5.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3586
    Cell Significance Index: -37.3400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3665
    Cell Significance Index: -19.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3778
    Cell Significance Index: -16.7100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3938
    Cell Significance Index: -6.5900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3997
    Cell Significance Index: -31.6600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4246
    Cell Significance Index: -9.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5148
    Cell Significance Index: -27.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5224
    Cell Significance Index: -32.0300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5490
    Cell Significance Index: -20.7900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5559
    Cell Significance Index: -10.8500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5636
    Cell Significance Index: -28.4800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6120
    Cell Significance Index: -15.6400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6234
    Cell Significance Index: -17.7900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6349
    Cell Significance Index: -13.2900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.7489
    Cell Significance Index: -10.6600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.7966
    Cell Significance Index: -9.0500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.8035
    Cell Significance Index: -19.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ETF1 is a multifunctional protein that exhibits several key characteristics, including: 1. **Translation termination factor activity**: ETF1 recognizes and binds to stop codons on mRNA, facilitating the release of the completed protein chain. 2. **Aminoacyl-tRNA hydrolase activity**: ETF1 possesses an aminoacyl-tRNA hydrolase activity, which is essential for the hydrolysis of aminoacyl-tRNA, a crucial step in the translation termination process. 3. **Regulation of expression of Slits and Robos**: ETF1 has been shown to regulate the expression of Slits and Robos, two key proteins involved in axon guidance and neuronal development. 4. **Post-translational protein modification**: ETF1 is involved in the regulation of post-translational protein modifications, including hydroxylation, methylation, and phosphorylation. **Pathways and Functions** ETF1 is involved in various cellular pathways, including: 1. **Aminoacyl-tRNA biosynthesis**: ETF1 plays a crucial role in the regulation of aminoacyl-tRNA biosynthesis, ensuring the proper loading of aminoacyl-tRNAs onto ribosomes. 2. **Translation termination**: ETF1 is essential for the termination of protein synthesis, recognizing and binding to stop codons on mRNA, and facilitating the release of the completed protein chain. 3. **Nonsense-mediated decay (NMD)**: ETF1 has been shown to regulate NMD, a process that involves the degradation of aberrant mRNAs containing premature stop codons. 4. **Protein synthesis regulation**: ETF1 regulates protein synthesis by controlling the translation of specific mRNAs, including those involved in axon guidance and neuronal development. **Clinical Significance** Dysregulation of ETF1 has been implicated in various diseases, including: 1. **Neurological disorders**: Mutations in ETF1 have been associated with neurological disorders, such as Charcot-Marie-Tooth disease and peripheral neuropathy. 2. **Cancer**: ETF1 has been shown to be overexpressed in several types of cancer, including breast cancer and prostate cancer, suggesting a potential role in tumorigenesis. 3. **Muscular dystrophy**: ETF1 has been implicated in muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. In conclusion, ETF1 is a multifunctional protein that plays a crucial role in the regulation of protein synthesis and termination in eukaryotic cells. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of ETF1.

Genular Protein ID: 1377199599

Symbol: ERF1_HUMAN

Name: Eukaryotic peptide chain release factor subunit 1

UniProtKB Accession Codes:

P62495 B2R6B4 D3DQC1 P46055 Q5M7Z7 Q96CG1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 13 EMDB 14 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 24 PDBsum 24 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 5 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1537561

Title: Identification of a human cDNA with high homology to yeast omnipotent suppressor 45.

PubMed ID: 1537561

DOI: 10.1016/0378-1119(92)90655-9

PubMed ID: 7990965

Title: A highly conserved eukaryotic protein family possessing properties of polypeptide chain release factor.

PubMed ID: 7990965

DOI: 10.1038/372701a0

PubMed ID: 9003791

Title: The catalytic subunit of protein phosphatase 2A associates with the translation termination factor eRF1.

PubMed ID: 9003791

DOI: 10.1002/j.1460-2075.1996.tb01107.x

PubMed ID: 10413110

Title: Human release factor eRF1: structural organisation of the unique functional gene on chromosome 5 and of the three processed pseudogenes.

PubMed ID: 10413110

DOI: 10.1016/s0014-5793(99)00795-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 10445876

Title: Mutations in the highly conserved GGQ motif of class 1 polypeptide release factors abolish ability of human eRF1 to trigger peptidyl-tRNA hydrolysis.

PubMed ID: 10445876

DOI: 10.1017/s135583829999043x

PubMed ID: 16777602

Title: In vitro reconstitution of eukaryotic translation reveals cooperativity between release factors eRF1 and eRF3.

PubMed ID: 16777602

DOI: 10.1016/j.cell.2006.04.035

PubMed ID: 18539146

Title: HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1.

PubMed ID: 18539146

DOI: 10.1016/j.febslet.2008.05.045

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19417104

Title: SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.

PubMed ID: 19417104

DOI: 10.1101/gad.1767209

PubMed ID: 20606008

Title: Deficiency in a glutamine-specific methyltransferase for release factor causes mouse embryonic lethality.

PubMed ID: 20606008

DOI: 10.1128/mcb.00218-10

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24486019

Title: Optimal translational termination requires C4 lysyl hydroxylation of eRF1.

PubMed ID: 24486019

DOI: 10.1016/j.molcel.2013.12.028

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26797129

Title: Substrate specificity of the HEMK2 protein glutamine methyltransferase and identification of novel substrates.

PubMed ID: 26797129

DOI: 10.1074/jbc.m115.711952

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30682371

Title: Regulation of HIV-1 Gag-Pol Expression by Shiftless, an Inhibitor of Programmed -1 Ribosomal Frameshifting.

PubMed ID: 30682371

DOI: 10.1016/j.cell.2018.12.030

PubMed ID: 36638793

Title: An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes.

PubMed ID: 36638793

DOI: 10.1016/j.cell.2022.12.025

PubMed ID: 37651229

Title: Drug-induced eRF1 degradation promotes readthrough and reveals a new branch of ribosome quality control.

PubMed ID: 37651229

DOI: 10.1016/j.celrep.2023.113056

PubMed ID: 10676813

Title: The crystal structure of human eukaryotic release factor eRF1 -- mechanism of stop codon recognition and peptidyl-tRNA hydrolysis.

PubMed ID: 10676813

DOI: 10.1016/s0092-8674(00)80667-4

PubMed ID: 17651434

Title: Eukaryotic class 1 translation termination factor eRF1 -- the NMR structure and dynamics of the middle domain involved in triggering ribosome-dependent peptidyl-tRNA hydrolysis.

PubMed ID: 17651434

DOI: 10.1111/j.1742-4658.2007.05949.x

PubMed ID: 19417105

Title: Structural insights into eRF3 and stop codon recognition by eRF1.

PubMed ID: 19417105

DOI: 10.1101/gad.1770109

PubMed ID: 26245381

Title: Structural basis for stop codon recognition in eukaryotes.

PubMed ID: 26245381

DOI: 10.1038/nature14896

PubMed ID: 27863242

Title: Decoding mammalian ribosome-mRNA states by translational GTPase complexes.

PubMed ID: 27863242

DOI: 10.1016/j.cell.2016.10.046

Sequence Information:

  • Length: 437
  • Mass: 49031
  • Checksum: CECC50D100E59D19
  • Sequence:
    • MADDPSAADR NVEIWKIKKL IKSLEAARGN GTSMISLIIP PKDQISRVAK MLADEFGTAS 
NIKSRVNRLS VLGAITSVQQ RLKLYNKVPP NGLVVYCGTI VTEEGKEKKV NIDFEPFKPI 
NTSLYLCDNK FHTEALTALL SDDSKFGFIV IDGSGALFGT LQGNTREVLH KFTVDLPKKH 
GRGGQSALRF ARLRMEKRHN YVRKVAETAV QLFISGDKVN VAGLVLAGSA DFKTELSQSD 
MFDQRLQSKV LKLVDISYGG ENGFNQAIEL STEVLSNVKF IQEKKLIGRY FDEISQDTGK 
YCFGVEDTLK ALEMGAVEIL IVYENLDIMR YVLHCQGTEE EKILYLTPEQ EKDKSHFTDK 
ETGQEHELIE SMPLLEWFAN NYKKFGATLE IVTDKSQEGS QFVKGFGGIG GILRYRVDFQ 
GMEYQGGDDE FFDLDDY

Genular Protein ID: 1216457318

Symbol: B7Z7P8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z7P8

Database IDs:

ARBA 6 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 3 Gene3D 3 GeneTree 1 HGNC 1 InterPro 7 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 2 SMART 2 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 423
  • Mass: 47476
  • Checksum: 2F927D1E6A45A3E4
  • Sequence:
    • MKQDVLNCTE GPIHSNGTSM ISLIIPPKDQ ISRVAKMLAD EFGTASNIKS RVNRLSVLGA 
ITSVQQRLKL YNKVPPNGLV VYCGTIVTEE GKEKKVNIDF EPFKPINTSL YLCDNKFHTE 
ALTALLSDDS KFGFIVIDGS GALFGTLQGN TREVLHKFTV DLPKKHGRGG QSALRFARLR 
MEKRHNYVRK VAETAVQLFI SGDKVNVAGL VLAGSADFKT ELSQSDMFDQ RLQSKVLKLV 
DISYGGENGF NQAIELSTEV LSNVKFIQEK KLIGRYFDEI SQDTGKYCFG VEDTLKALEM 
GAVEILIVYE NLDIMRYVLH CQGTEEEKIL YLTPEQEKDK SHFTDKETGQ EHELIESMPL 
LEWFANNYKK FGATLEIVTD KSQEGSQFVK GFGGIGGILR YRVDFQGMEY QGGDDEFFDL 
DDY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.